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Items: 41

1.

Activation of peroxisome proliferator-activated receptor delta suppresses BACE1 expression by up-regulating SOCS1 in a JAK2/STAT1-dependent manner.

Lee WJ, Ham SA, Lee GH, Choi MJ, Yoo H, Paek KS, Lim DS, Hong K, Hwang JS, Seo HG.

J Neurochem. 2019 Nov;151(3):370-385. doi: 10.1111/jnc.14715. Epub 2019 Jun 18.

PMID:
31063584
2.

Rosiglitazone-dependent dissociation of HuR from PPAR-γ regulates adiponectin expression at the posttranscriptional level.

Hwang JS, Lee WJ, Hur J, Lee HG, Kim E, Lee GH, Choi MJ, Lim DS, Paek KS, Seo HG.

FASEB J. 2019 Jun;33(6):7707-7720. doi: 10.1096/fj.201802643R. Epub 2019 Mar 21.

PMID:
30897345
3.

Ligand-activated PPARδ inhibits angiotensin II-stimulated hypertrophy of vascular smooth muscle cells by targeting ROS.

Kang ES, Hwang JS, Lee WJ, Lee GH, Choi MJ, Paek KS, Lim DS, Seo HG.

PLoS One. 2019 Jan 8;14(1):e0210482. doi: 10.1371/journal.pone.0210482. eCollection 2019.

4.

Ligand-activated interaction of PPARδ with c-Myc governs the tumorigenicity of breast cancer.

Ham SA, Kim E, Yoo T, Lee WJ, Youn JH, Choi MJ, Han SG, Lee CH, Paek KS, Hwang JS, Seo HG.

Int J Cancer. 2018 Dec 1;143(11):2985-2996. doi: 10.1002/ijc.31864. Epub 2018 Oct 4.

5.

Ligand-Activated Peroxisome Proliferator-Activated Receptor δ Attenuates Vascular Oxidative Stress by Inhibiting Thrombospondin-1 Expression.

Ahn MY, Ham SA, Yoo T, Lee WJ, Hwang JS, Paek KS, Lim DS, Han SG, Lee CH, Seo HG.

J Vasc Res. 2018;55(2):75-86. doi: 10.1159/000486570. Epub 2018 Feb 6.

PMID:
29408825
6.

Activation of PPARδ attenuates neurotoxicity by inhibiting lipopolysaccharide-triggered glutamate release in BV-2 microglial cells.

Lee WJ, Ham SA, Yoo H, Hwang JS, Yoo T, Paek KS, Lim DS, Han SG, Lee CH, Hong K, Seo HG.

J Cell Biochem. 2018 Jul;119(7):5609-5619. doi: 10.1002/jcb.26732. Epub 2018 Mar 12.

PMID:
29388693
7.

Formononetin inhibits lipopolysaccharide-induced release of high mobility group box 1 by upregulating SIRT1 in a PPARδ-dependent manner.

Hwang JS, Kang ES, Han SG, Lim DS, Paek KS, Lee CH, Seo HG.

PeerJ. 2018 Jan 3;6:e4208. doi: 10.7717/peerj.4208. eCollection 2018.

8.

Ligand-Dependent Interaction of PPARδ With T-Cell Protein Tyrosine Phosphatase 45 Enhances Insulin Signaling.

Yoo T, Ham SA, Lee WJ, Hwang SI, Park JA, Hwang JS, Hur J, Shin HC, Han SG, Lee CH, Han DW, Paek KS, Seo HG.

Diabetes. 2018 Mar;67(3):360-371. doi: 10.2337/db17-0499. Epub 2017 Dec 12.

9.

ADAMTS1-mediated targeting of TSP-1 by PPARδ suppresses migration and invasion of breast cancer cells.

Ham SA, Yoo T, Lee WJ, Hwang JS, Hur J, Paek KS, Lim DS, Han SG, Lee CH, Seo HG.

Oncotarget. 2017 Oct 6;8(55):94091-94103. doi: 10.18632/oncotarget.21584. eCollection 2017 Nov 7.

10.

A Dalbergia odorifera extract improves the survival of endotoxemia model mice by inhibiting HMGB1 release.

