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Items: 1 to 50 of 111

1.

Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging.

Robinson AR, Yousefzadeh MJ, Rozgaja TA, Wang J, Li X, Tilstra JS, Feldman CH, Gregg SQ, Johnson CH, Skoda EM, Frantz MC, Bell-Temin H, Pope-Varsalona H, Gurkar AU, Nasto LA, Robinson RAS, Fuhrmann-Stroissnigg H, Czerwinska J, McGowan SJ, Cantu-Medellin N, Harris JB, Maniar S, Ross MA, Trussoni CE, LaRusso NF, Cifuentes-Pagano E, Pagano PJ, Tudek B, Vo NV, Rigatti LH, Opresko PL, Stolz DB, Watkins SC, Burd CE, Croix CMS, Siuzdak G, Yates NA, Robbins PD, Wang Y, Wipf P, Kelley EE, Niedernhofer LJ.

Redox Biol. 2018 Jul;17:259-273. doi: 10.1016/j.redox.2018.04.007. Epub 2018 Apr 13.

2.

The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1.

Meijles DN, Sahoo S, Al Ghouleh I, Amaral JH, Bienes-Martinez R, Knupp HE, Attaran S, Sembrat JC, Nouraie SM, Rojas MM, Novelli EM, Gladwin MT, Isenberg JS, Cifuentes-Pagano E, Pagano PJ.

Sci Signal. 2017 Oct 17;10(501). pii: eaaj1784. doi: 10.1126/scisignal.aaj1784.

3.

Endothelial Nox1 oxidase assembly in human pulmonary arterial hypertension; driver of Gremlin1-mediated proliferation.

Ghouleh IA, Sahoo S, Meijles DN, Amaral JH, de Jesus DS, Sembrat J, Rojas M, Goncharov DA, Goncharova EA, Pagano PJ.

Clin Sci (Lond). 2017 Jul 16;131(15):2019-2035. doi: 10.1042/CS20160812. Print 2017 Aug 1.

PMID:
28522681
4.

Microvascular NADPH oxidase in health and disease.

Li Y, Pagano PJ.

Free Radic Biol Med. 2017 Aug;109:33-47. doi: 10.1016/j.freeradbiomed.2017.02.049. Epub 2017 Mar 6. Review.

5.

CD47 and Nox1 Mediate Dynamic Fluid-Phase Macropinocytosis of Native LDL.

Csányi G, Feck DM, Ghoshal P, Singla B, Lin H, Nagarajan S, Meijles DN, Al Ghouleh I, Cantu-Medellin N, Kelley EE, Mateuszuk L, Isenberg JS, Watkins S, Pagano PJ.

Antioxid Redox Signal. 2017 Jun 1;26(16):886-901. doi: 10.1089/ars.2016.6834. Epub 2017 Jan 31.

6.

Binding of EBP50 to Nox organizing subunit p47phox is pivotal to cellular reactive species generation and altered vascular phenotype.

Al Ghouleh I, Meijles DN, Mutchler S, Zhang Q, Sahoo S, Gorelova A, Henrich Amaral J, Rodríguez AI, Mamonova T, Song GJ, Bisello A, Friedman PA, Cifuentes-Pagano ME, Pagano PJ.

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):E5308-17. doi: 10.1073/pnas.1514161113. Epub 2016 Aug 18.

7.

MEF2C-MYOCD and Leiomodin1 Suppression by miRNA-214 Promotes Smooth Muscle Cell Phenotype Switching in Pulmonary Arterial Hypertension.

Sahoo S, Meijles DN, Al Ghouleh I, Tandon M, Cifuentes-Pagano E, Sembrat J, Rojas M, Goncharova E, Pagano PJ.

PLoS One. 2016 May 4;11(5):e0153780. doi: 10.1371/journal.pone.0153780. eCollection 2016.

8.

NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?

Sahoo S, Meijles DN, Pagano PJ.

Clin Sci (Lond). 2016 Mar;130(5):317-35. doi: 10.1042/CS20150087. Review.

9.

Nox and Inflammation in the Vascular Adventitia.

Meijles DN, Pagano PJ.

