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Items: 50

1.

N6-methyladenosine mRNA marking promotes selective translation of regulons required for human erythropoiesis.

Kuppers DA, Arora S, Lim Y, Lim AR, Carter LM, Corrin PD, Plaisier CL, Basom R, Delrow JJ, Wang S, Hansen He H, Torok-Storb B, Hsieh AC, Paddison PJ.

Nat Commun. 2019 Oct 10;10(1):4596. doi: 10.1038/s41467-019-12518-6.

2.

Molecular determinants of response to high-dose androgen therapy in prostate cancer.

Nyquist MD, Corella A, Mohamad O, Coleman I, Kaipainen A, Kuppers DA, Lucas JM, Paddison PJ, Plymate SR, Nelson PS, Mostaghel EA.

JCI Insight. 2019 Oct 3;4(19). pii: 129715. doi: 10.1172/jci.insight.129715.

3.

PIP4K2A as a negative regulator of PI3K in PTEN-deficient glioblastoma.

Shin YJ, Sa JK, Lee Y, Kim D, Chang N, Cho HJ, Son M, Oh MYT, Shin K, Lee JK, Park J, Jo YK, Kim M, Paddison PJ, Tergaonkar V, Lee J, Nam DH.

J Exp Med. 2019 May 6;216(5):1120-1134. doi: 10.1084/jem.20172170. Epub 2019 Mar 21.

4.

Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency.

Mathieu J, Detraux D, Kuppers D, Wang Y, Cavanaugh C, Sidhu S, Levy S, Robitaille AM, Ferreccio A, Bottorff T, McAlister A, Somasundaram L, Artoni F, Battle S, Hawkins RD, Moon RT, Ware CB, Paddison PJ, Ruohola-Baker H.

Nat Commun. 2019 Feb 7;10(1):632. doi: 10.1038/s41467-018-08020-0.

5.

Comparison of glioblastoma (GBM) molecular classification methods.

Lee E, Yong RL, Paddison P, Zhu J.

Semin Cancer Biol. 2018 Dec;53:201-211. doi: 10.1016/j.semcancer.2018.07.006. Epub 2018 Jul 19. Review.

PMID:
30031763
6.

Pan-cancer transcriptional signatures predictive of oncogenic mutations reveal that Fbw7 regulates cancer cell oxidative metabolism.

Davis RJ, Gönen M, Margineantu DH, Handeli S, Swanger J, Hoellerbauer P, Paddison PJ, Gu H, Raftery D, Grim JE, Hockenbery DM, Margolin AA, Clurman BE.

Proc Natl Acad Sci U S A. 2018 May 22;115(21):5462-5467. doi: 10.1073/pnas.1718338115. Epub 2018 May 7.

7.

Inducible CRISPR genome editing platform in naive human embryonic stem cells reveals JARID2 function in self-renewal.

Ferreccio A, Mathieu J, Detraux D, Somasundaram L, Cavanaugh C, Sopher B, Fischer K, Bello T, M Hussein A, Levy S, Cook S, Sidhu SB, Artoni F, Palpant NJ, Reinecke H, Wang Y, Paddison P, Murry C, Jayadev S, Ware C, Ruohola-Baker H.

Cell Cycle. 2018;17(5):535-549. doi: 10.1080/15384101.2018.1442621. Epub 2018 Apr 5.

8.

Sensitivity to BUB1B Inhibition Defines an Alternative Classification of Glioblastoma.

Lee E, Pain M, Wang H, Herman JA, Toledo CM, DeLuca JG, Yong RL, Paddison P, Zhu J.

Cancer Res. 2017 Oct 15;77(20):5518-5529. doi: 10.1158/0008-5472.CAN-17-0736. Epub 2017 Aug 30.

9.

Transcription elongation factors represent in vivo cancer dependencies in glioblastoma.

Miller TE, Liau BB, Wallace LC, Morton AR, Xie Q, Dixit D, Factor DC, Kim LJY, Morrow JJ, Wu Q, Mack SC, Hubert CG, Gillespie SM, Flavahan WA, Hoffmann T, Thummalapalli R, Hemann MT, Paddison PJ, Horbinski CM, Zuber J, Scacheri PC, Bernstein BE, Tesar PJ, Rich JN.

Nature. 2017 Jul 20;547(7663):355-359. doi: 10.1038/nature23000. Epub 2017 Jul 5.

10.

ZNF131 suppresses centrosome fragmentation in glioblastoma stem-like cells through regulation of HAUS5.

Ding Y, Herman JA, Toledo CM, Lang JM, Corrin P, Girard EJ, Basom R, Delrow JJ, Olson JM, Paddison PJ.

Oncotarget. 2017 Jul 25;8(30):48545-48562. doi: 10.18632/oncotarget.18153.

