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The impaired redox balance in peroxisomes of catalase knockout mice accelerates nonalcoholic fatty liver disease through endoplasmic reticulum stress.

Hwang I, Uddin MJ, Pak ES, Kang H, Jin EJ, Jo S, Kang D, Lee H, Ha H.

Free Radic Biol Med. 2020 Feb 20;148:22-32. doi: 10.1016/j.freeradbiomed.2019.12.025. Epub 2019 Dec 23.


Role of Palliative Care in the Outpatient Management of the Chronic Heart Failure Patient.

Chuzi S, Pak ES, Desai AS, Schaefer KG, Warraich HJ.

Curr Heart Fail Rep. 2019 Dec;16(6):220-228. doi: 10.1007/s11897-019-00440-3. Review.


A large-scale drug screen identifies selective inhibitors of class I HDACs as a potential therapeutic option for SHH medulloblastoma.

Pak E, MacKenzie EL, Zhao X, Pazyra-Murphy MF, Park PMC, Wu L, Shaw DL, Addleson EC, Cayer SS, Lopez BG, Agar NYR, Rubin LL, Qi J, Merk DJ, Segal RA.

Neuro Oncol. 2019 May 16. pii: noz089. doi: 10.1093/neuonc/noz089. [Epub ahead of print]


Chronic high-fat diet decreased detrusor mitochondrial respiration and increased nerve-mediated contractions.

Powers SA, Ryan TE, Pak ES, Fraser MO, McClung JM, Hannan JL.

Neurourol Urodyn. 2019 Aug;38(6):1524-1532. doi: 10.1002/nau.24015. Epub 2019 May 10.


The KRAS-variant and its impact on normal breast epithelial cell biology.

Jung SY, Malhotra P, Nguyen KC, Salzman D, Qi Y, Pak EH, King J, Vlashi E, Ann D, Weidhaas JB.

Cell Death Differ. 2019 Dec;26(12):2568-2576. doi: 10.1038/s41418-019-0320-y. Epub 2019 Apr 1.


Multiomic Profiling Identifies cis-Regulatory Networks Underlying Human Pancreatic β Cell Identity and Function.

Lawlor N, Márquez EJ, Orchard P, Narisu N, Shamim MS, Thibodeau A, Varshney A, Kursawe R, Erdos MR, Kanke M, Gu H, Pak E, Dutra A, Russell S, Li X, Piecuch E, Luo O, Chines PS, Fuchbserger C; NIH Intramural Sequencing Center, Sethupathy P, Aiden AP, Ruan Y, Aiden EL, Collins FS, Ucar D, Parker SCJ, Stitzel ML.

Cell Rep. 2019 Jan 15;26(3):788-801.e6. doi: 10.1016/j.celrep.2018.12.083.


Prostate-Confined Radiation Decreased Pelvic Ganglia Neuronal Survival and Outgrowth.

Powers SA, Odom MR, Pak ES, Moomaw MA, Ashcraft KA, Koontz BF, Hannan JL.

J Sex Med. 2019 Jan;16(1):27-41. doi: 10.1016/j.jsxm.2018.11.010.


Clarifying the Relative Impacts of Vascular and Nerve Injury That Culminate in Erectile Dysfunction in a Pilot Study Using a Rat Model of Prostate Irradiation and a Thrombopoietin Mimetic.

Ashcraft KA, Hannan JL, Eichenbaum G, Zhang X, Pak ES, Faught AM, Patel P, Dewhirst MW, Koontz BF.

Int J Radiat Oncol Biol Phys. 2019 Apr 1;103(5):1212-1220. doi: 10.1016/j.ijrobp.2018.11.064. Epub 2018 Dec 6.


Peroxiredoxin 3 deficiency accelerates chronic kidney injury in mice through interactions between macrophages and tubular epithelial cells.

Hwang I, Uddin MJ, Lee G, Jiang S, Pak ES, Ha H.

Free Radic Biol Med. 2019 Feb 1;131:162-172. doi: 10.1016/j.freeradbiomed.2018.12.002. Epub 2018 Dec 4.


Carbon monoxide releasing molecule-2 protects mice against acute kidney injury through inhibition of ER stress.

Uddin MJ, Pak ES, Ha H.

Korean J Physiol Pharmacol. 2018 Sep;22(5):567-575. doi: 10.4196/kjpp.2018.22.5.567. Epub 2018 Aug 27.


Regulation of the neuropathy-associated Pmp22 gene by a distal super-enhancer.

Pantera H, Moran JJ, Hung HA, Pak E, Dutra A, Svaren J.

