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Items: 29

1.

Ex vivo intracoronary gene transfer of adeno-associated virus 2 leads to superior transduction over serotypes 8 and 9 in rat heart transplants.

Raissadati A, Jokinen JJ, Syrjälä SO, Keränen MA, Krebs R, Tuuminen R, Arnaudova R, Rouvinen E, Anisimov A, Soronen J, Pajusola K, Alitalo K, Nykänen AI, Lemström K.

Transpl Int. 2013 Nov;26(11):1126-37. doi: 10.1111/tri.12182. Epub 2013 Sep 19.

2.

Cardiomyocyte-targeted HIF-1alpha gene therapy inhibits cardiomyocyte apoptosis and cardiac allograft vasculopathy in the rat.

Keränen MA, Nykänen AI, Krebs R, Pajusola K, Tuuminen R, Alitalo K, Lemström KB.

J Heart Lung Transplant. 2010 Sep;29(9):1058-66. doi: 10.1016/j.healun.2010.05.021. Epub 2010 Jun 26.

PMID:
20580263
3.

Differential sensitivity of the inner ear sensory cell populations to forced cell cycle re-entry and p53 induction.

Sulg M, Kirjavainen A, Pajusola K, Bueler H, Ylikoski J, Laiho M, Pirvola U.

J Neurochem. 2010 Mar;112(6):1513-26. doi: 10.1111/j.1471-4159.2009.06563.x. Epub 2009 Dec 26.

4.

PDGF-A, -C, and -D but not PDGF-B increase TGF-beta1 and chronic rejection in rat cardiac allografts.

Tuuminen R, Nykänen AI, Krebs R, Soronen J, Pajusola K, Keränen MA, Koskinen PK, Alitalo K, Lemström KB.

Arterioscler Thromb Vasc Biol. 2009 May;29(5):691-8. doi: 10.1161/ATVBAHA.108.178558. Epub 2009 Feb 12.

PMID:
19213942
5.

Distinct architecture of lymphatic vessels induced by chimeric vascular endothelial growth factor-C/vascular endothelial growth factor heparin-binding domain fusion proteins.

Tammela T, He Y, Lyytikkä J, Jeltsch M, Markkanen J, Pajusola K, Ylä-Herttuala S, Alitalo K.

Circ Res. 2007 May 25;100(10):1468-75. Epub 2007 May 3.

PMID:
17478733
6.

Common protective and diverse smooth muscle cell effects of AAV-mediated angiopoietin-1 and -2 expression in rat cardiac allograft vasculopathy.

Nykänen AI, Pajusola K, Krebs R, Keränen MA, Raisky O, Koskinen PK, Alitalo K, Lemström KB.

Circ Res. 2006 Jun 9;98(11):1373-80. Epub 2006 May 11.

PMID:
16690881
7.

Stabilized HIF-1alpha is superior to VEGF for angiogenesis in skeletal muscle via adeno-associated virus gene transfer.

Pajusola K, Künnapuu J, Vuorikoski S, Soronen J, André H, Pereira T, Korpisalo P, Ylä-Herttuala S, Poellinger L, Alitalo K.

FASEB J. 2005 Aug;19(10):1365-7. Epub 2005 Jun 15.

PMID:
15958522
8.

Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels.

He Y, Rajantie I, Pajusola K, Jeltsch M, Holopainen T, Yla-Herttuala S, Harding T, Jooss K, Takahashi T, Alitalo K.

Cancer Res. 2005 Jun 1;65(11):4739-46.

9.

Angiopoietin-1 promotes lymphatic sprouting and hyperplasia.

Tammela T, Saaristo A, Lohela M, Morisada T, Tornberg J, Norrmén C, Oike Y, Pajusola K, Thurston G, Suda T, Yla-Herttuala S, Alitalo K.

Blood. 2005 Jun 15;105(12):4642-8. Epub 2005 Mar 3.

PMID:
15746084
10.

PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis.

Uutela M, Wirzenius M, Paavonen K, Rajantie I, He Y, Karpanen T, Lohela M, Wiig H, Salven P, Pajusola K, Eriksson U, Alitalo K.

Blood. 2004 Nov 15;104(10):3198-204. Epub 2004 Jul 22.

PMID:
15271796
11.

Gene transfer into rabbit arteries with adeno-associated virus and adenovirus vectors.

Gruchała M, Bhardwaj S, Pajusola K, Roy H, Rissanen TT, Kokina I, Kholová I, Markkanen JE, Rutanen J, Heikura T, Alitalo K, Büeler H, Ylä-Herttuala S.

J Gene Med. 2004 May;6(5):545-54.

PMID:
15133765
12.

Adeno-associated virus-mediated gene transfer of a secreted decoy human macrophage scavenger receptor reduces atherosclerotic lesion formation in LDL receptor knockout mice.

Jalkanen J, Leppänen P, Pajusola K, Närvänen O, Mähönen A, Vähäkangas E, Greaves DR, Büeler H, Ylä-Herttuala S.

Mol Ther. 2003 Dec;8(6):903-10.

13.

