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Items: 1 to 50 of 160

1.

3-Carene, a Phytoncide from Pine Tree Has a Sleep-enhancing Effect by Targeting the GABAA-benzodiazepine Receptors.

Woo J, Yang H, Yoon M, Gadhe CG, Pae AN, Cho S, Lee CJ.

Exp Neurobiol. 2019 Oct 31;28(5):593-601. doi: 10.5607/en.2019.28.5.593.

2.

Development of Oxadiazole-Based ODZ10117 as a Small-Molecule Inhibitor of STAT3 for Targeted Cancer Therapy.

Kim BH, Lee H, Song Y, Park JS, Gadhe CG, Choi J, Lee CG, Pae AN, Kim S, Ye SK.

J Clin Med. 2019 Nov 2;8(11). pii: E1847. doi: 10.3390/jcm8111847.

3.

A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model.

Kim HJ, Jang BK, Park JH, Choi JW, Park SJ, Byeon SR, Pae AN, Lee YS, Cheong E, Park KD.

Eur J Med Chem. 2019 Oct 12;185:111777. doi: 10.1016/j.ejmech.2019.111777. [Epub ahead of print]

PMID:
31670201
4.

Aβ modulates actin cytoskeleton via SHIP2-mediated phosphoinositide metabolism.

Lee HN, Sim KM, Kim H, Ju J, Pae AN, Park JB, Ryu H, Seong J.

Sci Rep. 2019 Oct 29;9(1):15557. doi: 10.1038/s41598-019-51914-2.

5.

Development of an Aryloxazole Derivative as a Brain-Permeable Anti-Glioblastoma Agent.

Shin S, Lim S, Song JY, Kim D, Choi MJ, Gadhe CG, Park AY, Pae AN, Kim YK.

Pharmaceutics. 2019 Sep 28;11(10). pii: E497. doi: 10.3390/pharmaceutics11100497.

6.

Optimization study towards more potent thiazolidine-2,4-dione IKK-β modulator: Synthesis, biological evaluation and in silico docking simulation.

Elkamhawy A, Youn Kim N, Hassan AHE, Park JE, Yang JE, Elsherbeny MH, Paik S, Oh KS, Lee BH, Lee MY, Shin KJ, Pae AN, Lee KT, Roh EJ.

Bioorg Chem. 2019 Nov;92:103261. doi: 10.1016/j.bioorg.2019.103261. Epub 2019 Sep 7.

PMID:
31542718
7.

Recent tau-targeted clinical strategies for the treatment of Alzheimer's disease.

Lee HE, Lim D, Lee JY, Lim SM, Pae AN.

Future Med Chem. 2019 Aug;11(15):1845-1848. doi: 10.4155/fmc-2019-0151. No abstract available.

8.

Synthesis and Biological Evaluation of Disubstituted Pyrimidines as Selective 5-HT2C Agonists.

Kim J, Kim YJ, Londhe AM, Pae AN, Choo H, Kim HJ, Min SJ.

Molecules. 2019 Sep 5;24(18). pii: E3234. doi: 10.3390/molecules24183234.

9.

Antioxidant, Anti-inflammatory, and Neuroprotective Effects of Novel Vinyl Sulfonate Compounds as Nrf2 Activator.

Choi JW, Shin SJ, Kim HJ, Park JH, Kim HJ, Lee EH, Pae AN, Bahn YS, Park KD.

ACS Med Chem Lett. 2019 Jun 3;10(7):1061-1067. doi: 10.1021/acsmedchemlett.9b00163. eCollection 2019 Jul 11.

PMID:
31312409
10.

Gait Ignition Failure in JNPL3 Human Tau-mutant Mice.

Jang H, Ryu JH, Shin KM, Seo NY, Kim GH, Huh YH, Pae AN, Lee KJ.

Exp Neurobiol. 2019 Jun;28(3):404-413. doi: 10.5607/en.2019.28.3.404. Epub 2019 Jun 26.

11.

Structural hybridization of pyrrolidine-based T-type calcium channel inhibitors and exploration of their analgesic effects in a neuropathic pain model.

Son WS, Jeong KS, Lim SM, Pae AN.

Bioorg Med Chem Lett. 2019 May 15;29(10):1168-1172. doi: 10.1016/j.bmcl.2019.03.026. Epub 2019 Mar 21.

PMID:
30928197
12.

Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer's disease.