Hum Mol Genet. 2018 Aug 15;27(16):2830-2839. doi: 10.1093/hmg/ddy191.


miRNA-431 Prevents Amyloid-β-Induced Synapse Loss in Neuronal Cell Culture Model of Alzheimer's Disease by Silencing Kremen1.

Ross SP, Baker KE, Fisher A, Hoff L, Pak ES, Murashov AK.

Front Cell Neurosci. 2018 Mar 28;12:87. doi: 10.3389/fncel.2018.00087. eCollection 2018.


Enhanced Electrical Field Stimulated Nitrergic and Purinergic Vasoreactivity in Distal vs Proximal Internal Pudendal Arteries.

Odom MR, Pak ES, Brown DA, Hannan JL.

J Sex Med. 2017 Nov;14(11):1285-1296. doi: 10.1016/j.jsxm.2017.09.013.


NLRP3/IL-1β mediates denervation during bladder outlet obstruction in rats.

Lütolf R, Hughes FM Jr, Inouye BM, Jin H, McMains JC, Pak ES, Hannan JL, Purves JT.

Neurourol Urodyn. 2018 Mar;37(3):952-959. doi: 10.1002/nau.23419. Epub 2017 Oct 6.


A Transposon Screen Identifies Loss of Primary Cilia as a Mechanism of Resistance to SMO Inhibitors.

Zhao X, Pak E, Ornell KJ, Pazyra-Murphy MF, MacKenzie EL, Chadwick EJ, Ponomaryov T, Kelleher JF, Segal RA.

Cancer Discov. 2017 Dec;7(12):1436-1449. doi: 10.1158/2159-8290.CD-17-0281. Epub 2017 Sep 18.


First insight into the somatic mutation burden of neurofibromatosis type 2-associated grade I and grade II meningiomas: a case report comprehensive genomic study of two cranial meningiomas with vastly different clinical presentation.

Dewan R, Pemov A, Dutra AS, Pak ED, Edwards NA, Ray-Chaudhury A, Hansen NF, Chandrasekharappa SC, Mullikin JC, Asthagiri AR; NISC Comparative Sequencing Program, Heiss JD, Stewart DR, Germanwala AV.

BMC Cancer. 2017 Feb 13;17(1):127. doi: 10.1186/s12885-017-3127-6.


Membrane Distribution and Activity of a Neuronal Voltage-Gated K+ Channel is Modified by Replacement of Complex Type N-Glycans with Hybrid Type.

Hall MK, Weidner DA, Dayal S, Pak E, Murashov AK, Schwalbe RA.

J Glycobiol. 2017;6(3). pii: 128. doi: 10.4172/2168-958X.1000128. Epub 2017 Oct 31.


Hedgehog Signal Transduction: Key Players, Oncogenic Drivers, and Cancer Therapy.

Pak E, Segal RA.

Dev Cell. 2016 Aug 22;38(4):333-44. doi: 10.1016/j.devcel.2016.07.026. Review.


A new glucocerebrosidase-deficient neuronal cell model provides a tool to probe pathophysiology and therapeutics for Gaucher disease.

Westbroek W, Nguyen M, Siebert M, Lindstrom T, Burnett RA, Aflaki E, Jung O, Tamargo R, Rodriguez-Gil JL, Acosta W, Hendrix A, Behre B, Tayebi N, Fujiwara H, Sidhu R, Renvoise B, Ginns EI, Dutra A, Pak E, Cramer C, Ory DS, Pavan WJ, Sidransky E.

Dis Model Mech. 2016 Jul 1;9(7):769-78. doi: 10.1242/dmm.024588. Epub 2016 May 19.


Multimorbidity and End of Life Care in Patients with Cardiovascular Disease.

Pak E, Wald J, Kirkpatrick JN.

Clin Geriatr Med. 2016 May;32(2):385-97. doi: 10.1016/j.cger.2016.01.005. Review.


Paternal long-term exercise programs offspring for low energy expenditure and increased risk for obesity in mice.

Murashov AK, Pak ES, Koury M, Ajmera A, Jeyakumar M, Parker M, Williams O, Ding J, Walters D, Neufer PD.

FASEB J. 2016 Feb;30(2):775-84. doi: 10.1096/fj.15-274274. Epub 2015 Oct 27.


RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors.

Zhao X, Ponomaryov T, Ornell KJ, Zhou P, Dabral SK, Pak E, Li W, Atwood SX, Whitson RJ, Chang AL, Li J, Oro AE, Chan JA, Kelleher JF, Segal RA.

