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Items: 1 to 50 of 57

1.

The Chemical Synthesis, Stability, and Activity of MAIT Cell Prodrug Agonists That Access MR1 in Recycling Endosomes.

Lange J, Anderson RJ, Marshall AJ, Chan STS, Bilbrough TS, Gasser O, Gonzalez-Lopez C, Salio M, Cerundolo V, Hermans IF, Painter GF.

ACS Chem Biol. 2020 Feb 21;15(2):437-445. doi: 10.1021/acschembio.9b00902. Epub 2020 Jan 14.

PMID:
31909966
2.

Influence of Albumin in the Microfluidic Synthesis of PEG-PLGA Nanoparticles.

Poller B, Painter GF, Walker GF.

Pharm Nanotechnol. 2019;7(6):460-468. doi: 10.2174/2211738507666191023091938.

PMID:
31657694
3.

Structure-Function Implications of the Ability of Monoclonal Antibodies Against α-Galactosylceramide-CD1d Complex to Recognize β-Mannosylceramide Presentation by CD1d.

Clark K, Yau J, Bloom A, Wang J, Venzon DJ, Suzuki M, Pasquet L, Compton BJ, Cardell SL, Porcelli SA, Painter GF, Zajonc DM, Berzofsky JA, Terabe M.

Front Immunol. 2019 Oct 9;10:2355. doi: 10.3389/fimmu.2019.02355. eCollection 2019.

4.

Enhancing T cell responses and tumour immunity by vaccination with peptides conjugated to a weak NKT cell agonist.

Compton BJ, Farrand KJ, Tang CW, Osmond TL, Speir M, Authier-Hall A, Wang J, Ferguson PM, Chan STS, Anderson RJ, Cooney TR, Hayman CM, Williams GM, Brimble MA, Brooks CR, Yong LK, Metelitsa LS, Zajonc DM, Godfrey DI, Gasser O, Weinkove R, Painter GF, Hermans IF.

Org Biomol Chem. 2019 Jan 31;17(5):1225-1237. doi: 10.1039/c8ob02982b.

PMID:
30656346
5.

A phase I vaccination study with dendritic cells loaded with NY-ESO-1 and α-galactosylceramide: induction of polyfunctional T cells in high-risk melanoma patients.

Gasser O, Sharples KJ, Barrow C, Williams GM, Bauer E, Wood CE, Mester B, Dzhelali M, Caygill G, Jones J, Hayman CM, Hinder VA, Macapagal J, McCusker M, Weinkove R, Painter GF, Brimble MA, Findlay MP, Dunbar PR, Hermans IF.

Cancer Immunol Immunother. 2018 Feb;67(2):285-298. doi: 10.1007/s00262-017-2085-9. Epub 2017 Nov 1.

PMID:
29094183
6.

Glycolipid-peptide conjugate vaccines enhance CD8+ T cell responses against human viral proteins.

Speir M, Authier-Hall A, Brooks CR, Farrand KJ, Compton BJ, Anderson RJ, Heiser A, Osmond TL, Tang CW, Berzofsky JA, Terabe M, Painter GF, Hermans IF, Weinkove R.

Sci Rep. 2017 Oct 27;7(1):14273. doi: 10.1038/s41598-017-14690-5.

7.

Augmenting Influenza-Specific T Cell Memory Generation with a Natural Killer T Cell-Dependent Glycolipid-Peptide Vaccine.

Anderson RJ, Li J, Kedzierski L, Compton BJ, Hayman CM, Osmond TL, Tang CW, Farrand KJ, Koay HF, Almeida CFDSSE, Holz LR, Williams GM, Brimble MA, Wang Z, Koutsakos M, Kedzierska K, Godfrey DI, Hermans IF, Turner SJ, Painter GF.

ACS Chem Biol. 2017 Nov 17;12(11):2898-2905. doi: 10.1021/acschembio.7b00845. Epub 2017 Oct 27.

PMID:
29043774
8.

Synthesis and biological activities of d-chiro-inositol analogues with insulin-like actions.

Rendle PM, Kassibawi F, Johnston KA, Hart JB, Cameron SA, Falshaw A, Painter GF, Loomes KM.

