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Aspirin upregulates Suppressor of Cytokine Signaling 3 in glial cells via PPARα.

Chakrabarti S, Roy A, Prorok T, Patel D, Dasarathi S, Pahan K.

J Neurochem. 2019 Jul 5. doi: 10.1111/jnc.14813. [Epub ahead of print]


Mode of Action of Aspirin in Experimental Autoimmune Encephalomyelitis.

Pahan S, Pahan K.

DNA Cell Biol. 2019 Jul;38(7):593-596. doi: 10.1089/dna.2019.4814. Epub 2019 May 28.


Activation of Peroxisome Proliferator-Activated Receptor-α Increases the Expression of Nuclear Receptor Related 1 Protein (Nurr1) in Dopaminergic Neurons.

Gottschalk CG, Roy A, Jana M, Kundu M, Pahan K.

Mol Neurobiol. 2019 May 24. doi: 10.1007/s12035-019-01649-y. [Epub ahead of print]


Cinnamon and its Metabolite Protect the Nigrostriatum in a Mouse Model of Parkinson's Disease Via Astrocytic GDNF.

Patel D, Jana A, Roy A, Pahan K.

J Neuroimmune Pharmacol. 2019 May 22. doi: 10.1007/s11481-019-09855-0. [Epub ahead of print]


Low-Dose Maraviroc, an Antiretroviral Drug, Attenuates the Infiltration of T Cells into the Central Nervous System and Protects the Nigrostriatum in Hemiparkinsonian Monkeys.

Mondal S, Rangasamy SB, Roy A, Dasarathy S, Kordower JH, Pahan K.

J Immunol. 2019 May 1. pii: ji1800587. doi: 10.4049/jimmunol.1800587. [Epub ahead of print]


Upregulation of tripeptidyl-peptidase 1 by 3-hydroxy-(2,2)-dimethyl butyrate, a brain endogenous ligand of PPARα: Implications for late-infantile Batten disease therapy.

Chakrabarti S, Chandra S, Roy A, Dasarathi S, Kundu M, Pahan K.

Neurobiol Dis. 2019 Jul;127:362-373. doi: 10.1016/j.nbd.2019.03.025. Epub 2019 Mar 28.


Cinnamic Acid Protects the Nigrostriatum in a Mouse Model of Parkinson's Disease via Peroxisome Proliferator-Activated Receptorα.

Prorok T, Jana M, Patel D, Pahan K.

Neurochem Res. 2019 Apr;44(4):751-762. doi: 10.1007/s11064-018-02705-0. Epub 2019 Jan 5.


Chronic stress-induced gut dysfunction exacerbates Parkinson's disease phenotype and pathology in a rotenone-induced mouse model of Parkinson's disease.

Dodiya HB, Forsyth CB, Voigt RM, Engen PA, Patel J, Shaikh M, Green SJ, Naqib A, Roy A, Kordower JH, Pahan K, Shannon KM, Keshavarzian A.

Neurobiol Dis. 2018 Dec 21. pii: S0969-9961(18)30768-X. doi: 10.1016/j.nbd.2018.12.012. [Epub ahead of print] Review.


Cinnamic acid activates PPARα to stimulate Lysosomal biogenesis and lower Amyloid plaque pathology in an Alzheimer's disease mouse model.

Chandra S, Roy A, Jana M, Pahan K.

Neurobiol Dis. 2019 Apr;124:379-395. doi: 10.1016/j.nbd.2018.12.007. Epub 2018 Dec 19.


Dietary lysophosphatidylcholine-EPA enriches both EPA and DHA in the brain: potential treatment for depression.

Yalagala PCR, Sugasini D, Dasarathi S, Pahan K, Subbaiah PV.

J Lipid Res. 2019 Mar;60(3):566-578. doi: 10.1194/jlr.M090464. Epub 2018 Dec 10.


Aspirin ameliorates experimental autoimmune encephalomyelitis through interleukin-11-mediated protection of regulatory T cells.

Mondal S, Jana M, Dasarathi S, Roy A, Pahan K.

Sci Signal. 2018 Nov 27;11(558). pii: eaar8278. doi: 10.1126/scisignal.aar8278.


Low-Dose Aspirin Upregulates Tyrosine Hydroxylase and Increases Dopamine Production in Dopaminergic Neurons: Implications for Parkinson's Disease.

