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Cancer Progression Goes Viral: The Role of Oncoviruses in Aggressiveness of Malignancies.

Müller-Coan BG, Caetano BFR, Pagano JS, Elgui de Oliveira D.

Trends Cancer. 2018 Jul;4(7):485-498. doi: 10.1016/j.trecan.2018.04.006. Epub 2018 May 21. Review.


Antiviral Drugs for EBV.

Pagano JS, Whitehurst CB, Andrei G.

Cancers (Basel). 2018 Jun 13;10(6). pii: E197. doi: 10.3390/cancers10060197.


C-Terminal Farnesylation of UCH-L1 Plays a Role in Transport of Epstein-Barr Virus Primary Oncoprotein LMP1 to Exosomes.

Kobayashi E, Aga M, Kondo S, Whitehurst C, Yoshizaki T, Pagano JS, Shackelford J.

mSphere. 2018 Feb 7;3(1). pii: e00030-18. doi: 10.1128/mSphere.00030-18. eCollection 2018 Jan-Feb.


The Translesion Polymerase Pol η Is Required for Efficient Epstein-Barr Virus Infectivity and Is Regulated by the Viral Deubiquitinating Enzyme BPLF1.

Dyson OF, Pagano JS, Whitehurst CB.

J Virol. 2017 Sep 12;91(19). pii: e00600-17. doi: 10.1128/JVI.00600-17. Print 2017 Oct 1.


Expression of interferon regulatory factor 7 correlates with the expression of Epstein-Barr Virus latent membrane protein 1 and cervical lymph node metastasis in nasopharyngeal cancer.

Kondo S, Endo K, Wakisaka N, Aga M, Kano M, Seishima N, Imoto T, Kobayashi E, Moriyama-Kita M, Nakanishi Y, Murono S, Pagano JS, Yoshizaki T.

Pathol Int. 2017 Sep;67(9):461-466. doi: 10.1111/pin.12561. Epub 2017 Jul 16.


Viral Carcinogenesis Beyond Malignant Transformation: EBV in the Progression of Human Cancers.

Elgui de Oliveira D, Müller-Coan BG, Pagano JS.

Trends Microbiol. 2016 Aug;24(8):649-664. doi: 10.1016/j.tim.2016.03.008. Epub 2016 Apr 7. Review.


UCH-L1 in DLBCL: marker or target?

Pagano JS, Shackelford J.

Blood. 2016 Mar 24;127(12):1524-5. doi: 10.1182/blood-2016-01-689984.


Knockout of Epstein-Barr virus BPLF1 retards B-cell transformation and lymphoma formation in humanized mice.

Whitehurst CB, Li G, Montgomery SA, Montgomery ND, Su L, Pagano JS.

MBio. 2015 Oct 20;6(5):e01574-15. doi: 10.1128/mBio.01574-15.


LMP1-Induced Sumoylation Influences the Maintenance of Epstein-Barr Virus Latency through KAP1.

Bentz GL, Moss CR 2nd, Whitehurst CB, Moody CA, Pagano JS.

J Virol. 2015 Aug;89(15):7465-77. doi: 10.1128/JVI.00711-15. Epub 2015 May 6.


Viruses and human cancers: a long road of discovery of molecular paradigms.

White MK, Pagano JS, Khalili K.

Clin Microbiol Rev. 2014 Jul;27(3):463-81. doi: 10.1128/CMR.00124-13. Review.


The Rad6/18 ubiquitin complex interacts with the Epstein-Barr virus deubiquitinating enzyme, BPLF1, and contributes to virus infectivity.

Kumar R, Whitehurst CB, Pagano JS.

J Virol. 2014 Jun;88(11):6411-22. doi: 10.1128/JVI.00536-14. Epub 2014 Mar 26.


Exosomal HIF1α supports invasive potential of nasopharyngeal carcinoma-associated LMP1-positive exosomes.

Aga M, Bentz GL, Raffa S, Torrisi MR, Kondo S, Wakisaka N, Yoshizaki T, Pagano JS, Shackelford J.

Oncogene. 2014 Sep 11;33(37):4613-22. doi: 10.1038/onc.2014.66. Epub 2014 Mar 24.


KSHV LANA and EBV LMP1 induce the expression of UCH-L1 following viral transformation.

Bentz GL, Bheda-Malge A, Wang L, Shackelford J, Damania B, Pagano JS.

Virology. 2014 Jan 5;448:293-302. doi: 10.1016/j.virol.2013.10.018. Epub 2013 Nov 8.


Maribavir inhibits Epstein-Barr virus transcription through the EBV protein kinase.

Whitehurst CB, Sanders MK, Law M, Wang FZ, Xiong J, Dittmer DP, Pagano JS.

