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Items: 1 to 50 of 54

1.

The Evolution of Single Cell-derived Colorectal Cancer Cell Lines is Dominated by the Continued Selection of Tumor Specific Genomic Imbalances, Despite Random Chromosomal Instability.

Wangsa D, Braun R, Schiefer M, Gertz EM, Bronder D, Quintanilla I, Padilla-Nash HM, Torres I, Hunn C, Warner L, Buishand FO, Hu Y, Hirsch D, Gaiser T, Camps J, Schwartz R, Schäffer AA, Heselmeyer-Haddad K, Ried T.

Carcinogenesis. 2018 May 23. doi: 10.1093/carcin/bgy068. [Epub ahead of print]

PMID:
29800151
2.

SMYD5 Controls Heterochromatin and Chromosome Integrity during Embryonic Stem Cell Differentiation.

Kidder BL, He R, Wangsa D, Padilla-Nash HM, Bernardo MM, Sheng S, Ried T, Zhao K.

Cancer Res. 2017 Dec 1;77(23):6729-6745. doi: 10.1158/0008-5472.CAN-17-0828. Epub 2017 Sep 26.

3.

Genomic and metabolic characterization of a chromophobe renal cell carcinoma cell line model (UOK276).

Yang Y, Vocke CD, Ricketts CJ, Wei D, Padilla-Nash HM, Lang M, Sourbier C, Killian JK, Boyle SL, Worrell R, Meltzer PS, Ried T, Merino MJ, Metwalli AR, Linehan WM.

Genes Chromosomes Cancer. 2017 Oct;56(10):719-729. doi: 10.1002/gcc.22476. Epub 2017 Jul 24.

4.

Novel mouse model recapitulates genome and transcriptome alterations in human colorectal carcinomas.

McNeil NE, Padilla-Nash HM, Buishand FO, Hue Y, Ried T.

Genes Chromosomes Cancer. 2017 Mar;56(3):199-213. doi: 10.1002/gcc.22426. Epub 2016 Nov 1.

PMID:
27750367
5.

ATM deficiency promotes development of murine B-cell lymphomas that resemble diffuse large B-cell lymphoma in humans.

Hathcock KS, Padilla-Nash HM, Camps J, Shin DM, Triner D, Shaffer AL 3rd, Maul RW, Steinberg SM, Gearhart PJ, Staudt LM, Morse HC 3rd, Ried T, Hodes RJ.

Blood. 2015 Nov 12;126(20):2291-301. doi: 10.1182/blood-2015-06-654749. Epub 2015 Sep 23.

6.

Telomerase variant A279T induces telomere dysfunction and inhibits non-canonical telomerase activity in esophageal carcinomas.

Zhang Y, Calado R, Rao M, Hong JA, Meeker AK, Dumitriu B, Atay S, McCormick PJ, Garfield SH, Wangsa D, Padilla-Nash HM, Burkett S, Zhang M, Kunst TF, Peterson NR, Xi S, Inchauste S, Altorki NK, Casson AG, Beer DG, Harris CC, Ried T, Young NS, Schrump DS.

PLoS One. 2014 Jul 1;9(7):e101010. doi: 10.1371/journal.pone.0101010. eCollection 2014.

7.

Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability.

Akagi K, Li J, Broutian TR, Padilla-Nash H, Xiao W, Jiang B, Rocco JW, Teknos TN, Kumar B, Wangsa D, He D, Ried T, Symer DE, Gillison ML.

Genome Res. 2014 Feb;24(2):185-99. doi: 10.1101/gr.164806.113. Epub 2013 Nov 7.

8.

Aneuploidy, oncogene amplification and epithelial to mesenchymal transition define spontaneous transformation of murine epithelial cells.

Padilla-Nash HM, McNeil NE, Yi M, Nguyen QT, Hu Y, Wangsa D, Mack DL, Hummon AB, Case C, Cardin E, Stephens R, Difilippantonio MJ, Ried T.

Carcinogenesis. 2013 Aug;34(8):1929-39. doi: 10.1093/carcin/bgt138. Epub 2013 Apr 25.

9.

Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs.

Winkler T, Hong SG, Decker JE, Morgan MJ, Wu C, Hughes WM 5th, Yang Y, Wangsa D, Padilla-Nash HM, Ried T, Young NS, Dunbar CE, Calado RT.

J Clin Invest. 2013 May;123(5):1952-63. doi: 10.1172/JCI67146. Epub 2013 Apr 15.

10.

Spontaneous transformation of murine epithelial cells requires the early acquisition of specific chromosomal aneuploidies and genomic imbalances.

Padilla-Nash HM, Hathcock K, McNeil NE, Mack D, Hoeppner D, Ravin R, Knutsen T, Yonescu R, Wangsa D, Dorritie K, Barenboim L, Hu Y, Ried T.