11.

Ion channel expression patterns in glioblastoma stem cells with functional and therapeutic implications for malignancy.

Pollak J, Rai KG, Funk CC, Arora S, Lee E, Zhu J, Price ND, Paddison PJ, Ramirez JM, Rostomily RC.

PLoS One. 2017 Mar 6;12(3):e0172884. doi: 10.1371/journal.pone.0172884. eCollection 2017.

12.

Screen for reactivation of MeCP2 on the inactive X chromosome identifies the BMP/TGF-β superfamily as a regulator of XIST expression.

Sripathy S, Leko V, Adrianse RL, Loe T, Foss EJ, Dalrymple E, Lao U, Gatbonton-Schwager T, Carter KT, Payer B, Paddison PJ, Grady WM, Lee JT, Bartolomei MS, Bedalov A.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1619-1624. doi: 10.1073/pnas.1621356114. Epub 2017 Jan 31.

13.

Causal Mechanistic Regulatory Network for Glioblastoma Deciphered Using Systems Genetics Network Analysis.

Plaisier CL, O'Brien S, Bernard B, Reynolds S, Simon Z, Toledo CM, Ding Y, Reiss DJ, Paddison PJ, Baliga NS.

Cell Syst. 2016 Aug;3(2):172-186. doi: 10.1016/j.cels.2016.06.006. Epub 2016 Jul 14.

14.

Involvement of DDX6 gene in radio- and chemoresistance in glioblastoma.

Cho YJ, Kang W, Kim SH, Sa JK, Kim N, Paddison PJ, Kim M, Joo KM, Hwang YI, Nam DH.

Int J Oncol. 2016 Mar;48(3):1053-62. doi: 10.3892/ijo.2016.3328. Epub 2016 Jan 11.

PMID:
26783102
15.

Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells.

Toledo CM, Ding Y, Hoellerbauer P, Davis RJ, Basom R, Girard EJ, Lee E, Corrin P, Hart T, Bolouri H, Davison J, Zhang Q, Hardcastle J, Aronow BJ, Plaisier CL, Baliga NS, Moffat J, Lin Q, Li XN, Nam DH, Lee J, Pollard SM, Zhu J, Delrow JJ, Clurman BE, Olson JM, Paddison PJ.

Cell Rep. 2015 Dec 22;13(11):2425-2439. doi: 10.1016/j.celrep.2015.11.021. Epub 2015 Dec 7.

16.

CNS Anticancer Drug Discovery and Development Conference White Paper.

Levin VA, Tonge PJ, Gallo JM, Birtwistle MR, Dar AC, Iavarone A, Paddison PJ, Heffron TP, Elmquist WF, Lachowicz JE, Johnson TW, White FM, Sul J, Smith QR, Shen W, Sarkaria JN, Samala R, Wen PY, Berry DA, Petter RC.

Neuro Oncol. 2015 Nov;17 Suppl 6:vi1-26. doi: 10.1093/neuonc/nov169.

17.

Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells.

Nayak RC, Trump LR, Aronow BJ, Myers K, Mehta P, Kalfa T, Wellendorf AM, Valencia CA, Paddison PJ, Horwitz MS, Grimes HL, Lutzko C, Cancelas JA.

J Clin Invest. 2015 Aug 3;125(8):3103-16. doi: 10.1172/JCI80924. Epub 2015 Jul 20.

18.

In vivo RNAi screen identifies NLK as a negative regulator of mesenchymal activity in glioblastoma.

Sa JK, Yoon Y, Kim M, Kim Y, Cho HJ, Lee JK, Kim GS, Han S, Kim WJ, Shin YJ, Joo KM, Paddison PJ, Ishitani T, Lee J, Nam DH.

Oncotarget. 2015 Aug 21;6(24):20145-59.

19.

G9a/GLP-dependent H3K9me2 patterning alters chromatin structure at CpG islands in hematopoietic progenitors.

Schones DE, Chen X, Trac C, Setten R, Paddison PJ.

Epigenetics Chromatin. 2014 Sep 10;7:23. doi: 10.1186/1756-8935-7-23. eCollection 2014.

20.

Molecular pathways: regulation and targeting of kinetochore-microtubule attachment in cancer.

Herman JA, Toledo CM, Olson JM, DeLuca JG, Paddison PJ.

Clin Cancer Res. 2015 Jan 15;21(2):233-9. doi: 10.1158/1078-0432.CCR-13-0645. Epub 2014 Aug 7.

21.

BuGZ is required for Bub3 stability, Bub1 kinetochore function, and chromosome alignment.

Toledo CM, Herman JA, Olsen JB, Ding Y, Corrin P, Girard EJ, Olson JM, Emili A, DeLuca JG, Paddison PJ.

