Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 50

1.

Obesity-dependent CDK1 signaling stimulates mitochondrial respiration at complex I in pancreatic β-cells.

Gregg T, Sdao SM, Dhillon RS, Rensvold JW, Lewandowski SL, Pagliarini DJ, Denu JM, Merrins MJ.

J Biol Chem. 2019 Mar 22;294(12):4656-4666. doi: 10.1074/jbc.RA118.006085. Epub 2019 Jan 30.

PMID:
30700550
2.

Coenzyme Q biosynthetic proteins assemble in a substrate-dependent manner into domains at ER-mitochondria contacts.

Subramanian K, Jochem A, Le Vasseur M, Lewis S, Paulson BR, Reddy TR, Russell JD, Coon JJ, Pagliarini DJ, Nunnari J.

J Cell Biol. 2019 Apr 1;218(4):1353-1369. doi: 10.1083/jcb.201808044. Epub 2019 Jan 23.

PMID:
30674579
3.

An Isoprene Lipid-Binding Protein Promotes Eukaryotic Coenzyme Q Biosynthesis.

Lohman DC, Aydin D, Von Bank HC, Smith RW, Linke V, Weisenhorn E, McDevitt MT, Hutchins P, Wilkerson EM, Wancewicz B, Russell J, Stefely MS, Beebe ET, Jochem A, Coon JJ, Bingman CA, Dal Peraro M, Pagliarini DJ.

Mol Cell. 2019 Feb 21;73(4):763-774.e10. doi: 10.1016/j.molcel.2018.11.033. Epub 2019 Jan 17.

PMID:
30661980
4.

Identification and Quantification of Murine Mitochondrial Proteoforms Using an Integrated Top-Down and Intact-Mass Strategy.

Schaffer LV, Rensvold JW, Shortreed MR, Cesnik AJ, Jochem A, Scalf M, Frey BL, Pagliarini DJ, Smith LM.

J Proteome Res. 2018 Oct 5;17(10):3526-3536. doi: 10.1021/acs.jproteome.8b00469. Epub 2018 Sep 18.

PMID:
30180576
5.

Systems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species.

Jha P, McDevitt MT, Gupta R, Quiros PM, Williams EG, Gariani K, Sleiman MB, Diserens L, Jochem A, Ulbrich A, Coon JJ, Auwerx J, Pagliarini DJ.

Cell Syst. 2018 Jun 27;6(6):722-733.e6. doi: 10.1016/j.cels.2018.05.016. Epub 2018 Jun 13.

6.

Genetic Regulation of Plasma Lipid Species and Their Association with Metabolic Phenotypes.

Jha P, McDevitt MT, Halilbasic E, Williams EG, Quiros PM, Gariani K, Sleiman MB, Gupta R, Ulbrich A, Jochem A, Coon JJ, Trauner M, Pagliarini DJ, Auwerx J.

Cell Syst. 2018 Jun 27;6(6):709-721.e6. doi: 10.1016/j.cels.2018.05.009. Epub 2018 Jun 13.

7.

A path to the powerhouse: systems-to-structure approaches for studying mitochondrial proteins.

Pagliarini DJ.

Protein Sci. 2018 Aug;27(8):1518-1525. doi: 10.1002/pro.3430. Epub 2018 May 18.

PMID:
29675961
8.

DNA Polymerase θ Increases Mutational Rates in Mitochondrial DNA.

Wisnovsky S, Sack T, Pagliarini DJ, Laposa RR, Kelley SO.

ACS Chem Biol. 2018 Apr 20;13(4):900-908. doi: 10.1021/acschembio.8b00072. Epub 2018 Mar 15.

9.

Multi-omics Reveal Specific Targets of the RNA-Binding Protein Puf3p and Its Orchestration of Mitochondrial Biogenesis.

Lapointe CP, Stefely JA, Jochem A, Hutchins PD, Wilson GM, Kwiecien NW, Coon JJ, Wickens M, Pagliarini DJ.

Cell Syst. 2018 Jan 24;6(1):125-135.e6. doi: 10.1016/j.cels.2017.11.012. Epub 2017 Dec 13.

10.

