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Items: 1 to 50 of 130

1.

Histone methyltransferase PRDM9 is not essential for meiosis in male mice.

Mihola O, Pratto F, Brick K, Linhartova E, Kobets T, Flachs P, Baker CL, Sedlacek R, Paigen K, Petkov PM, Camerini-Otero RD, Trachtulec Z.

Genome Res. 2019 Jun 11. pii: gr.244426.118. doi: 10.1101/gr.244426.118. [Epub ahead of print]

PMID:
31186301
2.

Tissue-Specific Trans Regulation of the Mouse Epigenome.

Baker CL, Walker M, Arat S, Ananda G, Petkova P, Powers NR, Tian H, Spruce C, Ji B, Rausch D, Choi K, Petkov PM, Carter GW, Paigen K.

Genetics. 2019 Mar;211(3):831-845. doi: 10.1534/genetics.118.301697. Epub 2018 Dec 28.

PMID:
30593494
3.

PRDM9 and Its Role in Genetic Recombination.

Paigen K, Petkov PM.

Trends Genet. 2018 Apr;34(4):291-300. doi: 10.1016/j.tig.2017.12.017. Epub 2018 Jan 21. Review.

4.

PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal axis in meiosis.

Parvanov ED, Tian H, Billings T, Saxl RL, Spruce C, Aithal R, Krejci L, Paigen K, Petkov PM.

Mol Biol Cell. 2017 Feb 1;28(3):488-499. doi: 10.1091/mbc.E16-09-0686. Epub 2016 Dec 8.

5.

The Meiotic Recombination Activator PRDM9 Trimethylates Both H3K36 and H3K4 at Recombination Hotspots In Vivo.

Powers NR, Parvanov ED, Baker CL, Walker M, Petkov PM, Paigen K.

PLoS Genet. 2016 Jun 30;12(6):e1006146. doi: 10.1371/journal.pgen.1006146. eCollection 2016 Jun.

6.

Health and population effects of rare gene knockouts in adult humans with related parents.

Narasimhan VM, Hunt KA, Mason D, Baker CL, Karczewski KJ, Barnes MR, Barnett AH, Bates C, Bellary S, Bockett NA, Giorda K, Griffiths CJ, Hemingway H, Jia Z, Kelly MA, Khawaja HA, Lek M, McCarthy S, McEachan R, O'Donnell-Luria A, Paigen K, Parisinos CA, Sheridan E, Southgate L, Tee L, Thomas M, Xue Y, Schnall-Levin M, Petkov PM, Tyler-Smith C, Maher ER, Trembath RC, MacArthur DG, Wright J, Durbin R, van Heel DA.

Science. 2016 Apr 22;352(6284):474-7. doi: 10.1126/science.aac8624. Epub 2016 Mar 3.

7.

Multimer Formation Explains Allelic Suppression of PRDM9 Recombination Hotspots.

Baker CL, Petkova P, Walker M, Flachs P, Mihola O, Trachtulec Z, Petkov PM, Paigen K.

PLoS Genet. 2015 Sep 14;11(9):e1005512. doi: 10.1371/journal.pgen.1005512. eCollection 2015 Sep.

8.

Affinity-seq detects genome-wide PRDM9 binding sites and reveals the impact of prior chromatin modifications on mammalian recombination hotspot usage.

Walker M, Billings T, Baker CL, Powers N, Tian H, Saxl RL, Choi K, Hibbs MA, Carter GW, Handel MA, Paigen K, Petkov PM.

Epigenetics Chromatin. 2015 Sep 7;8:31. doi: 10.1186/s13072-015-0024-6. eCollection 2015.

9.

Nuclear localization of PRDM9 and its role in meiotic chromatin modifications and homologous synapsis.

Sun F, Fujiwara Y, Reinholdt LG, Hu J, Saxl RL, Baker CL, Petkov PM, Paigen K, Handel MA.

Chromosoma. 2015 Sep;124(3):397-415. doi: 10.1007/s00412-015-0511-3. Epub 2015 Apr 18.

10.

A multi-megabase copy number gain causes maternal transmission ratio distortion on mouse chromosome 2.

Didion JP, Morgan AP, Clayshulte AM, Mcmullan RC, Yadgary L, Petkov PM, Bell TA, Gatti DM, Crowley JJ, Hua K, Aylor DL, Bai L, Calaway M, Chesler EJ, French JE, Geiger TR, Gooch TJ, Garland T Jr, Harrill AH, Hunter K, McMillan L, Holt M, Miller DR, O'Brien DA, Paigen K, Pan W, Rowe LB, Shaw GD, Simecek P, Sullivan PF, Svenson KL, Weinstock GM, Threadgill DW, Pomp D, Churchill GA, Pardo-Manuel de Villena F.

PLoS Genet. 2015 Feb 13;11(2):e1004850. doi: 10.1371/journal.pgen.1004850. eCollection 2015 Feb.

11.

PRDM9 drives evolutionary erosion of hotspots in Mus musculus through haplotype-specific initiation of meiotic recombination.