J Virol. 2013 May;87(9):5311-5. doi: 10.1128/JVI.03505-12. Epub 2013 Feb 28.


Upregulation of special AT-rich-binding protein 1 by Epstein-Barr virus latent membrane protein 1 in human nasopharyngeal cells and nasopharyngeal cancer.

Endo K, Shackelford J, Aga M, Yoshizaki T, Pagano JS.

J Gen Virol. 2013 Mar;94(Pt 3):507-13. doi: 10.1099/vir.0.046243-0. Epub 2012 Dec 5.


Epstein-Barr virus latent membrane protein 1 regulates the function of interferon regulatory factor 7 by inducing its sumoylation.

Bentz GL, Shackelford J, Pagano JS.

J Virol. 2012 Nov;86(22):12251-61. doi: 10.1128/JVI.01407-12. Epub 2012 Sep 5.


Epstein-Barr virus BPLF1 deubiquitinates PCNA and attenuates polymerase η recruitment to DNA damage sites.

Whitehurst CB, Vaziri C, Shackelford J, Pagano JS.

J Virol. 2012 Aug;86(15):8097-106. doi: 10.1128/JVI.00588-12. Epub 2012 May 23.


Epstein-Barr virus latent membrane protein 1 induces cancer stem/progenitor-like cells in nasopharyngeal epithelial cell lines.

Kondo S, Wakisaka N, Muramatsu M, Zen Y, Endo K, Murono S, Sugimoto H, Yamaoka S, Pagano JS, Yoshizaki T.

J Virol. 2011 Nov;85(21):11255-64. doi: 10.1128/JVI.00188-11. Epub 2011 Aug 17.


Epstein-Barr virus latent membrane protein 1 (LMP1) C-terminal-activating region 3 contributes to LMP1-mediated cellular migration via its interaction with Ubc9.

Bentz GL, Whitehurst CB, Pagano JS.

J Virol. 2011 Oct;85(19):10144-53. doi: 10.1128/JVI.05035-11. Epub 2011 Jul 27.


PU.1-dependent regulation of UCH L1 expression in B-lymphoma cells.

Bheda A, Yue W, Gullapalli A, Shackelford J, Pagano JS.

Leuk Lymphoma. 2011 Jul;52(7):1336-47. doi: 10.3109/10428194.2011.562571. Epub 2011 Apr 20.


IRF7: activation, regulation, modification and function.

Ning S, Pagano JS, Barber GN.

Genes Immun. 2011 Sep;12(6):399-414. doi: 10.1038/gene.2011.21. Epub 2011 Apr 14. Review.


Epstein-Barr Virus latent membrane protein 1 induces Snail and epithelial-mesenchymal transition in metastatic nasopharyngeal carcinoma.

Horikawa T, Yoshizaki T, Kondo S, Furukawa M, Kaizaki Y, Pagano JS.

Br J Cancer. 2011 Mar 29;104(7):1160-7. doi: 10.1038/bjc.2011.38. Epub 2011 Mar 8.


The A20 deubiquitinase activity negatively regulates LMP1 activation of IRF7.

Ning S, Pagano JS.

J Virol. 2010 Jun;84(12):6130-8. doi: 10.1128/JVI.00364-10. Epub 2010 Apr 14.


Epstein-Barr virus BRLF1 inhibits transcription of IRF3 and IRF7 and suppresses induction of interferon-beta.

Bentz GL, Liu R, Hahn AM, Shackelford J, Pagano JS.

Virology. 2010 Jun 20;402(1):121-8. doi: 10.1016/j.virol.2010.03.014. Epub 2010 Apr 8.


The Epstein-Barr virus (EBV)-encoded protein kinase, EBV-PK, but not the thymidine kinase (EBV-TK), is required for ganciclovir and acyclovir inhibition of lytic viral production.

Meng Q, Hagemeier SR, Fingeroth JD, Gershburg E, Pagano JS, Kenney SC.

J Virol. 2010 May;84(9):4534-42. doi: 10.1128/JVI.02487-09. Epub 2010 Feb 24.


Ubiquitin editing enzyme UCH L1 and microtubule dynamics: implication in mitosis.

Bheda A, Gullapalli A, Caplow M, Pagano JS, Shackelford J.

Cell Cycle. 2010 Mar 1;9(5):980-94. Epub 2010 Mar 15.


Maribavir inhibits epstein-barr virus transcription in addition to viral DNA replication.

Wang FZ, Roy D, Gershburg E, Whitehurst CB, Dittmer DP, Pagano JS.

J Virol. 2009 Dec;83(23):12108-17. doi: 10.1128/JVI.01575-09. Epub 2009 Sep 16.


Expression and functional studies of ubiquitin C-terminal hydrolase L1 regulated genes.

