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Cross-resistance profiles of malaria mosquito P450s associated with pyrethroid resistance against WHO insecticides.

Yunta C, Hemmings K, Stevenson B, Koekemoer LL, Matambo T, Pignatelli P, Voice M, Nász S, Paine MJI.

Pestic Biochem Physiol. 2019 Nov;161:61-67. doi: 10.1016/j.pestbp.2019.06.007. Epub 2019 Jun 13.


Antimalarial activity of primaquine operates via a two-step biochemical relay.

Camarda G, Jirawatcharadech P, Priestley RS, Saif A, March S, Wong MHL, Leung S, Miller AB, Baker DA, Alano P, Paine MJI, Bhatia SN, O'Neill PM, Ward SA, Biagini GA.

Nat Commun. 2019 Jul 19;10(1):3226. doi: 10.1038/s41467-019-11239-0.


Development of a rapid field-applicable molecular diagnostic for knockdown resistance (kdr) markers in An. gambiae.

Unwin VT, Ainsworth S, Rippon EJ, Niang EHA, Paine MJI, Weetman D, Adams ER.

Parasit Vectors. 2018 May 18;11(1):307. doi: 10.1186/s13071-018-2893-6.


Characterisation of Anopheles gambiae heme oxygenase and metalloporphyrin feeding suggests a potential role in reproduction.

Spencer CS, Yunta C, de Lima GPG, Hemmings K, Lian LY, Lycett G, Paine MJI.

Insect Biochem Mol Biol. 2018 Jul;98:25-33. doi: 10.1016/j.ibmb.2018.04.010. Epub 2018 May 3.


Pyriproxyfen is metabolized by P450s associated with pyrethroid resistance in An. gambiae.

Yunta C, Grisales N, Nász S, Hemmings K, Pignatelli P, Voice M, Ranson H, Paine MJ.

Insect Biochem Mol Biol. 2016 Nov;78:50-57. doi: 10.1016/j.ibmb.2016.09.001. Epub 2016 Sep 7.


Induced thiacloprid insensitivity in honeybees (Apis mellifera L.) is associated with up-regulation of detoxification genes.

Alptekin S, Bass C, Nicholls C, Paine MJ, Clark SJ, Field L, Moores GD.

Insect Mol Biol. 2016 Apr;25(2):171-80. doi: 10.1111/imb.12211. Epub 2016 Jan 20.


Development of a Simple Dipstick Assay for Operational Monitoring of DDT.

Ismail HM, Kumar V, Singh RP, Williams C, Shivam P, Ghosh A, Deb R, Foster GM, Hemingway J, Coleman M, Coleman M, Das P, Paine MJ.

PLoS Negl Trop Dis. 2016 Jan 13;10(1):e0004324. doi: 10.1371/journal.pntd.0004324. eCollection 2016 Jan.


Mass Drug Administration and beyond: how can we strengthen health systems to deliver complex interventions to eliminate neglected tropical diseases?

Macpherson EE, Adams ER, Bockarie MJ, Hollingsworth TD, Kelly-Hope LA, Lehane M, Kovacic V, Harrison RA, Paine MJ, Reimer LJ, Torr SJ.

BMC Proc. 2015 Dec 18;9(Suppl 10):S7. doi: 10.1186/1753-6561-9-S10-S7. eCollection 2015.


Fit for purpose: do we have the right tools to sustain NTD elimination?

Reimer LJ, Adams ER, Paine MJ, Ranson H, Coleman M, Thomsen EK, MacPherson EE, Hollingsworth TD, Kelly-Hope LA, Bockarie MJ, Ford L, Harrison RA, Stothard JR, Taylor MJ, Hamon N, Torr SJ.

BMC Proc. 2015 Dec 18;9(Suppl 10):S5. doi: 10.1186/1753-6561-9-S10-S5. eCollection 2015.


Allelic Variation of Cytochrome P450s Drives Resistance to Bednet Insecticides in a Major Malaria Vector.

Ibrahim SS, Riveron JM, Bibby J, Irving H, Yunta C, Paine MJ, Wondji CS.