Multi-omic Mitoprotease Profiling Defines a Role for Oct1p in Coenzyme Q Production.

Veling MT, Reidenbach AG, Freiberger EC, Kwiecien NW, Hutchins PD, Drahnak MJ, Jochem A, Ulbrich A, Rush MJP, Russell JD, Coon JJ, Pagliarini DJ.

Mol Cell. 2017 Dec 7;68(5):970-977.e11. doi: 10.1016/j.molcel.2017.11.023.

11.

Conserved Lipid and Small-Molecule Modulation of COQ8 Reveals Regulation of the Ancient Kinase-like UbiB Family.

Reidenbach AG, Kemmerer ZA, Aydin D, Jochem A, McDevitt MT, Hutchins PD, Stark JL, Stefely JA, Reddy T, Hebert AS, Wilkerson EM, Johnson IE, Bingman CA, Markley JL, Coon JJ, Dal Peraro M, Pagliarini DJ.

Cell Chem Biol. 2018 Feb 15;25(2):154-165.e11. doi: 10.1016/j.chembiol.2017.11.001. Epub 2017 Nov 30.

12.

Biochemistry of Mitochondrial Coenzyme Q Biosynthesis.

Stefely JA, Pagliarini DJ.

Trends Biochem Sci. 2017 Oct;42(10):824-843. doi: 10.1016/j.tibs.2017.06.008. Epub 2017 Sep 17. Review.

13.

Erythropoietin signaling regulates heme biosynthesis.

Chung J, Wittig JG, Ghamari A, Maeda M, Dailey TA, Bergonia H, Kafina MD, Coughlin EE, Minogue CE, Hebert AS, Li L, Kaplan J, Lodish HF, Bauer DE, Orkin SH, Cantor AB, Maeda T, Phillips JD, Coon JJ, Pagliarini DJ, Dailey HA, Paw BH.

Elife. 2017 May 29;6. pii: e24767. doi: 10.7554/eLife.24767.

14.

Integrative proteomics and biochemical analyses define Ptc6p as the Saccharomyces cerevisiae pyruvate dehydrogenase phosphatase.

Guo X, Niemi NM, Coon JJ, Pagliarini DJ.

J Biol Chem. 2017 Jul 14;292(28):11751-11759. doi: 10.1074/jbc.M117.787341. Epub 2017 May 24.

15.

Ptc7p Dephosphorylates Select Mitochondrial Proteins to Enhance Metabolic Function.

Guo X, Niemi NM, Hutchins PD, Condon SGF, Jochem A, Ulbrich A, Higbee AJ, Russell JD, Senes A, Coon JJ, Pagliarini DJ.

Cell Rep. 2017 Jan 10;18(2):307-313. doi: 10.1016/j.celrep.2016.12.049.

16.

Mitochondrial protein functions elucidated by multi-omic mass spectrometry profiling.

Stefely JA, Kwiecien NW, Freiberger EC, Richards AL, Jochem A, Rush MJP, Ulbrich A, Robinson KP, Hutchins PD, Veling MT, Guo X, Kemmerer ZA, Connors KJ, Trujillo EA, Sokol J, Marx H, Westphall MS, Hebert AS, Pagliarini DJ, Coon JJ.

Nat Biotechnol. 2016 Nov;34(11):1191-1197. doi: 10.1038/nbt.3683. Epub 2016 Sep 26.

17.

Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.

Floyd BJ, Wilkerson EM, Veling MT, Minogue CE, Xia C, Beebe ET, Wrobel RL, Cho H, Kremer LS, Alston CL, Gromek KA, Dolan BK, Ulbrich A, Stefely JA, Bohl SL, Werner KM, Jochem A, Westphall MS, Rensvold JW, Taylor RW, Prokisch H, Kim JP, Coon JJ, Pagliarini DJ.

Mol Cell. 2016 Aug 18;63(4):621-632. doi: 10.1016/j.molcel.2016.06.033. Epub 2016 Aug 4.

18.

Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity.