Choi HS, Park JA, Hwang JS, Ham SA, Yoo T, Lee WJ, Paek KS, Shin HC, Lee CH, Seo HG.

BMC Complement Altern Med. 2017 Apr 12;17(1):212. doi: 10.1186/s12906-017-1725-0.

11.

Upregulation of MKP-7 in response to rosiglitazone treatment ameliorates lipopolysaccharide-induced destabilization of SIRT1 by inactivating JNK.

Hwang JS, Ham SA, Yoo T, Lee WJ, Paek KS, Kim JH, Lee CH, Seo HG.

Pharmacol Res. 2016 Dec;114:47-55. doi: 10.1016/j.phrs.2016.10.014. Epub 2016 Oct 19.

PMID:
27771463
12.
13.

Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia.

Hwang JS, Choi HS, Ham SA, Yoo T, Lee WJ, Paek KS, Seo HG.

Sci Rep. 2015 Nov 2;5:15971. doi: 10.1038/srep15971.

14.

Ligand-activated PPARδ upregulates α-smooth muscle actin expression in human dermal fibroblasts: A potential role for PPARδ in wound healing.

Ham SA, Hwang JS, Yoo T, Lee WJ, Paek KS, Oh JW, Park CK, Kim JH, Do JT, Kim JH, Seo HG.

J Dermatol Sci. 2015 Dec;80(3):186-95. doi: 10.1016/j.jdermsci.2015.10.005. Epub 2015 Oct 9.

PMID:
26481780
15.

Peroxisome proliferator-activated receptor δ inhibits Porphyromonas gingivalis lipopolysaccharide-induced activation of matrix metalloproteinase-2 by downregulating NADPH oxidase 4 in human gingival fibroblasts.

Yoo T, Ham SA, Hwang JS, Lee WJ, Paek KS, Oh JW, Kim JH, Do JT, Han CW, Kim JH, Seo HG.

Mol Oral Microbiol. 2016 Oct;31(5):398-409. doi: 10.1111/omi.12137. Epub 2015 Oct 27.

PMID:
26403493
16.

PPARδ modulates oxLDL-induced apoptosis of vascular smooth muscle cells through a TGF-β/FAK signaling axis.

Hwang JS, Eun SY, Ham SA, Yoo T, Lee WJ, Paek KS, Do JT, Lim DS, Seo HG.

Int J Biochem Cell Biol. 2015 May;62:54-61. doi: 10.1016/j.biocel.2015.02.014. Epub 2015 Feb 27.

PMID:
25732738
17.

Dalbergia odorifera Extract Ameliorates UVB-Induced Wrinkle Formation by Modulating Expression of Extracellular Matrix Proteins.

Ham SA, Kang ES, Yoo T, Lim HH, Lee WJ, Hwang JS, Paek KS, Seo HG.

Drug Dev Res. 2015 Feb;76(1):48-56. doi: 10.1002/ddr.21240. Epub 2015 Jan 25.

PMID:
25620496
18.

Ethanol extract of Dalbergia odorifera protects skin keratinocytes against ultraviolet B-induced photoaging by suppressing production of reactive oxygen species.

Ham SA, Hwang JS, Kang ES, Yoo T, Lim HH, Lee WJ, Paek KS, Seo HG.

Biosci Biotechnol Biochem. 2015;79(5):760-6. doi: 10.1080/09168451.2014.993916. Epub 2015 Jan 3.

PMID:
25560618
19.

Ligand-activated PPARδ modulates the migration and invasion of melanoma cells by regulating Snail expression.

Ham SA, Yoo T, Hwang JS, Kang ES, Lee WJ, Paek KS, Park C, Kim JH, Do JT, Lim DS, Seo HG.

Am J Cancer Res. 2014 Nov 19;4(6):674-82. eCollection 2014.

20.

Ligand-activated peroxisome proliferator-activated receptor-δ and -γ inhibit lipopolysaccharide-primed release of high mobility group box 1 through upregulation of SIRT1.

Hwang JS, Lee WJ, Kang ES, Ham SA, Yoo T, Paek KS, Lim DS, Do JT, Seo HG.

Cell Death Dis. 2014 Oct 2;5:e1432. doi: 10.1038/cddis.2014.406.

21.