PLoS Genet. 2015 Oct 30;11(10):e1005618. doi: 10.1371/journal.pgen.1005618. eCollection 2015 Oct.


DDT-based indoor residual spraying suboptimal for visceral leishmaniasis elimination in India.

Coleman M, Foster GM, Deb R, Pratap Singh R, Ismail HM, Shivam P, Ghosh AK, Dunkley S, Kumar V, Coleman M, Hemingway J, Paine MJ, Das P.

Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8573-8. doi: 10.1073/pnas.1507782112. Epub 2015 Jun 29.


Evaluating the feasibility of using insecticide quantification kits (IQK) for estimating cyanopyrethroid levels for indoor residual spraying in Vanuatu.

Russell TL, Morgan JC, Ismail H, Kaur H, Eggelte T, Oladepo F, Amon J, Hemingway J, Iata H, Paine MJ.

Malar J. 2014 May 9;13:178. doi: 10.1186/1475-2875-13-178.


Metabolic and target-site mechanisms combine to confer strong DDT resistance in Anopheles gambiae.

Mitchell SN, Rigden DJ, Dowd AJ, Lu F, Wilding CS, Weetman D, Dadzie S, Jenkins AM, Regna K, Boko P, Djogbenou L, Muskavitch MA, Ranson H, Paine MJ, Mayans O, Donnelly MJ.

PLoS One. 2014 Mar 27;9(3):e92662. doi: 10.1371/journal.pone.0092662. eCollection 2014.


CYP6 P450 enzymes and ACE-1 duplication produce extreme and multiple insecticide resistance in the malaria mosquito Anopheles gambiae.

Edi CV, Djogbénou L, Jenkins AM, Regna K, Muskavitch MA, Poupardin R, Jones CM, Essandoh J, Kétoh GK, Paine MJ, Koudou BG, Donnelly MJ, Ranson H, Weetman D.

PLoS Genet. 2014 Mar 20;10(3):e1004236. doi: 10.1371/journal.pgen.1004236. eCollection 2014 Mar.


Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions.

Ismail HM, O'Neill PM, Hong DW, Finn RD, Henderson CJ, Wright AT, Cravatt BF, Hemingway J, Paine MJ.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19766-71. doi: 10.1073/pnas.1320185110. Epub 2013 Nov 18.


Role of cytochrome P450s in insecticide resistance: impact on the control of mosquito-borne diseases and use of insecticides on Earth.

David JP, Ismail HM, Chandor-Proust A, Paine MJ.

Philos Trans R Soc Lond B Biol Sci. 2013 Jan 6;368(1612):20120429. doi: 10.1098/rstb.2012.0429. Print 2013 Feb 19. Review.


Directionally selected cytochrome P450 alleles are driving the spread of pyrethroid resistance in the major malaria vector Anopheles funestus.

Riveron JM, Irving H, Ndula M, Barnes KG, Ibrahim SS, Paine MJ, Wondji CS.

Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):252-7. doi: 10.1073/pnas.1216705110. Epub 2012 Dec 17.


A cis-regulatory sequence driving metabolic insecticide resistance in mosquitoes: functional characterisation and signatures of selection.

Wilding CS, Smith I, Lynd A, Yawson AE, Weetman D, Paine MJ, Donnelly MJ.

Insect Biochem Mol Biol. 2012 Sep;42(9):699-707. doi: 10.1016/j.ibmb.2012.06.003. Epub 2012 Jun 23.


Pinpointing P450s associated with pyrethroid metabolism in the dengue vector, Aedes aegypti: developing new tools to combat insecticide resistance.

Stevenson BJ, Pignatelli P, Nikou D, Paine MJ.

PLoS Negl Trop Dis. 2012;6(3):e1595. doi: 10.1371/journal.pntd.0001595. Epub 2012 Mar 27.


Identification and validation of a gene causing cross-resistance between insecticide classes in Anopheles gambiae from Ghana.

Mitchell SN, Stevenson BJ, Müller P, Wilding CS, Egyir-Yawson A, Field SG, Hemingway J, Paine MJ, Ranson H, Donnelly MJ.

Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6147-52. doi: 10.1073/pnas.1203452109. Epub 2012 Mar 28.


