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Items: 33

1.

Mechanisms of Fibrosis Development in NASH.

Schwabe RF, Tabas I, Pajvani UB.

Gastroenterology. 2020 Feb 7. pii: S0016-5085(20)30169-4. doi: 10.1053/j.gastro.2019.11.311. [Epub ahead of print]

PMID:
32044315
2.

Dietary Saturated Fat Promotes Arrhythmia by Activating NOX2 (NADPH Oxidase 2).

Joseph LC, Avula UMR, Wan EY, Reyes MV, Lakkadi KR, Subramanyam P, Nakanishi K, Homma S, Muchir A, Pajvani UB, Thorp EB, Reiken SR, Marks AR, Colecraft HM, Morrow JP.

Circ Arrhythm Electrophysiol. 2019 Nov;12(11):e007573. doi: 10.1161/CIRCEP.119.007573. Epub 2019 Oct 31.

PMID:
31665913
3.

Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis.

Zhu C, Kim K, Wang X, Bartolome A, Salomao M, Dongiovanni P, Meroni M, Graham MJ, Yates KP, Diehl AM, Schwabe RF, Tabas I, Valenti L, Lavine JE, Pajvani UB.

Sci Transl Med. 2018 Nov 21;10(468). pii: eaat0344. doi: 10.1126/scitranslmed.aat0344.

4.

Notch signaling dynamically regulates adult β cell proliferation and maturity.

Bartolome A, Zhu C, Sussel L, Pajvani UB.

J Clin Invest. 2019 Jan 2;129(1):268-280. doi: 10.1172/JCI98098. Epub 2018 Dec 3.

5.

γ-Secretase Inhibition Lowers Plasma Triglyceride-Rich Lipoproteins by Stabilizing the LDL Receptor.

Kim K, Goldberg IJ, Graham MJ, Sundaram M, Bertaggia E, Lee SX, Qiang L, Haeusler RA, Metzger D, Chambon P, Yao Z, Ginsberg HN, Pajvani UB.

Cell Metab. 2018 Apr 3;27(4):816-827.e4. doi: 10.1016/j.cmet.2018.02.010. Epub 2018 Mar 22.

6.

Pathophysiology of drug induced weight and metabolic effects: findings from an RCT in healthy volunteers treated with olanzapine, iloperidone, or placebo.

Ballon JS, Pajvani UB, Mayer LE, Freyberg Z, Freyberg R, Contreras I, Rosenbaum M, Leibel RL, Lieberman JA.

J Psychopharmacol. 2018 May;32(5):533-540. doi: 10.1177/0269881118754708. Epub 2018 Feb 15.

7.

MTORC1 Regulates both General Autophagy and Mitophagy Induction after Oxidative Phosphorylation Uncoupling.

Bartolomé A, García-Aguilar A, Asahara SI, Kido Y, Guillén C, Pajvani UB, Benito M.

Mol Cell Biol. 2017 Nov 13;37(23). pii: e00441-17. doi: 10.1128/MCB.00441-17. Print 2017 Dec 1.

8.

Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis.

Kim K, Ryu D, Dongiovanni P, Ozcan L, Nayak S, Ueberheide B, Valenti L, Auwerx J, Pajvani UB.

Gastroenterology. 2017 Dec;153(6):1568-1580.e10. doi: 10.1053/j.gastro.2017.08.039. Epub 2017 Aug 30.

9.

"Free" Raptor - a novel regulator of metabolism.

Kim K, Pajvani UB.

Cell Cycle. 2016 May 2;15(9):1174-5. doi: 10.1080/15384101.2016.1159835. No abstract available.

10.

Adipocyte-specific blockade of gamma-secretase, but not inhibition of Notch activity, reduces adipose insulin sensitivity.

Sparling DP, Yu J, Kim K, Zhu C, Brachs S, Birkenfeld AL, Pajvani UB.

Mol Metab. 2015 Dec 2;5(2):113-121. doi: 10.1016/j.molmet.2015.11.006. eCollection 2016 Feb.

11.

mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2.

Kim K, Qiang L, Hayden MS, Sparling DP, Purcell NH, Pajvani UB.

Nat Commun. 2016 Jan 8;7:10255. doi: 10.1038/ncomms10255.

12.

Hypoglycemia Secondary to Sulfonylurea Ingestion in a Patient with End Stage Renal Disease: Results from a 72-Hour Fast.

Abraham A, Rubin M, Accili D, Bilezikian JP, Pajvani UB.

Case Rep Endocrinol. 2015;2015:742781. doi: 10.1155/2015/742781. Epub 2015 Nov 17.

13.

Erratum to: The new biology of diabetes.

Pajvani UB, Accili D.

Diabetologia. 2015 Nov;58(11):2683. doi: 10.1007/s00125-015-3758-6. No abstract available.

PMID:
26376798
14.

The new biology of diabetes.

Pajvani UB, Accili D.

Diabetologia. 2015 Nov;58(11):2459-68. doi: 10.1007/s00125-015-3722-5. Epub 2015 Aug 7. Review. Erratum in: Diabetologia. 2015 Nov;58(11):2683.

15.

Calcitonin-secreting pancreatic neuroendocrine tumors: a case report and review of the literature.

Kováčová M, Filková M, Potočárová M, Kiňová S, Pajvani UB.

Endocr Pract. 2014 Aug;20(8):e140-4. doi: 10.4158/EP13505.CR.

PMID:
24793921
16.

Hepatic notch signaling correlates with insulin resistance and nonalcoholic fatty liver disease.

