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Items: 11

1.

Preclinical Reproductive and Developmental Toxicity Profile of a Glycine Transporter Type 1 (Glyt1) Inhibitor.

Barrow P, Parrott N, Alberati D, Paehler A, Koerner A.

Birth Defects Res B Dev Reprod Toxicol. 2016 Jun;107(3):148-56. doi: 10.1002/bdrb.21179. Epub 2016 May 24.

PMID:
27221585
2.

Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression.

Lindemann L, Porter RH, Scharf SH, Kuennecke B, Bruns A, von Kienlin M, Harrison AC, Paehler A, Funk C, Gloge A, Schneider M, Parrott NJ, Polonchuk L, Niederhauser U, Morairty SR, Kilduff TS, Vieira E, Kolczewski S, Wichmann J, Hartung T, Honer M, Borroni E, Moreau JL, Prinssen E, Spooren W, Wettstein JG, Jaeschke G.

J Pharmacol Exp Ther. 2015 Apr;353(1):213-33. doi: 10.1124/jpet.114.222463. Epub 2015 Feb 9.

PMID:
25665805
3.

Metabolism, excretion, and pharmacokinetics of [14c]-radiolabeled aleglitazar: a phase I, nonrandomized, open-label, single-center, single-dose study in healthy male volunteers.

Sturm S, Seiberling M, Weick I, Paehler A, Funk C, Ruf T.

Clin Ther. 2012 Feb;34(2):420-9. doi: 10.1016/j.clinthera.2011.12.009. Epub 2012 Jan 15.

PMID:
22244809
4.

Pharmacokinetics and metabolism of the dipeptidyl peptidase IV inhibitor carmegliptin in rats, dogs, and monkeys.

Kuhlmann O, Paehler A, Weick I, Funk C, Pantze M, Zell M, Timm U.

Xenobiotica. 2010 Dec;40(12):840-52. doi: 10.3109/00498254.2010.519406. Epub 2010 Sep 24.

PMID:
20868265
5.

Application of modern drug metabolism structure determination tools and assays to the in vitro metabolism of imiloxan.

Fitch WL, Chen Y, Liu L, Paehler A, Young M.

Drug Metab Lett. 2010 Apr;4(2):77-87.

PMID:
20446913
6.

Sulfonylureido thiazoles as fructose-1,6-bisphosphatase inhibitors for the treatment of type-2 diabetes.

Kitas E, Mohr P, Kuhn B, Hebeisen P, Wessel HP, Haap W, Ruf A, Benz J, Joseph C, Huber W, Sanchez RA, Paehler A, Benardeau A, Gubler M, Schott B, Tozzo E.

Bioorg Med Chem Lett. 2010 Jan 15;20(2):594-9. doi: 10.1016/j.bmcl.2009.11.093. Epub 2009 Nov 22.

PMID:
19969452
7.

Modelling of patient EMS exposure: translating pharmacokinetics of EMS in vitro and in animals into patients.

Lavé T, Paehler A, Grimm HP, Gocke E, Müller L.

Toxicol Lett. 2009 Nov 12;190(3):310-6. doi: 10.1016/j.toxlet.2009.07.031. Epub 2009 Aug 18.

PMID:
19695316
8.

Structure of creatine amidinohydrolase from Actinobacillus.

Padmanabhan B, Paehler A, Horikoshi M.

Acta Crystallogr D Biol Crystallogr. 2002 Aug;58(Pt 8):1322-8. Epub 2002 Jul 20.

PMID:
12136144
9.
10.

Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rat and human hepatocytes.

Langouët S, Paehler A, Welti DH, Kerriguy N, Guillouzo A, Turesky RJ.

Carcinogenesis. 2002 Jan;23(1):115-22.

PMID:
11756232

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