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Inconsistent Management of Neonatal Herpes Simplex Virus Infections.

Keuning MW, van der Kuip M, van Hattem JM, Pajkrt D.

Hosp Pediatr. 2019 Oct;9(10):808-812. doi: 10.1542/hpeds.2019-0001.


Enterovirus D68 serosurvey: evidence for endemic circulation in the Netherlands, 2006 to 2016.

Karelehto E, Koen G, Benschop K, van der Klis F, Pajkrt D, Wolthers K.

Euro Surveill. 2019 Aug;24(35). doi: 10.2807/1560-7917.ES.2019.24.35.1800671.


Longitudinal virological outcomes and factors associated with virological failure in behaviorally HIV-infected young adults on combination antiretroviral treatment in the Netherlands, 2000 to 2015.

Weijsenfeld AM, Blokhuis C, Stuiver MM, Wit FWNM, Pajkrt D; ATHENA observational HIV cohort.

Medicine (Baltimore). 2019 Aug;98(32):e16357. doi: 10.1097/MD.0000000000016357.


Blood and cerebrospinal fluid characteristics in neonates with a suspected central nervous system infection.

de Blauw D, Bruning A, Vijn LJ, Wildenbeest JG, Wolthers KC, Biezeveld MH, van Wermeskerken AM, Nauta F, Pajkrt D.

Medicine (Baltimore). 2019 Jun;98(25):e16079. doi: 10.1097/MD.0000000000016079.


Systemic and intrathecal immune activation in association with cerebral and cognitive outcomes in paediatric HIV.

Blokhuis C, Peeters CFW, Cohen S, Scherpbier HJ, Kuijpers TW, Reiss P, Kootstra NA, Teunissen CE, Pajkrt D.

Sci Rep. 2019 May 29;9(1):8004. doi: 10.1038/s41598-019-44198-z.


Neurocognitive development in perinatally HIV-infected adolescents on long-term treatment compared to healthy matched controls: a longitudinal study.

Van den Hof M, Ter Haar AM, Scherpbier HJ, van der Lee JH, Reiss P, Wit FWNM, Oostrom KJ, Pajkrt D.

Clin Infect Dis. 2019 May 18. pii: ciz386. doi: 10.1093/cid/ciz386. [Epub ahead of print]


High frequency and diversity of parechovirus A in a cohort of Malawian children.

Brouwer L, Karelehto E, Han AX, Thomas XV, Bruning AHL, Calis JCJ, van Hensbroek MB, Westerhuis BM, Amarthalingam D, Koekkoek SM, Rebers SPH, Phiri KS, Wolthers KC, Pajkrt D.

Arch Virol. 2019 Mar;164(3):799-806. doi: 10.1007/s00705-018-04131-7. Epub 2019 Jan 22.


Seroepidemiology of Parechovirus A3 Neutralizing Antibodies, Australia, the Netherlands, and United States.

Karelehto E, Brouwer L, Benschop K, Kok J, Basile K, McMullan B, Rawlinson W, Druce J, Nicholson S, Selvarangan R, Harrison C, Lankachandra K, van Eijk H, Koen G, de Jong M, Pajkrt D, Wolthers KC.

Emerg Infect Dis. 2019 Jan;25(1):148-152. doi: 10.3201/eid2501.180352.


Human Parechovirus 1, 3 and 4 Neutralizing Antibodies in Dutch Mothers and Infants and Their Role in Protection Against Disease.

Karelehto E, Wildenbeest JG, Benschop KSM, Koen G, Rebers S, Bouma-de Jongh S, Westerhuis BM, de Jong MD, Pajkrt D, Wolthers KC.

Pediatr Infect Dis J. 2018 Dec;37(12):1304-1308. doi: 10.1097/INF.0000000000001986.


Polarized Entry of Human Parechoviruses in the Airway Epithelium.

Karelehto E, Cristella C, Yu X, Sridhar A, Hulsdouw R, de Haan K, van Eijk H, Koekkoek S, Pajkrt D, de Jong MD, Wolthers KC.