The role of bioreductive activation of antitumour anthracycline drugs in cytotoxic activity against sensitive and multidrug resistant leukaemia HL60 cells.

Kostrzewa-Nowak D, Bieg B, Paine MJ, Wolf CR, Tarasiuk J.

Eur J Pharmacol. 2012 Jan 15;674(2-3):112-25. doi: 10.1016/j.ejphar.2011.10.047. Epub 2011 Nov 15.


Biochemical comparison of Anopheles gambiae and human NADPH P450 reductases reveals different 2'-5'-ADP and FMN binding traits.

Lian LY, Widdowson P, McLaughlin LA, Paine MJ.

PLoS One. 2011;6(5):e20574. doi: 10.1371/journal.pone.0020574. Epub 2011 May 31.


Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed.

Stevenson BJ, Bibby J, Pignatelli P, Muangnoicharoen S, O'Neill PM, Lian LY, Müller P, Nikou D, Steven A, Hemingway J, Sutcliffe MJ, Paine MJ.

Insect Biochem Mol Biol. 2011 Jul;41(7):492-502. doi: 10.1016/j.ibmb.2011.02.003. Epub 2011 Feb 13.


Sequence characterization of cytochrome P450 CYP6P9 in pyrethroid resistant and susceptible Anopheles funestus (Diptera: Culicidae).

Matambo TS, Paine MJ, Coetzee M, Koekemoer LL.

Genet Mol Res. 2010 Mar 30;9(1):554-64. doi: 10.4238/vol9-1gmr719.


Structural model and functional characterization of the Bemisia tabaci CYP6CM1vQ, a cytochrome P450 associated with high levels of imidacloprid resistance.

Karunker I, Morou E, Nikou D, Nauen R, Sertchook R, Stevenson BJ, Paine MJ, Morin S, Vontas J.

Insect Biochem Mol Biol. 2009 Oct;39(10):697-706. doi: 10.1016/j.ibmb.2009.08.006. Epub 2009 Aug 27.


Field-caught permethrin-resistant Anopheles gambiae overexpress CYP6P3, a P450 that metabolises pyrethroids.

Müller P, Warr E, Stevenson BJ, Pignatelli PM, Morgan JC, Steven A, Yawson AE, Mitchell SN, Ranson H, Hemingway J, Paine MJ, Donnelly MJ.

PLoS Genet. 2008 Nov;4(11):e1000286. doi: 10.1371/journal.pgen.1000286. Epub 2008 Nov 28.


Multiple substrate binding by cytochrome P450 3A4: estimation of the number of bound substrate molecules.

Kapelyukh Y, Paine MJ, Maréchal JD, Sutcliffe MJ, Wolf CR, Roberts GC.

Drug Metab Dispos. 2008 Oct;36(10):2136-44. doi: 10.1124/dmd.108.021733. Epub 2008 Jul 21.


Characterization of inhibitors and substrates of Anopheles gambiae CYP6Z2.

McLaughlin LA, Niazi U, Bibby J, David JP, Vontas J, Hemingway J, Ranson H, Sutcliffe MJ, Paine MJ.

Insect Mol Biol. 2008 Apr;17(2):125-35. doi: 10.1111/j.1365-2583.2007.00788.x.


Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions.

Maréchal JD, Kemp CA, Roberts GC, Paine MJ, Wolf CR, Sutcliffe MJ.

Br J Pharmacol. 2008 Mar;153 Suppl 1:S82-9. Epub 2007 Nov 19. Review.


Anopheles gambiae P450 reductase is highly expressed in oenocytes and in vivo knockdown increases permethrin susceptibility.

Lycett GJ, McLaughlin LA, Ranson H, Hemingway J, Kafatos FC, Loukeris TG, Paine MJ.

Insect Mol Biol. 2006 Jun;15(3):321-7.


In silico prediction of drug binding to CYP2D6: identification of a new metabolite of metoclopramide.

Yu J, Paine MJ, Maréchal JD, Kemp CA, Ward CJ, Brown S, Sutcliffe MJ, Roberts GC, Rankin EM, Wolf CR.

