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Items: 19


The Formation and Function of Granulomas.

Pagán AJ, Ramakrishnan L.

Annu Rev Immunol. 2018 Apr 26;36:639-665. doi: 10.1146/annurev-immunol-032712-100022. Epub 2018 Feb 5. Review.


TORmented macrophages spontaneously form granulomas.

Pagán AJ, Ramakrishnan L.

Nat Immunol. 2017 Feb 15;18(3):252-253. doi: 10.1038/ni.3689. No abstract available.


Most microbe-specific naïve CD4⁺ T cells produce memory cells during infection.

Tubo NJ, Fife BT, Pagan AJ, Kotov DI, Goldberg MF, Jenkins MK.

Science. 2016 Jan 29;351(6272):511-4. doi: 10.1126/science.aad0483.


Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment.

Pagán AJ, Yang CT, Cameron J, Swaim LE, Ellett F, Lieschke GJ, Ramakrishnan L.

Cell Host Microbe. 2015 Jul 8;18(1):15-26. doi: 10.1016/j.chom.2015.06.008.


Chronic parasitic infection maintains high frequencies of short-lived Ly6C+CD4+ effector T cells that are required for protection against re-infection.

Peters NC, Pagán AJ, Lawyer PG, Hand TW, Henrique Roma E, Stamper LW, Romano A, Sacks DL.

PLoS Pathog. 2014 Dec 4;10(12):e1004538. doi: 10.1371/journal.ppat.1004538. eCollection 2014 Dec.


Immunity and Immunopathology in the Tuberculous Granuloma.

Pagán AJ, Ramakrishnan L.

Cold Spring Harb Perspect Med. 2014 Nov 6;5(9). pii: a018499. doi: 10.1101/cshperspect.a018499. Review.


Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection.

Tubo NJ, Pagán AJ, Taylor JJ, Nelson RW, Linehan JL, Ertelt JM, Huseby ES, Way SS, Jenkins MK.

Cell. 2013 May 9;153(4):785-96. doi: 10.1016/j.cell.2013.04.007.


Tracking antigen-specific CD4+ T cells throughout the course of chronic Leishmania major infection in resistant mice.

Pagán AJ, Peters NC, Debrabant A, Ribeiro-Gomes F, Pepper M, Karp CL, Jenkins MK, Sacks DL.

Eur J Immunol. 2013 Feb;43(2):427-38. doi: 10.1002/eji.201242715. Epub 2012 Dec 11.


Acute gastrointestinal infection induces long-lived microbiota-specific T cell responses.

Hand TW, Dos Santos LM, Bouladoux N, Molloy MJ, Pagán AJ, Pepper M, Maynard CL, Elson CO 3rd, Belkaid Y.

Science. 2012 Sep 21;337(6101):1553-6. Epub 2012 Aug 23.


CD28 promotes CD4+ T cell clonal expansion during infection independently of its YMNM and PYAP motifs.

Pagán AJ, Pepper M, Chu HH, Green JM, Jenkins MK.

J Immunol. 2012 Sep 15;189(6):2909-17. doi: 10.4049/jimmunol.1103231. Epub 2012 Aug 15.


ADAP regulates cell cycle progression of T cells via control of cyclin E and Cdk2 expression through two distinct CARMA1-dependent signaling pathways.

Srivastava R, Burbach BJ, Mitchell JS, Pagán AJ, Shimizu Y.

Mol Cell Biol. 2012 May;32(10):1908-17. doi: 10.1128/MCB.06541-11. Epub 2012 Mar 12.


Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells.

Pepper M, Pagán AJ, Igyártó BZ, Taylor JJ, Jenkins MK.

Immunity. 2011 Oct 28;35(4):583-95. doi: 10.1016/j.immuni.2011.09.009. Epub 2011 Oct 20.


Cutting edge: CD28 and c-Rel-dependent pathways initiate regulatory T cell development.

Vang KB, Yang J, Pagán AJ, Li LX, Wang J, Green JM, Beg AA, Farrar MA.

J Immunol. 2010 Apr 15;184(8):4074-7. doi: 10.4049/jimmunol.0903933. Epub 2010 Mar 12.


Control of alpha4beta7 integrin expression and CD4 T cell homing by the beta1 integrin subunit.

DeNucci CC, Pagán AJ, Mitchell JS, Shimizu Y.

J Immunol. 2010 Mar 1;184(5):2458-67. doi: 10.4049/jimmunol.0902407. Epub 2010 Jan 29.


Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells.

Pepper M, Linehan JL, Pagán AJ, Zell T, Dileepan T, Cleary PP, Jenkins MK.

Nat Immunol. 2010 Jan;11(1):83-9. doi: 10.1038/ni.1826. Epub 2009 Nov 22.


Efficient help for autoreactive B-cell activation requires CD4+ T-cell recognition of an agonist peptide at the effector stage.

Hondowicz BD, Batheja AO, Metzgar MH, Pagán AJ, Perng OA, Willms S, Caton AJ, Erikson J.

Eur J Immunol. 2009 Sep;39(9):2377-82. doi: 10.1002/eji.200939471.


Tracking epitope-specific T cells.

Moon JJ, Chu HH, Hataye J, Pagán AJ, Pepper M, McLachlan JB, Zell T, Jenkins MK.

Nat Protoc. 2009;4(4):565-81. doi: 10.1038/nprot.2009.9.


The role of BLyS/BLyS receptors in anti-chromatin B cell regulation.

Hondowicz BD, Alexander ST, Quinn WJ 3rd, Pagán AJ, Metzgar MH, Cancro MP, Erikson J.

Int Immunol. 2007 Apr;19(4):465-75. Epub 2007 Mar 15.


T cell-mediated activation and regulation of anti-chromatin B cells.

Pagán AJ, Ramón HE, Hondowicz BD, Erikson J.

Autoimmun Rev. 2006 Jul;5(6):373-6. Epub 2005 Dec 19. Review.


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