Hypertension. 2016 Jan;67(1):14-9. doi: 10.1161/HYPERTENSIONAHA.115.03622. Epub 2015 Nov 9. Review. No abstract available.

10.

Platelet-derived HMGB1 is a critical mediator of thrombosis.

Vogel S, Bodenstein R, Chen Q, Feil S, Feil R, Rheinlaender J, Schäffer TE, Bohn E, Frick JS, Borst O, Münzer P, Walker B, Markel J, Csanyi G, Pagano PJ, Loughran P, Jessup ME, Watkins SC, Bullock GC, Sperry JL, Zuckerbraun BS, Billiar TR, Lotze MT, Gawaz M, Neal MD.

J Clin Invest. 2015 Dec;125(12):4638-54. doi: 10.1172/JCI81660. Epub 2015 Nov 9.

11.

Nox Inhibitors & Therapies: Rational Design of Peptidic and Small Molecule Inhibitors.

Cifuentes-Pagano ME, Meijles DN, Pagano PJ.

Curr Pharm Des. 2015;21(41):6023-35. Review.

12.

Selective inactivation of NADPH oxidase 2 causes regression of vascularization and the size and stability of atherosclerotic plaques.

Quesada IM, Lucero A, Amaya C, Meijles DN, Cifuentes ME, Pagano PJ, Castro C.

Atherosclerosis. 2015 Oct;242(2):469-75. doi: 10.1016/j.atherosclerosis.2015.08.011. Epub 2015 Aug 8.

13.

Redox-modulating agents target NOX2-dependent IKKε oncogenic kinase expression and proliferation in human breast cancer cell lines.

Mukawera E, Chartier S, Williams V, Pagano PJ, Lapointe R, Grandvaux N.

Redox Biol. 2015 Dec;6:9-18. doi: 10.1016/j.redox.2015.06.010. Epub 2015 Jun 23.

14.

Chemiluminescence and the Nox1-Nox2-Nox4 Triple Knockout.

Pagano PJ, Griendling KK, Miller FJ, Laurindo FR, Touyz RM.

Antioxid Redox Signal. 2015 Nov 20;23(15):1246-7. doi: 10.1089/ars.2015.6382. Epub 2015 Jul 14. No abstract available.

PMID:
26054248
15.

MEF2B-Nox1 signaling is critical for stretch-induced phenotypic modulation of vascular smooth muscle cells.

Rodríguez AI, Csányi G, Ranayhossaini DJ, Feck DM, Blose KJ, Assatourian L, Vorp DA, Pagano PJ.

Arterioscler Thromb Vasc Biol. 2015 Feb;35(2):430-8. doi: 10.1161/ATVBAHA.114.304936. Epub 2014 Dec 30.

16.

Early NADPH oxidase-2 activation is crucial in phenylephrine-induced hypertrophy of H9c2 cells.

Hahn NE, Musters RJ, Fritz JM, Pagano PJ, Vonk AB, Paulus WJ, van Rossum AC, Meischl C, Niessen HW, Krijnen PA.

Cell Signal. 2014 Sep;26(9):1818-24. doi: 10.1016/j.cellsig.2014.04.018. Epub 2014 May 2.

17.

Thrombospondin-1 activation of signal-regulatory protein-α stimulates reactive oxygen species production and promotes renal ischemia reperfusion injury.

Yao M, Rogers NM, Csányi G, Rodriguez AI, Ross MA, St Croix C, Knupp H, Novelli EM, Thomson AW, Pagano PJ, Isenberg JS.

J Am Soc Nephrol. 2014 Jun;25(6):1171-86. doi: 10.1681/ASN.2013040433. Epub 2014 Feb 7. Erratum in: J Am Soc Nephrol. 2014 Aug;25(8):1884.

18.

Bridged tetrahydroisoquinolines as selective NADPH oxidase 2 (Nox2) inhibitors.

Cifuentes-Pagano E, Saha J, Csányi G, Ghouleh IA, Sahoo S, Rodríguez A, Wipf P, Pagano PJ, Skoda EM.

Medchemcomm. 2013 Jul;4(7):1085-1092.

19.