Park JH, Ju YH, Choi JW, Song HJ, Jang BK, Woo J, Chun H, Kim HJ, Shin SJ, Yarishkin O, Jo S, Park M, Yeon SK, Kim S, Kim J, Nam MH, Londhe AM, Kim J, Cho SJ, Cho S, Lee C, Hwang SY, Kim SW, Oh SJ, Cho J, Pae AN, Lee CJ, Park KD.

Sci Adv. 2019 Mar 20;5(3):eaav0316. doi: 10.1126/sciadv.aav0316. eCollection 2019 Mar.

13.

Development of tau-directed small molecule modulators for Alzheimer's disease: a recent patent review (2014-2018).

Lee HE, Lim D, Lee JY, Lim SM, Pae AN.

Pharm Pat Anal. 2019 Jan;8(1):15-39. doi: 10.4155/ppa-2019-0003. Epub 2019 Mar 14. Review.

PMID:
30870110
14.

Optimization of Vinyl Sulfone Derivatives as Potent Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Activators for Parkinson's Disease Therapy.

Choi JW, Kim S, Park JH, Kim HJ, Shin SJ, Kim JW, Woo SY, Lee C, Han SM, Lee J, Pae AN, Han G, Park KD.

J Med Chem. 2019 Jan 24;62(2):811-830. doi: 10.1021/acs.jmedchem.8b01527. Epub 2018 Dec 20.

PMID:
30540174
15.

Novel 5,6-disubstituted pyrrolo[2,3-d]pyrimidine derivatives as broad spectrum antiproliferative agents: Synthesis, cell based assays, kinase profile and molecular docking study.

Lee JH, El-Damasy AK, Seo SH, Gadhe CG, Pae AN, Jeong N, Hong SS, Keum G.

Bioorg Med Chem. 2018 Nov 15;26(21):5596-5611. doi: 10.1016/j.bmc.2018.10.004. Epub 2018 Oct 9.

PMID:
30385226
16.

Synthesis and biological evaluation of pyrrolidine-based T-type calcium channel inhibitors for the treatment of neuropathic pain.

Yang HK, Son WS, Lim KS, Kim GH, Lim EJ, Gadhe CG, Lee JY, Jeong KS, Lim SM, Pae AN.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1460-1471. doi: 10.1080/14756366.2018.1513926.

17.

Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer's disease.

Lim JW, Kim SK, Choi SY, Kim DH, Gadhe CG, Lee HN, Kim HJ, Kim J, Cho SJ, Hwang H, Seong J, Jeong KS, Lee JY, Lim SM, Lee JW, Pae AN.

Eur J Med Chem. 2018 Sep 5;157:405-422. doi: 10.1016/j.ejmech.2018.07.071. Epub 2018 Aug 3.

PMID:
30103190
18.

Pyrazinyl ureas revisited: 1-(3-(Benzyloxy)pyrazin-2-yl)-3-(3,4-dichlorophenyl)urea, a new blocker of Aβ-induced mPTP opening for Alzheimer's disease.

Elkamhawy A, Park JE, Hassan AHE, Pae AN, Lee J, Paik S, Park BG, Roh EJ.

Eur J Med Chem. 2018 Sep 5;157:268-278. doi: 10.1016/j.ejmech.2018.07.068. Epub 2018 Jul 31.

PMID:
30098482
19.

Synthesis and evaluation of an orally available "Y"-shaped biaryl peroxisome proliferator-activated receptor δ agonist.

Kim DS, Lee J, Londhe AM, Kadayat TM, Joo J, Hwang H, Kim KH, Pae AN, Chin J, Cho SJ, Kang H.

Bioorg Med Chem. 2018 Aug 15;26(15):4382-4389. doi: 10.1016/j.bmc.2018.06.044. Epub 2018 Jul 20.

PMID:
30054191
20.

GRP78-targeted in-silico virtual screening of novel anticancer agents.

Viswanath ANI, Lim JW, Seo SH, Lee JY, Lim SM, Pae AN.

Chem Biol Drug Des. 2018 Aug;92(2):1555-1566. doi: 10.1111/cbdd.13322. Epub 2018 May 31.

PMID:
29718569
21.

A novel tropomyosin-related kinase A inhibitor, KK5101 to treat pancreatic cancer.

Fang Z, Han B, Jung KH, Lee JH, El-Damasy AK, Gadhe CG, Kim SJ, Yan HH, Park JH, Lee JE, Kang YW, Pae AN, Keum G, Hong SS.

Cancer Lett. 2018 Jul 10;426:25-36. doi: 10.1016/j.canlet.2018.03.041. Epub 2018 Mar 30.

