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Items: 1 to 50 of 71

1.

Betaine-homocysteine S-methyltransferase deficiency causes increased susceptibility to noise-induced hearing loss associated to plasma hyperhomocysteinemia.

Partearroyo T, Murillo-Cuesta S, Vallecillo N, Bermúdez-Muñoz JM, Rodríguez-de la Rosa L, Mandruzzato G, Celaya AM, Zeisel SH, Pajares MA, Varela-Moreiras G, Varela-Nieto I.

FASEB J. 2019 Feb 12:fj201801533R. doi: 10.1096/fj.201801533R. [Epub ahead of print]

PMID:
30753104
2.

Vimentin disruption by lipoxidation and electrophiles: Role of the cysteine residue and filament dynamics.

Mónico A, Duarte S, Pajares MA, Pérez-Sala D.

Redox Biol. 2019 Jan 8:101098. doi: 10.1016/j.redox.2019.101098. [Epub ahead of print]

3.

Interplay between Nutrition and Hearing Loss: State of Art.

Puga AM, Pajares MA, Varela-Moreiras G, Partearroyo T.

Nutrients. 2018 Dec 24;11(1). pii: E35. doi: 10.3390/nu11010035. Review.

4.

Identification of hepatic protein-protein interaction targets for betaine homocysteine S-methyltransferase.

Garrido F, Pacheco M, Vargas-Martínez R, Velasco-García R, Jorge I, Serrano H, Portillo F, Vázquez J, Pajares MÁ.

PLoS One. 2018 Jun 20;13(6):e0199472. doi: 10.1371/journal.pone.0199472. eCollection 2018.

5.

Asthma and allergic rhinitis associate with the rs2229542 variant that induces a p.Lys90Glu mutation and compromises AKR1B1 protein levels.

García-Martín E, Sánchez-Gómez FJ, Amo G, García Menaya J, Cordobés C, Ayuso P, Plaza Serón MC, Blanca M, Campo P, Esguevillas G, Pajares MA, G Agúndez JA, Pérez-Sala D.

Hum Mutat. 2018 Aug;39(8):1081-1091. doi: 10.1002/humu.23548. Epub 2018 May 25.

PMID:
29726087
6.

PDRG1 at the interface between intermediary metabolism and oncogenesis.

Pajares MÁ.

World J Biol Chem. 2017 Nov 26;8(4):175-186. doi: 10.4331/wjbc.v8.i4.175. Review.

7.

Mammalian Sulfur Amino Acid Metabolism: A Nexus Between Redox Regulation, Nutrition, Epigenetics, and Detoxification.

Pajares MA, Pérez-Sala D.

Antioxid Redox Signal. 2018 Aug 1;29(4):408-452. doi: 10.1089/ars.2017.7237. Epub 2018 Jan 9.

PMID:
29186975
8.

Cochlear Homocysteine Metabolism at the Crossroad of Nutrition and Sensorineural Hearing Loss.

Partearroyo T, Vallecillo N, Pajares MA, Varela-Moreiras G, Varela-Nieto I.

Front Mol Neurosci. 2017 Apr 25;10:107. doi: 10.3389/fnmol.2017.00107. eCollection 2017. Review.

9.

Betaine homocysteine S-methyltransferase emerges as a new player of the nuclear methionine cycle.

Pérez-Miguelsanz J, Vallecillo N, Garrido F, Reytor E, Pérez-Sala D, Pajares MA.

Biochim Biophys Acta Mol Cell Res. 2017 Jul;1864(7):1165-1182. doi: 10.1016/j.bbamcr.2017.03.004. Epub 2017 Mar 10.

10.

Correction: The Oncogene PDRG1 Is an Interaction Target of Methionine Adenosyltransferases.

Pérez C, Pérez-Zúñiga FJ, Garrido F, Reytor E, Portillo F, Pajares MA.

PLoS One. 2016 Sep 22;11(9):e0163761. doi: 10.1371/journal.pone.0163761. eCollection 2016.

11.