Rangasamy SB, Dasarathi S, Pahan P, Jana M, Pahan K.

J Neuroimmune Pharmacol. 2019 Jun;14(2):173-187. doi: 10.1007/s11481-018-9808-3. Epub 2018 Sep 5.


Aspirin binds to PPARα to stimulate hippocampal plasticity and protect memory.

Patel D, Roy A, Kundu M, Jana M, Luan CH, Gonzalez FJ, Pahan K.

Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7408-E7417. doi: 10.1073/pnas.1802021115. Epub 2018 Jul 16.


Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer's pathology.

Rangasamy SB, Jana M, Roy A, Corbett GT, Kundu M, Chandra S, Mondal S, Dasarathi S, Mufson EJ, Mishra RK, Luan CH, Bennett DA, Pahan K.

J Clin Invest. 2018 Oct 1;128(10):4297-4312. doi: 10.1172/JCI96209. Epub 2018 Jul 10.


Aspirin Induces Lysosomal Biogenesis and Attenuates Amyloid Plaque Pathology in a Mouse Model of Alzheimer's Disease via PPARα.

Chandra S, Jana M, Pahan K.

J Neurosci. 2018 Jul 25;38(30):6682-6699. doi: 10.1523/JNEUROSCI.0054-18.2018. Epub 2018 Jul 2.


Store depletion-induced h-channel plasticity rescues a channelopathy linked to Alzheimer's disease.

Musial TF, Molina-Campos E, Bean LA, Ybarra N, Borenstein R, Russo ML, Buss EW, Justus D, Neuman KM, Ayala GD, Mullen SA, Voskobiynyk Y, Tulisiak CT, Fels JA, Corbett NJ, Carballo G, Kennedy CD, Popovic J, Ramos-Franco J, Fill M, Pergande MR, Borgia JA, Corbett GT, Pahan K, Han Y, Chetkovich DM, Vassar RJ, Byrne RW, Matthew Oh M, Stoub TR, Remy S, Disterhoft JF, Nicholson DA.

Neurobiol Learn Mem. 2018 Oct;154:141-157. doi: 10.1016/j.nlm.2018.06.004. Epub 2018 Jun 12.


Upregulation of Suppressor of Cytokine Signaling 3 in Microglia by Cinnamic Acid.

Chakrabarti S, Jana M, Roy A, Pahan K.

Curr Alzheimer Res. 2018;15(10):894-904. doi: 10.2174/1567205015666180507104755.


Increase in Mitochondrial Biogenesis in Neuronal Cells by RNS60, a Physically-Modified Saline, via Phosphatidylinositol 3-Kinase-Mediated Upregulation of PGC1α.

Chandra G, Kundu M, Rangasamy SB, Dasarathy S, Ghosh S, Watson R, Pahan K.

J Neuroimmune Pharmacol. 2018 Jun;13(2):143-162. doi: 10.1007/s11481-017-9771-4. Epub 2017 Nov 29.


Selective neutralization of IL-12 p40 monomer induces death in prostate cancer cells via IL-12-IFN-γ.

Kundu M, Roy A, Pahan K.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11482-11487. doi: 10.1073/pnas.1705536114. Epub 2017 Oct 9.


Correction: A Physically-Modified Saline Suppresses Neuronal Apoptosis, Attenuates Tau Phosphorylation and Protects Memory in an Animal Model of Alzheimer's Disease.

Modi KK, Jana A, Ghosh S, Watson R, Pahan K.

PLoS One. 2017 Jun 27;12(6):e0180602. doi: 10.1371/journal.pone.0180602. eCollection 2017.


Safety and potential efficacy of gemfibrozil as a supportive treatment for children with late infantile neuronal ceroid lipofuscinosis and other lipid storage disorders.

Kim K, Kleinman HK, Lee HJ, Pahan K.

Orphanet J Rare Dis. 2017 Jun 17;12(1):113. doi: 10.1186/s13023-017-0663-8. Review.


Induction of Adaptive Immunity Leads to Nigrostriatal Disease Progression in MPTP Mouse Model of Parkinson's Disease.

Chandra G, Roy A, Rangasamy SB, Pahan K.

J Immunol. 2017 Jun 1;198(11):4312-4326. doi: 10.4049/jimmunol.1700149. Epub 2017 Apr 26.


