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Items: 43

1.

Small molecule antiviral β-D-N 4-hydroxycytidine inhibits a proofreading-intact coronavirus with a high genetic barrier to resistance.

Agostini ML, Pruijssers AJ, Chappell JD, Gribble J, Lu X, Andres EL, Bluemling GR, Lockwood MA, Sheahan TP, Sims AC, Natchus MG, Saindane M, Kolykhalov AA, Painter GR, Baric RS, Denison MR.

J Virol. 2019 Oct 2. pii: JVI.01348-19. doi: 10.1128/JVI.01348-19. [Epub ahead of print]

PMID:
31578288
2.

The prophylactic and therapeutic activity of a broadly active ribonucleoside analog in a murine model of intranasal venezuelan equine encephalitis virus infection.

Painter GR, Bowen RA, Bluemling GR, DeBergh J, Edpuganti V, Gruddanti PR, Guthrie DB, Hager M, Kuiper DL, Lockwood MA, Mitchell DG, Natchus MG, Sticher ZM, Kolykhalov AA.

Antiviral Res. 2019 Nov;171:104597. doi: 10.1016/j.antiviral.2019.104597. Epub 2019 Sep 5.

3.

Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses.

Yoon JJ, Toots M, Lee S, Lee ME, Ludeke B, Luczo JM, Ganti K, Cox RM, Sticher ZM, Edpuganti V, Mitchell DG, Lockwood MA, Kolykhalov AA, Greninger AL, Moore ML, Painter GR, Lowen AC, Tompkins SM, Fearns R, Natchus MG, Plemper RK.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e00766-18. doi: 10.1128/AAC.00766-18. Print 2018 Aug.

4.

Simple In Vitro Assay To Evaluate the Incorporation Efficiency of Ribonucleotide Analog 5'-Triphosphates into RNA by Human Mitochondrial DNA-Dependent RNA Polymerase.

Lu G, Bluemling GR, Mao S, Hager M, Gurale BP, Collop P, Kuiper D, Sana K, Painter GR, De La Rosa A, Kolykhalov AA.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e01830-17. doi: 10.1128/AAC.01830-17. Print 2018 Feb.

5.

β-d-N 4-Hydroxycytidine Is a Potent Anti-alphavirus Compound That Induces a High Level of Mutations in the Viral Genome.

Urakova N, Kuznetsova V, Crossman DK, Sokratian A, Guthrie DB, Kolykhalov AA, Lockwood MA, Natchus MG, Crowley MR, Painter GR, Frolova EI, Frolov I.

J Virol. 2018 Jan 17;92(3). pii: e01965-17. doi: 10.1128/JVI.01965-17. Print 2018 Feb 1.

6.

Analysis of Ribonucleotide 5'-Triphosphate Analogs as Potential Inhibitors of Zika Virus RNA-Dependent RNA Polymerase by Using Nonradioactive Polymerase Assays.

Lu G, Bluemling GR, Collop P, Hager M, Kuiper D, Gurale BP, Painter GR, De La Rosa A, Kolykhalov AA.

Antimicrob Agents Chemother. 2017 Feb 23;61(3). pii: e01967-16. doi: 10.1128/AAC.01967-16. Print 2017 Mar.

7.

Lassa and Ebola virus inhibitors identified using minigenome and recombinant virus reporter systems.

Welch SR, Guerrero LW, Chakrabarti AK, McMullan LK, Flint M, Bluemling GR, Painter GR, Nichol ST, Spiropoulou CF, Albariño CG.

Antiviral Res. 2016 Dec;136:9-18. doi: 10.1016/j.antiviral.2016.10.007. Epub 2016 Oct 19.

PMID:
27771389
8.

Discovery and Development of the Anti-Human Immunodeficiency Virus Drug, Emtricitabine (Emtriva, FTC).

Liotta DC, Painter GR.

Acc Chem Res. 2016;49(10):2091-2098. Epub 2016 Oct 5.

9.

Consortia's critical role in developing medical countermeasures for re-emerging viral infections: a USA perspective.

Everts M, Suto MJ, Painter GR, Whitley RJ.

Future Virol. 2016 Mar;11(3):187-195. Epub 2016 Feb 29.

10.

