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Disruption of the Key Ca2+ Binding Site in the Selectivity Filter of Neuronal Voltage-Gated Calcium Channels Inhibits Channel Trafficking.

Meyer JO, Dahimene S, Page KM, Ferron L, Kadurin I, Ellaway JIJ, Zhao P, Patel T, Rothwell SW, Lin P, Pratt WS, Dolphin AC.

Cell Rep. 2019 Oct 1;29(1):22-33.e5. doi: 10.1016/j.celrep.2019.08.079.


Hematopoietic Stem Cell Transplantation to Treat Leukodystrophies: Clinical Practice Guidelines from the Hunter's Hope Leukodystrophy Care Network.

Page KM, Stenger EO, Connelly JA, Shyr D, West T, Wood S, Case L, Kester M, Shim S, Hammond L, Hammond M, Webb C, Biffi A, Bambach B, Fatemi A, Kurtzberg J.

Biol Blood Marrow Transplant. 2019 Sep 6. pii: S1083-8791(19)30571-3. doi: 10.1016/j.bbmt.2019.09.003. [Epub ahead of print]


Increased overall and bacterial infections following myeloablative allogeneic HCT for patients with AML in CR1.

Ustun C, Kim S, Chen M, Beitinjaneh AM, Brown VI, Dahi PB, Daly A, Diaz MA, Freytes CO, Ganguly S, Hashmi S, Hildebrandt GC, Lazarus HM, Nishihori T, Olsson RF, Page KM, Papanicolaou G, Saad A, Seo S, William BM, Wingard JR, Wirk B, Yared JA, Perales MA, Auletta JJ, Komanduri KV, Lindemans CA, Riches ML.

Blood Adv. 2019 Sep 10;3(17):2525-2536. doi: 10.1182/bloodadvances.2019000226.


Oscillations in well-mixed, deterministic feedback systems: Beyond ring oscillators.

Page KM.

J Theor Biol. 2019 Nov 21;481:44-53. doi: 10.1016/j.jtbi.2019.05.004. Epub 2019 May 3.


The influence of stem cell source on transplant outcomes for pediatric patients with acute myeloid leukemia.

Keating AK, Langenhorst J, Wagner JE, Page KM, Veys P, Wynn RF, Stefanski H, Elfeky R, Giller R, Mitchell R, Milano F, O'Brien TA, Dahlberg A, Delaney C, Kurtzberg J, Verneris MR, Boelens JJ.

Blood Adv. 2019 Apr 9;3(7):1118-1128. doi: 10.1182/bloodadvances.2018025908.


Evolution of cooperation in an epithelium.

Renton J, Page KM.

J R Soc Interface. 2019 Mar 29;16(152):20180918. doi: 10.1098/rsif.2018.0918.


de la Cruz et al. Reply.

de la Cruz R, Perez-Carrasco R, Guerrero P, Alarcon T, Page KM.

Phys Rev Lett. 2019 Feb 8;122(5):059802. doi: 10.1103/PhysRevLett.122.059802. No abstract available.


Reduction in Mortality after Umbilical Cord Blood Transplantation in Children Over a 20-Year Period (1995-2014).

Spees LP, Martin PL, Kurtzberg J, Stokhuyzen A, McGill L, Prasad VK, Driscoll TA, Parikh SH, Page KM, Vinesett R, Severyn C, Sung AD, Proia AD, Jenkins K, Arshad M, Steinbach WJ, Seed PC, Kelly MS.

Biol Blood Marrow Transplant. 2019 Apr;25(4):756-763. doi: 10.1016/j.bbmt.2018.11.018. Epub 2018 Nov 24.


The α2δ-like Protein Cachd1 Increases N-type Calcium Currents and Cell Surface Expression and Competes with α2δ-1.

Dahimene S, Page KM, Kadurin I, Ferron L, Ho DY, Powell GT, Pratt WS, Wilson SW, Dolphin AC.

Cell Rep. 2018 Nov 6;25(6):1610-1621.e5. doi: 10.1016/j.celrep.2018.10.033.