Eur J Med Chem. 2016 Oct 21;122:442-451. doi: 10.1016/j.ejmech.2016.06.047. Epub 2016 Jun 29.

PMID:
27410479
9.

Synthesis and Activity of 6″-Deoxy-6″-thio-α-GalCer and Peptide Conjugates.

Compton BJ, Tang CW, Johnston KA, Osmond TL, Hayman CM, Larsen DS, Hermans IF, Painter GF.

Org Lett. 2015 Dec 18;17(24):5954-7. doi: 10.1021/acs.orglett.5b02836. Epub 2015 Nov 25.

PMID:
26606283
10.

NKT cell-dependent glycolipid-peptide vaccines with potent anti-tumour activity.

Anderson RJ, Compton BJ, Tang CW, Authier-Hall A, Hayman CM, Swinerd GW, Kowalczyk R, Harris P, Brimble MA, Larsen DS, Gasser O, Weinkove R, Hermans IF, Painter GF.

Chem Sci. 2015 Sep 1;6(9):5120-5127. doi: 10.1039/c4sc03599b. Epub 2015 Jun 25.

11.

Anxiogenic and Stressor Effects of the Hypothalamic Neuropeptide RFRP-3 Are Overcome by the NPFFR Antagonist GJ14.

Kim JS, Brownjohn PW, Dyer BS, Beltramo M, Walker CS, Hay DL, Painter GF, Tyndall JD, Anderson GM.

Endocrinology. 2015 Nov;156(11):4152-62. doi: 10.1210/en.2015-1532. Epub 2015 Aug 10.

PMID:
26259035
12.

Total synthesis of Lewis(X) using a late-stage crystalline intermediate.

Munneke S, Painter GF, Gainsford GJ, Stocker BL, Timmer MS.

Carbohydr Res. 2015 Sep 23;414:1-7. doi: 10.1016/j.carres.2015.05.017. Epub 2015 Jun 12.

PMID:
26162743
13.

Activated NKT Cells Can Condition Different Splenic Dendritic Cell Subsets To Respond More Effectively to TLR Engagement and Enhance Cross-Priming.

Osmond TL, Farrand KJ, Painter GF, Ruedl C, Petersen TR, Hermans IF.

J Immunol. 2015 Aug 1;195(3):821-31. doi: 10.4049/jimmunol.1401751. Epub 2015 Jun 15.

14.

The rapid and facile synthesis of oxyamine linkers for the preparation of hydrolytically stable glycoconjugates.

Munneke S, Prevost JR, Painter GF, Stocker BL, Timmer MS.

Org Lett. 2015 Feb 6;17(3):624-7. doi: 10.1021/ol503634j. Epub 2015 Jan 16.

PMID:
25594534
15.

Resolution of orthogonally protected myo-inositols with novozym 435 providing an enantioconvergent pathway to Ac2PIM1.

Lee AM, Painter GF, Compton BJ, Larsen DS.

J Org Chem. 2014 Nov 21;79(22):10916-31. doi: 10.1021/jo5019188. Epub 2014 Nov 7.

PMID:
25338261
16.

A self-adjuvanting vaccine induces cytotoxic T lymphocytes that suppress allergy.

Anderson RJ, Tang CW, Daniels NJ, Compton BJ, Hayman CM, Johnston KA, Knight DA, Gasser O, Poyntz HC, Ferguson PM, Larsen DS, Ronchese F, Painter GF, Hermans IF.

Nat Chem Biol. 2014 Nov;10(11):943-9. doi: 10.1038/nchembio.1640. Epub 2014 Oct 5.

PMID:
25282504
17.

An autologous leukemia cell vaccine prevents murine acute leukemia relapse after cytarabine treatment.

Gibbins JD, Ancelet LR, Weinkove R, Compton BJ, Painter GF, Petersen TR, Hermans IF.

Blood. 2014 Nov 6;124(19):2953-63. doi: 10.1182/blood-2014-04-568956. Epub 2014 Sep 18.

PMID:
25237205
18.

Soluble human TLR2 ectodomain binds diacylglycerol from microbial lipopeptides and glycolipids.

