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Reduced GM1 ganglioside in CFTR-deficient human airway cells results in decreased β1-integrin signaling and delayed wound repair.

Itokazu Y, Pagano RE, Schroeder AS, O'Grady SM, Limper AH, Marks DL.

Am J Physiol Cell Physiol. 2014 May 1;306(9):C819-30. doi: 10.1152/ajpcell.00168.2013. Epub 2014 Feb 5.


Prominin-2 expression increases protrusions, decreases caveolae and inhibits Cdc42 dependent fluid phase endocytosis.

Singh RD, Schroeder AS, Scheffer L, Holicky EL, Wheatley CL, Marks DL, Pagano RE.

Biochem Biophys Res Commun. 2013 May 10;434(3):466-72. doi: 10.1016/j.bbrc.2013.03.097. Epub 2013 Apr 10.


Viral attachment induces rapid recruitment of an innate immune sensor (TRIM5α) to the plasma membrane.

Ohmine S, Singh RD, Marks DL, Meyer MA, Pagano RE, Ikeda Y.

J Innate Immun. 2013;5(4):414-24. doi: 10.1159/000346963. Epub 2013 Mar 21.


Glycosphingolipids mediate pneumocystis cell wall β-glucan activation of the IL-23/IL-17 axis in human dendritic cells.

Carmona EM, Kottom TJ, Hebrink DM, Moua T, Singh RD, Pagano RE, Limper AH.

Am J Respir Cell Mol Biol. 2012 Jul;47(1):50-9. doi: 10.1165/rcmb.2011-0159OC. Epub 2012 Feb 16.


Role of protein kinase d in Golgi exit and lysosomal targeting of the transmembrane protein, Mcoln1.

Marks DL, Holicky EL, Wheatley CL, Frumkin A, Bach G, Pagano RE.

Traffic. 2012 Apr;13(4):565-75. doi: 10.1111/j.1600-0854.2012.01331.x. Epub 2012 Feb 16.


Endocytic response of type I alveolar epithelial cells to hypertonic stress.

Wang S, Singh RD, Godin L, Pagano RE, Hubmayr RD.

Am J Physiol Lung Cell Mol Physiol. 2011 Apr;300(4):L560-8. doi: 10.1152/ajplung.00309.2010. Epub 2011 Jan 21.


Spatiotemporal dynamics of actin remodeling and endomembrane trafficking in alveolar epithelial type I cell wound healing.

Godin LM, Vergen J, Prakash YS, Pagano RE, Hubmayr RD.

Am J Physiol Lung Cell Mol Physiol. 2011 Apr;300(4):L615-23. doi: 10.1152/ajplung.00265.2010. Epub 2011 Jan 7.


Type II transforming growth factor-beta receptor recycling is dependent upon the clathrin adaptor protein Dab2.

Penheiter SG, Singh RD, Repellin CE, Wilkes MC, Edens M, Howe PH, Pagano RE, Leof EB.

Mol Biol Cell. 2010 Nov 15;21(22):4009-19. doi: 10.1091/mbc.E09-12-1019. Epub 2010 Sep 29.


Human remyelination promoting antibody inhibits apoptotic signaling and differentiation through Lyn kinase in primary rat oligodendrocytes.

Watzlawik J, Holicky E, Edberg DD, Marks DL, Warrington AE, Wright BR, Pagano RE, Rodriguez M.

Glia. 2010 Nov 15;58(15):1782-93. doi: 10.1002/glia.21048.


Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress.

Bachar AR, Scheffer L, Schroeder AS, Nakamura HK, Cobb LJ, Oh YK, Lerman LO, Pagano RE, Cohen P, Lerman A.

Cardiovasc Res. 2010 Nov 1;88(2):360-6. doi: 10.1093/cvr/cvq191. Epub 2010 Jun 18.


Co-regulation of caveolar and Cdc42-dependent fluid phase endocytosis by phosphocaveolin-1.

Cheng ZJ, Singh RD, Holicky EL, Wheatley CL, Marks DL, Pagano RE.