Degradation rate uniformity determines success of oscillations in repressive feedback regulatory networks.

Page KM, Perez-Carrasco R.

J R Soc Interface. 2018 May;15(142). pii: 20180157. doi: 10.1098/rsif.2018.0157.


Minimum Action Path Theory Reveals the Details of Stochastic Transitions Out of Oscillatory States.

de la Cruz R, Perez-Carrasco R, Guerrero P, Alarcon T, Page KM.

Phys Rev Lett. 2018 Mar 23;120(12):128102. doi: 10.1103/PhysRevLett.120.128102.


Making the Connection: Using Videoconferencing to Increase Linkage to Care for Incarcerated Persons Living with HIV Post-release.

Brantley AD, Page KM, Zack B, Friedrich KR, Wendell D, Robinson WT, Gruber D.

AIDS Behav. 2019 Jan;23(Suppl 1):32-40. doi: 10.1007/s10461-018-2115-4.


Combining a Toggle Switch and a Repressilator within the AC-DC Circuit Generates Distinct Dynamical Behaviors.

Perez-Carrasco R, Barnes CP, Schaerli Y, Isalan M, Briscoe J, Page KM.

Cell Syst. 2018 Apr 25;6(4):521-530.e3. doi: 10.1016/j.cels.2018.02.008. Epub 2018 Mar 21.


The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a TYK2/JAK1 Inhibitor (PF-06700841) in Healthy Subjects and Patients With Plaque Psoriasis.

Banfield C, Scaramozza M, Zhang W, Kieras E, Page KM, Fensome A, Vincent M, Dowty ME, Goteti K, Winkle PJ, Peeva E.

J Clin Pharmacol. 2018 Apr;58(4):434-447. doi: 10.1002/jcph.1046. Epub 2017 Dec 21.


Durable Chimerism and Long-Term Survival after Unrelated Umbilical Cord Blood Transplantation for Pediatric Hemophagocytic Lymphohistiocytosis: A Single-Center Experience.

Patel SA, Allewelt HA, Troy JD, Martin PL, Driscoll TA, Prasad VK, Kurtzberg J, Page KM, Parikh SH.

Biol Blood Marrow Transplant. 2017 Oct;23(10):1722-1728. doi: 10.1016/j.bbmt.2017.06.013. Epub 2017 Jun 21.


Hematopoietic Stem Cell Transplantation Activity in Pediatric Cancer between 2008 and 2014 in the United States: A Center for International Blood and Marrow Transplant Research Report.

Khandelwal P, Millard HR, Thiel E, Abdel-Azim H, Abraham AA, Auletta JJ, Boulad F, Brown VI, Camitta BM, Chan KW, Chaudhury S, Cowan MJ, Angel-Diaz M, Gadalla SM, Gale RP, Hale G, Kasow KA, Keating AK, Kitko CL, MacMillan ML, Olsson RF, Page KM, Seber A, Smith AR, Warwick AB, Wirk B, Mehta PA.

Biol Blood Marrow Transplant. 2017 Aug;23(8):1342-1349. doi: 10.1016/j.bbmt.2017.04.018. Epub 2017 Apr 24.


Factors Associated with Long-Term Risk of Relapse after Unrelated Cord Blood Transplantation in Children with Acute Lymphoblastic Leukemia in Remission.

Page KM, Labopin M, Ruggeri A, Michel G, Diaz de Heredia C, O'Brien T, Picardi A, Ayas M, Bittencourt H, Vora AJ, Troy J, Bonfim C, Volt F, Gluckman E, Bader P, Kurtzberg J, Rocha V.

Biol Blood Marrow Transplant. 2017 Aug;23(8):1350-1358. doi: 10.1016/j.bbmt.2017.04.015. Epub 2017 Apr 21.


Intrinsic Noise Profoundly Alters the Dynamics and Steady State of Morphogen-Controlled Bistable Genetic Switches.

Perez-Carrasco R, Guerrero P, Briscoe J, Page KM.