Dev Cell. 2014 Feb 10;28(3):282-94. doi: 10.1016/j.devcel.2013.12.014. Epub 2014 Jan 23.

22.

A high-content small molecule screen identifies sensitivity of glioblastoma stem cells to inhibition of polo-like kinase 1.

Danovi D, Folarin A, Gogolok S, Ender C, Elbatsh AM, Engström PG, Stricker SH, Gagrica S, Georgian A, Yu D, U KP, Harvey KJ, Ferretti P, Paddison PJ, Preston JE, Abbott NJ, Bertone P, Smith A, Pollard SM.

PLoS One. 2013 Oct 30;8(10):e77053. doi: 10.1371/journal.pone.0077053. eCollection 2013.

23.

Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A.

Hubert CG, Bradley RK, Ding Y, Toledo CM, Herman J, Skutt-Kakaria K, Girard EJ, Davison J, Berndt J, Corrin P, Hardcastle J, Basom R, Delrow JJ, Webb T, Pollard SM, Lee J, Olson JM, Paddison PJ.

Genes Dev. 2013 May 1;27(9):1032-45. doi: 10.1101/gad.212548.112.

24.

Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3.

Betschinger J, Nichols J, Dietmann S, Corrin PD, Paddison PJ, Smith A.

Cell. 2013 Apr 11;153(2):335-47. doi: 10.1016/j.cell.2013.03.012.

25.

Integrative network analysis of signaling in human CD34(+) hematopoietic progenitor cells by global phosphoproteomic profiling using TiO2 enrichment combined with 2D LC-MS/MS and pathway mapping.

Guo H, Isserlin R, Chen X, Wang W, Phanse S, Zandstra PW, Paddison PJ, Emili A.

Proteomics. 2013 Apr;13(8):1325-33. doi: 10.1002/pmic.201200369. Epub 2013 Mar 6.

26.

Cancer-Specific requirement for BUB1B/BUBR1 in human brain tumor isolates and genetically transformed cells.

Ding Y, Hubert CG, Herman J, Corrin P, Toledo CM, Skutt-Kakaria K, Vazquez J, Basom R, Zhang B, Risler JK, Pollard SM, Nam DH, Delrow JJ, Zhu J, Lee J, DeLuca J, Olson JM, Paddison PJ.

Cancer Discov. 2013 Feb;3(2):198-211. doi: 10.1158/2159-8290.CD-12-0353. Epub 2012 Nov 15.

27.

G9a/GLP-dependent histone H3K9me2 patterning during human hematopoietic stem cell lineage commitment.

Chen X, Skutt-Kakaria K, Davison J, Ou YL, Choi E, Malik P, Loeb K, Wood B, Georges G, Torok-Storb B, Paddison PJ.

Genes Dev. 2012 Nov 15;26(22):2499-511. doi: 10.1101/gad.200329.112. Epub 2012 Oct 26.

28.

Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia.

Mavrakis KJ, Wolfe AL, Oricchio E, Palomero T, de Keersmaecker K, McJunkin K, Zuber J, James T, Khan AA, Leslie CS, Parker JS, Paddison PJ, Tam W, Ferrando A, Wendel HG.

Nat Cell Biol. 2010 Apr;12(4):372-9. doi: 10.1038/ncb2037. Epub 2010 Feb 28.

29.

Smarcc1/Baf155 couples self-renewal gene repression with changes in chromatin structure in mouse embryonic stem cells.

Schaniel C, Ang YS, Ratnakumar K, Cormier C, James T, Bernstein E, Lemischka IR, Paddison PJ.

Stem Cells. 2009 Dec;27(12):2979-91. doi: 10.1002/stem.223.

30.

RNA interference in mammalian cell systems.

Paddison PJ.

Curr Top Microbiol Immunol. 2008;320:1-19. Review.

PMID:
18268837
31.

Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells.

Gadue P, Huber TL, Paddison PJ, Keller GM.

Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16806-11. Epub 2006 Oct 31.

32.

Delivery of short hairpin RNAs--triggers of gene silencing--into mouse embryonic stem cells.

Schaniel C, Li F, Schafer XL, Moore T, Lemischka IR, Paddison PJ.

Nat Methods. 2006 May;3(5):397-400. No abstract available.

PMID:
16628211
33.

Second-generation shRNA libraries covering the mouse and human genomes.

Silva JM, Li MZ, Chang K, Ge W, Golding MC, Rickles RJ, Siolas D, Hu G, Paddison PJ, Schlabach MR, Sheth N, Bradshaw J, Burchard J, Kulkarni A, Cavet G, Sachidanandam R, McCombie WR, Cleary MA, Elledge SJ, Hannon GJ.

Nat Genet. 2005 Nov;37(11):1281-8. Epub 2005 Oct 2.