J Biol Chem. 2010 May 14;285(20):15119-25. doi: 10.1074/jbc.M109.069427. Epub 2010 Mar 12.


Stimulation of GLUT4 (glucose transporter isoform 4) storage vesicle formation by sphingolipid depletion.

Cheng ZJ, Singh RD, Wang TK, Holicky EL, Wheatley CL, Bernlohr DA, Marks DL, Pagano RE.

Biochem J. 2010 Mar 15;427(1):143-50. doi: 10.1042/BJ20091529.


Gangliosides and beta1-integrin are required for caveolae and membrane domains.

Singh RD, Marks DL, Holicky EL, Wheatley CL, Kaptzan T, Sato SB, Kobayashi T, Ling K, Pagano RE.

Traffic. 2010 Mar;11(3):348-60. doi: 10.1111/j.1600-0854.2009.01022.x. Epub 2009 Dec 3.


Proteomic identification of proteins translocated to membrane microdomains upon treatment of fibroblasts with the glycosphingolipid, C8-beta-D-lactosylceramide.

Kim SY, Wang TK, Singh RD, Wheatley CL, Marks DL, Pagano RE.

Proteomics. 2009 Sep;9(18):4321-8. doi: 10.1002/pmic.200900077.


Development of a Rab9 transgenic mouse and its ability to increase the lifespan of a murine model of Niemann-Pick type C disease.

Kaptzan T, West SA, Holicky EL, Wheatley CL, Marks DL, Wang T, Peake KB, Vance J, Walkley SU, Pagano RE.

Am J Pathol. 2009 Jan;174(1):14-20. doi: 10.2353/ajpath.2009.080660. Epub 2008 Dec 4.


Use of Bodipy-labeled sphingolipid and cholesterol analogs to examine membrane microdomains in cells.

Marks DL, Bittman R, Pagano RE.

Histochem Cell Biol. 2008 Nov;130(5):819-32. doi: 10.1007/s00418-008-0509-5. Epub 2008 Sep 27. Review.


Using fluorescent sphingolipid analogs to study intracellular lipid trafficking.

Singh RD, Marks DL, Pagano RE.

Curr Protoc Cell Biol. 2007 Jun;Chapter 24:Unit 24.1. doi: 10.1002/0471143030.cb2401s35.


Pathways of clathrin-independent endocytosis.

Mayor S, Pagano RE.

Nat Rev Mol Cell Biol. 2007 Aug;8(8):603-12. Review.


Inhibition of caveolar uptake, SV40 infection, and beta1-integrin signaling by a nonnatural glycosphingolipid stereoisomer.

Singh RD, Holicky EL, Cheng ZJ, Kim SY, Wheatley CL, Marks DL, Bittman R, Pagano RE.

J Cell Biol. 2007 Mar 26;176(7):895-901. Epub 2007 Mar 19.


Regulation of endocytic recycling of KCNQ1/KCNE1 potassium channels.

Seebohm G, Strutz-Seebohm N, Birkin R, Dell G, Bucci C, Spinosa MR, Baltaev R, Mack AF, Korniychuk G, Choudhury A, Marks D, Pagano RE, Attali B, Pfeufer A, Kass RS, Sanguinetti MC, Tavare JM, Lang F.

Circ Res. 2007 Mar 16;100(5):686-92. Epub 2007 Feb 9.


Misassembled mutant DeltaF508 CFTR in the distal secretory pathway alters cellular lipid trafficking.

Gentzsch M, Choudhury A, Chang XB, Pagano RE, Riordan JR.

J Cell Sci. 2007 Feb 1;120(Pt 3):447-55. Epub 2007 Jan 9.


Mutant huntingtin inhibits clathrin-independent endocytosis and causes accumulation of cholesterol in vitro and in vivo.

Trushina E, Singh RD, Dyer RB, Cao S, Shah VH, Parton RG, Pagano RE, McMurray CT.

Hum Mol Genet. 2006 Dec 15;15(24):3578-91.