Front Cell Infect Microbiol. 2018 Aug 22;8:294. doi: 10.3389/fcimb.2018.00294. eCollection 2018.


Rapid detection and monitoring of human coronavirus infections.

Bruning AHL, Aatola H, Toivola H, Ikonen N, Savolainen-Kopra C, Blomqvist S, Pajkrt D, Wolthers KC, Koskinen JO.

New Microbes New Infect. 2018 May 9;24:52-55. doi: 10.1016/j.nmni.2018.04.007. eCollection 2018 Jul.


High frequency of Polio-like Enterovirus C strains with differential clustering of CVA-13 and EV-C99 subgenotypes in a cohort of Malawian children.

Brouwer L, van der Sanden SMG, Calis JCJ, Bruning AHL, Wang S, Wildenbeest JG, Rebers SPH, Phiri KS, Westerhuis BM, van Hensbroek MB, Pajkrt D, Wolthers KC.

Arch Virol. 2018 Oct;163(10):2645-2653. doi: 10.1007/s00705-018-3878-7. Epub 2018 May 28.


Enterovirus 71 infection of human airway organoids reveals VP1-145 as a viral infectivity determinant.

van der Sanden SMG, Sachs N, Koekkoek SM, Koen G, Pajkrt D, Clevers H, Wolthers KC.

Emerg Microbes Infect. 2018 May 9;7(1):84. doi: 10.1038/s41426-018-0077-2.


Human Parechovirus Meningitis with Adverse Neurodevelopmental Outcome: A Case Report.

Berk MC, Bruning AHL, van Wassenaer-Leemhuis AG, Wolthers KC, Pajkrt D.

Pediatr Infect Dis J. 2018 Oct;37(10):e256-e257. doi: 10.1097/INF.0000000000001984.


Long-term trends in mortality and AIDS-defining events after combination ART initiation among children and adolescents with perinatal HIV infection in 17 middle- and high-income countries in Europe and Thailand: A cohort study.

European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) study group in EuroCoord, Judd A, Chappell E, Turkova A, Le Coeur S, Noguera-Julian A, Goetghebuer T, Doerholt K, Galli L, Pajkrt D, Marques L, Collins IJ, Gibb DM, González Tome MI, Navarro M, Warszawski J, Königs C, Spoulou V, Prata F, Chiappini E, Naver L, Giaquinto C, Thorne C, Marczynska M, Okhonskaia L, Posfay-Barbe K, Ounchanum P, Techakunakorn P, Kiseleva G, Malyuta R, Volokha A, Ene L, Goodall R.

PLoS Med. 2018 Jan 30;15(1):e1002491. doi: 10.1371/journal.pmed.1002491. eCollection 2018 Jan.


Correction: Long-Term Changes of Subcutaneous Fat Mass in HIV-Infected Children on Antiretroviral Therapy: A Retrospective Analysis of Longitudinal Data from Two Pediatric HIV-Cohorts.

Cohen S, Innes S, Geelen SPM, Wells JCK, Smit C, Wolfs TFW, van Eck-Smit BLF, Kuijpers TW, Reiss P, Scherpbier HJ, Pajkrt D, Bunders MJ.

PLoS One. 2018 Jan 2;13(1):e0190726. doi: 10.1371/journal.pone.0190726. eCollection 2018.


Congenital Cytomegalovirus Infection and the Occurrence of Cystic Periventricular Leukomalacia.

Elders PND, In 't Veld J, Termote J, de Vries LS, Hemels MAC, van Straaten HLM, van der Sluijs J, Kornelisse RF, Wolthers KC, van de Loo M, Pajkrt D.

Pediatr Neurol. 2018 Feb;79:59-60. doi: 10.1016/j.pediatrneurol.2017.10.016. Epub 2017 Nov 2. No abstract available.


Inflammatory and Neuronal Biomarkers Associated With Retinal Thinning in Pediatric HIV.

