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Items: 16


Patient and Disease-Specific Induced Pluripotent Stem Cells for Discovery of Personalized Cardiovascular Drugs and Therapeutics.

Paik DT, Chandy M, Wu JC.

Pharmacol Rev. 2020 Jan;72(1):320-342. doi: 10.1124/pr.116.013003. Review.


Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis.

Wirka RC, Wagh D, Paik DT, Pjanic M, Nguyen T, Miller CL, Kundu R, Nagao M, Coller J, Koyano TK, Fong R, Woo YJ, Liu B, Montgomery SB, Wu JC, Zhu K, Chang R, Alamprese M, Tallquist MD, Kim JB, Quertermous T.

Nat Med. 2019 Aug;25(8):1280-1289. doi: 10.1038/s41591-019-0512-5. Epub 2019 Jul 29.


Generation of Quiescent Cardiac Fibroblasts From Human Induced Pluripotent Stem Cells for In Vitro Modeling of Cardiac Fibrosis.

Zhang H, Tian L, Shen M, Tu C, Wu H, Gu M, Paik DT, Wu JC.

Circ Res. 2019 Aug 16;125(5):552-566. doi: 10.1161/CIRCRESAHA.119.315491. Epub 2019 Jul 10.


Transcriptomic Profiling of the Developing Cardiac Conduction System at Single-Cell Resolution.

Goodyer WR, Beyersdorf BM, Paik DT, Tian L, Li G, Buikema JW, Chirikian O, Choi S, Venkatraman S, Adams EL, Tessier-Lavigne M, Wu JC, Wu SM.

Circ Res. 2019 Aug 2;125(4):379-397. doi: 10.1161/CIRCRESAHA.118.314578. Epub 2019 Jul 9.


Single-Cell RNA Sequencing of Human Embryonic Stem Cell Differentiation Delineates Adverse Effects of Nicotine on Embryonic Development.

Guo H, Tian L, Zhang JZ, Kitani T, Paik DT, Lee WH, Wu JC.

Stem Cell Reports. 2019 Apr 9;12(4):772-786. doi: 10.1016/j.stemcr.2019.01.022. Epub 2019 Feb 28.


Marked Vascular Dysfunction in a Case of Peripartum Cardiomyopathy.

Khanamiri S, Rhee JW, Paik DT, Chen IY, Liu C, Sayed N.

J Vasc Res. 2019;56(1):11-15. doi: 10.1159/000496163. Epub 2019 Feb 14.


Systems-Wide Approaches in Induced Pluripotent Stem Cell Models.

Lau E, Paik DT, Wu JC.

Annu Rev Pathol. 2019 Jan 24;14:395-419. doi: 10.1146/annurev-pathmechdis-012418-013046. Epub 2018 Oct 31.


Large-Scale Single-Cell RNA-Seq Reveals Molecular Signatures of Heterogeneous Populations of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells.

Paik DT, Tian L, Lee J, Sayed N, Chen IY, Rhee S, Rhee JW, Kim Y, Wirka RC, Buikema JW, Wu SM, Red-Horse K, Quertermous T, Wu JC.

Circ Res. 2018 Aug 3;123(4):443-450. doi: 10.1161/CIRCRESAHA.118.312913.


SETD7 Drives Cardiac Lineage Commitment through Stage-Specific Transcriptional Activation.

Lee J, Shao NY, Paik DT, Wu H, Guo H, Termglinchan V, Churko JM, Kim Y, Kitani T, Zhao MT, Zhang Y, Wilson KD, Karakikes I, Snyder MP, Wu JC.

Cell Stem Cell. 2018 Mar 1;22(3):428-444.e5. doi: 10.1016/j.stem.2018.02.005.


Autologous iPSC-Based Vaccines Elicit Anti-tumor Responses In Vivo.

Kooreman NG, Kim Y, de Almeida PE, Termglinchan V, Diecke S, Shao NY, Wei TT, Yi H, Dey D, Nelakanti R, Brouwer TP, Paik DT, Sagiv-Barfi I, Han A, Quax PHA, Hamming JF, Levy R, Davis MM, Wu JC.

Cell Stem Cell. 2018 Apr 5;22(4):501-513.e7. doi: 10.1016/j.stem.2018.01.016. Epub 2018 Feb 15.


Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease.

Rhee S, Chung JI, King DA, D'amato G, Paik DT, Duan A, Chang A, Nagelberg D, Sharma B, Jeong Y, Diehn M, Wu JC, Morrison AJ, Red-Horse K.

Nat Commun. 2018 Jan 25;9(1):368. doi: 10.1038/s41467-017-02796-3.


Simply derived epicardial cells.

Paik DT, Wu JC.

Nat Biomed Eng. 2017;1. pii: 0015. doi: 10.1038/s41551-016-0015. Epub 2017 Jan 10.


Coordinated Proliferation and Differentiation of Human-Induced Pluripotent Stem Cell-Derived Cardiac Progenitor Cells Depend on Bone Morphogenetic Protein Signaling Regulation by GREMLIN 2.

Bylund JB, Trinh LT, Awgulewitsch CP, Paik DT, Jetter C, Jha R, Zhang J, Nolan K, Xu C, Thompson TB, Kamp TJ, Hatzopoulos AK.

Stem Cells Dev. 2017 May 1;26(9):678-693. doi: 10.1089/scd.2016.0226. Epub 2017 Mar 20.


Origin of Matrix-Producing Cells That Contribute to Aortic Fibrosis in Hypertension.

Wu J, Montaniel KR, Saleh MA, Xiao L, Chen W, Owens GK, Humphrey JD, Majesky MW, Paik DT, Hatzopoulos AK, Madhur MS, Harrison DG.

Hypertension. 2016 Feb;67(2):461-8. doi: 10.1161/HYPERTENSIONAHA.115.06123. Epub 2015 Dec 22.


Wnt10b Gain-of-Function Improves Cardiac Repair by Arteriole Formation and Attenuation of Fibrosis.

Paik DT, Rai M, Ryzhov S, Sanders LN, Aisagbonhi O, Funke MJ, Feoktistov I, Hatzopoulos AK.

Circ Res. 2015 Oct 9;117(9):804-16. doi: 10.1161/CIRCRESAHA.115.306886. Epub 2015 Sep 3.


Endothelial cells contribute to generation of adult ventricular myocytes during cardiac homeostasis.

Fioret BA, Heimfeld JD, Paik DT, Hatzopoulos AK.

Cell Rep. 2014 Jul 10;8(1):229-41. doi: 10.1016/j.celrep.2014.06.004. Epub 2014 Jul 4.

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