PLoS Comput Biol. 2016 Oct 21;12(10):e1005154. doi: 10.1371/journal.pcbi.1005154. eCollection 2016 Oct. Erratum in: PLoS Comput Biol. 2017 May 26;13(5):e1005563.


The CaVβ Subunit Protects the I-II Loop of the Voltage-gated Calcium Channel CaV2.2 from Proteasomal Degradation but Not Oligoubiquitination.

Page KM, Rothwell SW, Dolphin AC.

J Biol Chem. 2016 Sep 23;291(39):20402-16. doi: 10.1074/jbc.M116.737270. Epub 2016 Aug 3.


Objective assessment of gait in xylazine-induced ataxic horses.

Nout-Lomas YS, Page KM, Kang HG, Aanstoos ME, Greene HM.

Equine Vet J. 2017 May;49(3):334-340. doi: 10.1111/evj.12602. Epub 2016 Jul 23.


A CaV2.1 N-terminal fragment relieves the dominant-negative inhibition by an Episodic ataxia 2 mutant.

Dahimene S, Page KM, Nieto-Rostro M, Pratt WS, D'Arco M, Dolphin AC.

Neurobiol Dis. 2016 Sep;93:243-56. doi: 10.1016/j.nbd.2016.05.020. Epub 2016 May 31.


Mathematical models help explain experimental data. Response to 'Transcriptional interpretation of Shh morphogen signaling: computational modeling validates empirically established models'.

Cohen M, Page KM, Perez-Carrasco R, Barnes CP, Briscoe J.

Development. 2016 May 15;143(10):1640-3. doi: 10.1242/dev.138461. No abstract available.


Perception of Mattering and Suicide Ideation in the Australian Working Population: Evidence from a Cross-Sectional Survey.

Milner A, Page KM, LaMontagne AD.

Community Ment Health J. 2016 Jul;52(5):615-21. doi: 10.1007/s10597-016-0002-x. Epub 2016 Mar 3.


An integrated workplace mental health intervention in a policing context: Protocol for a cluster randomised control trial.

LaMontagne AD, Milner AJ, Allisey AF, Page KM, Reavley NJ, Martin A, Tchernitskaia I, Noblet AJ, Purnell LJ, Witt K, Keegel TG, Smith PM.

BMC Psychiatry. 2016 Feb 27;16:49. doi: 10.1186/s12888-016-0741-9.


The work-based predictors of job engagement and job satisfaction experienced by community health professionals.

Noblet AJ, Allisey AF, Nielsen IL, Cotton S, LaMontagne AD, Page KM.

Health Care Manage Rev. 2017 Jul/Sep;42(3):237-246. doi: 10.1097/HMR.0000000000000104.


Validation of Early Human Dose Prediction: A Key Metric for Compound Progression in Drug Discovery.

Page KM.

Mol Pharm. 2016 Feb 1;13(2):609-20. doi: 10.1021/acs.molpharmaceut.5b00840. Epub 2016 Jan 7.


Second Allogeneic Hematopoietic Cell Transplantation for Patients with Fanconi Anemia and Bone Marrow Failure.

Ayas M, Eapen M, Le-Rademacher J, Carreras J, Abdel-Azim H, Alter BP, Anderlini P, Battiwalla M, Bierings M, Buchbinder DK, Bonfim C, Camitta BM, Fasth AL, Gale RP, Lee MA, Lund TC, Myers KC, Olsson RF, Page KM, Prestidge TD, Radhi M, Shah AJ, Schultz KR, Wirk B, Wagner JE, Deeg HJ.

Biol Blood Marrow Transplant. 2015 Oct;21(10):1790-5. doi: 10.1016/j.bbmt.2015.06.012. Epub 2015 Jun 23.


Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms.

Cohen M, Kicheva A, Ribeiro A, Blassberg R, Page KM, Barnes CP, Briscoe J.

Nat Commun. 2015 Apr 2;6:6709. doi: 10.1038/ncomms7709.


Time dependent analysis of assay comparability: a novel approach to understand intra- and inter-site variability over time.