Glyceryl Tribenzoate: A Flavoring Ingredient, Inhibits the Adoptive Transfer of Experimental Allergic Encephalomyelitis via TGF-β: Implications for Multiple Sclerosis Therapy.

Mondal S, Dasarathi S, Pahan K.

J Clin Cell Immunol. 2017 Feb;8(1). pii: 488. doi: 10.4172/2155-9899.1000488. Epub 2017 Jan 31.


Nebulization of RNS60, a Physically-Modified Saline, Attenuates the Adoptive Transfer of Experimental Allergic Encephalomyelitis in Mice: Implications for Multiple Sclerosis Therapy.

Mondal S, Rangasamy SB, Ghosh S, Watson RL, Pahan K.

Neurochem Res. 2017 May;42(5):1555-1570. doi: 10.1007/s11064-017-2214-z. Epub 2017 Mar 7. Erratum in: Neurochem Res. 2018 Apr 2;:.


Gemfibrozil, food and drug administration-approved lipid-lowering drug, increases longevity in mouse model of late infantile neuronal ceroid lipofuscinosis.

Ghosh A, Rangasamy SB, Modi KK, Pahan K.

J Neurochem. 2017 May;141(3):423-435. doi: 10.1111/jnc.13987. Epub 2017 Apr 3.


Identification and characterization of PPARα ligands in the hippocampus.

Roy A, Kundu M, Jana M, Mishra RK, Yung Y, Luan CH, Gonzalez FJ, Pahan K.

Nat Chem Biol. 2016 Dec;12(12):1075-1083. doi: 10.1038/nchembio.2204. Epub 2016 Oct 17.


Sodium Benzoate, a Food Additive and a Metabolite of Cinnamon, Enriches Regulatory T Cells via STAT6-Mediated Upregulation of TGF-β.

Kundu M, Mondal S, Roy A, Martinson JL, Pahan K.

J Immunol. 2016 Oct 15;197(8):3099-3110. Epub 2016 Sep 7.


Structural Elucidation of the Cell-Penetrating Penetratin Peptide in Model Membranes at the Atomic Level: Probing Hydrophobic Interactions in the Blood-Brain Barrier.

Bera S, Kar RK, Mondal S, Pahan K, Bhunia A.

Biochemistry. 2016 Sep 6;55(35):4982-96. doi: 10.1021/acs.biochem.6b00518. Epub 2016 Aug 24.


Cinnamon Converts Poor Learning Mice to Good Learners: Implications for Memory Improvement.

Modi KK, Rangasamy SB, Dasarathi S, Roy A, Pahan K.

J Neuroimmune Pharmacol. 2016 Dec;11(4):693-707. Epub 2016 Jun 24.


Neutralization of RANTES and Eotaxin Prevents the Loss of Dopaminergic Neurons in a Mouse Model of Parkinson Disease.

Chandra G, Rangasamy SB, Roy A, Kordower JH, Pahan K.

J Biol Chem. 2016 Jul 15;291(29):15267-81. doi: 10.1074/jbc.M116.714824. Epub 2016 May 12.


BPOZ-2 Gene Delivery Ameliorates Alpha-Synucleinopathy in A53T Transgenic Mouse Model of Parkinson's Disease.

Roy A, Rangasamy SB, Kundu M, Pahan K.

Sci Rep. 2016 Feb 26;6:22067. doi: 10.1038/srep22067.


PPARα in lysosomal biogenesis: A perspective.

Ghosh A, Pahan K.

Pharmacol Res. 2016 Jan;103:144-8. doi: 10.1016/j.phrs.2015.11.011. Epub 2015 Nov 24.


Intranasal Delivery of NEMO-Binding Domain Peptide Prevents Memory Loss in a Mouse Model of Alzheimer's Disease.

Rangasamy SB, Corbett GT, Roy A, Modi KK, Bennett DA, Mufson EJ, Ghosh S, Pahan K.

J Alzheimers Dis. 2015;47(2):385-402. doi: 10.3233/JAD-150040.


Sodium Benzoate, a Metabolite of Cinnamon and a Food Additive, Upregulates Ciliary Neurotrophic Factor in Astrocytes and Oligodendrocytes.

Modi KK, Jana M, Mondal S, Pahan K.