Cancer Res. 2015 Sep 1;75(17):3623-35. doi: 10.1158/0008-5472.CAN-14-2999-T. Epub 2015 Jun 30.


Juvenile myelomonocytic leukemia due to a germline CBL Y371C mutation: 35-year follow-up of a large family.

Pathak A, Pemov A, McMaster ML, Dewan R, Ravichandran S, Pak E, Dutra A, Lee HJ, Vogt A, Zhang X, Yeager M, Anderson S, Kirby M; NCI DCEG Cancer Genomics Research Laboratory; NCI DCEG Cancer Sequencing Working Group, Caporaso N, Greene MH, Goldin LR, Stewart DR.

Hum Genet. 2015 Jul;134(7):775-87. doi: 10.1007/s00439-015-1550-9. Epub 2015 May 5.


Neurogenic potential of spinal cord organotypic culture.

Glazova MV, Pak ES, Murashov AK.

Neurosci Lett. 2015 May 6;594:60-5. doi: 10.1016/j.neulet.2015.03.041. Epub 2015 Mar 21.


Tandem Duplication of Exons 1-7 Neither Impairs ATP7A Expression Nor Causes a Menkes Disease Phenotype.

Choi EY, Patel K, Haddad MR, Yi L, Holmes C, Goldstein DS, Dutra A, Pak E, Kaler SG.

JIMD Rep. 2015;20:57-63. doi: 10.1007/8904_2014_391. Epub 2015 Feb 1.


Long term maintenance of myeloid leukemic stem cells cultured with unrelated human mesenchymal stromal cells.

Ito S, Barrett AJ, Dutra A, Pak E, Miner S, Keyvanfar K, Hensel NF, Rezvani K, Muranski P, Liu P, Larochelle A, Melenhorst JJ.

Stem Cell Res. 2015 Jan;14(1):95-104. doi: 10.1016/j.scr.2014.11.007. Epub 2014 Dec 6.


Cadmium inhibits neurite outgrowth in differentiating human SH-SY5Y neuroblastoma cells.

Pak EJ, Son GD, Yoo BS.

Int J Toxicol. 2014 Sep-Oct;33(5):412-8. doi: 10.1177/1091581814550338. Epub 2014 Sep 22.


Recent weather extremes and impacts on agricultural production and vector-borne disease outbreak patterns.

Anyamba A, Small JL, Britch SC, Tucker CJ, Pak EW, Reynolds CA, Crutchfield J, Linthicum KJ.

PLoS One. 2014 Mar 21;9(3):e92538. doi: 10.1371/journal.pone.0092538. eCollection 2014.


Generation of a cre recombinase-conditional Nos1ap over-expression transgenic mouse.

Auer DR, Sysa-Shah P, Bedja D, Simmers JL, Pak E, Dutra A, Cohn R, Gabrielson KL, Chakravarti A, Kapoor A.

Biotechnol Lett. 2014 Jun;36(6):1179-85. doi: 10.1007/s10529-014-1473-x. Epub 2014 Feb 22.


Genetics of low spinal muscular atrophy carrier frequency in sub-Saharan Africa.

Sangaré M, Hendrickson B, Sango HA, Chen K, Nofziger J, Amara A, Dutra A, Schindler AB, Guindo A, Traoré M, Harmison G, Pak E, Yaro FN, Bricceno K, Grunseich C, Chen G, Boehm M, Zukosky K, Bocoum N, Meilleur KG, Daou F, Bagayogo K, Coulibaly YI, Diakité M, Fay MP, Lee HS, Saad A, Gribaa M, Singleton AB, Maiga Y, Auh S, Landouré G, Fairhurst RM, Burnett BG, Scholl T, Fischbeck KH.

Ann Neurol. 2014 Apr;75(4):525-32. doi: 10.1002/ana.24114. Epub 2014 Apr 2.


New progenitors NESTIN(g) in the EGL.

Pak E, Segal RA, Stiles CD.

Nat Neurosci. 2013 Dec;16(12):1710-2. doi: 10.1038/nn.3580. No abstract available.


Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities.

Filbin MG, Dabral SK, Pazyra-Murphy MF, Ramkissoon S, Kung AL, Pak E, Chung J, Theisen MA, Sun Y, Franchetti Y, Sun Y, Shulman DS, Redjal N, Tabak B, Beroukhim R, Wang Q, Zhao J, Dorsch M, Buonamici S, Ligon KL, Kelleher JF, Segal RA.

Nat Med. 2013 Nov;19(11):1518-23. doi: 10.1038/nm.3328. Epub 2013 Sep 29.