Caveolar endocytosis and microdomain association of a glycosphingolipid analog is dependent on its sphingosine stereochemistry.

Singh RD, Liu Y, Wheatley CL, Holicky EL, Makino A, Marks DL, Kobayashi T, Subramaniam G, Bittman R, Pagano RE.

J Biol Chem. 2006 Oct 13;281(41):30660-8. Epub 2006 Aug 7.


Cryptosporidium parvum infects human cholangiocytes via sphingolipid-enriched membrane microdomains.

Nelson JB, O'Hara SP, Small AJ, Tietz PS, Choudhury AK, Pagano RE, Chen XM, LaRusso NF.

Cell Microbiol. 2006 Dec;8(12):1932-45. Epub 2006 Jul 18.


Distinct mechanisms of clathrin-independent endocytosis have unique sphingolipid requirements.

Cheng ZJ, Singh RD, Sharma DK, Holicky EL, Hanada K, Marks DL, Pagano RE.

Mol Biol Cell. 2006 Jul;17(7):3197-210. Epub 2006 May 3.


Membrane microdomains, caveolae, and caveolar endocytosis of sphingolipids.

Cheng ZJ, Singh RD, Marks DL, Pagano RE.

Mol Membr Biol. 2006 Jan-Feb;23(1):101-10. Review.


Regulation of caveolar endocytosis by syntaxin 6-dependent delivery of membrane components to the cell surface.

Choudhury A, Marks DL, Proctor KM, Gould GW, Pagano RE.

Nat Cell Biol. 2006 Apr;8(4):317-28. Epub 2006 Mar 26.


Use of Rab GTPases to study lipid trafficking in normal and sphingolipid storage disease fibroblasts.

Choudhury A, Marks DL, Pagano RE.

Methods Enzymol. 2005;403:166-82.


Transforming growth factor-beta activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2.

Wilkes MC, Mitchell H, Penheiter SG, Doré JJ, Suzuki K, Edens M, Sharma DK, Pagano RE, Leof EB.

Cancer Res. 2005 Nov 15;65(22):10431-40.


Macrophage internalization of fungal beta-glucans is not necessary for initiation of related inflammatory responses.

McCann F, Carmona E, Puri V, Pagano RE, Limper AH.

Infect Immun. 2005 Oct;73(10):6340-9.


The glycosphingolipid, lactosylceramide, regulates beta1-integrin clustering and endocytosis.

Sharma DK, Brown JC, Cheng Z, Holicky EL, Marks DL, Pagano RE.

Cancer Res. 2005 Sep 15;65(18):8233-41.


Protein transduction of Rab9 in Niemann-Pick C cells reduces cholesterol storage.

Narita K, Choudhury A, Dobrenis K, Sharma DK, Holicky EL, Marks DL, Walkley SU, Pagano RE.

FASEB J. 2005 Sep;19(11):1558-60. Epub 2005 Jun 22.


Use of fluorescent sphingolipid analogs to study lipid transport along the endocytic pathway.

Marks DL, Singh RD, Choudhury A, Wheatley CL, Pagano RE.

Methods. 2005 Jun;36(2):186-95.


Ultrastructural identification of uncoated caveolin-independent early endocytic vehicles.

Kirkham M, Fujita A, Chadda R, Nixon SJ, Kurzchalia TV, Sharma DK, Pagano RE, Hancock JF, Mayor S, Parton RG.

J Cell Biol. 2005 Jan 31;168(3):465-76. Epub 2005 Jan 24.


Differential effects of modification of membrane cholesterol and sphingolipids on the conformation, function, and trafficking of the G protein-coupled cholecystokinin receptor.

Harikumar KG, Puri V, Singh RD, Hanada K, Pagano RE, Miller LJ.

J Biol Chem. 2005 Jan 21;280(3):2176-85. Epub 2004 Nov 10.


Elevated endosomal cholesterol levels in Niemann-Pick cells inhibit rab4 and perturb membrane recycling.

Choudhury A, Sharma DK, Marks DL, Pagano RE.

