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Inhibition of Polo-like kinase 2 ameliorates pathogenesis in Alzheimer's disease model mice.

Lee JS, Lee Y, André EA, Lee KJ, Nguyen T, Feng Y, Jia N, Harris BT, Burns MP, Pak DTS.

PLoS One. 2019 Jul 15;14(7):e0219691. doi: 10.1371/journal.pone.0219691. eCollection 2019.


What goes up must come down: homeostatic synaptic plasticity strategies in neurological disease.

André EA, Forcelli PA, Pak DT.

Future Neurol. 2018 Feb;13(1):13-21. doi: 10.2217/fnl-2017-0028. Epub 2018 Jan 17. Review.


Divergent effects of levetiracetam and tiagabine against spontaneous seizures in adult rats following neonatal hypoxia.

Dunn R, Queenan BN, Pak DTS, Forcelli PA.

Epilepsy Res. 2018 Feb;140:1-7. doi: 10.1016/j.eplepsyres.2017.12.006. Epub 2017 Dec 5.


Kappa opioid receptors regulate hippocampal synaptic homeostasis and epileptogenesis.

Queenan BN, Dunn RL, Santos VR, Feng Y, Huizenga MN, Hammack RJ, Vicini S, Forcelli PA, Pak DTS.

Epilepsia. 2018 Jan;59(1):106-122. doi: 10.1111/epi.13941. Epub 2017 Nov 8.


Polo-like kinase 2 phosphorylation of amyloid precursor protein regulates activity-dependent amyloidogenic processing.

Lee Y, Lee JS, Lee KJ, Turner RS, Hoe HS, Pak DTS.

Neuropharmacology. 2017 May 1;117:387-400. doi: 10.1016/j.neuropharm.2017.02.027. Epub 2017 Mar 1.


A Mercaptoacetamide-Based Class II Histone Deacetylase Inhibitor Increases Dendritic Spine Density via RasGRF1/ERK Pathway.

Song JM, Sung YM, Nam JH, Yoon H, Chung A, Moffat E, Jung M, Pak DT, Kim J, Hoe HS.

J Alzheimers Dis. 2016;51(2):591-604. doi: 10.3233/JAD-150717.


Mapping homeostatic synaptic plasticity using cable properties of dendrites.

Queenan BN, Lee KJ, Tan H, Huganir RL, Vicini S, Pak DT.

Neuroscience. 2016 Feb 19;315:206-16. doi: 10.1016/j.neuroscience.2015.12.017. Epub 2015 Dec 14.


Hexa (ethylene glycol) derivative of benzothiazole aniline promotes dendritic spine formation through the RasGRF1-Ras dependent pathway.

Lee NJ, Song JM, Cho HJ, Sung YM, Lee T, Chung A, Hong SH, Cifelli JL, Rubinshtein M, Habib LK, Capule CC, Turner RS, Pak DT, Yang J, Hoe HS.

Biochim Biophys Acta. 2016 Feb;1862(2):284-95. doi: 10.1016/j.bbadis.2015.12.007. Epub 2015 Dec 8.


Evidence for glycinergic GluN1/GluN3 NMDA receptors in hippocampal metaplasticity.

Rozeboom AM, Queenan BN, Partridge JG, Farnham C, Wu JY, Vicini S, Pak DT.

Neurobiol Learn Mem. 2015 Nov;125:265-73. doi: 10.1016/j.nlm.2015.10.005. Epub 2015 Oct 19.


Synapses need coordination to learn motor skills.

Lee KJ, Rhyu IJ, Pak DT.

Rev Neurosci. 2014;25(2):223-30. doi: 10.1515/revneuro-2013-0068. Review.


A tetra(ethylene glycol) derivative of benzothiazole aniline ameliorates dendritic spine density and cognitive function in a mouse model of Alzheimer's disease.

Song JM, DiBattista AM, Sung YM, Ahn JM, Turner RS, Yang J, Pak DT, Lee HK, Hoe HS.