Cellular calibrators to quantitate T-cell receptor excision circles (TRECs) in clinical samples.

Punwani D, Gonzalez-Espinosa D, Comeau AM, Dutra A, Pak E, Puck J.

Mol Genet Metab. 2012 Nov;107(3):586-91. doi: 10.1016/j.ymgme.2012.09.018. Epub 2012 Sep 21.


Transcription factor zinc finger and BTB domain 1 is essential for lymphocyte development.

Punwani D, Simon K, Choi Y, Dutra A, Gonzalez-Espinosa D, Pak E, Naradikian M, Song CH, Zhang J, Bodine DM, Puck JM.

J Immunol. 2012 Aug 1;189(3):1253-64. doi: 10.4049/jimmunol.1200623. Epub 2012 Jun 29.


Climate teleconnections and recent patterns of human and animal disease outbreaks.

Anyamba A, Linthicum KJ, Small JL, Collins KM, Tucker CJ, Pak EW, Britch SC, Eastman JR, Pinzon JE, Russell KL.

PLoS Negl Trop Dis. 2012 Jan;6(1):e1465. doi: 10.1371/journal.pntd.0001465. Epub 2012 Jan 24.


Mitotic recombination of chromosome arm 17q as a cause of loss of heterozygosity of NF1 in neurofibromatosis type 1-associated glomus tumors.

Stewart DR, Pemov A, Van Loo P, Beert E, Brems H, Sciot R, Claes K, Pak E, Dutra A, Lee CC, Legius E.

Genes Chromosomes Cancer. 2012 May;51(5):429-37. doi: 10.1002/gcc.21928. Epub 2012 Jan 17.


Effect of enrollment in the Program of All-inclusive Care for the Elderly on end-of-life care.

Pak E, Perfetto C, Yu Q, McNabney M.

J Am Geriatr Soc. 2012 Jan;60(1):166-7. doi: 10.1111/j.1532-5415.2011.03745.x. No abstract available.


Dicer-microRNA pathway is critical for peripheral nerve regeneration and functional recovery in vivo and regenerative axonogenesis in vitro.

Wu D, Raafat A, Pak E, Clemens S, Murashov AK.

Exp Neurol. 2012 Jan;233(1):555-65. doi: 10.1016/j.expneurol.2011.11.041. Epub 2011 Dec 8.


Multi-walled carbon nanotubes inhibit regenerative axon growth of dorsal root ganglia neurons of mice.

Wu D, Pak ES, Wingard CJ, Murashov AK.

Neurosci Lett. 2012 Jan 17;507(1):72-7. doi: 10.1016/j.neulet.2011.11.056. Epub 2011 Dec 6.


A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD.

Renton AE, Majounie E, Waite A, Simón-Sánchez J, Rollinson S, Gibbs JR, Schymick JC, Laaksovirta H, van Swieten JC, Myllykangas L, Kalimo H, Paetau A, Abramzon Y, Remes AM, Kaganovich A, Scholz SW, Duckworth J, Ding J, Harmer DW, Hernandez DG, Johnson JO, Mok K, Ryten M, Trabzuni D, Guerreiro RJ, Orrell RW, Neal J, Murray A, Pearson J, Jansen IE, Sondervan D, Seelaar H, Blake D, Young K, Halliwell N, Callister JB, Toulson G, Richardson A, Gerhard A, Snowden J, Mann D, Neary D, Nalls MA, Peuralinna T, Jansson L, Isoviita VM, Kaivorinne AL, Hölttä-Vuori M, Ikonen E, Sulkava R, Benatar M, Wuu J, Chiò A, Restagno G, Borghero G, Sabatelli M; ITALSGEN Consortium, Heckerman D, Rogaeva E, Zinman L, Rothstein JD, Sendtner M, Drepper C, Eichler EE, Alkan C, Abdullaev Z, Pack SD, Dutra A, Pak E, Hardy J, Singleton A, Williams NM, Heutink P, Pickering-Brown S, Morris HR, Tienari PJ, Traynor BJ.

Neuron. 2011 Oct 20;72(2):257-68. doi: 10.1016/j.neuron.2011.09.010. Epub 2011 Sep 21.


MicroRNA machinery responds to peripheral nerve lesion in an injury-regulated pattern.

Wu D, Raafat M, Pak E, Hammond S, Murashov AK.

Neuroscience. 2011 Sep 8;190:386-97. doi: 10.1016/j.neuroscience.2011.06.017. Epub 2011 Jun 12.


Myelodysplasia in autosomal dominant and sporadic monocytopenia immunodeficiency syndrome: diagnostic features and clinical implications.