Mol Biol Cell. 2004 Oct;15(10):4500-11. Epub 2004 Aug 3.


Ligand-dependent and -independent transforming growth factor-beta receptor recycling regulated by clathrin-mediated endocytosis and Rab11.

Mitchell H, Choudhury A, Pagano RE, Leof EB.

Mol Biol Cell. 2004 Sep;15(9):4166-78. Epub 2004 Jun 30.


Selective stimulation of caveolar endocytosis by glycosphingolipids and cholesterol.

Sharma DK, Brown JC, Choudhury A, Peterson TE, Holicky E, Marks DL, Simari R, Parton RG, Pagano RE.

Mol Biol Cell. 2004 Jul;15(7):3114-22. Epub 2004 Apr 23.


Endocytic trafficking routes of wild type and DeltaF508 cystic fibrosis transmembrane conductance regulator.

Gentzsch M, Chang XB, Cui L, Wu Y, Ozols VV, Choudhury A, Pagano RE, Riordan JR.

Mol Biol Cell. 2004 Jun;15(6):2684-96. Epub 2004 Apr 9.


Selective caveolin-1-dependent endocytosis of glycosphingolipids.

Singh RD, Puri V, Valiyaveettil JT, Marks DL, Bittman R, Pagano RE.

Mol Biol Cell. 2003 Aug;14(8):3254-65. Epub 2003 May 18.


Endocytic trafficking of glycosphingolipids in sphingolipid storage diseases.

Pagano RE.

Philos Trans R Soc Lond B Biol Sci. 2003 May 29;358(1433):885-91. Review.


Sphingolipid storage induces accumulation of intracellular cholesterol by stimulating SREBP-1 cleavage.

Puri V, Jefferson JR, Singh RD, Wheatley CL, Marks DL, Pagano RE.

J Biol Chem. 2003 Jun 6;278(23):20961-70. Epub 2003 Mar 25.


Endocytosis and sorting of glycosphingolipids in sphingolipid storage disease.

Marks DL, Pagano RE.

Trends Cell Biol. 2002 Dec;12(12):605-13. Review.


Glycosphingolipids internalized via caveolar-related endocytosis rapidly merge with the clathrin pathway in early endosomes and form microdomains for recycling.

Sharma DK, Choudhury A, Singh RD, Wheatley CL, Marks DL, Pagano RE.

J Biol Chem. 2003 Feb 28;278(9):7564-72. Epub 2002 Dec 12.


Pneumocystis carinii cell wall beta-glucan induces release of macrophage inflammatory protein-2 from alveolar epithelial cells via a lactosylceramide-mediated mechanism.

Hahn PY, Evans SE, Kottom TJ, Standing JE, Pagano RE, Limper AH.

J Biol Chem. 2003 Jan 17;278(3):2043-50. Epub 2002 Nov 4.


Role of deformation-induced lipid trafficking in the prevention of plasma membrane stress failure.

Vlahakis NE, Schroeder MA, Pagano RE, Hubmayr RD.

Am J Respir Crit Care Med. 2002 Nov 1;166(9):1282-9.


Glucosylceramide modulates membrane traffic along the endocytic pathway.

Sillence DJ, Puri V, Marks DL, Butters TD, Dwek RA, Pagano RE, Platt FM.

J Lipid Res. 2002 Nov;43(11):1837-45.


Rab proteins mediate Golgi transport of caveola-internalized glycosphingolipids and correct lipid trafficking in Niemann-Pick C cells.

Choudhury A, Dominguez M, Puri V, Sharma DK, Narita K, Wheatley CL, Marks DL, Pagano RE.

J Clin Invest. 2002 Jun;109(12):1541-50.


Clathrin-dependent and -independent internalization of plasma membrane sphingolipids initiates two Golgi targeting pathways.

Puri V, Watanabe R, Singh RD, Dominguez M, Brown JC, Wheatley CL, Marks DL, Pagano RE.

J Cell Biol. 2001 Aug 6;154(3):535-47. Epub 2001 Jul 30.

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