PMID:
16200065
34.

Cloning of short hairpin RNAs for gene knockdown in mammalian cells.

Paddison PJ, Cleary M, Silva JM, Chang K, Sheth N, Sachidanandam R, Hannon GJ.

Nat Methods. 2004 Nov;1(2):163-7. No abstract available.

PMID:
16144086
35.

Production of complex nucleic acid libraries using highly parallel in situ oligonucleotide synthesis.

Cleary MA, Kilian K, Wang Y, Bradshaw J, Cavet G, Ge W, Kulkarni A, Paddison PJ, Chang K, Sheth N, Leproust E, Coffey EM, Burchard J, McCombie WR, Linsley P, Hannon GJ.

Nat Methods. 2004 Dec;1(3):241-8. Epub 2004 Nov 18.

PMID:
15782200
36.

Synthetic shRNAs as potent RNAi triggers.

Siolas D, Lerner C, Burchard J, Ge W, Linsley PS, Paddison PJ, Hannon GJ, Cleary MA.

Nat Biotechnol. 2005 Feb;23(2):227-31. Epub 2004 Dec 26.

PMID:
15619616
37.

Short hairpin activated gene silencing in mammalian cells.

Paddison PJ, Caudy AA, Sachidanandam R, Hannon GJ.

Methods Mol Biol. 2004;265:85-100.

PMID:
15103070
38.

A resource for large-scale RNA-interference-based screens in mammals.

Paddison PJ, Silva JM, Conklin DS, Schlabach M, Li M, Aruleba S, Balija V, O'Shaughnessy A, Gnoj L, Scobie K, Chang K, Westbrook T, Cleary M, Sachidanandam R, McCombie WR, Elledge SJ, Hannon GJ.

Nature. 2004 Mar 25;428(6981):427-31.

PMID:
15042091
39.

siRNAs and shRNAs: skeleton keys to the human genome.

Paddison PJ, Hannon GJ.

Curr Opin Mol Ther. 2003 Jun;5(3):217-24. Review.

PMID:
12870430
40.

An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo.

Hemann MT, Fridman JS, Zilfou JT, Hernando E, Paddison PJ, Cordon-Cardo C, Hannon GJ, Lowe SW.

Nat Genet. 2003 Mar;33(3):396-400. Epub 2003 Feb 3.

PMID:
12567186
41.

RNA interference: the new somatic cell genetics?

Paddison PJ, Hannon GJ.

Cancer Cell. 2002 Jul;2(1):17-23. Review.

42.

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells.

Paddison PJ, Caudy AA, Bernstein E, Hannon GJ, Conklin DS.

Genes Dev. 2002 Apr 15;16(8):948-58.

43.

Stable suppression of gene expression by RNAi in mammalian cells.

Paddison PJ, Caudy AA, Hannon GJ.

Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1443-8. Epub 2002 Jan 29.

44.

The roles of the bacteriophage T4 r genes in lysis inhibition and fine-structure genetics: a new perspective.

Paddison P, Abedon ST, Dressman HK, Gailbreath K, Tracy J, Mosser E, Neitzel J, Guttman B, Kutter E.

Genetics. 1998 Apr;148(4):1539-50.

45.

Utility of the dexamethasone suppression test in the diagnosis of poststroke depression.

Grober SE, Gordon WA, Sliwinski MJ, Hibbard MR, Aletta EG, Paddison PL.

Arch Phys Med Rehabil. 1991 Dec;72(13):1076-9.

PMID:
1741660
46.

Cost offset from a psychiatric consultation-liaison intervention with elderly hip fracture patients.

Strain JJ, Lyons JS, Hammer JS, Fahs M, Lebovits A, Paddison PL, Snyder S, Strauss E, Burton R, Nuber G, et al.

Am J Psychiatry. 1991 Aug;148(8):1044-9.

PMID:
1853954
47.

Issues in the identification of premenstrual syndromes.

Gise LH, Lebovits AH, Paddison PL, Strain JJ.

J Nerv Ment Dis. 1990 Apr;178(4):228-34.

PMID:
2319230
48.

Sexual abuse and premenstrual syndrome: comparison between a lower and higher socioeconomic group.

Paddison PL, Gise LH, Lebovits A, Strain JJ, Cirasole DM, Levine JP.

Psychosomatics. 1990 Summer;31(3):265-72.

PMID:
2388980
49.

Psychiatric consults on medical and surgical wards: a six year study.

Paddison PL, Strain JP, Strain JJ, Strain JJ.

Int J Psychiatry Med. 1989;19(4):347-61.

PMID:
2630508
50.

Rape, sexual abuse, and its victims.

Gise LH, Paddison P.

Psychiatr Clin North Am. 1988 Dec;11(4):629-48. Review.

PMID:
3062595

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