Blokhuis C, Doeleman S, Cohen S, Demirkaya N, Scherpbier HJ, Kootstra NA, Kuhle J, Teunissen CE, Verbraak FD, Pajkrt D.

Invest Ophthalmol Vis Sci. 2017 Nov 1;58(13):5985-5992. doi: 10.1167/iovs.17-22252.


Congenital Cytomegalovirus: A European Expert Consensus Statement on Diagnosis and Management.

Luck SE, Wieringa JW, Blázquez-Gamero D, Henneke P, Schuster K, Butler K, Capretti MG, Cilleruelo MJ, Curtis N, Garofoli F, Heath P, Iosifidis E, Klein N, Lombardi G, Lyall H, Nieminen T, Pajkrt D, Papaevangelou V, Posfay-Barbe K, Puhakka L, Roilides E, Rojo P, Saavedra-Lozano J, Shah T, Sharland M, Saxen H, Vossen ACTM; ESPID Congenital CMV Group Meeting, Leipzig 2015.

Pediatr Infect Dis J. 2017 Dec;36(12):1205-1213. doi: 10.1097/INF.0000000000001763. Review. No abstract available.


CNS penetration of ART in HIV-infected children.

Van den Hof M, Blokhuis C, Cohen S, Scherpbier HJ, Wit FWNM, Pistorius MCM, Kootstra NA, Teunissen CE, Mathot RAA, Pajkrt D.

J Antimicrob Chemother. 2018 Feb 1;73(2):484-489. doi: 10.1093/jac/dkx396.


Reply to Vos et al.

Bruning AHL, Leeflang MMG, Wolthers KC, Pajkrt D.

Clin Infect Dis. 2017 Nov 13;65(11):1959. doi: 10.1093/cid/cix701. No abstract available.


Strain-dependent neutralization reveals antigenic variation of human parechovirus 3.

Karelehto E, van der Sanden S, Geraets JA, Domanska A, van der Linden L, Hoogendoorn D, Koen G, van Eijk H, Shakeel S, Beaumont T, de Jong M, Pajkrt D, Butcher SJ, Wolthers KC.

Sci Rep. 2017 Sep 21;7(1):12075. doi: 10.1038/s41598-017-12458-5.


Intravenous immunoglobulins in children with new onset dilated cardiomyopathy.

Heidendael JF, Den Boer SL, Wildenbeest JG, Dalinghaus M, Straver B, Pajkrt D.

Cardiol Young. 2018 Jan;28(1):46-54. doi: 10.1017/S1047951117001561. Epub 2017 Aug 11.


Lyme Borreliosis in Children: A Tertiary Referral Hospital-Based Retrospective Analysis.

Nassar-Sheikh Rashid A, Boele van Hensbroek M, Kolader M, Hovius JW, Pajkrt D.

Pediatr Infect Dis J. 2018 Feb;37(2):e45-e47. doi: 10.1097/INF.0000000000001735.


Rapid Tests for Influenza, Respiratory Syncytial Virus, and Other Respiratory Viruses: A Systematic Review and Meta-analysis.

Bruning AHL, Leeflang MMG, Vos JMBW, Spijker R, de Jong MD, Wolthers KC, Pajkrt D.

Clin Infect Dis. 2017 Sep 15;65(6):1026-1032. doi: 10.1093/cid/cix461. Review.


Diagnostic performance and clinical feasibility of a point-of-care test for respiratory viral infections in primary health care.

Bruning AHL, de Kruijf WB, van Weert HCPM, Willems WLM, de Jong MD, Pajkrt D, Wolthers KC.

Fam Pract. 2017 Sep 1;34(5):558-563. doi: 10.1093/fampra/cmx019.


Higher subcortical and white matter cerebral blood flow in perinatally HIV-infected children.

Blokhuis C, Mutsaerts HJ, Cohen S, Scherpbier HJ, Caan MW, Majoie CB, Kuijpers TW, Reiss P, Wit FW, Pajkrt D.

Medicine (Baltimore). 2017 Feb;96(7):e5891. doi: 10.1097/MD.0000000000005891.