PMID:
29605512
22.

Synthesis and evaluation of 2-(3-arylureido)pyridines and 2-(3-arylureido)pyrazines as potential modulators of Aβ-induced mitochondrial dysfunction in Alzheimer's disease.

Elkamhawy A, Park JE, Hassan AHE, Pae AN, Lee J, Park BG, Roh EJ.

Eur J Med Chem. 2018 Jan 20;144:529-543. doi: 10.1016/j.ejmech.2017.12.045. Epub 2017 Dec 14.

PMID:
29288949
23.

Synthesis and evaluation of biaryl derivatives for structural characterization of selective monoamine oxidase B inhibitors toward Parkinson's disease therapy.

Yeon SK, Choi JW, Park JH, Lee YR, Kim HJ, Shin SJ, Jang BK, Kim S, Bahn YS, Han G, Lee YS, Pae AN, Park KD.

Bioorg Med Chem. 2018 Jan 1;26(1):232-244. doi: 10.1016/j.bmc.2017.11.036. Epub 2017 Nov 24.

PMID:
29198609
24.

Direct interaction with 14-3-3γ promotes surface expression of Best1 channel in astrocyte.

Oh SJ, Woo J, Lee YS, Cho M, Kim E, Cho NC, Park JY, Pae AN, Justin Lee C, Hwang EM.

Mol Brain. 2017 Nov 9;10(1):51. doi: 10.1186/s13041-017-0331-x.

25.

Novel LCK/FMS inhibitors based on phenoxypyrimidine scaffold as potential treatment for inflammatory disorders.

Farag AK, Elkamhawy A, Londhe AM, Lee KT, Pae AN, Roh EJ.

Eur J Med Chem. 2017 Dec 1;141:657-675. doi: 10.1016/j.ejmech.2017.10.003. Epub 2017 Oct 4.

PMID:
29107425
26.

Synthesis and evaluation of new pyridyl/pyrazinyl thiourea derivatives: Neuroprotection against amyloid-β-induced toxicity.

Park JE, Elkamhawy A, Hassan AHE, Pae AN, Lee J, Paik S, Park BG, Roh EJ.

Eur J Med Chem. 2017 Dec 1;141:322-334. doi: 10.1016/j.ejmech.2017.09.043. Epub 2017 Sep 22.

PMID:
29031076
27.

Discovery of thienopyrrolotriazine derivatives to protect mitochondrial function against Aβ-induced neurotoxicity.

Kim T, Son WS, Morshed MN, Londhe AM, Jung SY, Park JH, Park WK, Lim SM, Park KD, Cho SJ, Jeong KS, Lee J, Pae AN.

Eur J Med Chem. 2017 Dec 1;141:240-256. doi: 10.1016/j.ejmech.2017.09.033. Epub 2017 Sep 21.

PMID:
29031071
28.

Discovery of non-peptidic small molecule inhibitors of cyclophilin D as neuroprotective agents in Aβ-induced mitochondrial dysfunction.

Park I, Londhe AM, Lim JW, Park BG, Jung SY, Lee JY, Lim SM, No KT, Lee J, Pae AN.

J Comput Aided Mol Des. 2017 Oct;31(10):929-941. doi: 10.1007/s10822-017-0067-9. Epub 2017 Sep 14.

PMID:
28913661
29.

In silico probing and biological evaluation of SETDB1/ESET-targeted novel compounds that reduce tri-methylated histone H3K9 (H3K9me3) level.

Park I, Hwang YJ, Kim T, Viswanath ANI, Londhe AM, Jung SY, Sim KM, Min SJ, Lee JE, Seong J, Kim YK, No KT, Ryu H, Pae AN.

J Comput Aided Mol Des. 2017 Oct;31(10):877-889. doi: 10.1007/s10822-017-0052-3. Epub 2017 Sep 6.

PMID:
28879500
30.

Identification of Optically Active Pyrimidine Derivatives as Selective 5-HT2C Modulators.

Kim J, Jo H, Lee H, Choo H, Kim HJ, Pae AN, Cho YS, Min SJ.

Molecules. 2017 Aug 26;22(9). pii: E1416. doi: 10.3390/molecules22091416.

31.

In silico-designed novel non-peptidic ABAD LD hot spot mimetics reverse Aβ-induced mitochondrial impairments in vitro.

Viswanath ANI, Kim T, Jung SY, Lim SM, Pae AN.

