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Items: 28

1.

Plasma and urine pharmacokinetics of intravenously administered flunixin in greyhound dogs.

Morris T, Paine SW, Zahra P, Li E, Colgan S, Karamatic S.

J Vet Pharmacol Ther. 2019 May 14. doi: 10.1111/jvp.12775. [Epub ahead of print]

PMID:
31090076
2.

The pharmacokinetics of orally administered butylscopolamine in greyhound dogs.

Morris T, Paine SW, Viljanto M, Hudson S, Gower S, Pittorino M, Colgan S.

J Vet Pharmacol Ther. 2018 Dec;41(6):790-794. doi: 10.1111/jvp.12701. Epub 2018 Aug 3.

PMID:
30076627
3.

Machine learning for improved image-based wavefront sensing.

Paine SW, Fienup JR.

Opt Lett. 2018 Mar 15;43(6):1235-1238. doi: 10.1364/OL.43.001235.

PMID:
29543260
4.

Re-evaluation of the regulation of omeprazole in racehorses: An evidence-based approach.

Viljanto M, Hillyer L, Hincks P, Pearce C, Paine SW.

J Vet Pharmacol Ther. 2018 Jun;41(3):469-475. doi: 10.1111/jvp.12491. Epub 2018 Feb 22.

PMID:
29468684
5.

Extending capture range for piston retrieval in segmented systems.

Paine SW, Fienup JR.

Appl Opt. 2017 Nov 20;56(33):9186-9192. doi: 10.1364/AO.56.009186.

PMID:
29216088
6.

The effects of aging on hepatic microsomal scaling factor and hepatocellularity number in the horse.

Shibany KA, Tötemeyer S, Pratt SL, Paine SW.

Xenobiotica. 2018 Dec;48(12):1237-1244. doi: 10.1080/00498254.2017.1413263. Epub 2017 Dec 19.

PMID:
29198170
7.

Pharmacokinetics of inorganic cobalt and a vitamin B12 supplement in the Thoroughbred horse: Differentiating cobalt abuse from supplementation.

Hillyer LL, Ridd Z, Fenwick S, Hincks P, Paine SW.

Equine Vet J. 2018 May;50(3):343-349. doi: 10.1111/evj.12774. Epub 2017 Nov 12.

PMID:
29053883
8.

A quantitative systems pharmacology approach, incorporating a novel liver model, for predicting pharmacokinetic drug-drug interactions.

Cherkaoui-Rbati MH, Paine SW, Littlewood P, Rauch C.

PLoS One. 2017 Sep 14;12(9):e0183794. doi: 10.1371/journal.pone.0183794. eCollection 2017.

9.

Detection and pharmacokinetics of salmeterol in thoroughbred horses following inhaled administration.

Fenwick SJ, Hincks PR, Scarth JP, Wieder ME, Hillyer LL, Paine SW.

J Vet Pharmacol Ther. 2017 Oct;40(5):486-492. doi: 10.1111/jvp.12382. Epub 2017 Jan 17.

PMID:
28097668
10.

Equine hepatocytes: isolation, cryopreservation, and applications to in vitro drug metabolism studies.

Shibany KA, Tötemeyer S, Pratt SL, Paine SW.

Pharmacol Res Perspect. 2016 Sep 30;4(5):e00268. eCollection 2016 Oct.

11.

Detection and pharmacokinetics of salbutamol in thoroughbred racehorses following inhaled administration.

Wieder ME, Paine SW, Hincks PR, Pearce CM, Scarth J, Hillyer L.

J Vet Pharmacol Ther. 2015 Feb;38(1):41-7. doi: 10.1111/jvp.12150. Epub 2014 Sep 17.

PMID:
25229326
12.

Polyethylene glycol-drug ester conjugates for prolonged retention of small inhaled drugs in the lung.

Bayard FJ, Thielemans W, Pritchard DI, Paine SW, Young SS, Bäckman P, Ewing P, Bosquillon C.

J Control Release. 2013 Oct 28;171(2):234-40. doi: 10.1016/j.jconrel.2013.07.023. Epub 2013 Aug 3.

13.

Can long range mechanical interaction between drugs and membrane proteins define the notion of molecular promiscuity? Application to P-glycoprotein-mediated multidrug resistance (MDR).

Rauch C, Paine SW, Littlewood P.

Biochim Biophys Acta. 2013 Nov;1830(11):5112-8. doi: 10.1016/j.bbagen.2013.06.038. Epub 2013 Jul 10.

PMID:
23850561
14.

Species differences in biliary clearance and possible relevance of hepatic uptake and efflux transporters involvement.

Grime K, Paine SW.

Drug Metab Dispos. 2013 Feb;41(2):372-8. doi: 10.1124/dmd.112.049312. Epub 2012 Nov 8.

PMID:
23139379
15.

Characteristics of AZD9708, a novel, selective β2-adrenoceptor agonist with rapid onset and long duration of action.

Nicholls DJ, Jordan S, Cadogan E, Lawson M, Austin RP, Paine SW, Gardiner P, Bonnert R, Connolly S, Young A.