In-utero exposure to tenofovir is associated with impaired fetal and infant growth: need for follow-up studies in combination antiretroviral therapy/HIV-exposed infants: author's reply.

Denneman L, Cohen S, Godfried MH, van Leeuwen E, Nellen JF, Kuijpers TW, Pajkrt D, van de Plas A, Smit C, Weijsenfeld AM, Scherpbier HJ, Bunders MJ.

AIDS. 2017 Feb 20;31(4):596-598. doi: 10.1097/QAD.0000000000001364. No abstract available.


Reply to Sainz and Navarro.

Weijsenfeld AM, Pajkrt D.

Clin Infect Dis. 2017 Jan 15;64(2):230-231. doi: 10.1093/cid/ciw704. Epub 2016 Oct 19. No abstract available.


Neonate with Mycoplasma hominis meningoencephalitis given moxifloxacin.

Wildenbeest JG, Said I, Jaeger B, van Hest RM, van de Beek D, Pajkrt D.

Lancet Infect Dis. 2016 Nov;16(11):e261-e266. doi: 10.1016/S1473-3099(16)30162-1. Epub 2016 Sep 16. Review.


A molecular epidemiological perspective of rhinovirus types circulating in Amsterdam from 2007 to 2012.

van der Linden L, Bruning AH, Thomas XV, Minnaar RP, Rebers SP, Schinkel J, de Jong MD, Pajkrt D, Wolthers KC.

Clin Microbiol Infect. 2016 Dec;22(12):1002.e9-1002.e14. doi: 10.1016/j.cmi.2016.08.007. Epub 2016 Aug 21.


In-utero exposure to tenofovir is associated with impaired fetal and infant growth: need for follow-up studies in combination antiretroviral therapy/HIV-exposed infants.

Denneman L, Cohen S, Godfried MH, van Leeuwen E, Nellen JF, Kuijpers TW, Pajkrt D, van de Plas A, Smit C, Weijsenfeld AM, Scherpbier HJ, Bunders MJ.

AIDS. 2016 Aug 24;30(13):2135-7. doi: 10.1097/QAD.0000000000001156. No abstract available.


The Eye as a Window to the Brain: Neuroretinal Thickness Is Associated With Microstructural White Matter Injury in HIV-Infected Children.

Blokhuis C, Demirkaya N, Cohen S, Wit FW, Scherpbier HJ, Reiss P, Abramoff MD, Caan MW, Majoie CB, Verbraak FD, Pajkrt D.

Invest Ophthalmol Vis Sci. 2016 Jul 1;57(8):3864-71. doi: 10.1167/iovs.16-19716.


Virological and Social Outcomes of HIV-Infected Adolescents and Young Adults in The Netherlands Before and After Transition to Adult Care.

Weijsenfeld AM, Smit C, Cohen S, Wit FWNM, Mutschelknauss M, van der Knaap LC, van Zonneveld LM, Zomer BJ, Nauta N, Patist JC, Kuipers-Jansen MHJ, Smit EP, Blokhuis C, Pajkrt D; Dutch HIV Adolescents and Young Adults (AYA) Study Group, Weijsenfeld AM, Cohen S, Blokhuis C, van der Plas A, Scherpbier HJ, Mutschelknauss M, Nellen FJB, Prins JM, Pajkrt D, Smit C, Wit FWNM, Reiss P, van der Knaap L, Visser E, van Zonneveld LM, Vriesde ME, Bassant NY, van der Ende ME, van Rossum AMC, Driessen GJA, Fraaij PLA, Smit JV, Smit EP, Kastelijns MPW, den Hollander JG, Pogány K, Moons C, Kroon FP, Oude Geerdink E, van der Meche IB, Schouten WEM, Brinkman K, Ter Beest G, Gisolf EH, Richter C, Zomer BJ, Strik-Albers R, van der Flier M, Henriet SS, Koopmans PP, Patist JC, Nauta N, Geelen SPM, Wolfs TFW, Hoepelman IM, Mudrikova T, van der Meulen PA, de Jonge H, Scholvink EH, Bierman WFW, van den Berg JF, Bouwhuis JW, Faber S, van Vonderen M, Schippers JA, Lowe SH, Kuipers-Jansen MHJ, van Kasteren MEE, Brouwer AE, Pronk DC, Kortmann W.