Drug Metab Dispos. 2006 Aug;34(8):1386-92. Epub 2006 May 12.


Bioreductive activation of mitoxantrone by NADPH cytochrome P450 reductase. Implications for increasing its ability to inhibit the growth of sensitive and multidrug resistant leukaemia HL60 cells.

Kostrzewa-Nowak D, Paine MJ, Korytowska A, Serwatka K, Piotrowska S, Wolf CR, Tarasiuk J.

Cancer Lett. 2007 Jan 8;245(1-2):252-62. Epub 2006 Mar 29.


In silico and in vitro screening for inhibition of cytochrome P450 CYP3A4 by comedications commonly used by patients with cancer.

Marechal JD, Yu J, Brown S, Kapelioukh I, Rankin EM, Wolf CR, Roberts GC, Paine MJ, Sutcliffe MJ.

Drug Metab Dispos. 2006 Apr;34(4):534-8. Epub 2006 Jan 13.


Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.

McLaughlin LA, Paine MJ, Kemp CA, Maréchal JD, Flanagan JU, Ward CJ, Sutcliffe MJ, Roberts GC, Wolf CR.

J Biol Chem. 2005 Nov 18;280(46):38617-24. Epub 2005 Sep 14.


Identification of a functionally impaired allele of human novel oxidoreductase 1 (NDOR1), NDOR1*1.

Finn RD, Wilkie M, Smith G, Paine MJ.

Pharmacogenet Genomics. 2005 Jun;15(6):381-6.


Rainbow tags: a visual tag system for recombinant protein expression and purification.

Finn RD, Kapelioukh I, Paine MJ.

Biotechniques. 2005 Mar;38(3):387-8, 390-2.


Validation of model of cytochrome P450 2D6: an in silico tool for predicting metabolism and inhibition.

Kemp CA, Flanagan JU, van Eldik AJ, Maréchal JD, Wolf CR, Roberts GC, Paine MJ, Sutcliffe MJ.

J Med Chem. 2004 Oct 21;47(22):5340-6.


Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.

Flanagan JU, Maréchal JD, Ward R, Kemp CA, McLaughlin LA, Sutcliffe MJ, Roberts GC, Paine MJ, Wolf CR.

Biochem J. 2004 Jun 1;380(Pt 2):353-60.


Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1.

Finn RD, Basran J, Roitel O, Wolf CR, Munro AW, Paine MJ, Scrutton NS.

Eur J Biochem. 2003 Mar;270(6):1164-75.


Role of conserved Asp293 of cytochrome P450 2C9 in substrate recognition and catalytic activity.

Flanagan JU, McLaughlin LA, Paine MJ, Sutcliffe MJ, Roberts GC, Wolf CR.

Biochem J. 2003 Mar 15;370(Pt 3):921-6.


Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.

Paine MJ, McLaughlin LA, Flanagan JU, Kemp CA, Sutcliffe MJ, Roberts GC, Wolf CR.

J Biol Chem. 2003 Feb 7;278(6):4021-7. Epub 2002 Nov 22.


Expression, purification, and biochemical characterization of a human cytochrome P450 CYP2D6-NADPH cytochrome P450 reductase fusion protein.

Deeni YY, Paine MJ, Ayrton AD, Clarke SE, Chenery R, Wolf CR.

Arch Biochem Biophys. 2001 Dec 1;396(1):16-24.


Role of the conserved phenylalanine 181 of NADPH-cytochrome P450 oxidoreductase in FMN binding and catalytic activity.

Paine MJ, Ayivor S, Munro A, Tsan P, Lian LY, Roberts GC, Wolf CR.

Biochemistry. 2001 Nov 13;40(45):13439-47.


Engineering of a functional human NADH-dependent cytochrome P450 system.

Döhr O, Paine MJ, Friedberg T, Roberts GC, Wolf CR.

Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):81-6.


Cloning and characterization of a novel human dual flavin reductase.

Paine MJ, Garner AP, Powell D, Sibbald J, Sales M, Pratt N, Smith T, Tew DG, Wolf CR.

J Biol Chem. 2000 Jan 14;275(2):1471-8.

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