Neurochem Res. 2015 Nov;40(11):2333-47. doi: 10.1007/s11064-015-1723-x. Epub 2015 Sep 23.


Prospects of Cinnamon in Multiple Sclerosis.

Pahan K.

J Mult Scler (Foster City). 2015;2(3):1000149. No abstract available.


HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice.

Roy A, Jana M, Kundu M, Corbett GT, Rangaswamy SB, Mishra RK, Luan CH, Gonzalez FJ, Pahan K.

Cell Metab. 2015 Aug 4;22(2):253-65. doi: 10.1016/j.cmet.2015.05.022. Epub 2015 Jun 25.


Cinnamon and Its Metabolite Sodium Benzoate Attenuate the Activation of p21rac and Protect Memory and Learning in an Animal Model of Alzheimer's Disease.

Modi KK, Roy A, Brahmachari S, Rangasamy SB, Pahan K.

PLoS One. 2015 Jun 23;10(6):e0130398. doi: 10.1371/journal.pone.0130398. eCollection 2015.


Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP.

Corbett GT, Gonzalez FJ, Pahan K.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8445-50. doi: 10.1073/pnas.1504890112. Epub 2015 Jun 15.


Can cinnamon bring aroma in Parkinson's disease treatment?

Pahan P, Pahan K.

Neural Regen Res. 2015 Jan;10(1):30-2. doi: 10.4103/1673-5374.150647. No abstract available.


Attenuation of microglial RANTES by NEMO-binding domain peptide inhibits the infiltration of CD8(+) T cells in the nigra of hemiparkinsonian monkey.

Roy A, Mondal S, Kordower JH, Pahan K.

Neuroscience. 2015 Aug 27;302:36-46. doi: 10.1016/j.neuroscience.2015.03.011. Epub 2015 Mar 14.


Activation of peroxisome proliferator-activated receptor α induces lysosomal biogenesis in brain cells: implications for lysosomal storage disorders.

Ghosh A, Jana M, Modi K, Gonzalez FJ, Sims KB, Berry-Kravis E, Pahan K.

J Biol Chem. 2015 Apr 17;290(16):10309-24. doi: 10.1074/jbc.M114.610659. Epub 2015 Mar 6.


PPARα signaling in the hippocampus: crosstalk between fat and memory.

Roy A, Pahan K.

J Neuroimmune Pharmacol. 2015 Mar;10(1):30-4. doi: 10.1007/s11481-014-9582-9. Epub 2015 Jan 10. Review.


Cinnamon ameliorates experimental allergic encephalomyelitis in mice via regulatory T cells: implications for multiple sclerosis therapy.

Mondal S, Pahan K.

PLoS One. 2015 Jan 8;10(1):e0116566. doi: 10.1371/journal.pone.0116566. eCollection 2015.


A physically-modified saline suppresses neuronal apoptosis, attenuates tau phosphorylation and protects memory in an animal model of Alzheimer's disease.

Modi KK, Jana A, Ghosh S, Watson R, Pahan K.

PLoS One. 2014 Aug 4;9(8):e103606. doi: 10.1371/journal.pone.0103606. eCollection 2014. Erratum in: PLoS One. 2017 Jun 27;12 (6):e0180602.


Enhancement of morphological plasticity in hippocampal neurons by a physically modified saline via phosphatidylinositol-3 kinase.

Roy A, Modi KK, Khasnavis S, Ghosh S, Watson R, Pahan K.

PLoS One. 2014 Jul 9;9(7):e101883. doi: 10.1371/journal.pone.0101883. eCollection 2014.


Optimization of Amylase Production from B. amyloliquefaciens (MTCC 1270) Using Solid State Fermentation.

Saha K, Maity S, Roy S, Pahan K, Pathak R, Majumdar S, Gupta S.

Int J Microbiol. 2014;2014:764046. doi: 10.1155/2014/764046. Epub 2014 May 11.


Cinnamon treatment upregulates neuroprotective proteins Parkin and DJ-1 and protects dopaminergic neurons in a mouse model of Parkinson's disease.

Khasnavis S, Pahan K.

J Neuroimmune Pharmacol. 2014 Sep;9(4):569-81. doi: 10.1007/s11481-014-9552-2. Epub 2014 Jun 20.

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