Baker CL, Kajita S, Walker M, Saxl RL, Raghupathy N, Choi K, Petkov PM, Paigen K.

PLoS Genet. 2015 Jan 8;11(1):e1004916. doi: 10.1371/journal.pgen.1004916. eCollection 2015 Jan.

12.

PRDM9 binding organizes hotspot nucleosomes and limits Holliday junction migration.

Baker CL, Walker M, Kajita S, Petkov PM, Paigen K.

Genome Res. 2014 May;24(5):724-32. doi: 10.1101/gr.170167.113. Epub 2014 Mar 6.

13.

DNA binding specificities of the long zinc-finger recombination protein PRDM9.

Billings T, Parvanov ED, Baker CL, Walker M, Paigen K, Petkov PM.

Genome Biol. 2013 Apr 24;14(4):R35. doi: 10.1186/gb-2013-14-4-r35.

14.

Meiotic DSBs and the control of mammalian recombination.

Paigen K, Petkov P.

Cell Res. 2012 Dec;22(12):1624-6. doi: 10.1038/cr.2012.109. Epub 2012 Jul 17.

15.

Clusters of ancestrally related genes that show paralogy in whole or in part are a major feature of the genomes of humans and other species.

Walker MB, King BL, Paigen K.

PLoS One. 2012;7(4):e35274. doi: 10.1371/journal.pone.0035274. Epub 2012 Apr 26.

16.

Mammalian recombination hot spots: properties, control and evolution.

Paigen K, Petkov P.

Nat Rev Genet. 2010 Mar;11(3):221-33. doi: 10.1038/nrg2712. Review.

17.

Prdm9 controls activation of mammalian recombination hotspots.

Parvanov ED, Petkov PM, Paigen K.

Science. 2010 Feb 12;327(5967):835. doi: 10.1126/science.1181495. Epub 2009 Dec 31.

18.

Colocalization of somatic and meiotic double strand breaks near the Myc oncogene on mouse chromosome 15.

Ng SH, Maas SA, Petkov PM, Mills KD, Paigen K.

Genes Chromosomes Cancer. 2009 Oct;48(10):925-30. doi: 10.1002/gcc.20693.

19.

Parental origin of chromosomes influences crossover activity within the Kcnq1 transcriptionally imprinted domain of Mus musculus.

Ng SH, Madeira R, Parvanov ED, Petros LM, Petkov PM, Paigen K.

BMC Mol Biol. 2009 May 13;10:43. doi: 10.1186/1471-2199-10-43.

20.

Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans.

Harrill AH, Watkins PB, Su S, Ross PK, Harbourt DE, Stylianou IM, Boorman GA, Russo MW, Sackler RS, Harris SC, Smith PC, Tennant R, Bogue M, Paigen K, Harris C, Contractor T, Wiltshire T, Rusyn I, Threadgill DW.

Genome Res. 2009 Sep;19(9):1507-15. doi: 10.1101/gr.090241.108. Epub 2009 May 5.

21.

Trans-regulation of mouse meiotic recombination hotspots by Rcr1.

Parvanov ED, Ng SH, Petkov PM, Paigen K.

PLoS Biol. 2009 Feb 17;7(2):e36. doi: 10.1371/journal.pbio.1000036.

22.

A quantitative assay for crossover and noncrossover molecular events at individual recombination hotspots in both male and female gametes.

Ng SH, Parvanov E, Petkov PM, Paigen K.

Genomics. 2008 Oct;92(4):204-9. doi: 10.1016/j.ygeno.2008.06.008. Epub 2008 Aug 12.

23.

The recombinational anatomy of a mouse chromosome.

Paigen K, Szatkiewicz JP, Sawyer K, Leahy N, Parvanov ED, Ng SH, Graber JH, Broman KW, Petkov PM.

PLoS Genet. 2008 Jul 11;4(7):e1000119. doi: 10.1371/journal.pgen.1000119.

24.

Crossover interference underlies sex differences in recombination rates.

Petkov PM, Broman KW, Szatkiewicz JP, Paigen K.

Trends Genet. 2007 Nov;23(11):539-42. Epub 2007 Oct 26.

PMID:
17964681
25.

Evidence of a large-scale functional organization of Mammalian chromosomes.

Petkov PM, Graber JH, Churchill GA, DiPetrillo K, King BL, Paigen K.

PLoS Biol. 2007 May;5(5):e127; author reply e128. No abstract available.

26.

Patterns and mechanisms of genome organization in the mouse.

Graber JH, Churchill GA, Dipetrillo KJ, King BL, Petkov PM, Paigen K.

J Exp Zool A Comp Exp Biol. 2006 Sep 1;305(9):683-8. Review.

PMID:
16902958
27.

Evidence of a large-scale functional organization of mammalian chromosomes.

Petkov PM, Graber JH, Churchill GA, DiPetrillo K, King BL, Paigen K.

PLoS Genet. 2005 Sep;1(3):e33.

28.

The Collaborative Cross, a community resource for the genetic analysis of complex traits.