Thrombospondin-1 and CD47 regulation of cardiac, pulmonary and vascular responses in health and disease.

Rogers NM, Sharifi-Sanjani M, Csányi G, Pagano PJ, Isenberg JS.

Matrix Biol. 2014 Jul;37:92-101. doi: 10.1016/j.matbio.2014.01.002. Epub 2014 Jan 11. Review.

20.

Nox-derived ROS are acutely activated in pressure overload pulmonary hypertension: indications for a seminal role for mitochondrial Nox4.

Frazziano G, Al Ghouleh I, Baust J, Shiva S, Champion HC, Pagano PJ.

Am J Physiol Heart Circ Physiol. 2014 Jan 15;306(2):H197-205. doi: 10.1152/ajpheart.00977.2012. Epub 2013 Nov 8.

21.

Selective recapitulation of conserved and nonconserved regions of putative NOXA1 protein activation domain confers isoform-specific inhibition of Nox1 oxidase and attenuation of endothelial cell migration.

Ranayhossaini DJ, Rodriguez AI, Sahoo S, Chen BB, Mallampalli RK, Kelley EE, Csanyi G, Gladwin MT, Romero G, Pagano PJ.

J Biol Chem. 2013 Dec 20;288(51):36437-50. doi: 10.1074/jbc.M113.521344. Epub 2013 Nov 1.

22.

Proteomic analysis identifies an NADPH oxidase 1 (Nox1)-mediated role for actin-related protein 2/3 complex subunit 2 (ARPC2) in promoting smooth muscle cell migration.

Al Ghouleh I, Rodríguez A, Pagano PJ, Csányi G.

Int J Mol Sci. 2013 Oct 11;14(10):20220-35. doi: 10.3390/ijms141020220.

23.

The quest for selective nox inhibitors and therapeutics: challenges, triumphs and pitfalls.

Cifuentes-Pagano E, Meijles DN, Pagano PJ.

Antioxid Redox Signal. 2014 Jun 10;20(17):2741-54. doi: 10.1089/ars.2013.5620. Epub 2013 Dec 14. Review.

24.

Strategies Aimed at Nox4 Oxidase Inhibition Employing Peptides from Nox4 B-Loop and C-Terminus and p22 (phox) N-Terminus: An Elusive Target.

Csányi G, Pagano PJ.

Int J Hypertens. 2013;2013:842827. doi: 10.1155/2013/842827. Epub 2013 Mar 31.

25.

Thrombospondin-1 regulates blood flow via CD47 receptor-mediated activation of NADPH oxidase 1.

Csányi G, Yao M, Rodríguez AI, Al Ghouleh I, Sharifi-Sanjani M, Frazziano G, Huang X, Kelley EE, Isenberg JS, Pagano PJ.

Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2966-73. doi: 10.1161/ATVBAHA.112.300031. Epub 2012 Oct 18.

26.

TrACEing angiotensin II type 1 to right ventricular hypertrophy: are the "sartans" a viable course to treating pulmonary arterial hypertension?

Ranayhossaini D, Pagano PJ.

Am J Respir Crit Care Med. 2012 Oct 15;186(8):705-7. doi: 10.1164/rccm.201208-1480ED. No abstract available.

27.

Aquaporin 1, Nox1, and Ask1 mediate oxidant-induced smooth muscle cell hypertrophy.

Al Ghouleh I, Frazziano G, Rodriguez AI, Csányi G, Maniar S, St Croix CM, Kelley EE, Egaña LA, Song GJ, Bisello A, Lee YJ, Pagano PJ.

Cardiovasc Res. 2013 Jan 1;97(1):134-42. doi: 10.1093/cvr/cvs295. Epub 2012 Sep 20.

28.

NADPH oxidase inhibitors: a decade of discovery from Nox2ds to HTS.

Cifuentes-Pagano E, Csanyi G, Pagano PJ.

Cell Mol Life Sci. 2012 Jul;69(14):2315-25. doi: 10.1007/s00018-012-1009-2. Epub 2012 May 15. Review.

29.

NADPH oxidase-derived ROS and the regulation of pulmonary vessel tone.

Frazziano G, Champion HC, Pagano PJ.