Jiménez-Dalmaroni MJ, Radcliffe CM, Harvey DJ, Wormald MR, Verdino P, Ainge GD, Larsen DS, Painter GF, Ulevitch R, Beutler B, Rudd PM, Dwek RA, Wilson IA.

Innate Immun. 2015 Feb;21(2):175-93. doi: 10.1177/1753425914524077. Epub 2014 Mar 3.

19.

The dimethoxyphenylbenzyl protecting group: an alternative to the p-methoxybenzyl group for protection of carbohydrates.

Rankin GM, Maxwell-Cameron I, Painter GF, Larsen DS.

J Org Chem. 2013 Jun 7;78(11):5264-72. doi: 10.1021/jo4004184. Epub 2013 May 16.

PMID:
23678997
20.

Physicochemical and biological characterization of synthetic phosphatidylinositol dimannosides and analogues.

Hubert M, Compton BJ, Hayman CM, Larsen DS, Painter GF, Rades T, Hook S.

Mol Pharm. 2013 May 6;10(5):1928-39. doi: 10.1021/mp300707a. Epub 2013 Mar 25.

PMID:
23469864
21.

Synthesis and mass spectral characterization of mycobacterial phosphatidylinositol and its dimannosides.

Rankin GM, Compton BJ, Johnston KA, Hayman CM, Painter GF, Larsen DS.

J Org Chem. 2012 Aug 17;77(16):6743-59. doi: 10.1021/jo301189y. Epub 2012 Aug 7.

PMID:
22845613
22.

Phosphatidylinositol di-mannoside and derivates modulate the immune response to and efficacy of a tuberculosis protein vaccine against Mycobacterium bovis infection.

Parlane NA, Compton BJ, Hayman CM, Painter GF, Basaraba RJ, Heiser A, Buddle BM.

Vaccine. 2012 Jan 11;30(3):580-8. doi: 10.1016/j.vaccine.2011.11.055. Epub 2011 Nov 24.

PMID:
22120192
23.

Synthesis and Toll-like receptor 4 (TLR4) activity of phosphatidylinositol dimannoside analogues.

Ainge GD, Martin WJ, Compton BJ, Hayman CM, Larsen DS, Yoon SI, Wilson IA, Harper JL, Painter GF.

J Med Chem. 2011 Oct 27;54(20):7268-79. doi: 10.1021/jm2008419. Epub 2011 Oct 5.

24.

Analysis of the CD1 antigen presenting system in humanized SCID mice.

Lockridge JL, Chen X, Zhou Y, Rajesh D, Roenneburg DA, Hegde S, Gerdts S, Cheng TY, Anderson RJ, Painter GF, Moody DB, Burlingham WJ, Gumperz JE.

PLoS One. 2011;6(6):e21701. doi: 10.1371/journal.pone.0021701. Epub 2011 Jun 30.

25.

Chemical synthesis and immunosuppressive activity of dipalmitoyl phosphatidylinositol hexamannoside.

Ainge GD, Compton BJ, Hayman CM, Martin WJ, Toms SM, Larsen DS, Harper JL, Painter GF.

J Org Chem. 2011 Jun 17;76(12):4941-51. doi: 10.1021/jo200588u. Epub 2011 May 24.

PMID:
21574597
26.

A PIM₂ analogue suppresses allergic airway disease.

Harper JL, Hayman CM, Larsen DS, Painter GF, Singh-Gill G.

Bioorg Med Chem. 2011 Jan 15;19(2):917-25. doi: 10.1016/j.bmc.2010.11.058. Epub 2010 Dec 2.

PMID:
21215641
27.

The Vα14 invariant natural killer T cell TCR forces microbial glycolipids and CD1d into a conserved binding mode.

Li Y, Girardi E, Wang J, Yu ED, Painter GF, Kronenberg M, Zajonc DM.

J Exp Med. 2010 Oct 25;207(11):2383-93. doi: 10.1084/jem.20101335. Epub 2010 Oct 4.

28.

Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function.