Exp Neurol. 2014 Feb;252:105-13. doi: 10.1016/j.expneurol.2013.11.023. Epub 2013 Dec 6.


Antihypertensive drug Valsartan promotes dendritic spine density by altering AMPA receptor trafficking.

Sohn YI, Lee NJ, Chung A, Saavedra JM, Scott Turner R, Pak DT, Hoe HS.

Biochem Biophys Res Commun. 2013 Oct 4;439(4):464-70. doi: 10.1016/j.bbrc.2013.08.091. Epub 2013 Sep 6.


Motor skill training induces coordinated strengthening and weakening between neighboring synapses.

Lee KJ, Park IS, Kim H, Greenough WT, Pak DT, Rhyu IJ.

J Neurosci. 2013 Jun 5;33(23):9794-9. doi: 10.1523/JNEUROSCI.0848-12.2013.


A tetra(ethylene glycol) derivative of benzothiazole aniline enhances Ras-mediated spinogenesis.

Megill A, Lee T, DiBattista AM, Song JM, Spitzer MH, Rubinshtein M, Habib LK, Capule CC, Mayer M, Turner RS, Kirkwood A, Yang J, Pak DT, Lee HK, Hoe HS.

J Neurosci. 2013 May 29;33(22):9306-18. doi: 10.1523/JNEUROSCI.1615-12.2013. Erratum in: J Neurosci. 2014 Oct 1;34(40):13567.


Mossy fiber-CA3 synapses mediate homeostatic plasticity in mature hippocampal neurons.

Lee KJ, Queenan BN, Rozeboom AM, Bellmore R, Lim ST, Vicini S, Pak DT.

Neuron. 2013 Jan 9;77(1):99-114. doi: 10.1016/j.neuron.2012.10.033.


GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling.

Shin SM, Zhang N, Hansen J, Gerges NZ, Pak DT, Sheng M, Lee SH.

Nat Neurosci. 2012 Dec;15(12):1655-66. doi: 10.1038/nn.3259. Epub 2012 Nov 11.


Wherefore art thou, homeo(stasis)? Functional diversity in homeostatic synaptic plasticity.

Queenan BN, Lee KJ, Pak DT.

Neural Plast. 2012;2012:718203. doi: 10.1155/2012/718203. Epub 2012 May 17. Review.


FE65 as a link between VLDLR and APP to regulate their trafficking and processing.

Dumanis SB, Chamberlain KA, Jin Sohn Y, Jin Lee Y, Guénette SY, Suzuki T, Mathews PM, Pak DTs, Rebeck GW, Suh YH, Park HS, Hoe HS.

Mol Neurodegener. 2012 Mar 19;7:9. doi: 10.1186/1750-1326-7-9.


Identification and functional characterization of polo-like kinase 2 autoregulatory sites.

Rozeboom AM, Pak DT.

Neuroscience. 2012 Jan 27;202:147-57. doi: 10.1016/j.neuroscience.2011.11.003. Epub 2011 Nov 11.


Decreased dendritic spine density and abnormal spine morphology in Fyn knockout mice.

Babus LW, Little EM, Keenoy KE, Minami SS, Chen E, Song JM, Caviness J, Koo SY, Pak DT, Rebeck GW, Turner RS, Hoe HS.

Brain Res. 2011 Sep 30;1415:96-102. doi: 10.1016/j.brainres.2011.07.059. Epub 2011 Aug 5.


Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density.

Rogers JT, Rusiana I, Trotter J, Zhao L, Donaldson E, Pak DT, Babus LW, Peters M, Banko JL, Chavis P, Rebeck GW, Hoe HS, Weeber EJ.

Learn Mem. 2011 Aug 18;18(9):558-64. doi: 10.1101/lm.2153511. Print 2011 Sep.


Plk2 Raps up Ras to subdue synapses.

Lee KJ, Hoe HS, Pak DT.