Cell-type-specific characteristics modulate the transduction efficiency of adeno-associated virus type 2 and restrain infection of endothelial cells.

Pajusola K, Gruchala M, Joch H, Lüscher TF, Ylä-Herttuala S, Büeler H.

J Virol. 2002 Nov;76(22):11530-40.

14.

Lymphangiogenic gene therapy with minimal blood vascular side effects.

Saaristo A, Veikkola T, Tammela T, Enholm B, Karkkainen MJ, Pajusola K, Bueler H, Ylä-Herttuala S, Alitalo K.

J Exp Med. 2002 Sep 16;196(6):719-30.

15.

Adenoviral VEGF-C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes.

Saaristo A, Veikkola T, Enholm B, Hytönen M, Arola J, Pajusola K, Turunen P, Jeltsch M, Karkkainen MJ, Kerjaschki D, Bueler H, Ylä-Herttuala S, Alitalo K.

FASEB J. 2002 Jul;16(9):1041-9.

PMID:
12087065
16.

A model for gene therapy of human hereditary lymphedema.

Karkkainen MJ, Saaristo A, Jussila L, Karila KA, Lawrence EC, Pajusola K, Bueler H, Eichmann A, Kauppinen R, Kettunen MI, Yla-Herttuala S, Finegold DN, Ferrell RE, Alitalo K.

Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12677-82. Epub 2001 Oct 9.

17.

VEGFR3 gene structure, regulatory region, and sequence polymorphisms.

Iljin K, Karkkainen MJ, Lawrence EC, Kimak MA, Uutela M, Taipale J, Pajusola K, Alhonen L, Halmekytö M, Finegold DN, Ferrell RE, Alitalo K.

FASEB J. 2001 Apr;15(6):1028-36.

PMID:
11292664
18.

Cardiovascular failure in mouse embryos deficient in VEGF receptor-3.

Dumont DJ, Jussila L, Taipale J, Lymboussaki A, Mustonen T, Pajusola K, Breitman M, Alitalo K.

Science. 1998 Oct 30;282(5390):946-9.

19.

Vascular endothelial growth factors VEGF-B and VEGF-C.

Joukov V, Kaipainen A, Jeltsch M, Pajusola K, Olofsson B, Kumar V, Eriksson U, Alitalo K.

J Cell Physiol. 1997 Nov;173(2):211-5. Review. No abstract available.

PMID:
9365524
20.

Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform.

Olofsson B, Pajusola K, von Euler G, Chilov D, Alitalo K, Eriksson U.

J Biol Chem. 1996 Aug 9;271(32):19310-7.

21.

A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.

Joukov V, Pajusola K, Kaipainen A, Chilov D, Lahtinen I, Kukk E, Saksela O, Kalkkinen N, Alitalo K.

EMBO J. 1996 Apr 1;15(7):1751. No abstract available.

22.

Vascular endothelial growth factor B, a novel growth factor for endothelial cells.

Olofsson B, Pajusola K, Kaipainen A, von Euler G, Joukov V, Saksela O, Orpana A, Pettersson RF, Alitalo K, Eriksson U.

Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2576-81.

23.

Novel human vascular endothelial growth factor genes VEGF-B and VEGF-C localize to chromosomes 11q13 and 4q34, respectively.

Paavonen K, Horelli-Kuitunen N, Chilov D, Kukk E, Pennanen S, Kallioniemi OP, Pajusola K, Olofsson B, Eriksson U, Joukov V, Palotie A, Alitalo K.

Circulation. 1996 Mar 15;93(6):1079-82.

PMID:
8653826
24.

A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.

Joukov V, Pajusola K, Kaipainen A, Chilov D, Lahtinen I, Kukk E, Saksela O, Kalkkinen N, Alitalo K.

EMBO J. 1996 Jan 15;15(2):290-98. Erratum in: EMBO J. 1996 Apr 1;15(7):1751.

25.

Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors.

Pajusola K, Aprelikova O, Pelicci G, Weich H, Claesson-Welsh L, Alitalo K.

Oncogene. 1994 Dec;9(12):3545-55.

PMID:
7970715
26.

The related FLT4, FLT1, and KDR receptor tyrosine kinases show distinct expression patterns in human fetal endothelial cells.

Kaipainen A, Korhonen J, Pajusola K, Aprelikova O, Persico MG, Terman BI, Alitalo K.

J Exp Med. 1993 Dec 1;178(6):2077-88.

27.
28.

FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines.

Pajusola K, Aprelikova O, Korhonen J, Kaipainen A, Pertovaara L, Alitalo R, Alitalo K.

Cancer Res. 1992 Oct 15;52(20):5738-43. Erratum in: Cancer Res 1993 Aug 15;53(16):3845.

29.

FLT4, a novel class III receptor tyrosine kinase in chromosome 5q33-qter.

Aprelikova O, Pajusola K, Partanen J, Armstrong E, Alitalo R, Bailey SK, McMahon J, Wasmuth J, Huebner K, Alitalo K.

Cancer Res. 1992 Feb 1;52(3):746-8.

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