Stefely JA, Licitra F, Laredj L, Reidenbach AG, Kemmerer ZA, Grangeray A, Jaeg-Ehret T, Minogue CE, Ulbrich A, Hutchins PD, Wilkerson EM, Ruan Z, Aydin D, Hebert AS, Guo X, Freiberger EC, Reutenauer L, Jochem A, Chergova M, Johnson IE, Lohman DC, Rush MJP, Kwiecien NW, Singh PK, Schlagowski AI, Floyd BJ, Forsman U, Sindelar PJ, Westphall MS, Pierrel F, Zoll J, Dal Peraro M, Kannan N, Bingman CA, Coon JJ, Isope P, Puccio H, Pagliarini DJ.

Mol Cell. 2016 Aug 18;63(4):608-620. doi: 10.1016/j.molcel.2016.06.030. Epub 2016 Aug 4.

19.

Iron Deprivation Induces Transcriptional Regulation of Mitochondrial Biogenesis.

Rensvold JW, Krautkramer KA, Dowell JA, Denu JM, Pagliarini DJ.

J Biol Chem. 2016 Sep 30;291(40):20827-20837. Epub 2016 Aug 5.

20.

Transomics: Mitochondrial Systems Analyses Get Supercomplex.

Pagliarini DJ.

Cell Metab. 2016 Jul 12;24(1):13-4. doi: 10.1016/j.cmet.2016.06.018.

21.

Mitochondrial protein hyperacetylation in the failing heart.

Horton JL, Martin OJ, Lai L, Riley NM, Richards AL, Vega RB, Leone TC, Pagliarini DJ, Muoio DM, Bedi KC Jr, Margulies KB, Coon JJ, Kelly DP.

JCI Insight. 2016 Feb;2(1). pii: e84897. Epub 2016 Feb 25.

22.

A Single Kinase Generates the Majority of the Secreted Phosphoproteome.

Tagliabracci VS, Wiley SE, Guo X, Kinch LN, Durrant E, Wen J, Xiao J, Cui J, Nguyen KB, Engel JL, Coon JJ, Grishin N, Pinna LA, Pagliarini DJ, Dixon JE.

Cell. 2015 Jun 18;161(7):1619-32. doi: 10.1016/j.cell.2015.05.028.

23.

Maximal oxidative capacity during exercise is associated with skeletal muscle fuel selection and dynamic changes in mitochondrial protein acetylation.

Overmyer KA, Evans CR, Qi NR, Minogue CE, Carson JJ, Chermside-Scabbo CJ, Koch LG, Britton SL, Pagliarini DJ, Coon JJ, Burant CF.

Cell Metab. 2015 Mar 3;21(3):468-78. doi: 10.1016/j.cmet.2015.02.007.

24.

Multiplexed quantification for data-independent acquisition.

Minogue CE, Hebert AS, Rensvold JW, Westphall MS, Pagliarini DJ, Coon JJ.

Anal Chem. 2015 Mar 3;87(5):2570-5. doi: 10.1021/ac503593d. Epub 2015 Feb 11.

25.

Mitochondrial ADCK3 employs an atypical protein kinase-like fold to enable coenzyme Q biosynthesis.

Stefely JA, Reidenbach AG, Ulbrich A, Oruganty K, Floyd BJ, Jochem A, Saunders JM, Johnson IE, Minogue CE, Wrobel RL, Barber GE, Lee D, Li S, Kannan N, Coon JJ, Bingman CA, Pagliarini DJ.

Mol Cell. 2015 Jan 8;57(1):83-94. doi: 10.1016/j.molcel.2014.11.002. Epub 2014 Dec 11.

26.

Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis.

Lohman DC, Forouhar F, Beebe ET, Stefely MS, Minogue CE, Ulbrich A, Stefely JA, Sukumar S, Luna-Sánchez M, Jochem A, Lew S, Seetharaman J, Xiao R, Wang H, Westphall MS, Wrobel RL, Everett JK, Mitchell JC, López LC, Coon JJ, Tong L, Pagliarini DJ.

Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):E4697-705. doi: 10.1073/pnas.1413128111. Epub 2014 Oct 22.

27.

A Gly-zipper motif mediates homodimerization of the transmembrane domain of the mitochondrial kinase ADCK3.

Khadria AS, Mueller BK, Stefely JA, Tan CH, Pagliarini DJ, Senes A.