Small GTPases. 2011 May;2(3):162-166.


Requirement for Plk2 in orchestrated ras and rap signaling, homeostatic structural plasticity, and memory.

Lee KJ, Lee Y, Rozeboom A, Lee JY, Udagawa N, Hoe HS, Pak DT.

Neuron. 2011 Mar 10;69(5):957-73. doi: 10.1016/j.neuron.2011.02.004.


ApoE receptor 2 regulates synapse and dendritic spine formation.

Dumanis SB, Cha HJ, Song JM, Trotter JH, Spitzer M, Lee JY, Weeber EJ, Turner RS, Pak DT, Rebeck GW, Hoe HS.

PLoS One. 2011 Feb 15;6(2):e17203. doi: 10.1371/journal.pone.0017203.


The upside of APP at synapses.

Hoe HS, Lee HK, Pak DT.

CNS Neurosci Ther. 2012 Jan;18(1):47-56. doi: 10.1111/j.1755-5949.2010.00221.x. Epub 2010 Dec 27. Review.


Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation.

Evers DM, Matta JA, Hoe HS, Zarkowsky D, Lee SH, Isaac JT, Pak DT.

Nat Neurosci. 2010 Oct;13(10):1199-207. doi: 10.1038/nn.2624. Epub 2010 Aug 29.


Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines.

Lee KJ, Moussa CE, Lee Y, Sung Y, Howell BW, Turner RS, Pak DT, Hoe HS.

Neuroscience. 2010 Aug 11;169(1):344-56. doi: 10.1016/j.neuroscience.2010.04.078. Epub 2010 May 6.


ApoE mimetic peptide decreases Abeta production in vitro and in vivo.

Minami SS, Cordova A, Cirrito JR, Tesoriero JA, Babus LW, Davis GC, Dakshanamurthy S, Turner RS, Pak DTs, Rebeck GW, Paige M, Hoe HS.

Mol Neurodegener. 2010 Apr 20;5:16. doi: 10.1186/1750-1326-5-16.


Postsynaptic PDLIM5/Enigma Homolog binds SPAR and causes dendritic spine shrinkage.

Herrick S, Evers DM, Lee JY, Udagawa N, Pak DT.

Mol Cell Neurosci. 2010 Feb;43(2):188-200. doi: 10.1016/j.mcn.2009.10.009. Epub 2009 Nov 10.


The cytoplasmic adaptor protein X11alpha and extracellular matrix protein Reelin regulate ApoE receptor 2 trafficking and cell movement.

Minami SS, Sung YM, Dumanis SB, Chi SH, Burns MP, Ann EJ, Suzuki T, Turner RS, Park HS, Pak DT, Rebeck GW, Hoe HS.

FASEB J. 2010 Jan;24(1):58-69. doi: 10.1096/fj.09-138123. Epub 2009 Aug 31.


Interaction of reelin with amyloid precursor protein promotes neurite outgrowth.

Hoe HS, Lee KJ, Carney RS, Lee J, Markova A, Lee JY, Howell BW, Hyman BT, Pak DT, Bu G, Rebeck GW.

J Neurosci. 2009 Jun 10;29(23):7459-73. doi: 10.1523/JNEUROSCI.4872-08.2009.


Hippocampal spine-associated Rap-specific GTPase-activating protein induces enhancement of learning and memory in postnatally hypoxia-exposed mice.

Lu XJ, Chen XQ, Weng J, Zhang HY, Pak DT, Luo JH, Du JZ.

Neuroscience. 2009 Aug 18;162(2):404-14. doi: 10.1016/j.neuroscience.2009.05.011. Epub 2009 May 12.


Combinatorial morphogenesis of dendritic spines and filopodia by SPAR and alpha-actinin2.

Hoe HS, Lee JY, Pak DT.

Biochem Biophys Res Commun. 2009 Jun 19;384(1):55-60. doi: 10.1016/j.bbrc.2009.04.069. Epub 2009 Apr 23.


