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Small molecule screening identifies inhibitors of the Epstein-Barr virus deubiquitinating enzyme, BPLF1.

Atkins SL, Motaib S, Wiser LC, Hopcraft SE, Hardy PB, Shackelford J, Foote P, Wade AH, Damania B, Pagano JS, Pearce KH, Whitehurst CB.

Antiviral Res. 2020 Jan;173:104649. doi: 10.1016/j.antiviral.2019.104649. Epub 2019 Nov 8.


Inhibition of UCH-L1 Deubiquitinating Activity with Two Forms of LDN-57444 Has Anti-Invasive Effects in Metastatic Carcinoma Cells.

Kobayashi E, Hwang D, Bheda-Malge A, Whitehurst CB, Kabanov AV, Kondo S, Aga M, Yoshizaki T, Pagano JS, Sokolsky M, Shakelford J.

Int J Mol Sci. 2019 Jul 31;20(15). pii: E3733. doi: 10.3390/ijms20153733.


Epstein-Barr Virus Latent Membrane Protein-1 Induces the Expression of SUMO-1 and SUMO-2/3 in LMP1-positive Lymphomas and Cells.

Salahuddin S, Fath EK, Biel N, Ray A, Moss CR, Patel A, Patel S, Hilding L, Varn M, Ross T, Cramblet WT, Lowrey A, Pagano JS, Shackelford J, Bentz GL.

Sci Rep. 2019 Jan 18;9(1):208. doi: 10.1038/s41598-018-36312-4.


Prevalence of Epstein–Barr Virus Genotypes in Pakistani Lymphoma Patients

Salahuddin S, Khan J, Azhar J, B. Whitehurst C, Qadri I, Shackelford J, Pagano JS, Muhammad D, Richards KL.

Asian Pac J Cancer Prev. 2018 Nov 29;19(11):3153-3159.


Cancer Progression Goes Viral: The Role of Oncoviruses in Aggressiveness of Malignancies.

Müller-Coan BG, Caetano BFR, Pagano JS, Elgui de Oliveira D.

Trends Cancer. 2018 Jul;4(7):485-498. doi: 10.1016/j.trecan.2018.04.006. Epub 2018 May 21. Review.


Antiviral Drugs for EBV.

Pagano JS, Whitehurst CB, Andrei G.

Cancers (Basel). 2018 Jun 13;10(6). pii: E197. doi: 10.3390/cancers10060197.


C-Terminal Farnesylation of UCH-L1 Plays a Role in Transport of Epstein-Barr Virus Primary Oncoprotein LMP1 to Exosomes.

Kobayashi E, Aga M, Kondo S, Whitehurst C, Yoshizaki T, Pagano JS, Shackelford J.

mSphere. 2018 Feb 7;3(1). pii: e00030-18. doi: 10.1128/mSphere.00030-18. eCollection 2018 Jan-Feb.


The Translesion Polymerase Pol η Is Required for Efficient Epstein-Barr Virus Infectivity and Is Regulated by the Viral Deubiquitinating Enzyme BPLF1.

Dyson OF, Pagano JS, Whitehurst CB.

J Virol. 2017 Sep 12;91(19). pii: e00600-17. doi: 10.1128/JVI.00600-17. Print 2017 Oct 1.


Expression of interferon regulatory factor 7 correlates with the expression of Epstein-Barr Virus latent membrane protein 1 and cervical lymph node metastasis in nasopharyngeal cancer.

Kondo S, Endo K, Wakisaka N, Aga M, Kano M, Seishima N, Imoto T, Kobayashi E, Moriyama-Kita M, Nakanishi Y, Murono S, Pagano JS, Yoshizaki T.

Pathol Int. 2017 Sep;67(9):461-466. doi: 10.1111/pin.12561. Epub 2017 Jul 16.


Viral Carcinogenesis Beyond Malignant Transformation: EBV in the Progression of Human Cancers.

Elgui de Oliveira D, Müller-Coan BG, Pagano JS.

Trends Microbiol. 2016 Aug;24(8):649-664. doi: 10.1016/j.tim.2016.03.008. Epub 2016 Apr 7. Review.


UCH-L1 in DLBCL: marker or target?

Pagano JS, Shackelford J.

Blood. 2016 Mar 24;127(12):1524-5. doi: 10.1182/blood-2016-01-689984.


Knockout of Epstein-Barr virus BPLF1 retards B-cell transformation and lymphoma formation in humanized mice.

Whitehurst CB, Li G, Montgomery SA, Montgomery ND, Su L, Pagano JS.

mBio. 2015 Oct 20;6(5):e01574-15. doi: 10.1128/mBio.01574-15.


LMP1-Induced Sumoylation Influences the Maintenance of Epstein-Barr Virus Latency through KAP1.

Bentz GL, Moss CR 2nd, Whitehurst CB, Moody CA, Pagano JS.

J Virol. 2015 Aug;89(15):7465-77. doi: 10.1128/JVI.00711-15. Epub 2015 May 6.


Viruses and human cancers: a long road of discovery of molecular paradigms.