Churchill GA, Airey DC, Allayee H, Angel JM, Attie AD, Beatty J, Beavis WD, Belknap JK, Bennett B, Berrettini W, Bleich A, Bogue M, Broman KW, Buck KJ, Buckler E, Burmeister M, Chesler EJ, Cheverud JM, Clapcote S, Cook MN, Cox RD, Crabbe JC, Crusio WE, Darvasi A, Deschepper CF, Doerge RW, Farber CR, Forejt J, Gaile D, Garlow SJ, Geiger H, Gershenfeld H, Gordon T, Gu J, Gu W, de Haan G, Hayes NL, Heller C, Himmelbauer H, Hitzemann R, Hunter K, Hsu HC, Iraqi FA, Ivandic B, Jacob HJ, Jansen RC, Jepsen KJ, Johnson DK, Johnson TE, Kempermann G, Kendziorski C, Kotb M, Kooy RF, Llamas B, Lammert F, Lassalle JM, Lowenstein PR, Lu L, Lusis A, Manly KF, Marcucio R, Matthews D, Medrano JF, Miller DR, Mittleman G, Mock BA, Mogil JS, Montagutelli X, Morahan G, Morris DG, Mott R, Nadeau JH, Nagase H, Nowakowski RS, O'Hara BF, Osadchuk AV, Page GP, Paigen B, Paigen K, Palmer AA, Pan HJ, Peltonen-Palotie L, Peirce J, Pomp D, Pravenec M, Prows DR, Qi Z, Reeves RH, Roder J, Rosen GD, Schadt EE, Schalkwyk LC, Seltzer Z, Shimomura K, Shou S, Sillanpää MJ, Siracusa LD, Snoeck HW, Spearow JL, Svenson K, Tarantino LM, Threadgill D, Toth LA, Valdar W, de Villena FP, Warden C, Whatley S, Williams RW, Wiltshire T, Yi N, Zhang D, Zhang M, Zou F; Complex Trait Consortium.

Nat Genet. 2004 Nov;36(11):1133-7.

PMID:
15514660
29.

A torrid zone on mouse chromosome 1 containing a cluster of recombinational hotspots.

Kelmenson PM, Petkov P, Wang X, Higgins DC, Paigen BJ, Paigen K.

Genetics. 2005 Feb;169(2):833-41. Epub 2004 Oct 16.

30.
31.
32.
33.

Crossover interference in the mouse.

Broman KW, Rowe LB, Churchill GA, Paigen K.

Genetics. 2002 Mar;160(3):1123-31.

34.

A mouse phenome project.

Paigen K, Eppig JT.

Mamm Genome. 2000 Sep;11(9):715-7. Review. Erratum in: Mamm Genome 2000 Dec;11(12):1185.

PMID:
10967127
35.

A miracle enough: the power of mice.

Paigen K.

Nat Med. 1995 Mar;1(3):215-20. Review.

PMID:
7585036
36.

Allele capture by selection for flanking markers: a new method for analyzing multigenic traits.

Harrison DE, Roderick TH, Paigen K.

Growth Dev Aging. 1995 Fall;59(3):73-6. No abstract available.

PMID:
8675370
37.

The Gus-e locus regulates estrogen repression of androgen-induced beta-glucuronidase expression in mouse kidney.

Watson G, Jaussi R, Tabron D, Paigen K.

Biochem Genet. 1993 Apr;31(3-4):155-66.

PMID:
8363554
38.

Modulation of androgen-responsive gene expression by estrogen.

Jaussi R, Watson G, Paigen K.

Mol Cell Endocrinol. 1992 Aug;86(3):187-92.

PMID:
1511788
39.

EVOLUTION OF β-GLUCURONIDASE REGULATION IN THE GENUS MUS.

Bush RM, Paigen K.

Evolution. 1992 Feb;46(1):1-15. doi: 10.1111/j.1558-5646.1992.tb01980.x.

PMID:
28564958
40.
41.
42.

Progressive induction of mRNA synthesis for androgen-responsive genes in mouse kidney.

Watson G, Paigen K.

Mol Cell Endocrinol. 1990 Jan 2;68(1):67-74.

PMID:
2303161
44.

Mammalian beta-glucuronidase: genetics, molecular biology, and cell biology.

Paigen K.

Prog Nucleic Acid Res Mol Biol. 1989;37:155-205. Review. No abstract available.

PMID:
2672109
45.
46.

Characterization of the AdhSL regulatory mutation in Drosophila melanogaster.

Schott DR, East PD, Paigen K.

Genetics. 1988 Jul;119(3):631-7.

47.
49.

Genome organization and polymorphism of the murine beta-glucuronidase region.

Moore KJ, Paigen K.

Genomics. 1988 Jan;2(1):25-31.

PMID:
2838410
50.

Changes in translational yield regulate tissue-specific expression of beta-glucuronidase.

Bracey LT, Paigen K.

Proc Natl Acad Sci U S A. 1987 Dec;84(24):9020-4.

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