Long-Term Dietary Folate Deficiency Accelerates Progressive Hearing Loss on CBA/Ca Mice.

Martínez-Vega R, Murillo-Cuesta S, Partearroyo T, Varela-Moreiras G, Varela-Nieto I, Pajares MA.

Front Aging Neurosci. 2016 Aug 31;8:209. doi: 10.3389/fnagi.2016.00209. eCollection 2016.

12.

The Oncogene PDRG1 Is an Interaction Target of Methionine Adenosyltransferases.

Pérez C, Pérez-Zúñiga FJ, Garrido F, Reytor E, Portillo F, Pajares MA.

PLoS One. 2016 Aug 22;11(8):e0161672. doi: 10.1371/journal.pone.0161672. eCollection 2016. Erratum in: PLoS One. 2016;11(9):e0163761.

13.

Detoxifying Enzymes at the Cross-Roads of Inflammation, Oxidative Stress, and Drug Hypersensitivity: Role of Glutathione Transferase P1-1 and Aldose Reductase.

Sánchez-Gómez FJ, Díez-Dacal B, García-Martín E, Agúndez JA, Pajares MA, Pérez-Sala D.

Front Pharmacol. 2016 Aug 4;7:237. doi: 10.3389/fphar.2016.00237. eCollection 2016.

14.

Long-term omega-3 fatty acid supplementation prevents expression changes in cochlear homocysteine metabolism and ameliorates progressive hearing loss in C57BL/6J mice.

Martínez-Vega R, Partearroyo T, Vallecillo N, Varela-Moreiras G, Pajares MA, Varela-Nieto I.

J Nutr Biochem. 2015 Dec;26(12):1424-33. doi: 10.1016/j.jnutbio.2015.07.011. Epub 2015 Jul 31.

15.

Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism.

Martínez-Vega R, Garrido F, Partearroyo T, Cediel R, Zeisel SH, Martínez-Álvarez C, Varela-Moreiras G, Varela-Nieto I, Pajares MA.

FASEB J. 2015 Feb;29(2):418-32. doi: 10.1096/fj.14-259283. Epub 2014 Nov 10.

16.

Acute liver injury induces nucleocytoplasmic redistribution of hepatic methionine metabolism enzymes.

Delgado M, Garrido F, Pérez-Miguelsanz J, Pacheco M, Partearroyo T, Pérez-Sala D, Pajares MA.

Antioxid Redox Signal. 2014 Jun 1;20(16):2541-54. doi: 10.1089/ars.2013.5342. Epub 2014 Jan 3.

17.

How are mammalian methionine adenosyltransferases regulated in the liver? A focus on redox stress.

Pajares MA, Alvarez L, Pérez-Sala D.

FEBS Lett. 2013 Jun 19;587(12):1711-6. doi: 10.1016/j.febslet.2013.04.034. Epub 2013 May 11.

18.

Modulation of GSTP1-1 oligomerization by electrophilic inflammatory mediators and reactive drugs.

Sánchez-Gómez FJ, Dorado CG, Ayuso P, Agúndez JA, Pajares MA, Pérez-Sala D.

Inflamm Allergy Drug Targets. 2013 Jun;12(3):162-71.

PMID:
23596995
19.

NADP+ binding to the regulatory subunit of methionine adenosyltransferase II increases intersubunit binding affinity in the hetero-trimer.

González B, Garrido F, Ortega R, Martínez-Júlvez M, Revilla-Guarinos A, Pérez-Pertejo Y, Velázquez-Campoy A, Sanz-Aparicio J, Pajares MA.

PLoS One. 2012;7(11):e50329. doi: 10.1371/journal.pone.0050329. Epub 2012 Nov 26.

20.

Methionine adenosyltransferase (s-adenosylmethionine synthetase).

Pajares MA, Markham GD.

Adv Enzymol Relat Areas Mol Biol. 2011;78:449-521. Review. No abstract available.

PMID:
22220481
21.

Refolding and characterization of methionine adenosyltransferase from Euglena gracilis.