Chem Biol Drug Des. 2017 Dec;90(6):1041-1055. doi: 10.1111/cbdd.13065. Epub 2017 Jul 27.

PMID:
28660722
32.

Remodeling of heterochromatin structure slows neuropathological progression and prolongs survival in an animal model of Huntington's disease.

Lee J, Hwang YJ, Kim Y, Lee MY, Hyeon SJ, Lee S, Kim DH, Jang SJ, Im H, Min SJ, Choo H, Pae AN, Kim DJ, Cho KS, Kowall NW, Ryu H.

Acta Neuropathol. 2017 Nov;134(5):729-748. doi: 10.1007/s00401-017-1732-8. Epub 2017 Jun 7.

PMID:
28593442
33.

Design, synthesis, biological evaluation and molecular modelling of 2-(2-aryloxyphenyl)-1,4-dihydroisoquinolin-3(2H)-ones: A novel class of TSPO ligands modulating amyloid-β-induced mPTP opening.

Elkamhawy A, Park JE, Hassan AHE, Pae AN, Lee J, Park BG, Paik S, Do J, Park JH, Park KD, Moon B, Park WK, Cho H, Jeong DY, Roh EJ.

Eur J Pharm Sci. 2017 Jun 15;104:366-381. doi: 10.1016/j.ejps.2017.04.015. Epub 2017 Apr 21.

PMID:
28435076
34.

Discovery of Potent Antiallodynic Agents for Neuropathic Pain Targeting P2X3 Receptors.

Jung YH, Kim YO, Lin H, Cho JH, Park JH, Lee SD, Bae J, Kang KM, Kim YG, Pae AN, Ko H, Park CS, Yoon MH, Kim YC.

ACS Chem Neurosci. 2017 Jul 19;8(7):1465-1478. doi: 10.1021/acschemneuro.6b00401. Epub 2017 Apr 6.

PMID:
28323403
35.

A Potential PET Radiotracer for the 5-HT2C Receptor: Synthesis and in Vivo Evaluation of 4-(3-[18F]fluorophenethoxy)pyrimidine.

Kim J, Moon BS, Lee BC, Lee HY, Kim HJ, Choo H, Pae AN, Cho YS, Min SJ.

ACS Chem Neurosci. 2017 May 17;8(5):996-1003. doi: 10.1021/acschemneuro.6b00445. Epub 2017 Feb 27.

PMID:
28194935
36.

Discovery of 1-(3-(benzyloxy)pyridin-2-yl)-3-(2-(piperazin-1-yl)ethyl)urea: A new modulator for amyloid beta-induced mitochondrial dysfunction.

Elkamhawy A, Park JE, Hassan AHE, Ra H, Pae AN, Lee J, Park BG, Moon B, Park HM, Roh EJ.

Eur J Med Chem. 2017 Mar 10;128:56-69. doi: 10.1016/j.ejmech.2016.12.057. Epub 2016 Dec 29.

PMID:
28152427
37.

Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease.

Kim T, Yang HY, Park BG, Jung SY, Park JH, Park KD, Min SJ, Tae J, Yang H, Cho S, Cho SJ, Song H, Mook-Jung I, Lee J, Pae AN.

Eur J Med Chem. 2017 Jan 5;125:1172-1192. doi: 10.1016/j.ejmech.2016.11.017. Epub 2016 Nov 9.

PMID:
27855359
38.

Identification of the first in silico-designed TREK1 antagonists that block channel currents dose dependently.

Viswanath AN, Jung SY, Hwang EM, Park KD, Lim SM, Min SJ, Cho YS, Pae AN.

Chem Biol Drug Des. 2016 Dec;88(6):807-819. doi: 10.1111/cbdd.12810. Epub 2016 Jul 27.

PMID:
27346364
39.

Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).

Kim T, Pae AN.

Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. Epub 2016 Sep 13. Review.

PMID:
27607364
40.

Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2).

Kim T, Pae AN.

Expert Opin Ther Pat. 2016 Nov;26(11):1353-1366. Epub 2016 Sep 16. Review.

PMID:
27599163
41.

Pharmacophore-based virtual screening, biological evaluation and binding mode analysis of a novel protease-activated receptor 2 antagonist.

Cho NC, Seo SH, Kim D, Shin JS, Ju J, Seong J, Seo SH, Lee I, Lee KT, Kim YK, No KT, Pae AN.

J Comput Aided Mol Des. 2016 Aug;30(8):625-37. doi: 10.1007/s10822-016-9937-9. Epub 2016 Sep 6.