Winiwarter S, Middleton B, Jones B, Courtney P, Lindmark B, Page KM, Clark A, Landqvist C.

J Comput Aided Mol Des. 2015 Sep;29(9):795-807. doi: 10.1007/s10822-015-9836-5. Epub 2015 Feb 20.


A theoretical framework for the regulation of Shh morphogen-controlled gene expression.

Cohen M, Page KM, Perez-Carrasco R, Barnes CP, Briscoe J.

Development. 2014 Oct;141(20):3868-78. doi: 10.1242/dev.112573.


Alpha-ethyltryptamines as dual dopamine-serotonin releasers.

Blough BE, Landavazo A, Partilla JS, Decker AM, Page KM, Baumann MH, Rothman RB.

Bioorg Med Chem Lett. 2014 Oct 1;24(19):4754-4758. doi: 10.1016/j.bmcl.2014.07.062. Epub 2014 Jul 29.


Directional collective cell migration emerges as a property of cell interactions.

Woods ML, Carmona-Fontaine C, Barnes CP, Couzin ID, Mayor R, Page KM.

PLoS One. 2014 Sep 2;9(9):e104969. doi: 10.1371/journal.pone.0104969. eCollection 2014.


Workplace stress: what is the role of positive mental health?

Page KM, Milner AJ, Martin A, Turrell G, Giles-Corti B, LaMontagne AD.

J Occup Environ Med. 2014 Aug;56(8):814-9. doi: 10.1097/JOM.0000000000000230.


Hybrid dopamine uptake blocker-serotonin releaser ligands: a new twist on transporter-focused therapeutics.

Blough BE, Landavazo A, Partilla JS, Baumann MH, Decker AM, Page KM, Rothman RB.

ACS Med Chem Lett. 2014 Apr 15;5(6):623-7. doi: 10.1021/ml500113s. eCollection 2014 Jun 12.


Workplace mental health: developing an integrated intervention approach.

LaMontagne AD, Martin A, Page KM, Reavley NJ, Noblet AJ, Milner AJ, Keegel T, Smith PM.

BMC Psychiatry. 2014 May 9;14:131. doi: 10.1186/1471-244X-14-131.


Therapeutic activity of an interleukin-4/interleukin-13 dual antagonist on oxazolone-induced colitis in mice.

Kasaian MT, Page KM, Fish S, Brennan A, Cook TA, Moreira K, Zhang M, Jesson M, Marquette K, Agostinelli R, Lee J, Williams CM, Tchistiakova L, Thakker P.

Immunology. 2014 Nov;143(3):416-27. doi: 10.1111/imm.12319.


In reply.

Page KM, Kurtzberg J.

Transfusion. 2014 Feb;54(2):496. doi: 10.1111/trf.12465. No abstract available.


Differential upregulation in DRG neurons of an α2δ-1 splice variant with a lower affinity for gabapentin after peripheral sensory nerve injury.

Lana B, Schlick B, Martin S, Pratt WS, Page KM, Goncalves L, Rahman W, Dickenson AH, Bauer CS, Dolphin AC.

Pain. 2014 Mar;155(3):522-33. doi: 10.1016/j.pain.2013.12.001. Epub 2013 Dec 6.


A novel reduced-intensity conditioning regimen for unrelated umbilical cord blood transplantation in children with nonmalignant diseases.

Parikh SH, Mendizabal A, Benjamin CL, Komanduri KV, Antony J, Petrovic A, Hale G, Driscoll TA, Martin PL, Page KM, Flickinger K, Moffet J, Niedzwiecki D, Kurtzberg J, Szabolcs P.

Biol Blood Marrow Transplant. 2014 Mar;20(3):326-36. doi: 10.1016/j.bbmt.2013.11.021. Epub 2013 Dec 1.


Hydantoin based inhibitors of MMP13--discovery of AZD6605.

De Savi C, Waterson D, Pape A, Lamont S, Hadley E, Mills M, Page KM, Bowyer J, Maciewicz RA.