Valenti L, Mendoza RM, Rametta R, Maggioni M, Kitajewski C, Shawber CJ, Pajvani UB.

Diabetes. 2013 Dec;62(12):4052-62. doi: 10.2337/db13-0769. Epub 2013 Aug 29.

17.

Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability.

Pajvani UB, Qiang L, Kangsamaksin T, Kitajewski J, Ginsberg HN, Accili D.

Nat Med. 2013 Aug;19(8):1054-60. doi: 10.1038/nm.3259. Epub 2013 Jul 7.

18.

Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner.

Pajvani UB, Shawber CJ, Samuel VT, Birkenfeld AL, Shulman GI, Kitajewski J, Accili D.

Nat Med. 2011 Jul 31;17(8):961-7. doi: 10.1038/nm.2378.

20.

Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists.

Nawrocki AR, Rajala MW, Tomas E, Pajvani UB, Saha AK, Trumbauer ME, Pang Z, Chen AS, Ruderman NB, Chen H, Rossetti L, Scherer PE.

J Biol Chem. 2006 Feb 3;281(5):2654-60. Epub 2005 Dec 2.

21.

Apoptosis through targeted activation of caspase 8 ("ATTAC-mice"): novel mouse models of inducible and reversible tissue ablation.

Trujillo ME, Pajvani UB, Scherer PE.

Cell Cycle. 2005 Sep;4(9):1141-5. Epub 2005 Sep 11.

PMID:
16096375
22.

Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy.

Pajvani UB, Trujillo ME, Combs TP, Iyengar P, Jelicks L, Roth KA, Kitsis RN, Scherer PE.

Nat Med. 2005 Jul;11(7):797-803. Epub 2005 Jun 19.

PMID:
15965483
23.

Adiponectin: a relevant player in PPARgamma-agonist-mediated improvements in hepatic insulin sensitivity?

Bouskila M, Pajvani UB, Scherer PE.

Int J Obes (Lond). 2005 Mar;29 Suppl 1:S17-23. Review.

PMID:
15711577
24.

Thiazolidinediones improve insulin sensitivity in adipose tissue and reduce the hyperlipidaemia without affecting the hyperglycaemia in a transgenic model of type 2 diabetes.

Kim H, Haluzik M, Gavrilova O, Yakar S, Portas J, Sun H, Pajvani UB, Scherer PE, LeRoith D.

Diabetologia. 2004 Dec;47(12):2215-25. Epub 2004 Dec 15.

PMID:
15662559
25.

Regulation of resistin expression and circulating levels in obesity, diabetes, and fasting.

Rajala MW, Qi Y, Patel HR, Takahashi N, Banerjee R, Pajvani UB, Sinha MK, Gingerich RL, Scherer PE, Ahima RS.

Diabetes. 2004 Jul;53(7):1671-9.

26.

Mechanisms of early insulin-sensitizing effects of thiazolidinediones in type 2 diabetes.

Tonelli J, Li W, Kishore P, Pajvani UB, Kwon E, Weaver C, Scherer PE, Hawkins M.

Diabetes. 2004 Jun;53(6):1621-9. Erratum in: Diabetes. 2005 Feb;54(2):587.

27.

Adiponectin acts in the brain to decrease body weight.

Qi Y, Takahashi N, Hileman SM, Patel HR, Berg AH, Pajvani UB, Scherer PE, Ahima RS.

Nat Med. 2004 May;10(5):524-9. Epub 2004 Apr 11. Erratum in: Nat Med. 2004 Jun;10(6):649.

PMID:
15077108
28.

Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity.

Pajvani UB, Hawkins M, Combs TP, Rajala MW, Doebber T, Berger JP, Wagner JA, Wu M, Knopps A, Xiang AH, Utzschneider KM, Kahn SE, Olefsky JM, Buchanan TA, Scherer PE.

J Biol Chem. 2004 Mar 26;279(13):12152-62. Epub 2003 Dec 29.

29.

A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity.

Combs TP, Pajvani UB, Berg AH, Lin Y, Jelicks LA, Laplante M, Nawrocki AR, Rajala MW, Parlow AF, Cheeseboro L, Ding YY, Russell RG, Lindemann D, Hartley A, Baker GR, Obici S, Deshaies Y, Ludgate M, Rossetti L, Scherer PE.

Endocrinology. 2004 Jan;145(1):367-83. Epub 2003 Oct 23.

PMID:
14576179
30.

Adiponectin: systemic contributor to insulin sensitivity.

Pajvani UB, Scherer PE.

Curr Diab Rep. 2003 Jun;3(3):207-13. Review.

PMID:
12762967
31.

Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity.

Pajvani UB, Du X, Combs TP, Berg AH, Rajala MW, Schulthess T, Engel J, Brownlee M, Scherer PE.

J Biol Chem. 2003 Mar 14;278(11):9073-85. Epub 2002 Dec 20.

32.

Colorimetric analysis of surface reactive amino groups on poly(lactic acid-co-lysine):poly(lactic acid) blends.

Cook AD, Pajvani UB, Hrkach JS, Cannizzaro SM, Langer R.

Biomaterials. 1997 Nov;18(21):1417-24.

PMID:
9375843
33.

Characterization and development of RGD-peptide-modified poly(lactic acid-co-lysine) as an interactive, resorbable biomaterial.

Cook AD, Hrkach JS, Gao NN, Johnson IM, Pajvani UB, Cannizzaro SM, Langer R.

J Biomed Mater Res. 1997 Jun 15;35(4):513-23.

PMID:
9189829

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