Calvo KR, Vinh DC, Maric I, Wang W, Noel P, Stetler-Stevenson M, Arthur DC, Raffeld M, Dutra A, Pak E, Myung K, Hsu AP, Hickstein DD, Pittaluga S, Holland SM.

Haematologica. 2011 Aug;96(8):1221-5. doi: 10.3324/haematol.2011.041152. Epub 2011 Apr 20.


The AFHSC-Division of GEIS Operations Predictive Surveillance Program: a multidisciplinary approach for the early detection and response to disease outbreaks.

Witt CJ, Richards AL, Masuoka PM, Foley DH, Buczak AL, Musila LA, Richardson JH, Colacicco-Mayhugh MG, Rueda LM, Klein TA, Anyamba A, Small J, Pavlin JA, Fukuda MM, Gaydos J, Russell KL; AFHSC-GEIS Predictive Surveillance Writing Group, Wilkerson RC, Gibbons RV, Jarman RG, Myint KS, Pendergast B, Lewis S, Pinzon JE, Collins K, Smith M, Pak E, Tucker C, Linthicum K, Myers T, Mansour M, Earhart K, Kim HC, Jiang J, Schnabel D, Clark JW, Sang RC, Kioko E, Abuom DC, Grieco JP, Richards EE, Tobias S, Kasper MR, Montgomery JM, Florin D, Chretien JP, Philip TL.

BMC Public Health. 2011 Mar 4;11 Suppl 2:S10. doi: 10.1186/1471-2458-11-S2-S10. Review.


Minimal evidence for a direct involvement of twisted gastrulation homolog 1 (TWSG1) gene in human holoprosencephaly.

Kauvar EF, Hu P, Pineda-Alvarez DE, Solomon BD, Dutra A, Pak E, Blessing B, Proud V, Shanske AL, Stevens CA, Rosenfeld JA, Shaffer LG, Roessler E, Muenke M.

Mol Genet Metab. 2011 Apr;102(4):470-80. doi: 10.1016/j.ymgme.2010.12.008. Epub 2010 Dec 21.


Embryonic stem cells inhibit expression of erythropoietin in the injured spinal cord.

Glazova M, Hollis S, Pak ES, Murashov AK.

Neurosci Lett. 2011 Jan 13;488(1):55-9. doi: 10.1016/j.neulet.2010.11.002. Epub 2010 Nov 5.


Prediction, assessment of the Rift Valley fever activity in East and Southern Africa 2006-2008 and possible vector control strategies.

Anyamba A, Linthicum KJ, Small J, Britch SC, Pak E, de La Rocque S, Formenty P, Hightower AW, Breiman RF, Chretien JP, Tucker CJ, Schnabel D, Sang R, Haagsma K, Latham M, Lewandowski HB, Magdi SO, Mohamed MA, Nguku PM, Reynes JM, Swanepoel R.

Am J Trop Med Hyg. 2010 Aug;83(2 Suppl):43-51. doi: 10.4269/ajtmh.2010.09-0289.


Nuclear bud formation: a novel manifestation of Zidovudine genotoxicity.

Dutra A, Pak E, Wincovitch S, John K, Poirier MC, Olivero OA.

Cytogenet Genome Res. 2010;128(1-3):105-10. doi: 10.1159/000298794. Epub 2010 Apr 20.


Species composition, larval habitats, seasonal occurrence and distribution of potential malaria vectors and associated species of Anopheles (Diptera: Culicidae) from the Republic of Korea.

Rueda LM, Brown TL, Kim HC, Chong ST, Klein TA, Foley DH, Anyamba A, Smith M, Pak EP, Wilkerson RC.

Malar J. 2010 Feb 17;9:55. doi: 10.1186/1475-2875-9-55.


DNA damage responses by human ELG1 in S phase are important to maintain genomic integrity.

Sikdar N, Banerjee S, Lee KY, Wincovitch S, Pak E, Nakanishi K, Jasin M, Dutra A, Myung K.

Cell Cycle. 2009 Oct 1;8(19):3199-207. Epub 2009 Oct 7.


TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans.

Washington AV, Gibot S, Acevedo I, Gattis J, Quigley L, Feltz R, De La Mota A, Schubert RL, Gomez-Rodriguez J, Cheng J, Dutra A, Pak E, Chertov O, Rivera L, Morales J, Lubkowski J, Hunter R, Schwartzberg PL, McVicar DW.

J Clin Invest. 2009 Jun;119(6):1489-501. doi: 10.1172/JCI36175. Epub 2009 May 11.

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