White MK, Pagano JS, Khalili K.

Clin Microbiol Rev. 2014 Jul;27(3):463-81. doi: 10.1128/CMR.00124-13. Review.


The Rad6/18 ubiquitin complex interacts with the Epstein-Barr virus deubiquitinating enzyme, BPLF1, and contributes to virus infectivity.

Kumar R, Whitehurst CB, Pagano JS.

J Virol. 2014 Jun;88(11):6411-22. doi: 10.1128/JVI.00536-14. Epub 2014 Mar 26.


Exosomal HIF1α supports invasive potential of nasopharyngeal carcinoma-associated LMP1-positive exosomes.

Aga M, Bentz GL, Raffa S, Torrisi MR, Kondo S, Wakisaka N, Yoshizaki T, Pagano JS, Shackelford J.

Oncogene. 2014 Sep 11;33(37):4613-22. doi: 10.1038/onc.2014.66. Epub 2014 Mar 24.


KSHV LANA and EBV LMP1 induce the expression of UCH-L1 following viral transformation.

Bentz GL, Bheda-Malge A, Wang L, Shackelford J, Damania B, Pagano JS.

Virology. 2014 Jan 5;448:293-302. doi: 10.1016/j.virol.2013.10.018. Epub 2013 Nov 8.


Maribavir inhibits Epstein-Barr virus transcription through the EBV protein kinase.

Whitehurst CB, Sanders MK, Law M, Wang FZ, Xiong J, Dittmer DP, Pagano JS.

J Virol. 2013 May;87(9):5311-5. doi: 10.1128/JVI.03505-12. Epub 2013 Feb 28.


Upregulation of special AT-rich-binding protein 1 by Epstein-Barr virus latent membrane protein 1 in human nasopharyngeal cells and nasopharyngeal cancer.

Endo K, Shackelford J, Aga M, Yoshizaki T, Pagano JS.

J Gen Virol. 2013 Mar;94(Pt 3):507-13. doi: 10.1099/vir.0.046243-0. Epub 2012 Dec 5.


Epstein-Barr virus latent membrane protein 1 regulates the function of interferon regulatory factor 7 by inducing its sumoylation.

Bentz GL, Shackelford J, Pagano JS.

J Virol. 2012 Nov;86(22):12251-61. doi: 10.1128/JVI.01407-12. Epub 2012 Sep 5.


Epstein-Barr virus BPLF1 deubiquitinates PCNA and attenuates polymerase η recruitment to DNA damage sites.

Whitehurst CB, Vaziri C, Shackelford J, Pagano JS.

J Virol. 2012 Aug;86(15):8097-106. doi: 10.1128/JVI.00588-12. Epub 2012 May 23.


Epstein-Barr virus latent membrane protein 1 induces cancer stem/progenitor-like cells in nasopharyngeal epithelial cell lines.

Kondo S, Wakisaka N, Muramatsu M, Zen Y, Endo K, Murono S, Sugimoto H, Yamaoka S, Pagano JS, Yoshizaki T.

J Virol. 2011 Nov;85(21):11255-64. doi: 10.1128/JVI.00188-11. Epub 2011 Aug 17.


Epstein-Barr virus latent membrane protein 1 (LMP1) C-terminal-activating region 3 contributes to LMP1-mediated cellular migration via its interaction with Ubc9.

Bentz GL, Whitehurst CB, Pagano JS.

J Virol. 2011 Oct;85(19):10144-53. doi: 10.1128/JVI.05035-11. Epub 2011 Jul 27.


PU.1-dependent regulation of UCH L1 expression in B-lymphoma cells.

Bheda A, Yue W, Gullapalli A, Shackelford J, Pagano JS.

Leuk Lymphoma. 2011 Jul;52(7):1336-47. doi: 10.3109/10428194.2011.562571. Epub 2011 Apr 20.


IRF7: activation, regulation, modification and function.

Ning S, Pagano JS, Barber GN.

Genes Immun. 2011 Sep;12(6):399-414. doi: 10.1038/gene.2011.21. Epub 2011 Apr 14. Review.


Epstein-Barr Virus latent membrane protein 1 induces Snail and epithelial-mesenchymal transition in metastatic nasopharyngeal carcinoma.

Horikawa T, Yoshizaki T, Kondo S, Furukawa M, Kaizaki Y, Pagano JS.

Br J Cancer. 2011 Mar 29;104(7):1160-7. doi: 10.1038/bjc.2011.38. Epub 2011 Mar 8.


The A20 deubiquitinase activity negatively regulates LMP1 activation of IRF7.

Ning S, Pagano JS.

J Virol. 2010 Jun;84(12):6130-8. doi: 10.1128/JVI.00364-10. Epub 2010 Apr 14.


Epstein-Barr virus BRLF1 inhibits transcription of IRF3 and IRF7 and suppresses induction of interferon-beta.

Bentz GL, Liu R, Hahn AM, Shackelford J, Pagano JS.

Virology. 2010 Jun 20;402(1):121-8. doi: 10.1016/j.virol.2010.03.014. Epub 2010 Apr 8.