Zeissig S, Dougan SK, Barral DC, Junker Y, Chen Z, Kaser A, Ho M, Mandel H, McIntyre A, Kennedy SM, Painter GF, Veerapen N, Besra GS, Cerundolo V, Yue S, Beladi S, Behar SM, Chen X, Gumperz JE, Breckpot K, Raper A, Baer A, Exley MA, Hegele RA, Cuchel M, Rader DJ, Davidson NO, Blumberg RS.

J Clin Invest. 2010 Aug;120(8):2889-99. doi: 10.1172/JCI42703. Epub 2010 Jul 1.

29.

Regioselective approach to phosphatidylinositol 3,5-bisphosphates: syntheses of the native phospholipid and biotinylated short-chain derivative.

Anderson RJ, Osborne SL, Meunier FA, Painter GF.

J Org Chem. 2010 Jun 4;75(11):3541-51. doi: 10.1021/jo100393c.

PMID:
20443612
30.

Lipid binding orientation within CD1d affects recognition of Borrelia burgorferi antigens by NKT cells.

Wang J, Li Y, Kinjo Y, Mac TT, Gibson D, Painter GF, Kronenberg M, Zajonc DM.

Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1535-40. doi: 10.1073/pnas.0909479107. Epub 2009 Dec 30.

31.

Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes.

Conway SJ, Gardiner J, Grove SJ, Johns MK, Lim ZY, Painter GF, Robinson DE, Schieber C, Thuring JW, Wong LS, Yin MX, Burgess AW, Catimel B, Hawkins PT, Ktistakis NT, Stephens LR, Holmes AB.

Org Biomol Chem. 2010 Jan 7;8(1):66-76. doi: 10.1039/b913399b. Epub 2009 Nov 9.

PMID:
20024134
32.

A synthetic analogue of phosphatidylinositol mannoside is an efficient adjuvant.

Denis M, Ainge GD, Larsen DS, Severn WB, Painter GF.

Immunopharmacol Immunotoxicol. 2009;31(4):577-82. doi: 10.3109/08923970902824862.

PMID:
19874225
33.

Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2.

Jimenez-Dalmaroni MJ, Xiao N, Corper AL, Verdino P, Ainge GD, Larsen DS, Painter GF, Rudd PM, Dwek RA, Hoebe K, Beutler B, Wilson IA.

PLoS One. 2009 Oct 22;4(10):e7411. doi: 10.1371/journal.pone.0007411.

34.

Role of phosphatidylinositol mannosides in the interaction between mycobacteria and DC-SIGN.

Driessen NN, Ummels R, Maaskant JJ, Gurcha SS, Besra GS, Ainge GD, Larsen DS, Painter GF, Vandenbroucke-Grauls CM, Geurtsen J, Appelmelk BJ.

Infect Immun. 2009 Oct;77(10):4538-47. doi: 10.1128/IAI.01256-08. Epub 2009 Aug 3.

35.

2-Benzyl-myo-inositol monohydrate.

Fröhlich RF, Gainsford GJ, Painter GF.

Acta Crystallogr Sect E Struct Rep Online. 2009 Oct 17;65(Pt 11):o2782. doi: 10.1107/S1600536809041750.

36.

Natural killer T-cell autoreactivity leads to a specialized activation state.

Wang X, Chen X, Rodenkirch L, Simonson W, Wernimont S, Ndonye RM, Veerapen N, Gibson D, Howell AR, Besra GS, Painter GF, Huttenlocher A, Gumperz JE.

Blood. 2008 Nov 15;112(10):4128-38. doi: 10.1182/blood-2008-05-157529. Epub 2008 Sep 8.

37.

Enhanced protection against bovine tuberculosis after coadministration of Mycobacterium bovis BCG with a Mycobacterial protein vaccine-adjuvant combination but not after coadministration of adjuvant alone.

Wedlock DN, Denis M, Painter GF, Ainge GD, Vordermeier HM, Hewinson RG, Buddle BM.

Clin Vaccine Immunol. 2008 May;15(5):765-72. doi: 10.1128/CVI.00034-08. Epub 2008 Mar 12.

38.

Phosphatidylinositol mannosides are efficient mucosal adjuvants.

Parlane NA, Denis M, Severn WB, Skinner MA, Painter GF, La Flamme AC, Ainge GD, Larsen DS, Buddle BM.