J Am Chem Soc. 2014 Oct 8;136(40):14068-77. doi: 10.1021/ja505017f. Epub 2014 Sep 24.

28.

Intelligent data acquisition blends targeted and discovery methods.

Bailey DJ, McDevitt MT, Westphall MS, Pagliarini DJ, Coon JJ.

J Proteome Res. 2014 Apr 4;13(4):2152-61. doi: 10.1021/pr401278j. Epub 2014 Mar 18.

29.

Mitochondrial DNA variant in COX1 subunit significantly alters energy metabolism of geographically divergent wild isolates in Caenorhabditis elegans.

Dingley SD, Polyak E, Ostrovsky J, Srinivasan S, Lee I, Rosenfeld AB, Tsukikawa M, Xiao R, Selak MA, Coon JJ, Hebert AS, Grimsrud PA, Kwon YJ, Pagliarini DJ, Gai X, Schurr TG, Hüttemann M, Nakamaru-Ogiso E, Falk MJ.

J Mol Biol. 2014 May 29;426(11):2199-216. doi: 10.1016/j.jmb.2014.02.009. Epub 2014 Feb 14.

30.

Neutron-encoded mass signatures for quantitative top-down proteomics.

Rhoads TW, Rose CM, Bailey DJ, Riley NM, Molden RC, Nestler AJ, Merrill AE, Smith LM, Hebert AS, Westphall MS, Pagliarini DJ, Garcia BA, Coon JJ.

Anal Chem. 2014 Mar 4;86(5):2314-9. doi: 10.1021/ac403579s. Epub 2014 Feb 19.

31.

Hallmarks of a new era in mitochondrial biochemistry.

Pagliarini DJ, Rutter J.

Genes Dev. 2013 Dec 15;27(24):2615-27. doi: 10.1101/gad.229724.113. Review.

32.

Amine-reactive neutron-encoded labels for highly plexed proteomic quantitation.

Hebert AS, Merrill AE, Stefely JA, Bailey DJ, Wenger CD, Westphall MS, Pagliarini DJ, Coon JJ.

Mol Cell Proteomics. 2013 Nov;12(11):3360-9. doi: 10.1074/mcp.M113.032011. Epub 2013 Jul 23.

33.

Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.

Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.

J Biol Chem. 2013 Sep 6;288(36):26209-19. doi: 10.1074/jbc.M113.483396. Epub 2013 Jul 17.

34.

Inhibitors of bacterial tubulin target bacterial membranes in vivo.

Foss MH, Eun YJ, Grove CI, Pauw DA, Sorto NA, Rensvold JW, Pagliarini DJ, Shaw JT, Weibel DB.

Medchemcomm. 2013 Jan 1;4(1):112-119. Epub 2012 Jul 18.

35.

Neutron-encoded mass signatures for multiplexed proteome quantification.

Hebert AS, Merrill AE, Bailey DJ, Still AJ, Westphall MS, Strieter ER, Pagliarini DJ, Coon JJ.

Nat Methods. 2013 Apr;10(4):332-4. doi: 10.1038/nmeth.2378. Epub 2013 Feb 24.

36.

Complementary RNA and protein profiling identifies iron as a key regulator of mitochondrial biogenesis.

Rensvold JW, Ong SE, Jeevananthan A, Carr SA, Mootha VK, Pagliarini DJ.

Cell Rep. 2013 Jan 31;3(1):237-45. doi: 10.1016/j.celrep.2012.11.029. Epub 2013 Jan 10.

37.

Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.

Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.

Mol Cell. 2013 Jan 10;49(1):186-99. doi: 10.1016/j.molcel.2012.10.024. Epub 2012 Nov 29.

38.

A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis.

Grimsrud PA, Carson JJ, Hebert AS, Hubler SL, Niemi NM, Bailey DJ, Jochem A, Stapleton DS, Keller MP, Westphall MS, Yandell BS, Attie AD, Coon JJ, Pagliarini DJ.

Cell Metab. 2012 Nov 7;16(5):672-83. doi: 10.1016/j.cmet.2012.10.004.

39.