The effects of amyloid precursor protein on postsynaptic composition and activity.

Hoe HS, Fu Z, Makarova A, Lee JY, Lu C, Feng L, Pajoohesh-Ganji A, Matsuoka Y, Hyman BT, Ehlers MD, Vicini S, Pak DT, Rebeck GW.

J Biol Chem. 2009 Mar 27;284(13):8495-506. doi: 10.1074/jbc.M900141200. Epub 2009 Jan 21.


Cortical injury increases cholesterol 24S hydroxylase (Cyp46) levels in the rat brain.

Cartagena CM, Ahmed F, Burns MP, Pajoohesh-Ganji A, Pak DT, Faden AI, Rebeck GW.

J Neurotrauma. 2008 Sep;25(9):1087-98. doi: 10.1089/neu.2007.0444.


Critical role of CDK5 and Polo-like kinase 2 in homeostatic synaptic plasticity during elevated activity.

Seeburg DP, Feliu-Mojer M, Gaiottino J, Pak DT, Sheng M.

Neuron. 2008 May 22;58(4):571-83. doi: 10.1016/j.neuron.2008.03.021.


The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases.

Richter M, Murai KK, Bourgin C, Pak DT, Pasquale EB.

J Neurosci. 2007 Dec 19;27(51):14205-15.


The metalloprotease inhibitor TIMP-3 regulates amyloid precursor protein and apolipoprotein E receptor proteolysis.

Hoe HS, Cooper MJ, Burns MP, Lewis PA, van der Brug M, Chakraborty G, Cartagena CM, Pak DT, Cookson MR, Rebeck GW.

J Neurosci. 2007 Oct 3;27(40):10895-905.


Differential roles of Rap1 and Rap2 small GTPases in neurite retraction and synapse elimination in hippocampal spiny neurons.

Fu Z, Lee SH, Simonetta A, Hansen J, Sheng M, Pak DT.

J Neurochem. 2007 Jan;100(1):118-31.


LAR receptor protein tyrosine phosphatases in the development and maintenance of excitatory synapses.

Dunah AW, Hueske E, Wyszynski M, Hoogenraad CC, Jaworski J, Pak DT, Simonetta A, Liu G, Sheng M.

Nat Neurosci. 2005 Apr;8(4):458-67. Epub 2005 Mar 6.


Targeted protein degradation and synapse remodeling by an inducible protein kinase.

Pak DT, Sheng M.

Science. 2003 Nov 21;302(5649):1368-73. Epub 2003 Oct 23.


Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP.

Pak DT, Yang S, Rudolph-Correia S, Kim E, Sheng M.

Neuron. 2001 Aug 2;31(2):289-303.


Ligand-gated ion channel interactions with cytoskeletal and signaling proteins.

Sheng M, Pak DT.

Annu Rev Physiol. 2000;62:755-78. Review.


Glutamate receptor anchoring proteins and the molecular organization of excitatory synapses.

Sheng M, Pak DT.

Ann N Y Acad Sci. 1999 Apr 30;868:483-93.


Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotes.

Pak DT, Pflumm M, Chesnokov I, Huang DW, Kellum R, Marr J, Romanowski P, Botchan MR.

Cell. 1997 Oct 31;91(3):311-23.


Drosophila Homolog of Yeast ORC: Correction.

Gossen M, Pak DT, Botchan MR.

Science. 1996 Mar 8;271(5254):1349b. No abstract available.


Drosophila homolog of yeast ORC: correction.

Gossen M, Pak DT, Botchan MR.

Science. 1996 Mar 8;271(5254):1349. No abstract available.


A Drosophila homolog of the yeast origin recognition complex.

Gossen M, Pak DT, Hansen SK, Acharya JK, Botchan MR.

Science. 1995 Dec 8;270(5242):1674-7. Erratum in: Science. 1996 Mar 8;271(5254):1349.


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