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Items: 44

1.

Dietary Saturated Fat Promotes Arrhythmia by Activating NOX2 (NADPH Oxidase 2).

Joseph LC, Avula UMR, Wan EY, Reyes MV, Lakkadi KR, Subramanyam P, Nakanishi K, Homma S, Muchir A, Pajvani UB, Thorp EB, Reiken SR, Marks AR, Colecraft HM, Morrow JP.

Circ Arrhythm Electrophysiol. 2019 Nov;12(11):e007573. doi: 10.1161/CIRCEP.119.007573. Epub 2019 Oct 31.

PMID:
31665913
2.

Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis.

Zhu C, Kim K, Wang X, Bartolome A, Salomao M, Dongiovanni P, Meroni M, Graham MJ, Yates KP, Diehl AM, Schwabe RF, Tabas I, Valenti L, Lavine JE, Pajvani UB.

Sci Transl Med. 2018 Nov 21;10(468). pii: eaat0344. doi: 10.1126/scitranslmed.aat0344.

3.

Notch signaling dynamically regulates adult β cell proliferation and maturity.

Bartolome A, Zhu C, Sussel L, Pajvani UB.

J Clin Invest. 2019 Jan 2;129(1):268-280. doi: 10.1172/JCI98098. Epub 2018 Dec 3.

4.

γ-Secretase Inhibition Lowers Plasma Triglyceride-Rich Lipoproteins by Stabilizing the LDL Receptor.

Kim K, Goldberg IJ, Graham MJ, Sundaram M, Bertaggia E, Lee SX, Qiang L, Haeusler RA, Metzger D, Chambon P, Yao Z, Ginsberg HN, Pajvani UB.

Cell Metab. 2018 Apr 3;27(4):816-827.e4. doi: 10.1016/j.cmet.2018.02.010. Epub 2018 Mar 22.

5.

Pathophysiology of drug induced weight and metabolic effects: findings from an RCT in healthy volunteers treated with olanzapine, iloperidone, or placebo.

Ballon JS, Pajvani UB, Mayer LE, Freyberg Z, Freyberg R, Contreras I, Rosenbaum M, Leibel RL, Lieberman JA.

J Psychopharmacol. 2018 May;32(5):533-540. doi: 10.1177/0269881118754708. Epub 2018 Feb 15.

PMID:
29444618
6.

MTORC1 Regulates both General Autophagy and Mitophagy Induction after Oxidative Phosphorylation Uncoupling.

Bartolomé A, García-Aguilar A, Asahara SI, Kido Y, Guillén C, Pajvani UB, Benito M.

Mol Cell Biol. 2017 Nov 13;37(23). pii: e00441-17. doi: 10.1128/MCB.00441-17. Print 2017 Dec 1.

7.

Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis.

Kim K, Ryu D, Dongiovanni P, Ozcan L, Nayak S, Ueberheide B, Valenti L, Auwerx J, Pajvani UB.

Gastroenterology. 2017 Dec;153(6):1568-1580.e10. doi: 10.1053/j.gastro.2017.08.039. Epub 2017 Aug 30.

8.

Correction: Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes.

Joseph LC, Barca E, Subramanyam P, Komrowski M, Pajvani U, Colecraft HM, Hirano M, Morrow JP.

PLoS One. 2017 Mar 20;12(3):e0174525. doi: 10.1371/journal.pone.0174525. eCollection 2017.

9.

Nonalcoholic fatty liver disease: cause or consequence of type 2 diabetes?

Valenti L, Bugianesi E, Pajvani U, Targher G.

Liver Int. 2016 Nov;36(11):1563-1579. doi: 10.1111/liv.13185. Epub 2016 Jun 30. Review.

10.

"Free" Raptor - a novel regulator of metabolism.

Kim K, Pajvani UB.

Cell Cycle. 2016 May 2;15(9):1174-5. doi: 10.1080/15384101.2016.1159835. No abstract available.

11.

Adipocyte-specific blockade of gamma-secretase, but not inhibition of Notch activity, reduces adipose insulin sensitivity.

Sparling DP, Yu J, Kim K, Zhu C, Brachs S, Birkenfeld AL, Pajvani UB.

Mol Metab. 2015 Dec 2;5(2):113-121. doi: 10.1016/j.molmet.2015.11.006. eCollection 2016 Feb.

12.

Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes.

Joseph LC, Barca E, Subramanyam P, Komrowski M, Pajvani U, Colecraft HM, Hirano M, Morrow JP.

PLoS One. 2016 Jan 12;11(1):e0145750. doi: 10.1371/journal.pone.0145750. eCollection 2016. Erratum in: PLoS One. 2017 Mar 20;12 (3):e0174525.

13.

mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2.

Kim K, Qiang L, Hayden MS, Sparling DP, Purcell NH, Pajvani UB.

Nat Commun. 2016 Jan 8;7:10255. doi: 10.1038/ncomms10255.

14.