Genes Chromosomes Cancer. 2012 Apr;51(4):353-74. doi: 10.1002/gcc.21921. Epub 2011 Dec 8.

11.

Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia.

Calado RT, Cooper JN, Padilla-Nash HM, Sloand EM, Wu CO, Scheinberg P, Ried T, Young NS.

Leukemia. 2012 Apr;26(4):700-7. doi: 10.1038/leu.2011.272. Epub 2011 Oct 18.

12.

Effects of granulocyte-colony-stimulating factor on Monosomy 7 aneuploidy in healthy hematopoietic stem cell and granulocyte donors.

Olnes MJ, Poon A, Miranda SJ, Pfannes L, Tucker Z, Loeliger K, Padilla-Nash H, Yau YY, Ried T, Leitman SF, Young NS, Sloand EM.

Transfusion. 2012 Mar;52(3):537-41. doi: 10.1111/j.1537-2995.2011.03313.x. Epub 2011 Aug 29.

13.

UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer.

Yang Y, Valera VA, Padilla-Nash HM, Sourbier C, Vocke CD, Vira MA, Abu-Asab MS, Bratslavsky G, Tsokos M, Merino MJ, Pinto PA, Srinivasan R, Ried T, Neckers L, Linehan WM.

Cancer Genet Cytogenet. 2010 Jan 1;196(1):45-55. doi: 10.1016/j.cancergencyto.2009.08.018.

14.

Definitive molecular cytogenetic characterization of 15 colorectal cancer cell lines.

Knutsen T, Padilla-Nash HM, Wangsa D, Barenboim-Stapleton L, Camps J, McNeil N, Difilippantonio MJ, Ried T.

Genes Chromosomes Cancer. 2010 Mar;49(3):204-23. doi: 10.1002/gcc.20730.

15.

Integrative genomics reveals mechanisms of copy number alterations responsible for transcriptional deregulation in colorectal cancer.

Camps J, Nguyen QT, Padilla-Nash HM, Knutsen T, McNeil NE, Wangsa D, Hummon AB, Grade M, Ried T, Difilippantonio MJ.

Genes Chromosomes Cancer. 2009 Nov;48(11):1002-17. doi: 10.1002/gcc.20699.

16.

BCR/ABL induces chromosomal instability after genotoxic stress and alters the cell death threshold.

Dierov J, Sanchez PV, Burke BA, Padilla-Nash H, Putt ME, Ried T, Carroll M.

Leukemia. 2009 Feb;23(2):279-86. doi: 10.1038/leu.2008.308. Epub 2008 Nov 20.

17.

A sequence-based survey of the complex structural organization of tumor genomes.

Raphael BJ, Volik S, Yu P, Wu C, Huang G, Linardopoulou EV, Trask BJ, Waldman F, Costello J, Pienta KJ, Mills GB, Bajsarowicz K, Kobayashi Y, Sridharan S, Paris PL, Tao Q, Aerni SJ, Brown RP, Bashir A, Gray JW, Cheng JF, de Jong P, Nefedov M, Ried T, Padilla-Nash HM, Collins CC.

Genome Biol. 2008;9(3):R59. doi: 10.1186/gb-2008-9-3-r59. Epub 2008 Mar 25.

18.

The ancestral carnivore karyotype (2n = 38) lives today in ringtails.

Nash WG, Menninger JC, Padilla-Nash HM, Stone G, Perelman PL, O'Brien SJ.

J Hered. 2008 May-Jun;99(3):241-53. doi: 10.1093/jhered/esm130. Epub 2008 Mar 13.

PMID:
18339652
19.

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin.

Michishita E, McCord RA, Berber E, Kioi M, Padilla-Nash H, Damian M, Cheung P, Kusumoto R, Kawahara TL, Barrett JC, Chang HY, Bohr VA, Ried T, Gozani O, Chua KF.

Nature. 2008 Mar 27;452(7186):492-6. doi: 10.1038/nature06736. Epub 2008 Mar 12.

20.

The UOK 257 cell line: a novel model for studies of the human Birt-Hogg-Dubé gene pathway.

Yang Y, Padilla-Nash HM, Vira MA, Abu-Asab MS, Val D, Worrell R, Tsokos M, Merino MJ, Pavlovich CP, Ried T, Linehan WM, Vocke CD.

Cancer Genet Cytogenet. 2008 Jan 15;180(2):100-9. doi: 10.1016/j.cancergencyto.2007.10.010.

21.

Cisplatin depletes TREX2 and causes Robertsonian translocations as seen in TREX2 knockout cells.

Chen MJ, Dumitrache LC, Wangsa D, Ma SM, Padilla-Nash H, Ried T, Hasty P.

Cancer Res. 2007 Oct 1;67(19):9077-83.

22.

Spectral karyotyping analysis of human and mouse chromosomes.