Clin Infect Dis. 2016 Oct 15;63(8):1105-1112. doi: 10.1093/cid/ciw487. Epub 2016 Jul 20.


Prevalence of rhinoviruses in young children of an unselected birth cohort from the Netherlands.

Wildenbeest JG, van der Schee MP, Hashimoto S, Benschop KS, Minnaar RP, Sprikkelman AB, Haarman EG, van Aalderen WM, Sterk PJ, Pajkrt D, Wolthers KC.

Clin Microbiol Infect. 2016 Aug;22(8):736.e9-736.e15. doi: 10.1016/j.cmi.2016.05.022. Epub 2016 Jun 3.


Noncirrhotic Portal Hypertension in Perinatally HIV-infected Adolescents Treated With Didanosine-containing Antiretroviral Regimens in Childhood.

Scherpbier HJ, Terpstra V, Pajkrt D, Puthakanit T, Ananworanich J, Foster C, van den Bergh Weerman M, Deurloo EE, van der Valk M, Kuijpers TW, Koot BG.

Pediatr Infect Dis J. 2016 Aug;35(8):e248-52. doi: 10.1097/INF.0000000000001202.


Neurometabolite Alterations Associated With Cognitive Performance in Perinatally HIV-Infected Children.

Van Dalen YW, Blokhuis C, Cohen S, Ter Stege JA, Teunissen CE, Kuhle J, Kootstra NA, Scherpbier HJ, Kuijpers TW, Reiss P, Majoie CB, Caan MW, Pajkrt D.

Medicine (Baltimore). 2016 Mar;95(12):e3093. doi: 10.1097/MD.0000000000003093.


Prolonged Shedding of Human Parechovirus in Feces of Young Children after Symptomatic Infection.

Wildenbeest JG, Benschop KS, Bouma-de Jongh S, Wolthers KC, Pajkrt D.

Pediatr Infect Dis J. 2016 May;35(5):580-3. doi: 10.1097/INF.0000000000001082.


Neurotropic virus infections as the cause of immediate and delayed neuropathology.

Ludlow M, Kortekaas J, Herden C, Hoffmann B, Tappe D, Trebst C, Griffin DE, Brindle HE, Solomon T, Brown AS, van Riel D, Wolthers KC, Pajkrt D, Wohlsein P, Martina BEE, Baumgärtner W, Verjans GM, Osterhaus ADME.

Acta Neuropathol. 2016 Feb;131(2):159-184. doi: 10.1007/s00401-015-1511-3. Epub 2015 Dec 10. Review.


Clinical, virological and epidemiological characteristics of rhinovirus infections in early childhood: A comparison between non-hospitalised and hospitalised children.

Bruning AHL, Thomas XV, van der Linden L, Wildenbeest JG, Minnaar RP, Jansen RR, de Jong MD, Sterk PJ, van der Schee MP, Wolthers KC, Pajkrt D.

J Clin Virol. 2015 Dec;73:120-126. doi: 10.1016/j.jcv.2015.10.024. Epub 2015 Nov 10.


Cerebral injury in perinatally HIV-infected children compared to matched healthy controls.

Cohen S, Caan MW, Mutsaerts HJ, Scherpbier HJ, Kuijpers TW, Reiss P, Majoie CB, Pajkrt D.

Neurology. 2016 Jan 5;86(1):19-27. doi: 10.1212/WNL.0000000000002209. Epub 2015 Nov 11.


Health-related quality of life in perinatally HIV-infected children in the Netherlands.

Cohen S, ter Stege JA, Weijsenfeld AM, van der Plas A, Kuijpers TW, Reiss P, Scherpbier HJ, Haverman L, Pajkrt D.