Hypoglycemia Secondary to Sulfonylurea Ingestion in a Patient with End Stage Renal Disease: Results from a 72-Hour Fast.

Abraham A, Rubin M, Accili D, Bilezikian JP, Pajvani UB.

Case Rep Endocrinol. 2015;2015:742781. doi: 10.1155/2015/742781. Epub 2015 Nov 17.

15.

Erratum to: The new biology of diabetes.

Pajvani UB, Accili D.

Diabetologia. 2015 Nov;58(11):2683. doi: 10.1007/s00125-015-3758-6. No abstract available.

PMID:
26376798
16.

The new biology of diabetes.

Pajvani UB, Accili D.

Diabetologia. 2015 Nov;58(11):2459-68. doi: 10.1007/s00125-015-3722-5. Epub 2015 Aug 7. Review. Erratum in: Diabetologia. 2015 Nov;58(11):2683.

17.

Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions.

Qiang L, Kon N, Zhao W, Jiang L, Knight CM, Welch C, Pajvani U, Gu W, Accili D.

Cell Rep. 2015 Jun 23;11(11):1797-808. doi: 10.1016/j.celrep.2015.05.025. Epub 2015 Jun 11.

18.

Molecular pathophysiology of metabolic effects of antipsychotic medications.

Ballon JS, Pajvani U, Freyberg Z, Leibel RL, Lieberman JA.

Trends Endocrinol Metab. 2014 Nov;25(11):593-600. doi: 10.1016/j.tem.2014.07.004. Epub 2014 Sep 2. Review.

PMID:
25190097
19.

Calcitonin-secreting pancreatic neuroendocrine tumors: a case report and review of the literature.

Kováčová M, Filková M, Potočárová M, Kiňová S, Pajvani UB.

Endocr Pract. 2014 Aug;20(8):e140-4. doi: 10.4158/EP13505.CR.

PMID:
24793921
20.

Hepatic notch signaling correlates with insulin resistance and nonalcoholic fatty liver disease.

Valenti L, Mendoza RM, Rametta R, Maggioni M, Kitajewski C, Shawber CJ, Pajvani UB.

Diabetes. 2013 Dec;62(12):4052-62. doi: 10.2337/db13-0769. Epub 2013 Aug 29.

21.

Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability.

Pajvani UB, Qiang L, Kangsamaksin T, Kitajewski J, Ginsberg HN, Accili D.

Nat Med. 2013 Aug;19(8):1054-60. doi: 10.1038/nm.3259. Epub 2013 Jul 7.

22.

Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity.

Ozcan L, Wong CC, Li G, Xu T, Pajvani U, Park SK, Wronska A, Chen BX, Marks AR, Fukamizu A, Backs J, Singer HA, Yates JR 3rd, Accili D, Tabas I.

Cell Metab. 2012 May 2;15(5):739-51. doi: 10.1016/j.cmet.2012.03.002. Epub 2012 Apr 12.

23.

Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner.

Pajvani UB, Shawber CJ, Samuel VT, Birkenfeld AL, Shulman GI, Kitajewski J, Accili D.

Nat Med. 2011 Jul 31;17(8):961-7. doi: 10.1038/nm.2378.

24.

Diabetes insipidus associated with hemophagocytic lymphohistiocytosis: first case report.

Pajvani U, Lipton ML, Grajower MM.

Endocr Pract. 2011 Sep-Oct;17(5):e118-22. doi: 10.4158/EP10409.CR.

PMID:
21742615
26.

Thrombogenic vasculopathy with diffuse neutrophilic inflammation: a histologic manifestation of a tick bite.

Pajvani U, Zeikus PS, Basile O, Toback N, Robinson-Bostom L.

Cutis. 2006 Nov;78(5):321-4.

PMID:
17186789
27.

The relationship between family medical history and childhood vitiligo.

Pajvani U, Ahmad N, Wiley A, Levy RM, Kundu R, Mancini AJ, Chamlin S, Wagner A, Paller AS.

J Am Acad Dermatol. 2006 Aug;55(2):238-44. Epub 2006 May 18.

PMID:
16844505
28.

Safety of radiofrequency treatment over human skin previously injected with medium-term injectable soft-tissue augmentation materials: a controlled pilot trial.

Alam M, Levy R, Pajvani U, Ramierez JA, Guitart J, Veen H, Gladstone HB.

Lasers Surg Med. 2006 Mar;38(3):205-10. Erratum in: Lasers Surg Med. 2007 Jun;39(5):468. Pavjani, Urvi [corrected to Pajvani, Urvi].

PMID:
16532442
29.

Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists.

Nawrocki AR, Rajala MW, Tomas E, Pajvani UB, Saha AK, Trumbauer ME, Pang Z, Chen AS, Ruderman NB, Chen H, Rossetti L, Scherer PE.

J Biol Chem. 2006 Feb 3;281(5):2654-60. Epub 2005 Dec 2.

30.