Garrido F, Estrela S, Alves C, Sánchez-Pérez GF, Sillero A, Pajares MA.

Protein Expr Purif. 2011 Sep;79(1):128-36. doi: 10.1016/j.pep.2011.05.004. Epub 2011 May 14.

PMID:
21605677
22.

Structural basis for the stability of a thermophilic methionine adenosyltransferase against guanidinium chloride.

Garrido F, Taylor JC, Alfonso C, Markham GD, Pajares MA.

Amino Acids. 2012 Jan;42(1):361-73. doi: 10.1007/s00726-010-0813-y. Epub 2010 Dec 4.

23.

Cyclopentenone prostaglandins with dienone structure promote cross-linking of the chemoresistance-inducing enzyme glutathione transferase P1-1.

Sánchez-Gómez FJ, Díez-Dacal B, Pajares MA, Llorca O, Pérez-Sala D.

Mol Pharmacol. 2010 Oct;78(4):723-33. doi: 10.1124/mol.110.065391. Epub 2010 Jul 14.

PMID:
20631055
24.

Conformational signals in the C-terminal domain of methionine adenosyltransferase I/III determine its nucleocytoplasmic distribution.

Reytor E, Pérez-Miguelsanz J, Alvarez L, Pérez-Sala D, Pajares MA.

FASEB J. 2009 Oct;23(10):3347-60. doi: 10.1096/fj.09-130187. Epub 2009 Jun 4.

25.

Subunit association as the stabilizing determinant for archaeal methionine adenosyltransferases.

Garrido F, Alfonso C, Taylor JC, Markham GD, Pajares MA.

Biochim Biophys Acta. 2009 Jul;1794(7):1082-90. doi: 10.1016/j.bbapap.2009.03.018. Epub 2009 Apr 5.

26.

Structure-function relationships in methionine adenosyltransferases.

Markham GD, Pajares MA.

Cell Mol Life Sci. 2009 Feb;66(4):636-48. doi: 10.1007/s00018-008-8516-1. Review.

27.

Early effects of copper accumulation on methionine metabolism.

Delgado M, Pérez-Miguelsanz J, Garrido F, Rodríguez-Tarduchy G, Pérez-Sala D, Pajares MA.

Cell Mol Life Sci. 2008 Jul;65(13):2080-90. doi: 10.1007/s00018-008-8201-4.

28.

Betaine homocysteine S-methyltransferase: just a regulator of homocysteine metabolism?

Pajares MA, Pérez-Sala D.

Cell Mol Life Sci. 2006 Dec;63(23):2792-803. Review.

29.
30.

Methionine adenosyltransferase alpha-helix structure unfolds at lower temperatures than beta-sheet: a 2D-IR study.

Iloro I, Chehín R, Goñi FM, Pajares MA, Arrondo JL.

Biophys J. 2004 Jun;86(6):3951-8.

31.

Crystal structure of rat liver betaine homocysteine s-methyltransferase reveals new oligomerization features and conformational changes upon substrate binding.

González B, Pajares MA, Martínez-Ripoll M, Blundell TL, Sanz-Aparicio J.

J Mol Biol. 2004 May 7;338(4):771-82.

PMID:
15099744
32.

Cu2+ binding triggers alphaBoPrP assembly into insoluble laminar polymers.

González-Iglesias R, Elvira G, Rodríguez-Navarro JA, Vélez M, Calero M, Pajares MA, Gasset M.

FEBS Lett. 2004 Jan 2;556(1-3):161-6.

33.

Methionine adenosyltransferase as a useful molecular systematics tool revealed by phylogenetic and structural analyses.

Sánchez-Pérez GF, Bautista JM, Pajares MA.

J Mol Biol. 2004 Jan 16;335(3):693-706.

PMID:
14687567
34.

Crystal structures of methionine adenosyltransferase complexed with substrates and products reveal the methionine-ATP recognition and give insights into the catalytic mechanism.