The Epstein-Barr virus (EBV)-encoded protein kinase, EBV-PK, but not the thymidine kinase (EBV-TK), is required for ganciclovir and acyclovir inhibition of lytic viral production.

Meng Q, Hagemeier SR, Fingeroth JD, Gershburg E, Pagano JS, Kenney SC.

J Virol. 2010 May;84(9):4534-42. doi: 10.1128/JVI.02487-09. Epub 2010 Feb 24.


Ubiquitin editing enzyme UCH L1 and microtubule dynamics: implication in mitosis.

Bheda A, Gullapalli A, Caplow M, Pagano JS, Shackelford J.

Cell Cycle. 2010 Mar 1;9(5):980-94. Epub 2010 Mar 15.


Maribavir inhibits epstein-barr virus transcription in addition to viral DNA replication.

Wang FZ, Roy D, Gershburg E, Whitehurst CB, Dittmer DP, Pagano JS.

J Virol. 2009 Dec;83(23):12108-17. doi: 10.1128/JVI.01575-09. Epub 2009 Sep 16.


Expression and functional studies of ubiquitin C-terminal hydrolase L1 regulated genes.

Bheda A, Shackelford J, Pagano JS.

PLoS One. 2009 Aug 26;4(8):e6764. doi: 10.1371/journal.pone.0006764.


Positive reciprocal regulation of ubiquitin C-terminal hydrolase L1 and beta-catenin/TCF signaling.

Bheda A, Yue W, Gullapalli A, Whitehurst C, Liu R, Pagano JS, Shackelford J.

PLoS One. 2009 Jun 18;4(6):e5955. doi: 10.1371/journal.pone.0005955.


The Epstein-Barr virus (EBV) deubiquitinating enzyme BPLF1 reduces EBV ribonucleotide reductase activity.

Whitehurst CB, Ning S, Bentz GL, Dufour F, Gershburg E, Shackelford J, Langelier Y, Pagano JS.

J Virol. 2009 May;83(9):4345-53. doi: 10.1128/JVI.02195-08. Epub 2009 Feb 25.


Phosphorylated ezrin is associated with EBV latent membrane protein 1 in nasopharyngeal carcinoma and induces cell migration.

Endo K, Kondo S, Shackleford J, Horikawa T, Kitagawa N, Yoshizaki T, Furukawa M, Zen Y, Pagano JS.

Oncogene. 2009 Apr 9;28(14):1725-35. doi: 10.1038/onc.2009.20. Epub 2009 Feb 23.


TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the tumor necrosis factor receptor family member latent membrane protein 1.

Ning S, Campos AD, Darnay BG, Bentz GL, Pagano JS.

Mol Cell Biol. 2008 Oct;28(20):6536-46. doi: 10.1128/MCB.00785-08. Epub 2008 Aug 18.


Role of the ubiquitin system and tumor viruses in AIDS-related cancer.

Shackelford J, Pagano JS.

BMC Biochem. 2007 Nov 22;8 Suppl 1:S8. Review.


Conserved herpesvirus protein kinases.

Gershburg E, Pagano JS.

Biochim Biophys Acta. 2008 Jan;1784(1):203-12. Epub 2007 Aug 16. Review.


Epstein-Barr virus latent membrane protein 1 promotes concentration in multivesicular bodies of fibroblast growth factor 2 and its release through exosomes.

Ceccarelli S, Visco V, Raffa S, Wakisaka N, Pagano JS, Torrisi MR.

Int J Cancer. 2007 Oct 1;121(7):1494-506.


Epstein-Barr virus-encoded protein kinase (BGLF4) is involved in production of infectious virus.

Gershburg E, Raffa S, Torrisi MR, Pagano JS.

J Virol. 2007 May;81(10):5407-12. Epub 2007 Mar 14.


Interferon regulatory factor 7 is activated by a viral oncoprotein through RIP-dependent ubiquitination.

Huye LE, Ning S, Kelliher M, Pagano JS.

Mol Cell Biol. 2007 Apr;27(8):2910-8. Epub 2007 Feb 12.


Is Epstein-Barr virus transmitted sexually?

Pagano JS.

J Infect Dis. 2007 Feb 15;195(4):469-70. Epub 2007 Jan 10. No abstract available.


MUC1 induced by Epstein-Barr virus latent membrane protein 1 causes dissociation of the cell-matrix interaction and cellular invasiveness via STAT signaling.

Kondo S, Yoshizaki T, Wakisaka N, Horikawa T, Murono S, Jang KL, Joab I, Furukawa M, Pagano JS.

J Virol. 2007 Feb;81(4):1554-62. Epub 2006 Dec 6.


Up-regulation of beta-catenin by a viral oncogene correlates with inhibition of the seven in absentia homolog 1 in B lymphoma cells.

Jang KL, Shackelford J, Seo SY, Pagano JS.

Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18431-6. Epub 2005 Dec 12.


Targeting of host-cell ubiquitin pathways by viruses.

Shackelford J, Pagano JS.

Essays Biochem. 2005;41:139-56. Review.


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