Solution NMR structure of yeast succinate dehydrogenase flavinylation factor Sdh5 reveals a putative Sdh1 binding site.

Eletsky A, Jeong MY, Kim H, Lee HW, Xiao R, Pagliarini DJ, Prestegard JH, Winge DR, Montelione GT, Szyperski T.

Biochemistry. 2012 Oct 30;51(43):8475-7. doi: 10.1021/bi301171u. Epub 2012 Oct 19.

40.

Automated gas-phase purification for accurate, multiplexed quantification on a stand-alone ion-trap mass spectrometer.

Vincent CE, Rensvold JW, Westphall MS, Pagliarini DJ, Coon JJ.

Anal Chem. 2013 Feb 19;85(4):2079-86. doi: 10.1021/ac302156t. Epub 2012 Oct 24.

41.

Analysis of the acidic proteome with negative electron-transfer dissociation mass spectrometry.

McAlister GC, Russell JD, Rumachik NG, Hebert AS, Syka JE, Geer LY, Westphall MS, Pagliarini DJ, Coon JJ.

Anal Chem. 2012 Mar 20;84(6):2875-82. doi: 10.1021/ac203430u. Epub 2012 Mar 1.

42.

Pharmacological targeting of the mitochondrial phosphatase PTPMT1.

Doughty-Shenton D, Joseph JD, Zhang J, Pagliarini DJ, Kim Y, Lu D, Dixon JE, Casey PJ.

J Pharmacol Exp Ther. 2010 May;333(2):584-92. doi: 10.1124/jpet.109.163329. Epub 2010 Feb 18.

43.

Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.

Calvo SE, Pagliarini DJ, Mootha VK.

Proc Natl Acad Sci U S A. 2009 May 5;106(18):7507-12. doi: 10.1073/pnas.0810916106. Epub 2009 Apr 16.

44.

Mutation of C20orf7 disrupts complex I assembly and causes lethal neonatal mitochondrial disease.

Sugiana C, Pagliarini DJ, McKenzie M, Kirby DM, Salemi R, Abu-Amero KK, Dahl HH, Hutchison WM, Vascotto KA, Smith SM, Newbold RF, Christodoulou J, Calvo S, Mootha VK, Ryan MT, Thorburn DR.

Am J Hum Genet. 2008 Oct;83(4):468-78. doi: 10.1016/j.ajhg.2008.09.009.

45.

A mitochondrial protein compendium elucidates complex I disease biology.

Pagliarini DJ, Calvo SE, Chang B, Sheth SA, Vafai SB, Ong SE, Walford GA, Sugiana C, Boneh A, Chen WK, Hill DE, Vidal M, Evans JG, Thorburn DR, Carr SA, Mootha VK.

Cell. 2008 Jul 11;134(1):112-23. doi: 10.1016/j.cell.2008.06.016.

46.

Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane.

Rardin MJ, Wiley SE, Murphy AN, Pagliarini DJ, Dixon JE.

J Biol Chem. 2008 May 30;283(22):15440-50. doi: 10.1074/jbc.M709547200. Epub 2008 Apr 2.

47.

Mitochondrial modulation: reversible phosphorylation takes center stage?

Pagliarini DJ, Dixon JE.

Trends Biochem Sci. 2006 Jan;31(1):26-34. Epub 2005 Dec 5. Review.

PMID:
16337125
48.

Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells.

Pagliarini DJ, Wiley SE, Kimple ME, Dixon JR, Kelly P, Worby CA, Casey PJ, Dixon JE.

Mol Cell. 2005 Jul 22;19(2):197-207.

49.

A PTEN-like phosphatase with a novel substrate specificity.

Pagliarini DJ, Worby CA, Dixon JE.

J Biol Chem. 2004 Sep 10;279(37):38590-6. Epub 2004 Jul 9.

50.

A PTEN-related 5-phosphatidylinositol phosphatase localized in the Golgi.

Merlot S, Meili R, Pagliarini DJ, Maehama T, Dixon JE, Firtel RA.

J Biol Chem. 2003 Oct 10;278(41):39866-73. Epub 2003 Jul 23.

Supplemental Content

Loading ...
Support Center