Bioorg Med Chem Lett. 2013 Aug 15;23(16):4705-12. doi: 10.1016/j.bmcl.2013.05.089. Epub 2013 Jun 10.


Stakeholder perceptions of job stress in an industrialized country: implications for policy and practice.

Page KM, LaMontagne AD, Louie AM, Ostry AS, Shaw A, Shoveller JA.

J Public Health Policy. 2013 Aug;34(3):447-61. doi: 10.1057/jphp.2013.24. Epub 2013 Jun 20.


Optimizing donor selection for public cord blood banking: influence of maternal, infant, and collection characteristics on cord blood unit quality.

Page KM, Mendizabal A, Betz-Stablein B, Wease S, Shoulars K, Gentry T, Prasad VK, Sun J, Carter S, Balber AE, Kurtzberg J.

Transfusion. 2014 Feb;54(2):340-52. doi: 10.1111/trf.12257. Epub 2013 May 27.


What can be learnt about disease progression in breast cancer dormancy from relapse data?

Willis L, Graham TA, Alarcón T, Alison MR, Tomlinson IP, Page KM.

PLoS One. 2013 May 6;8(5):e62320. doi: 10.1371/journal.pone.0062320. Print 2013.


A gene regulatory motif that generates oscillatory or multiway switch outputs.

Panovska-Griffiths J, Page KM, Briscoe J.

J R Soc Interface. 2012 Dec 12;10(79):20120826. doi: 10.1098/rsif.2012.0826. Print 2013 Feb.


Pharmacokinetic benefits of 3,4-dimethoxy substitution of a phenyl ring and design of isosteres yielding orally available cathepsin K inhibitors.

Crawford JJ, Kenny PW, Bowyer J, Cook CR, Finlayson JE, Heyes C, Highton AJ, Hudson JA, Jestel A, Krapp S, Martin S, Macfaul PA, McDermott BP, McGuire TM, Morley AD, Morris JJ, Page KM, Ribeiro LR, Sawney H, Steinbacher S, Smith C, Dossetter AG.

J Med Chem. 2012 Oct 25;55(20):8827-37. doi: 10.1021/jm301119s. Epub 2012 Oct 11.


Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition.

Dossetter AG, Bowyer J, Cook CR, Crawford JJ, Finlayson JE, Heron NM, Heyes C, Highton AJ, Hudson JA, Jestel A, Krapp S, MacFaul PA, McGuire TM, Morley AD, Morris JJ, Page KM, Ribeiro LR, Sawney H, Steinbacher S, Smith C.

Bioorg Med Chem Lett. 2012 Sep 1;22(17):5563-8. doi: 10.1016/j.bmcl.2012.07.012. Epub 2012 Jul 15.


(1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis.

Dossetter AG, Beeley H, Bowyer J, Cook CR, Crawford JJ, Finlayson JE, Heron NM, Heyes C, Highton AJ, Hudson JA, Jestel A, Kenny PW, Krapp S, Martin S, MacFaul PA, McGuire TM, Gutierrez PM, Morley AD, Morris JJ, Page KM, Ribeiro LR, Sawney H, Steinbacher S, Smith C, Vickers M.

J Med Chem. 2012 Jul 26;55(14):6363-74. doi: 10.1021/jm3007257. Epub 2012 Jul 10.


Myeloablative transplantation using either cord blood or bone marrow leads to immune recovery, high long-term donor chimerism and excellent survival in chronic granulomatous disease.

Tewari P, Martin PL, Mendizabal A, Parikh SH, Page KM, Driscoll TA, Malech HL, Kurtzberg J, Prasad VK.

Biol Blood Marrow Transplant. 2012 Sep;18(9):1368-77. doi: 10.1016/j.bbmt.2012.02.002. Epub 2012 Feb 10.


Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube.

Balaskas N, Ribeiro A, Panovska J, Dessaud E, Sasai N, Page KM, Briscoe J, Ribes V.

Cell. 2012 Jan 20;148(1-2):273-84. doi: 10.1016/j.cell.2011.10.047.

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