PMID:
27600555
42.

α-Pinene, a Major Constituent of Pine Tree Oils, Enhances Non-Rapid Eye Movement Sleep in Mice through GABAA-benzodiazepine Receptors.

Yang H, Woo J, Pae AN, Um MY, Cho NC, Park KD, Yoon M, Kim J, Lee CJ, Cho S.

Mol Pharmacol. 2016 Nov;90(5):530-539. Epub 2016 Aug 29.

PMID:
27573669
43.

Design and synthesis of new 2-anilinoquinolines bearing N-methylpicolinamide moiety as potential antiproliferative agents.

El-Damasy AK, Seo SH, Cho NC, Pae AN, Kim EE, Keum G.

Chem Biol Drug Des. 2017 Jan;89(1):98-113. doi: 10.1111/cbdd.12836. Epub 2016 Sep 9.

PMID:
27496071
44.

Discovery of a Nanomolar Multikinase Inhibitor (KST016366): A New Benzothiazole Derivative with Remarkable Broad-Spectrum Antiproliferative Activity.

El-Damasy AK, Cho NC, Nam G, Pae AN, Keum G.

ChemMedChem. 2016 Aug 5;11(15):1587-95. doi: 10.1002/cmdc.201600224. Epub 2016 Jul 12.

PMID:
27405013
45.

Novel 5-substituted-2-anilinoquinolines with 3-(morpholino or 4-methylpiperazin-1-yl)propoxy moiety as broad spectrum antiproliferative agents: Synthesis, cell based assays and kinase screening.

El-Damasy AK, Cho NC, Pae AN, Kim EE, Keum G.

Bioorg Med Chem Lett. 2016 Jul 15;26(14):3307-3312. doi: 10.1016/j.bmcl.2016.05.047. Epub 2016 May 17.

PMID:
27241691
46.

Design and synthesis of new potent anticancer benzothiazole amides and ureas featuring pyridylamide moiety and possessing dual B-Raf(V600E) and C-Raf kinase inhibitory activities.

El-Damasy AK, Lee JH, Seo SH, Cho NC, Pae AN, Keum G.

Eur J Med Chem. 2016 Jun 10;115:201-16. doi: 10.1016/j.ejmech.2016.02.039. Epub 2016 Feb 18.

PMID:
27017549
47.

Screening, Synthesis, and In Vitro Evaluation of Vinyl Sulfones as Inhibitors of Complement-Dependent Cytotoxicity in Neuromyelitis Optica.

Ju EJ, Yeon SK, Park JH, Cheon SY, Choi JW, Ha T, Jang BK, Kim S, Kang YG, Hwang H, Cho SJ, Cheong E, Bahn YS, Pae AN, Kim SM, Park KD.

ChemMedChem. 2016 Feb 17;11(4):377-81. doi: 10.1002/cmdc.201500546. Epub 2016 Jan 25.

PMID:
26804736
48.

Immunomodulatory Activities of the Benzoxathiole Derivative BOT-4-One Ameliorate Pathogenic Skin Inflammation in Mice.

Lee HG, Cho NC, Jeong AJ, Li YC, Rhie SJ, Choi JS, Lee KH, Kim Y, Kim YN, Kim MH, Pae AN, Ye SK, Kim BH.

J Invest Dermatol. 2016 Jan;136(1):107-16. doi: 10.1038/JID.2015.384.

49.

Discovery of 2-aryloxy-4-amino-quinazoline derivatives as novel protease-activated receptor 2 (PAR2) antagonists.

Cho NC, Cha JH, Kim H, Kwak J, Kim D, Seo SH, Shin JS, Kim T, Park KD, Lee J, No KT, Kim YK, Lee KT, Pae AN.

Bioorg Med Chem. 2015 Dec 15;23(24):7717-27. doi: 10.1016/j.bmc.2015.11.016. Epub 2015 Nov 18.

PMID:
26631441
50.

Synthesis and biological evaluation of picolinamides and thiazole-2-carboxamides as mGluR5 (metabotropic glutamate receptor 5) antagonists.

Vu HN, Kim JY, Hassan AH, Choi K, Park JH, Park KD, Lee JK, Pae AN, Choo H, Min SJ, Cho YS.

Bioorg Med Chem Lett. 2016 Jan 1;26(1):140-4. doi: 10.1016/j.bmcl.2015.11.012. Epub 2015 Nov 5.

PMID:
26598462

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