Pulm Pharmacol Ther. 2012 Aug;25(4):293-302. doi: 10.1016/j.pupt.2012.05.008. Epub 2012 May 29.

PMID:
22659538
16.

The impact of hepatic uptake on the pharmacokinetics of organic anions.

Gardiner P, Paine SW.

Drug Metab Dispos. 2011 Oct;39(10):1930-8. doi: 10.1124/dmd.111.039842. Epub 2011 Jul 21.

PMID:
21778353
17.

Switching between agonists and antagonists at CRTh2 in a series of highly potent and selective biaryl phenoxyacetic acids.

Luker T, Bonnert R, Schmidt J, Sargent C, Paine SW, Thom S, Pairaudeau G, Patel A, Mohammed R, Akam E, Dougall I, Davis AM, Abbott P, Brough S, Millichip I, McInally T.

Bioorg Med Chem Lett. 2011 Jun 15;21(12):3616-21. doi: 10.1016/j.bmcl.2011.04.101. Epub 2011 Apr 28.

PMID:
21592791
18.

Prediction of human renal clearance from preclinical species for a diverse set of drugs that exhibit both active secretion and net reabsorption.

Paine SW, Ménochet K, Denton R, McGinnity DF, Riley RJ.

Drug Metab Dispos. 2011 Jun;39(6):1008-13. doi: 10.1124/dmd.110.037267. Epub 2011 Feb 28.

PMID:
21357702
19.

Zwitterionic CRTh2 antagonists.

Luker T, Bonnert R, Paine SW, Schmidt J, Sargent C, Cook AR, Cook A, Gardiner P, Hill S, Weyman-Jones C, Patel A, Thom S, Thorne P.

J Med Chem. 2011 Mar 24;54(6):1779-88. doi: 10.1021/jm1014549. Epub 2011 Feb 28.

PMID:
21355602
20.

A rapid computational filter for predicting the rate of human renal clearance.

Paine SW, Barton P, Bird J, Denton R, Menochet K, Smith A, Tomkinson NP, Chohan KK.

J Mol Graph Model. 2010 Dec;29(4):529-37. doi: 10.1016/j.jmgm.2010.10.003. Epub 2010 Oct 20.

PMID:
21075652
21.

Prediction of the pharmacokinetics of atorvastatin, cerivastatin, and indomethacin using kinetic models applied to isolated rat hepatocytes.

Paine SW, Parker AJ, Gardiner P, Webborn PJ, Riley RJ.

Drug Metab Dispos. 2008 Jul;36(7):1365-74. doi: 10.1124/dmd.107.019455. Epub 2008 Apr 21.

PMID:
18426955
22.

Generation of in-silico cytochrome P450 1A2, 2C9, 2C19, 2D6, and 3A4 inhibition QSAR models.

Gleeson MP, Davis AM, Chohan KK, Paine SW, Boyer S, Gavaghan CL, Arnby CH, Kankkonen C, Albertson N.

J Comput Aided Mol Des. 2007 Oct-Nov;21(10-11):559-73. Epub 2007 Nov 22.

PMID:
18034311
23.

From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis.

Springthorpe B, Bailey A, Barton P, Birkinshaw TN, Bonnert RV, Brown RC, Chapman D, Dixon J, Guile SD, Humphries RG, Hunt SF, Ince F, Ingall AH, Kirk IP, Leeson PD, Leff P, Lewis RJ, Martin BP, McGinnity DF, Mortimore MP, Paine SW, Pairaudeau G, Patel A, Rigby AJ, Riley RJ, Teobald BJ, Tomlinson W, Webborn PJ, Willis PA.

Bioorg Med Chem Lett. 2007 Nov 1;17(21):6013-8. Epub 2007 Aug 19.

PMID:
17827008
24.

Quantitative structure activity relationships in drug metabolism.

Chohan KK, Paine SW, Waters NJ.

Curr Top Med Chem. 2006;6(15):1569-78. Review.

PMID:
16918469
25.
26.

Discovery of potent CRTh2 (DP2) receptor antagonists.

Birkinshaw TN, Teague SJ, Beech C, Bonnert RV, Hill S, Patel A, Reakes S, Sanganee H, Dougall IG, Phillips TT, Salter S, Schmidt J, Arrowsmith EC, Carrillo JJ, Bell FM, Paine SW, Weaver R.

Bioorg Med Chem Lett. 2006 Aug 15;16(16):4287-90. Epub 2006 Jun 5.

PMID:
16753296
27.

In silico human and rat Vss quantitative structure-activity relationship models.

Gleeson MP, Waters NJ, Paine SW, Davis AM.

J Med Chem. 2006 Mar 23;49(6):1953-63.

PMID:
16539383
28.

A rapid computational filter for cytochrome P450 1A2 inhibition potential of compound libraries.

Chohan KK, Paine SW, Mistry J, Barton P, Davis AM.

J Med Chem. 2005 Aug 11;48(16):5154-61.

PMID:
16078835

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