Apoptosis through targeted activation of caspase 8 ("ATTAC-mice"): novel mouse models of inducible and reversible tissue ablation.

Trujillo ME, Pajvani UB, Scherer PE.

Cell Cycle. 2005 Sep;4(9):1141-5. Epub 2005 Sep 11.

PMID:
16096375
31.

Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy.

Pajvani UB, Trujillo ME, Combs TP, Iyengar P, Jelicks L, Roth KA, Kitsis RN, Scherer PE.

Nat Med. 2005 Jul;11(7):797-803. Epub 2005 Jun 19.

PMID:
15965483
32.

Adiponectin: a relevant player in PPARgamma-agonist-mediated improvements in hepatic insulin sensitivity?

Bouskila M, Pajvani UB, Scherer PE.

Int J Obes (Lond). 2005 Mar;29 Suppl 1:S17-23. Review.

PMID:
15711577
33.

Thiazolidinediones improve insulin sensitivity in adipose tissue and reduce the hyperlipidaemia without affecting the hyperglycaemia in a transgenic model of type 2 diabetes.

Kim H, Haluzik M, Gavrilova O, Yakar S, Portas J, Sun H, Pajvani UB, Scherer PE, LeRoith D.

Diabetologia. 2004 Dec;47(12):2215-25. Epub 2004 Dec 15.

PMID:
15662559
34.

Regulation of resistin expression and circulating levels in obesity, diabetes, and fasting.

Rajala MW, Qi Y, Patel HR, Takahashi N, Banerjee R, Pajvani UB, Sinha MK, Gingerich RL, Scherer PE, Ahima RS.

Diabetes. 2004 Jul;53(7):1671-9.

35.

Mechanisms of early insulin-sensitizing effects of thiazolidinediones in type 2 diabetes.

Tonelli J, Li W, Kishore P, Pajvani UB, Kwon E, Weaver C, Scherer PE, Hawkins M.

Diabetes. 2004 Jun;53(6):1621-9. Erratum in: Diabetes. 2005 Feb;54(2):587.

36.

Adiponectin acts in the brain to decrease body weight.

Qi Y, Takahashi N, Hileman SM, Patel HR, Berg AH, Pajvani UB, Scherer PE, Ahima RS.

Nat Med. 2004 May;10(5):524-9. Epub 2004 Apr 11. Erratum in: Nat Med. 2004 Jun;10(6):649.

PMID:
15077108
37.

Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity.

Pajvani UB, Hawkins M, Combs TP, Rajala MW, Doebber T, Berger JP, Wagner JA, Wu M, Knopps A, Xiang AH, Utzschneider KM, Kahn SE, Olefsky JM, Buchanan TA, Scherer PE.

J Biol Chem. 2004 Mar 26;279(13):12152-62. Epub 2003 Dec 29.

38.

A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity.

Combs TP, Pajvani UB, Berg AH, Lin Y, Jelicks LA, Laplante M, Nawrocki AR, Rajala MW, Parlow AF, Cheeseboro L, Ding YY, Russell RG, Lindemann D, Hartley A, Baker GR, Obici S, Deshaies Y, Ludgate M, Rossetti L, Scherer PE.

Endocrinology. 2004 Jan;145(1):367-83. Epub 2003 Oct 23.

PMID:
14576179
39.

Adiponectin: systemic contributor to insulin sensitivity.

Pajvani UB, Scherer PE.

Curr Diab Rep. 2003 Jun;3(3):207-13. Review.

PMID:
12762967
40.

Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity.

Pajvani UB, Du X, Combs TP, Berg AH, Rajala MW, Schulthess T, Engel J, Brownlee M, Scherer PE.

J Biol Chem. 2003 Mar 14;278(11):9073-85. Epub 2002 Dec 20.

41.

Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway.

Dolmetsch RE, Pajvani U, Fife K, Spotts JM, Greenberg ME.

Science. 2001 Oct 12;294(5541):333-9.

42.

Differential glycosylation of interleukin 2, the molecular basis for the NOD Idd3 type 1 diabetes gene?

Podolin PL, Wilusz MB, Cubbon RM, Pajvani U, Lord CJ, Todd JA, Peterson LB, Wicker LS, Lyons PA.

Cytokine. 2000 May;12(5):477-82.

PMID:
10857762
43.

Colorimetric analysis of surface reactive amino groups on poly(lactic acid-co-lysine):poly(lactic acid) blends.

Cook AD, Pajvani UB, Hrkach JS, Cannizzaro SM, Langer R.

Biomaterials. 1997 Nov;18(21):1417-24.

PMID:
9375843
44.

Characterization and development of RGD-peptide-modified poly(lactic acid-co-lysine) as an interactive, resorbable biomaterial.

Cook AD, Hrkach JS, Gao NN, Johnson IM, Pajvani UB, Cannizzaro SM, Langer R.

J Biomed Mater Res. 1997 Jun 15;35(4):513-23.

PMID:
9189829

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