Am J Physiol Heart Circ Physiol. 2012 Jun 1;302(11):H2166-77. doi: 10.1152/ajpheart.00780.2011. Epub 2012 Mar 16. Review.

30.

Oxidases and peroxidases in cardiovascular and lung disease: new concepts in reactive oxygen species signaling.

Al Ghouleh I, Khoo NK, Knaus UG, Griendling KK, Touyz RM, Thannickal VJ, Barchowsky A, Nauseef WM, Kelley EE, Bauer PM, Darley-Usmar V, Shiva S, Cifuentes-Pagano E, Freeman BA, Gladwin MT, Pagano PJ.

Free Radic Biol Med. 2011 Oct 1;51(7):1271-88. doi: 10.1016/j.freeradbiomed.2011.06.011. Epub 2011 Jun 14. Review.

31.

Nox2 B-loop peptide, Nox2ds, specifically inhibits the NADPH oxidase Nox2.

Csányi G, Cifuentes-Pagano E, Al Ghouleh I, Ranayhossaini DJ, Egaña L, Lopes LR, Jackson HM, Kelley EE, Pagano PJ.

Free Radic Biol Med. 2011 Sep 15;51(6):1116-25. doi: 10.1016/j.freeradbiomed.2011.04.025. Epub 2011 Apr 17.

32.

Endosomal ClC-3 and Nox1: moving marksmen of redox signaling?

Al Ghouleh I, Pagano PJ.

Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):240-2. doi: 10.1161/ATVBAHA.110.220053. No abstract available.

33.

Mitogen-activated protein kinase-activated protein kinase 2 in angiotensin II-induced inflammation and hypertension: regulation of oxidative stress.

Ebrahimian T, Li MW, Lemarié CA, Simeone SM, Pagano PJ, Gaestel M, Paradis P, Wassmann S, Schiffrin EL.

Hypertension. 2011 Feb;57(2):245-54. doi: 10.1161/HYPERTENSIONAHA.110.159889. Epub 2010 Dec 20.

34.

Adventitia-derived hydrogen peroxide impairs relaxation of the rat carotid artery via smooth muscle cell p38 mitogen-activated protein kinase.

Cascino T, Csanyi G, Al Ghouleh I, Montezano AC, Touyz RM, Haurani MJ, Pagano PJ.

Antioxid Redox Signal. 2011 Sep 15;15(6):1507-15. doi: 10.1089/ars.2010.3631. Epub 2011 Apr 8.

35.

Thrombospondin-1 supports blood pressure by limiting eNOS activation and endothelial-dependent vasorelaxation.

Bauer EM, Qin Y, Miller TW, Bandle RW, Csanyi G, Pagano PJ, Bauer PM, Schnermann J, Roberts DD, Isenberg JS.

Cardiovasc Res. 2010 Dec 1;88(3):471-81. doi: 10.1093/cvr/cvq218. Epub 2010 Jul 7.

36.

Enhanced myogenic response in the afferent arteriole of spontaneously hypertensive rats.

Ren Y, D'Ambrosio MA, Liu R, Pagano PJ, Garvin JL, Carretero OA.

Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H1769-75. doi: 10.1152/ajpheart.00537.2009. Epub 2010 Apr 2.

37.

Lack of glutathione peroxidase 1 accelerates cardiac-specific hypertrophy and dysfunction in angiotensin II hypertension.

Ardanaz N, Yang XP, Cifuentes ME, Haurani MJ, Jackson KW, Liao TD, Carretero OA, Pagano PJ.

Hypertension. 2010 Jan;55(1):116-23. doi: 10.1161/HYPERTENSIONAHA.109.135715. Epub 2009 Nov 16.

38.

HO-1 and CO decrease platelet-derived growth factor-induced vascular smooth muscle cell migration via inhibition of Nox1.

Rodriguez AI, Gangopadhyay A, Kelley EE, Pagano PJ, Zuckerbraun BS, Bauer PM.

Arterioscler Thromb Vasc Biol. 2010 Jan;30(1):98-104. doi: 10.1161/ATVBAHA.109.197822. Epub 2009 Oct 29.

39.

NOX and inflammation in the vascular adventitia.