Efficacy of CMX001 against herpes simplex virus infections in mice and correlations with drug distribution studies.

Quenelle DC, Lampert B, Collins DJ, Rice TL, Painter GR, Kern ER.

J Infect Dis. 2010 Nov 15;202(10):1492-9. doi: 10.1086/656717. Epub 2010 Oct 5.

11.

Development of hexadecyloxypropyl tenofovir (CMX157) for treatment of infection caused by wild-type and nucleoside/nucleotide-resistant HIV.

Lanier ER, Ptak RG, Lampert BM, Keilholz L, Hartman T, Buckheit RW Jr, Mankowski MK, Osterling MC, Almond MR, Painter GR.

Antimicrob Agents Chemother. 2010 Jul;54(7):2901-9. doi: 10.1128/AAC.00068-10. Epub 2010 May 3.

12.

Hexadecyloxypropyl-cidofovir, CMX001, prevents adenovirus-induced mortality in a permissive, immunosuppressed animal model.

Toth K, Spencer JF, Dhar D, Sagartz JE, Buller RM, Painter GR, Wold WS.

Proc Natl Acad Sci U S A. 2008 May 20;105(20):7293-7. doi: 10.1073/pnas.0800200105. Epub 2008 May 19.

13.

Synergistic efficacy of the combination of ST-246 with CMX001 against orthopoxviruses.

Quenelle DC, Prichard MN, Keith KA, Hruby DE, Jordan R, Painter GR, Robertson A, Kern ER.

Antimicrob Agents Chemother. 2007 Nov;51(11):4118-24. Epub 2007 Aug 27.

14.

Evaluation of hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)propyl]- adenine, CMX157, as a potential treatment for human immunodeficiency virus type 1 and hepatitis B virus infections.

Painter GR, Almond MR, Trost LC, Lampert BM, Neyts J, De Clercq E, Korba BE, Aldern KA, Beadle JR, Hostetler KY.

Antimicrob Agents Chemother. 2007 Oct;51(10):3505-9. Epub 2007 Jul 23. Erratum in: Antimicrob Agents Chemother. 2007 Dec;51(12):4538.

15.

Design and development of oral drugs for the prophylaxis and treatment of smallpox infection.

Painter GR, Hostetler KY.

Trends Biotechnol. 2004 Aug;22(8):423-7.

PMID:
15283988
16.

Biochemical and mechanistic basis for the activity of nucleoside analogue inhibitors of HIV reverse transcriptase.

Painter GR, Almond MR, Mao S, Liotta DC.

Curr Top Med Chem. 2004;4(10):1035-44. Review.

PMID:
15193137
17.

Esterification of cidofovir with alkoxyalkanols increases oral bioavailability and diminishes drug accumulation in kidney.

Ciesla SL, Trahan J, Wan WB, Beadle JR, Aldern KA, Painter GR, Hostetler KY.

Antiviral Res. 2003 Aug;59(3):163-71.

PMID:
12927306
18.

Mechanism of action of 1-beta-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-beta-D-dioxolane guanosine.

Furman PA, Jeffrey J, Kiefer LL, Feng JY, Anderson KS, Borroto-Esoda K, Hill E, Copeland WC, Chu CK, Sommadossi JP, Liberman I, Schinazi RF, Painter GR.

Antimicrob Agents Chemother. 2001 Jan;45(1):158-65.

19.
20.

Conformation and local environment of nucleotides bound to HIV type 1 reverse transcriptase (HIV-1 RT) in the ground state.

Painter GR, Andrews CW, Furman PA.

Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):13-29.

PMID:
10772700
21.

Safety assessment, in vitro and in vivo, and pharmacokinetics of emivirine, a potent and selective nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1.

Szczech GM, Furman P, Painter GR, Barry DW, Borroto-Esoda K, Grizzle TB, Blum MR, Sommadossi J, Endoh R, Niwa T, Yamamoto M, Moxham C.

Antimicrob Agents Chemother. 2000 Jan;44(1):123-30.

22.

DNA polymerase activity of hepatitis B virus particles: differential inhibition by L-enantiomers of nucleotide analogs.

Davis MG, Wilson JE, VanDraanen NA, Miller WH, Freeman GA, Daluge SM, Boyd FL, Aulabaugh AE, Painter GR, Boone LR.