Bheda A, Shackelford J, Pagano JS.

PLoS One. 2009 Aug 26;4(8):e6764. doi: 10.1371/journal.pone.0006764.


Positive reciprocal regulation of ubiquitin C-terminal hydrolase L1 and beta-catenin/TCF signaling.

Bheda A, Yue W, Gullapalli A, Whitehurst C, Liu R, Pagano JS, Shackelford J.

PLoS One. 2009 Jun 18;4(6):e5955. doi: 10.1371/journal.pone.0005955.


The Epstein-Barr virus (EBV) deubiquitinating enzyme BPLF1 reduces EBV ribonucleotide reductase activity.

Whitehurst CB, Ning S, Bentz GL, Dufour F, Gershburg E, Shackelford J, Langelier Y, Pagano JS.

J Virol. 2009 May;83(9):4345-53. doi: 10.1128/JVI.02195-08. Epub 2009 Feb 25.


Phosphorylated ezrin is associated with EBV latent membrane protein 1 in nasopharyngeal carcinoma and induces cell migration.

Endo K, Kondo S, Shackleford J, Horikawa T, Kitagawa N, Yoshizaki T, Furukawa M, Zen Y, Pagano JS.

Oncogene. 2009 Apr 9;28(14):1725-35. doi: 10.1038/onc.2009.20. Epub 2009 Feb 23.


TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the tumor necrosis factor receptor family member latent membrane protein 1.

Ning S, Campos AD, Darnay BG, Bentz GL, Pagano JS.

Mol Cell Biol. 2008 Oct;28(20):6536-46. doi: 10.1128/MCB.00785-08. Epub 2008 Aug 18.


Role of the ubiquitin system and tumor viruses in AIDS-related cancer.

Shackelford J, Pagano JS.

BMC Biochem. 2007 Nov 22;8 Suppl 1:S8. Review.


Conserved herpesvirus protein kinases.

Gershburg E, Pagano JS.

Biochim Biophys Acta. 2008 Jan;1784(1):203-12. Epub 2007 Aug 16. Review.


Epstein-Barr virus latent membrane protein 1 promotes concentration in multivesicular bodies of fibroblast growth factor 2 and its release through exosomes.

Ceccarelli S, Visco V, Raffa S, Wakisaka N, Pagano JS, Torrisi MR.

Int J Cancer. 2007 Oct 1;121(7):1494-506.


Epstein-Barr virus-encoded protein kinase (BGLF4) is involved in production of infectious virus.

Gershburg E, Raffa S, Torrisi MR, Pagano JS.

J Virol. 2007 May;81(10):5407-12. Epub 2007 Mar 14.


Interferon regulatory factor 7 is activated by a viral oncoprotein through RIP-dependent ubiquitination.

Huye LE, Ning S, Kelliher M, Pagano JS.

Mol Cell Biol. 2007 Apr;27(8):2910-8. Epub 2007 Feb 12.


Is Epstein-Barr virus transmitted sexually?

Pagano JS.

J Infect Dis. 2007 Feb 15;195(4):469-70. Epub 2007 Jan 10. No abstract available.


MUC1 induced by Epstein-Barr virus latent membrane protein 1 causes dissociation of the cell-matrix interaction and cellular invasiveness via STAT signaling.

Kondo S, Yoshizaki T, Wakisaka N, Horikawa T, Murono S, Jang KL, Joab I, Furukawa M, Pagano JS.

J Virol. 2007 Feb;81(4):1554-62. Epub 2006 Dec 6.


Up-regulation of beta-catenin by a viral oncogene correlates with inhibition of the seven in absentia homolog 1 in B lymphoma cells.

Jang KL, Shackelford J, Seo SY, Pagano JS.

Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18431-6. Epub 2005 Dec 12.


Targeting of host-cell ubiquitin pathways by viruses.

Shackelford J, Pagano JS.

Essays Biochem. 2005;41:139-56. Review.


Interferon regulatory factor 7 is negatively regulated by the Epstein-Barr virus immediate-early gene, BZLF-1.

Hahn AM, Huye LE, Ning S, Webster-Cyriaque J, Pagano JS.

J Virol. 2005 Aug;79(15):10040-52.


Epstein-Barr virus infections: prospects for treatment.

Gershburg E, Pagano JS.

J Antimicrob Chemother. 2005 Aug;56(2):277-81. Epub 2005 Jul 8. Review.


Ribonucleotide reductase inhibitors enhance cidofovir-induced apoptosis in EBV-positive nasopharyngeal carcinoma xenografts.

Wakisaka N, Yoshizaki T, Raab-Traub N, Pagano JS.

Int J Cancer. 2005 Sep 10;116(4):640-5.

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