Csányi G, Taylor WR, Pagano PJ.

Free Radic Biol Med. 2009 Nov 1;47(9):1254-66. doi: 10.1016/j.freeradbiomed.2009.07.022. Epub 2009 Jul 21.

40.

Synthesis and structure-activity studies of novel homomorpholine oxazolidinone antibacterial agents.

Kim JY, Boyer FE, Choy AL, Huband MD, Pagano PJ, Vara Prasad JV.

Bioorg Med Chem Lett. 2009 Jan 15;19(2):550-3. doi: 10.1016/j.bmcl.2008.02.052. Epub 2008 Feb 26.

PMID:
19064317
41.

Arsenic-stimulated liver sinusoidal capillarization in mice requires NADPH oxidase-generated superoxide.

Straub AC, Clark KA, Ross MA, Chandra AG, Li S, Gao X, Pagano PJ, Stolz DB, Barchowsky A.

J Clin Invest. 2008 Dec;118(12):3980-9. doi: 10.1172/JCI35092. Epub 2008 Nov 13.

42.

Deletion of inducible nitric oxide synthase provides cardioprotection in mice with 2-kidney, 1-clip hypertension.

Sun Y, Carretero OA, Xu J, Rhaleb NE, Yang JJ, Pagano PJ, Yang XP.

Hypertension. 2009 Jan;53(1):49-56. doi: 10.1161/HYPERTENSIONAHA.108.121822. Epub 2008 Nov 10.

43.

Identification and characterization of VPO1, a new animal heme-containing peroxidase.

Cheng G, Salerno JC, Cao Z, Pagano PJ, Lambeth JD.

Free Radic Biol Med. 2008 Dec 15;45(12):1682-94. doi: 10.1016/j.freeradbiomed.2008.09.009. Epub 2008 Sep 23.

44.

Role of inflammation in the development of renal damage and dysfunction in angiotensin II-induced hypertension.

Liao TD, Yang XP, Liu YH, Shesely EG, Cavasin MA, Kuziel WA, Pagano PJ, Carretero OA.

Hypertension. 2008 Aug;52(2):256-63. doi: 10.1161/HYPERTENSIONAHA.108.112706. Epub 2008 Jun 9.

45.

Nox4 oxidase overexpression specifically decreases endogenous Nox4 mRNA and inhibits angiotensin II-induced adventitial myofibroblast migration.

Haurani MJ, Cifuentes ME, Shepard AD, Pagano PJ.

Hypertension. 2008 Jul;52(1):143-9. doi: 10.1161/HYPERTENSIONAHA.107.101667. Epub 2008 May 12.

46.
47.

Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound.

Poel TJ, Thomas RC, Adams WJ, Aristoff PA, Barbachyn MR, Boyer FE, Brieland J, Brideau R, Brodfuehrer J, Brown AP, Choy AL, Dermyer M, Dority M, Ford CW, Gadwood RC, Hanna D, Hongliang C, Huband MD, Huber C, Kelly R, Kim JY, Martin JP Jr, Pagano PJ, Ross D, Skerlos L, Sulavik MC, Zhu T, Zurenko GE, Prasad JV.

J Med Chem. 2007 Nov 29;50(24):5886-9. Epub 2007 Nov 8.

PMID:
17988109
48.

Comparison of H2O2-induced vasoconstriction in the abdominal aorta and mesenteric artery of the mouse.

Ardanaz N, Beierwaltes WH, Pagano PJ.

Vascul Pharmacol. 2007 Nov-Dec;47(5-6):288-94. Epub 2007 Sep 7.

PMID:
17900993
49.

Adventitial fibroblast reactive oxygen species as autacrine and paracrine mediators of remodeling: bellwether for vascular disease?

Haurani MJ, Pagano PJ.

Cardiovasc Res. 2007 Sep 1;75(4):679-89. Epub 2007 Jun 22. Review.

PMID:
17689510
50.

The adventitia: the outs and ins of vascular disease.

Pagano PJ, Gutterman DD.

Cardiovasc Res. 2007 Sep 1;75(4):636-9. Epub 2007 Jul 16. No abstract available.

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