Peroxisome proliferator-activated receptor δ modulates MMP-2 secretion and elastin expression in human dermal fibroblasts exposed to ultraviolet B radiation.

Ham SA, Yoo T, Hwang JS, Kang ES, Paek KS, Park C, Kim JH, Do JT, Seo HG.

J Dermatol Sci. 2014 Oct;76(1):44-50. doi: 10.1016/j.jdermsci.2014.07.011. Epub 2014 Aug 7.

PMID:
25149191
22.

Activation of peroxisome proliferator-activated receptor δ inhibits angiotensin II-induced activation of matrix metalloproteinase-2 in vascular smooth muscle cells.

Ham SA, Lee H, Hwang JS, Kang ES, Yoo T, Paek KS, Do JT, Park C, Oh JW, Kim JH, Han CW, Seo HG.

J Vasc Res. 2014;51(3):221-30. doi: 10.1159/000365250. Epub 2014 Aug 9.

PMID:
25116733
23.

PPARδ reduces abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice by regulating extracellular matrix homeostasis and inflammatory responses.

Hwang JS, Kim HJ, Kim G, Kang ES, Ham SA, Yoo T, Paek KS, Yabe-Nishimura C, Kim HJ, Seo HG.

Int J Cardiol. 2014 Jun 1;174(1):43-50. doi: 10.1016/j.ijcard.2014.03.138. Epub 2014 Mar 21.

PMID:
24698256
24.

15-Deoxy-Δ(12,14)-prostaglandin J2 prevents oxidative injury by upregulating the expression of aldose reductase in vascular smooth muscle cells.

Kang ES, Hwang JS, Ham SA, Park MH, Kim GH, Paek KS, Yoo T, Lee WJ, Kang KR, Lee JH, Choi YJ, Seo HG.

Free Radic Res. 2014 Feb;48(2):218-29. doi: 10.3109/10715762.2013.860224. Epub 2013 Nov 25.

PMID:
24180671
25.

PPARδ inhibits UVB-induced secretion of MMP-1 through MKP-7-mediated suppression of JNK signaling.

Ham SA, Kang ES, Lee H, Hwang JS, Yoo T, Paek KS, Park C, Kim JH, Lim DS, Seo HG.

J Invest Dermatol. 2013 Nov;133(11):2593-2600. doi: 10.1038/jid.2013.202. Epub 2013 May 2.

26.

Activation of peroxisome proliferator-activated receptor γ by rosiglitazone inhibits lipopolysaccharide-induced release of high mobility group box 1.

Hwang JS, Kang ES, Ham SA, Yoo T, Lee H, Paek KS, Park C, Kim JH, Lim DS, Seo HG.

Mediators Inflamm. 2012;2012:352807. doi: 10.1155/2012/352807. Epub 2012 Dec 20.

27.

The PPARδ-mediated inhibition of angiotensin II-induced premature senescence in human endothelial cells is SIRT1-dependent.

Kim MY, Kang ES, Ham SA, Hwang JS, Yoo TS, Lee H, Paek KS, Park C, Lee HT, Kim JH, Han CW, Seo HG.

Biochem Pharmacol. 2012 Dec 15;84(12):1627-34. doi: 10.1016/j.bcp.2012.09.008. Epub 2012 Sep 20.

PMID:
23000914
28.

Activation of PPARδ counteracts angiotensin II-induced ROS generation by inhibiting rac1 translocation in vascular smooth muscle cells.

Lee H, Ham SA, Kim MY, Kim JH, Paek KS, Kang ES, Kim HJ, Hwang JS, Yoo T, Park C, Kim JH, Lim DS, Han CW, Seo HG.

Free Radic Res. 2012 Jul;46(7):912-9. doi: 10.3109/10715762.2012.687448. Epub 2012 May 10.

PMID:
22519881
29.

PPARδ coordinates angiotensin II-induced senescence in vascular smooth muscle cells through PTEN-mediated inhibition of superoxide generation.

Kim HJ, Ham SA, Kim MY, Hwang JS, Lee H, Kang ES, Yoo T, Woo IS, Yabe-Nishimura C, Paek KS, Kim JH, Seo HG.

J Biol Chem. 2011 Dec 30;286(52):44585-93. doi: 10.1074/jbc.M111.222562. Epub 2011 Nov 9.