Padilla-Nash HM, Barenboim-Stapleton L, Difilippantonio MJ, Ried T.

Nat Protoc. 2006;1(6):3129-42.

23.

A virus causes cancer by inducing massive chromosomal instability through cell fusion.

Duelli DM, Padilla-Nash HM, Berman D, Murphy KM, Ried T, Lazebnik Y.

Curr Biol. 2007 Mar 6;17(5):431-7. Epub 2007 Feb 22.

24.

Spectral karyotyping demonstrates genetically unstable skin-homing T lymphocytes in cutaneous T-cell lymphoma.

Padilla-Nash HM, Wu K, Just H, Ried T, Thestrup-Pedersen K.

Exp Dermatol. 2007 Feb;16(2):98-103.

PMID:
17222222
25.

Comparative genome hybridization reveals specific genomic imbalances during the genesis from benign through borderline to malignant ovarian tumors.

Helou K, Padilla-Nash H, Wangsa D, Karlsson E, Osterberg L, Karlsson P, Ried T, Knutsen T.

Cancer Genet Cytogenet. 2006 Oct 1;170(1):1-8.

PMID:
16965948
26.

Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation.

Miura M, Miura Y, Padilla-Nash HM, Molinolo AA, Fu B, Patel V, Seo BM, Sonoyama W, Zheng JJ, Baker CC, Chen W, Ried T, Shi S.

Stem Cells. 2006 Apr;24(4):1095-103. Epub 2005 Nov 10.

27.

Genetic and epigenetic modeling of the origins of multidrug-resistant cells in a human sarcoma cell line.

Chen KG, Wang YC, Schaner ME, Francisco B, Durán GE, Juric D, Huff LM, Padilla-Nash H, Ried T, Fojo T, Sikic BI.

Cancer Res. 2005 Oct 15;65(20):9388-97.

28.

The interactive online SKY/M-FISH & CGH database and the Entrez cancer chromosomes search database: linkage of chromosomal aberrations with the genome sequence.

Knutsen T, Gobu V, Knaus R, Padilla-Nash H, Augustus M, Strausberg RL, Kirsch IR, Sirotkin K, Ried T.

Genes Chromosomes Cancer. 2005 Sep;44(1):52-64.

29.

Pediatric pancreatoblastoma: histopathologic and cytogenetic characterization of tumor and derived cell line.

Barenboim-Stapleton L, Yang X, Tsokos M, Wigginton JM, Padilla-Nash H, Ried T, Thiele CJ.

Cancer Genet Cytogenet. 2005 Mar;157(2):109-17.

PMID:
15721631
30.

Gene expression profiles in human non-small and small-cell lung cancers.

Difilippantonio S, Chen Y, Pietas A, Schlüns K, Pacyna-Gengelbach M, Deutschmann N, Padilla-Nash HM, Ried T, Petersen I.

Eur J Cancer. 2003 Sep;39(13):1936-47.

PMID:
12932674
31.

Cytogenetic, spectral karyotyping, fluorescence in situ hybridization, and comparative genomic hybridization characterization of two new secondary leukemia cell lines with 5q deletions, and MYC and MLL amplification.

Knutsen T, Pack S, Petropavlovskaja M, Padilla-Nash H, Knight C, Mickley LA, Ried T, Elwood PC, Roberts SJ.

Genes Chromosomes Cancer. 2003 Jul;37(3):270-81. Erratum in: Genes Chromosomes Cancer. 2003 Jul;37(3):332.

PMID:
12759925
32.

Patterns of aneuploidy in stage IV clear cell renal cell carcinoma revealed by comparative genomic hybridization and spectral karyotyping.

Pavlovich CP, Padilla-Nash H, Wangsa D, Nickerson ML, Matrosova V, Linehan WM, Ried T, Phillips JL.

Genes Chromosomes Cancer. 2003 Jul;37(3):252-60.

PMID:
12759923
33.

Novel translocation in acute megakaryoblastic leukemia (AML-M7).

Toretsky JA, Everly EM, Padilla-Nash HM, Chen A, Abruzzo LV, Eskenazi AE, Frantz C, Ried T, Stamberg J.

J Pediatr Hematol Oncol. 2003 May;25(5):396-402.

PMID:
12759627
34.

The pattern of phylogenomic evolution of the Canidae.

Nash WG, Menninger JC, Wienberg J, Padilla-Nash HM, O'Brien SJ.

Cytogenet Cell Genet. 2001;95(3-4):210-24.

PMID:
12063402
35.

Spectral karyotyping in cancer cytogenetics.

Hilgenfeld E, Montagna C, Padilla-Nash H, Stapleton L, Heselmeyer-Haddad K, Ried T.

Methods Mol Med. 2002;68:29-44. No abstract available.

PMID:
11901510
36.
37.