Antiviral Res. 1996 May;30(2-3):133-45.

PMID:
8783805
23.

Recombinant human immunodeficiency virus type 1 reverse transcriptase is heterogeneous.

Wilson JE, Wright LL, Martin JL, Haire SE, Ray PH, Painter GR, Furman PA.

J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jan 1;11(1):20-30.

PMID:
8528729
24.

Weak binding of VX-478 to human plasma proteins and implications for anti-human immunodeficiency virus therapy.

Livington DJ, Pazhanisamy S, Porter DJ, Partaledis JA, Tung RD, Painter GR.

J Infect Dis. 1995 Nov;172(5):1238-45.

PMID:
7594659
25.

Evaluation of the potent anti-hepatitis B virus agent (-) cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in a novel in vivo model.

Condreay LD, Jansen RW, Powdrill TF, Johnson LC, Selleseth DW, Paff MT, Daluge SM, Painter GR, Furman PA, Ellis MN, et al.

Antimicrob Agents Chemother. 1994 Mar;38(3):616-9.

26.

Structural and functional characterization of the HPV16 E7 protein expressed in bacteria.

Pahel G, Aulabaugh A, Short SA, Barnes JA, Painter GR, Ray P, Phelps WC.

J Biol Chem. 1993 Dec 5;268(34):26018-25.

27.
28.

Identification of the nucleotide binding site of HIV-1 reverse transcriptase using dTTP as a photoaffinity label.

Cheng N, Merrill BM, Painter GR, Frick LW, Furman PA.

Biochemistry. 1993 Aug 3;32(30):7630-4.

PMID:
7688565
29.

A comparison of the conformations of the 5'-triphosphates of zidovudine (AZT) and thymidine bound to HIV-1 reverse transcriptase.

Painter GR, Aulabaugh AE, Andrews CW.

Biochem Biophys Res Commun. 1993 Mar 31;191(3):1166-71.

PMID:
7682061
30.

Conformational changes induced in herpes simplex virus DNA polymerase upon DNA binding.

Weisshart K, Kuo AA, Painter GR, Wright LL, Furman PA, Coen DM.

Proc Natl Acad Sci U S A. 1993 Feb 1;90(3):1028-32. Erratum in: Proc Natl Acad Sci U S A 1993 May 15;90(10):4763.

31.
32.

Initial binding of 2'-deoxynucleoside 5'-triphosphates to human immunodeficiency virus type 1 reverse transcriptase.

Painter GR, Wright LL, Hopkins S, Furman PA.

J Biol Chem. 1991 Oct 15;266(29):19362-8.

33.

Crosslinking of substrates occurs exclusively to the p66 subunit of heterodimeric HIV-1 reverse transcriptase.

Cheng N, Painter GR, Furman PA.

Biochem Biophys Res Commun. 1991 Jan 31;174(2):785-9.

PMID:
1704228
34.

The effects of lipid composition on the binding of lasalocid A to small unilamellar vesicles.

Grunwald R, Painter GR.

Biochim Biophys Acta. 1990 Sep 7;1027(3):245-52.

PMID:
2397235
35.

Carrier-independent entry of 1-methyl-4-phenylpyridinium (MPP+) into adrenal chromaffin cells as a consequence of charge delocalization.

Reinhard JF Jr, Daniels AJ, Painter GR.

Biochem Biophys Res Commun. 1990 May 16;168(3):1143-8.

PMID:
2346481
36.

Investigation of the stereochemical course of DNA synthesis catalysed by human immunodeficiency virus type 1 reverse transcriptase.

Hopkins S, Furman PA, Painter GR.

Biochem Biophys Res Commun. 1989 Aug 30;163(1):106-10.

PMID:
2476123
37.
38.
39.
40.

Equilibrium cation binding selectivity of the carboxylic ionophore narasin A: a comparison with transport selectivities reported in two biological test systems.

Caughey B, Painter GR, Gibbons WA.

Biochem Pharmacol. 1986 Nov 15;35(22):4103-5. No abstract available.

PMID:
3778530
41.
42.
43.

Dynamic aspects of ionophore mediated membrane transport.

Painter GR, Pressman BC.

Top Curr Chem. 1982;101:83-110. Review. No abstract available.

PMID:
7036411

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