30.

Transcriptional up-regulation of antioxidant genes by PPARδ inhibits angiotensin II-induced premature senescence in vascular smooth muscle cells.

Kim HJ, Ham SA, Paek KS, Hwang JS, Jung SY, Kim MY, Jin H, Kang ES, Woo IS, Kim HJ, Lee JH, Chang KC, Han CW, Seo HG.

Biochem Biophys Res Commun. 2011 Mar 25;406(4):564-9. doi: 10.1016/j.bbrc.2011.02.091. Epub 2011 Feb 23.

PMID:
21352808
31.

Up-regulation of aldose reductase expression mediated by phosphatidylinositol 3-kinase/Akt and Nrf2 is involved in the protective effect of curcumin against oxidative damage.

Kang ES, Woo IS, Kim HJ, Eun SY, Paek KS, Kim HJ, Chang KC, Lee JH, Lee HT, Kim JH, Nishinaka T, Yabe-Nishimura C, Seo HG.

Free Radic Biol Med. 2007 Aug 15;43(4):535-45. Epub 2007 May 16.

PMID:
17640564
32.

Human originated bacteria, Lactobacillus rhamnosus PL60, produce conjugated linoleic acid and show anti-obesity effects in diet-induced obese mice.

Lee HY, Park JH, Seok SH, Baek MW, Kim DJ, Lee KE, Paek KS, Lee Y, Park JH.

Biochim Biophys Acta. 2006 Jul;1761(7):736-44. Epub 2006 May 20.

PMID:
16807088
34.

Involvement of nuclear factor kappaB in up-regulation of aldose reductase gene expression by 12-O-tetradecanoylphorbol-13-acetate in HeLa cells.

Lee YS, Paek KS, Kang ES, Jang HS, Kim HJ, Kang YJ, Kim JH, Lee HT, Lee JH, Chang KC, Nishinaka T, Seo HG.

Int J Biochem Cell Biol. 2005 Nov;37(11):2297-309.

PMID:
15936242
35.

Phorbol ester up-regulates aldose reductase expression in A549 cells: a potential role for aldose reductase in cell cycle modulation.

Kang ES, Kim HJ, Paek KS, Jang HS, Chang KC, Lee JH, Nishinaka T, Yabe-Nishimura C, Seo HG.

Cell Mol Life Sci. 2005 May;62(10):1146-55.

PMID:
15928807
36.

Substrate-induced up-regulation of aldose reductase by methylglyoxal, a reactive oxoaldehyde elevated in diabetes.

Chang KC, Paek KS, Kim HJ, Lee YS, Yabe-Nishimura C, Seo HG.

Mol Pharmacol. 2002 May;61(5):1184-91.

PMID:
11961137
37.

Synthesis and antibacterial activities of novel C(3)-aminopyrimidinyl substituted cephalosporins.

Lee CS, Oh SH, Ryu EJ, Kim MY, Paek KS.

J Antibiot (Tokyo). 2000 Nov;53(11):1305-9. No abstract available.

38.

In vitro and In vivo activities of LB 10827, a new oral cephalosporin, against respiratory pathogens.

Paek KS, Kim MY, Lee CS, Youn H.

Antimicrob Agents Chemother. 2000 Dec;44(12):3272-7.

39.

Synthesis and antibacterial activities of novel C(3)-aminopyrimidinyl substituted cephalosporins including against respiratory tract pathogens.

Lee CS, Ryu EJ, Oh SH, Paek KS, Kim MY, Youn H.

Bioorg Med Chem Lett. 2000 Sep 18;10(18):2123-7.

PMID:
10999485
40.

In vitro and in vivo activities of LB10522, a new catecholic cephalosporin.

Kim MY, Oh JI, Paek KS, Kim YZ, Kim IC, Kwak JH.

Antimicrob Agents Chemother. 1996 Aug;40(8):1825-31.

41.

In vitro and in vivo evaluations of LB20304, a new fluoronaphthyridone.

Oh JI, Paek KS, Ahn MJ, Kim MY, Hong CY, Kim IC, Kwak JH.

Antimicrob Agents Chemother. 1996 Jun;40(6):1564-8.

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