The consequences of chromosomal aneuploidy on gene expression profiles in a cell line model for prostate carcinogenesis.

Phillips JL, Hayward SW, Wang Y, Vasselli J, Pavlovich C, Padilla-Nash H, Pezullo JR, Ghadimi BM, Grossfeld GD, Rivera A, Linehan WM, Cunha GR, Ried T.

Cancer Res. 2001 Nov 15;61(22):8143-9.

38.

Spectral karyotyping and fluorescence in situ hybridization detect novel chromosomal aberrations, a recurring involvement of chromosome 21 and amplification of the MYC oncogene in acute myeloid leukaemia M2.

Hilgenfeld E, Padilla-Nash H, McNeil N, Knutsen T, Montagna C, Tchinda J, Horst J, Ludwig WD, Serve H, Büchner T, Berdel WE, Schröck E, Ried T.

Br J Haematol. 2001 May;113(2):305-17.

PMID:
11380393
39.

Molecular cytogenetic characterization of early and late renal cell carcinomas in von Hippel-Lindau disease.

Phillips JL, Ghadimi BM, Wangsa D, Padilla-Nash H, Worrell R, Hewitt S, Walther M, Linehan WM, Klausner RD, Ried T.

Genes Chromosomes Cancer. 2001 May;31(1):1-9.

PMID:
11284029
40.

Jumping translocations are common in solid tumor cell lines and result in recurrent fusions of whole chromosome arms.

Padilla-Nash HM, Heselmeyer-Haddad K, Wangsa D, Zhang H, Ghadimi BM, Macville M, Augustus M, Schröck E, Hilgenfeld E, Ried T.

Genes Chromosomes Cancer. 2001 Apr;30(4):349-63.

PMID:
11241788
41.

Spectral Karyotyping (SKY) of Hematologic Malignancies.

Hilgenfeld E, Padilla-Nash H, Schröck E, Ried T, Haas OA, Serve H.

Methods Mol Med. 2001;55:65-79. doi: 10.1385/1-59259-074-8:65.

PMID:
21312104
42.
43.

Amplification of 4q21-q22 and the MXR gene in independently derived mitoxantrone-resistant cell lines.

Knutsen T, Rao VK, Ried T, Mickley L, Schneider E, Miyake K, Ghadimi BM, Padilla-Nash H, Pack S, Greenberger L, Cowan K, Dean M, Fojo T, Bates S.

Genes Chromosomes Cancer. 2000 Jan;27(1):110-6.

PMID:
10564593
44.

Tyramide signal amplification (TSA)-FISH applied to mapping PCR-labeled probes less than 1 kb in size.

Schriml LM, Padilla-Nash HM, Coleman A, Moen P, Nash WG, Menninger J, Jones G, Ried T, Dean M.

Biotechniques. 1999 Sep;27(3):608-13.

45.

Spectral karyotypic study of the HL-60 cell line: detection of complex rearrangements involving chromosomes 5, 7, and 16 and delineation of critical region of deletion on 5q31.1.

Liang JC, Ning Y, Wang RY, Padilla-Nash HM, Schröck E, Soenksen D, Nagarajan L, Ried T.

Cancer Genet Cytogenet. 1999 Sep;113(2):105-9.

PMID:
10484974
46.

Analysis of B-cell neoplasias by spectral karyotyping (SKY).

Hilgenfeld E, Padilla-Nash H, Schröck E, Ried T.

Curr Top Microbiol Immunol. 1999;246:169-74. Review.

PMID:
10396053
47.

Molecular cytogenetic analysis of the bladder carcinoma cell line BK-10 by spectral karyotyping.

Padilla-Nash HM, Nash WG, Padilla GM, Roberson KM, Robertson CN, Macville M, Schröck E, Ried T.

Genes Chromosomes Cancer. 1999 May;25(1):53-9.

PMID:
10221340
48.

Comprehensive and definitive molecular cytogenetic characterization of HeLa cells by spectral karyotyping.

Macville M, Schröck E, Padilla-Nash H, Keck C, Ghadimi BM, Zimonjic D, Popescu N, Ried T.

Cancer Res. 1999 Jan 1;59(1):141-50.

49.

Isolation and characterization of a novel human bladder cancer cell line: BK10.

Roberson KM, Yancey DR, Padilla-Nash H, Edwards DW, Nash W, Jacobs S, Padilla GM, Larchian WA, Robertson CN.

In Vitro Cell Dev Biol Anim. 1998 Jul-Aug;34(7):537-44.

PMID:
9719413
50.

SHOT, a SHOX-related homeobox gene, is implicated in craniofacial, brain, heart, and limb development.

Blaschke RJ, Monaghan AP, Schiller S, Schechinger B, Rao E, Padilla-Nash H, Ried T, Rappold GA.

Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2406-11.

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