AIDS Care. 2015;27(10):1279-88. doi: 10.1080/09540121.2015.1050986. Epub 2015 Aug 14.


Long-Term Changes of Subcutaneous Fat Mass in HIV-Infected Children on Antiretroviral Therapy: A Retrospective Analysis of Longitudinal Data from Two Pediatric HIV-Cohorts.

Cohen S, Innes S, Geelen SP, Wells JC, Smit C, Wolfs TF, van Eck-Smit BL, Kuijpers TW, Reiss P, Scherpbier HJ, Pajkrt D, Bunders MJ.

PLoS One. 2015 Jul 6;10(7):e0120927. doi: 10.1371/journal.pone.0120927. eCollection 2015. Erratum in: PLoS One. 2018 Jan 2;13(1):e0190726.


Retinal Structure and Function in Perinatally HIV-Infected and cART-Treated Children: A Matched Case-Control Study.

Demirkaya N, Cohen S, Wit FW, Abramoff MD, Schlingemann RO, Kuijpers TW, Reiss P, Pajkrt D, Verbraak FD.

Invest Ophthalmol Vis Sci. 2015 Jun;56(6):3945-54. doi: 10.1167/iovs.15-16855.


An atypical course of coxsackievirus A6 associated hand, foot and mouth disease in extremely low birth weight preterm twins.

Bruning AH, van der Sanden SM, ten Hoedt AE, Wolthers KC, van Kaam AH, Pajkrt D.

J Clin Virol. 2015 Apr;65:20-2. doi: 10.1016/j.jcv.2015.01.020. Epub 2015 Jan 29.


Poorer cognitive performance in perinatally HIV-infected children versus healthy socioeconomically matched controls.

Cohen S, Ter Stege JA, Geurtsen GJ, Scherpbier HJ, Kuijpers TW, Reiss P, Schmand B, Pajkrt D.

Clin Infect Dis. 2015 Apr 1;60(7):1111-9. doi: 10.1093/cid/ciu1144. Epub 2014 Dec 16.


Presence of human non-polio enterovirus and parechovirus genotypes in an Amsterdam hospital in 2007 to 2011 compared to national and international published surveillance data: a comprehensive review.

Janes VA, Minnaar R, Koen G, van Eijk H, Dijkman-de Haan K, Pajkrt D, Wolthers KC, Benschop KS.

Euro Surveill. 2014 Nov 20;19(46). pii: 20964. Review.


Country of birth does not influence long-term clinical, virologic, and immunological outcome of HIV-infected children living in the Netherlands: a cohort study comparing children born in the Netherlands with children born in Sub-Saharan Africa.

Cohen S, van Bilsen WP, Smit C, Fraaij PL, Warris A, Kuijpers TW, Geelen SP, Wolfs TF, Scherpbier HJ, van Rossum AM, Pajkrt D.

J Acquir Immune Defic Syndr. 2015 Feb 1;68(2):178-85. doi: 10.1097/QAI.0000000000000431.


Genetic and antigenic structural characterization for resistance of echovirus 11 to pleconaril in an immunocompromised patient.

Benschop KS, Wildenbeest JG, Koen G, Minnaar RP, van Hemert FJ, Westerhuis BM, Pajkrt D, van den Broek PJ, Vossen AC, Wolthers KC.

J Gen Virol. 2015 Mar;96(Pt 3):571-9. doi: 10.1099/vir.0.069773-0. Epub 2014 Nov 13.


Evaluation of a rapid antigen detection point-of-care test for respiratory syncytial virus and influenza in a pediatric hospitalized population in the Netherlands.

Bruning AH, van Dijk K, van Eijk HW, Koen G, van Woensel JB, Kruisinga FH, Pajkrt D, Wolthers KC.

Diagn Microbiol Infect Dis. 2014 Dec;80(4):292-3. doi: 10.1016/j.diagmicrobio.2014.08.010. Epub 2014 Aug 30.


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