Immunol Invest. 2008;37(2):129-42. doi: 10.1080/08820130701690782.

PMID:
18300038
39.

Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases.

Gutierrez JA, Luo M, Singh V, Li L, Brown RL, Norris GE, Evans GB, Furneaux RH, Tyler PC, Painter GF, Lenz DH, Schramm VL.

ACS Chem Biol. 2007 Nov 20;2(11):725-34.

PMID:
18030989
40.

Steady-state and pre-steady-state kinetic analysis of Mycobacterium smegmatis cysteine ligase (MshC).

Fan F, Luxenburger A, Painter GF, Blanchard JS.

Biochemistry. 2007 Oct 9;46(40):11421-9. Epub 2007 Sep 12.

41.

Phosphatidylinositol mannoside ether analogues: syntheses and interleukin-12-inducing properties.

Ainge GD, Parlane NA, Denis M, Dyer BS, Härer A, Hayman CM, Larsen DS, Painter GF.

J Org Chem. 2007 Jul 6;72(14):5291-6. Epub 2007 Jun 9.

PMID:
17559276
42.

Synthesis and structure of phosphatidylinositol dimannoside.

Dyer BS, Jones JD, Ainge GD, Denis M, Larsen DS, Painter GF.

J Org Chem. 2007 Apr 27;72(9):3282-8. Epub 2007 Mar 27.

PMID:
17385918
43.

Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae.

Singh V, Shi W, Almo SC, Evans GB, Furneaux RH, Tyler PC, Painter GF, Lenz DH, Mee S, Zheng R, Schramm VL.

Biochemistry. 2006 Oct 31;45(43):12929-41.

44.

Novel synthesis of alpha-galactosyl-ceramides and confirmation of their powerful NKT cell agonist activity.

Lee A, Farrand KJ, Dickgreber N, Hayman CM, Jürs S, Hermans IF, Painter GF.

Carbohydr Res. 2006 Dec 11;341(17):2785-98. Epub 2006 Oct 2.

PMID:
17014832
45.

Structural characterization of mycobacterial phosphatidylinositol mannoside binding to mouse CD1d.

Zajonc DM, Ainge GD, Painter GF, Severn WB, Wilson IA.

J Immunol. 2006 Oct 1;177(7):4577-83.

46.

Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria.

Kinjo Y, Tupin E, Wu D, Fujio M, Garcia-Navarro R, Benhnia MR, Zajonc DM, Ben-Menachem G, Ainge GD, Painter GF, Khurana A, Hoebe K, Behar SM, Beutler B, Wilson IA, Tsuji M, Sellati TJ, Wong CH, Kronenberg M.

Nat Immunol. 2006 Sep;7(9):978-86. Epub 2006 Aug 20.

PMID:
16921381
47.

Phosphatidylinositol mannosides: synthesis and adjuvant properties of phosphatidylinositol di- and tetramannosides.

Ainge GD, Parlane NA, Denis M, Hayman CM, Larsen DS, Painter GF.

Bioorg Med Chem. 2006 Nov 15;14(22):7615-24. Epub 2006 Jul 27.

PMID:
16876422
48.

Phosphatidylinositol mannosides: synthesis and suppression of allergic airway disease.

Ainge GD, Hudson J, Larsen DS, Painter GF, Gill GS, Harper JL.

Bioorg Med Chem. 2006 Aug 15;14(16):5632-42. Epub 2006 May 11.

PMID:
16697208
49.

Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase.

Evans GB, Furneaux RH, Lenz DH, Painter GF, Schramm VL, Singh V, Tyler PC.

J Med Chem. 2005 Jul 14;48(14):4679-89.

PMID:
16000004
50.

Energetic mapping of transition state analogue interactions with human and Plasmodium falciparum purine nucleoside phosphorylases.

Lewandowicz A, Ringia EA, Ting LM, Kim K, Tyler PC, Evans GB, Zubkova OV, Mee S, Painter GF, Lenz DH, Furneaux RH, Schramm VL.

J Biol Chem. 2005 Aug 26;280(34):30320-8. Epub 2005 Jun 16.

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