González B, Pajares MA, Hermoso JA, Guillerm D, Guillerm G, Sanz-Aparicio J.

J Mol Biol. 2003 Aug 8;331(2):407-16.

PMID:
12888348
35.

Role of an intrasubunit disulfide in the association state of the cytosolic homo-oligomer methionine adenosyltransferase.

Sanchez-Perez GF, Gasset M, Calvete JJ, Pajares MA.

J Biol Chem. 2003 Feb 28;278(9):7285-93. Epub 2002 Dec 20.

36.

Leishmania donovani methionine adenosyltransferase. Role of cysteine residues in the recombinant enzyme.

Pérez-Pertejo Y, Reguera RM, Villa H, García-Estrada C, Balaña-Fouce R, Pajares MA, Ordóñez D.

Eur J Biochem. 2003 Jan;270(1):28-35.

37.

Active-site-mutagenesis study of rat liver betaine-homocysteine S-methyltransferase.

González B, Campillo N, Garrido F, Gasset M, Sanz-Aparicio J, Pajares MA.

Biochem J. 2003 Mar 15;370(Pt 3):945-52.

38.

Crystallization and preliminary X-ray study of recombinant betaine-homocysteine S-methyltransferase from rat liver.

González B, Pajares MA, Too HP, Garrido F, Blundell TL, Sanz-Aparicio J.

Acta Crystallogr D Biol Crystallogr. 2002 Sep;58(Pt 9):1507-10. Epub 2002 Aug 23.

39.

Prion protein interaction with glycosaminoglycan occurs with the formation of oligomeric complexes stabilized by Cu(II) bridges.

González-Iglesias R, Pajares MA, Ocal C, Espinosa JC, Oesch B, Gasset M.

J Mol Biol. 2002 May 31;319(2):527-40.

PMID:
12051926
40.
41.

Refolding and characterization of rat liver methionine adenosyltransferase from Escherichia coli inclusion bodies.

López-Vara MC, Gasset M, Pajares MA.

Protein Expr Purif. 2000 Jul;19(2):219-26.

PMID:
10873534
42.

The crystal structure of tetrameric methionine adenosyltransferase from rat liver reveals the methionine-binding site.

González B, Pajares MA, Hermoso JA, Alvarez L, Garrido F, Sufrin JR, Sanz-Aparicio J.

J Mol Biol. 2000 Jul 7;300(2):363-75.

PMID:
10873471
43.

Assignment of a single disulfide bridge in rat liver methionine adenosyltransferase.

Martínez-Chantar ML, Pajares MA.

Eur J Biochem. 2000 Jan;267(1):132-7.

44.
45.

Recombinant rat liver S-adenosyl-L-methionine synthetase tetramers and dimers are in equilibrium.

Mingorance J, Alvarez L, Pajares MA, Mato JM.

Int J Biochem Cell Biol. 1997 Mar;29(3):485-91.

PMID:
9202427
46.

Glucocorticoid regulation of hepatic S-adenosylmethionine synthetase gene expression.

Gil B, Pajares MA, Mato JM, Alvarez L.

Endocrinology. 1997 Mar;138(3):1251-8.

47.

S-adenosylmethionine synthesis: molecular mechanisms and clinical implications.

Mato JM, Alvarez L, Ortiz P, Pajares MA.

Pharmacol Ther. 1997;73(3):265-80. Review.

PMID:
9175157
48.
49.

Increased sensitivity to oxidative injury in chinese hamster ovary cells stably transfected with rat liver S-adenosylmethionine synthetase cDNA.

Sánchez-Góngora E, Pastorino JG, Alvarez L, Pajares MA, García C, Viña JR, Mato JM, Farber JL.

Biochem J. 1996 Nov 1;319 ( Pt 3):767-73.

50.

Differential expression pattern of S-adenosylmethionine synthetase isoenzymes during rat liver development.

Gil B, Casado M, Pajares MA, Boscá L, Mato JM, Martín-Sanz P, Alvarez L.

Hepatology. 1996 Oct;24(4):876-81.

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