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Items: 1 to 50 of 147

1.

Cardiolipin is an Optimal Phospholipid for the Assembly, Stability, and Proper Functionality of the Dimeric Form of NhaA Na+/H+ Antiporter.

Rimon A, Mondal R, Friedler A, Padan E.

Sci Rep. 2019 Nov 27;9(1):17662. doi: 10.1038/s41598-019-54198-8.

2.

Replacement of Lys-300 with a glutamine in the NhaA Na+/H+ antiporter of Escherichia coli yields a functional electrogenic transporter.

Patiño-Ruiz M, Dwivedi M, Călinescu O, Karabel M, Padan E, Fendler K.

J Biol Chem. 2019 Jan 4;294(1):246-256. doi: 10.1074/jbc.RA118.004903. Epub 2018 Nov 8.

PMID:
30409911
3.

Broad phylogenetic analysis of cation/proton antiporters reveals transport determinants.

Masrati G, Dwivedi M, Rimon A, Gluck-Margolin Y, Kessel A, Ashkenazy H, Mayrose I, Padan E, Ben-Tal N.

Nat Commun. 2018 Oct 11;9(1):4205. doi: 10.1038/s41467-018-06770-5.

4.

Asp133 Residue in NhaA Na+/H+ Antiporter Is Required for Stability Cation Binding and Transport.

Rimon A, Dwivedi M, Friedler A, Padan E.

J Mol Biol. 2018 Mar 16;430(6):867-880. doi: 10.1016/j.jmb.2018.01.014. Epub 2018 Feb 2.

PMID:
29410365
5.

Ligand-induced conformational dynamics of the Escherichia coli Na+/H+ antiporter NhaA revealed by hydrogen/deuterium exchange mass spectrometry.

Eisinger ML, Dörrbaum AR, Michel H, Padan E, Langer JD.

Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):11691-11696. doi: 10.1073/pnas.1703422114. Epub 2017 Oct 16.

6.

Lysine 300 is essential for stability but not for electrogenic transport of the Escherichia coli NhaA Na+/H+ antiporter.

Călinescu O, Dwivedi M, Patiño-Ruiz M, Padan E, Fendler K.

J Biol Chem. 2017 May 12;292(19):7932-7941. doi: 10.1074/jbc.M117.778175. Epub 2017 Mar 22.

7.

The Ec-NhaA antiporter switches from antagonistic to synergistic antiport upon a single point mutation.

Dwivedi M, Sukenik S, Friedler A, Padan E.

Sci Rep. 2016 Mar 29;6:23339. doi: 10.1038/srep23339.

8.

Sodium-Proton (Na(+)/H(+)) Antiporters: Properties and Roles in Health and Disease.

Padan E, Landau M.

Met Ions Life Sci. 2016;16:391-458. doi: 10.1007/978-3-319-21756-7_12.

PMID:
26860308
9.

NhaA antiporter functions using 10 helices, and an additional 2 contribute to assembly/stability.

Padan E, Danieli T, Keren Y, Alkoby D, Masrati G, Haliloglu T, Ben-Tal N, Rimon A.

Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):E5575-82. doi: 10.1073/pnas.1510964112. Epub 2015 Sep 28.

10.

Overexpression, Isolation, Purification, and Crystallization of NhaA.

Padan E, Dwivedi M.

Methods Enzymol. 2015;557:135-48. doi: 10.1016/bs.mie.2014.12.003. Epub 2015 Mar 17.

PMID:
25950963
11.

NhaA Na+/H+ antiporter mutants that hardly react to the membrane potential.

Alkoby D, Rimon A, Budak M, Patino-Ruiz M, Călinescu O, Fendler K, Padan E.

PLoS One. 2014 Apr 3;9(4):e93200. doi: 10.1371/journal.pone.0093200. eCollection 2014. Erratum in: PLoS One. 2014;9(7):e102206. Burdak, Maral [corrected to Budak, Maral].

12.

Functional and structural dynamics of NhaA, a prototype for Na(+) and H(+) antiporters, which are responsible for Na(+) and H(+) homeostasis in cells.

Padan E.

Biochim Biophys Acta. 2014 Jul;1837(7):1047-62. doi: 10.1016/j.bbabio.2013.12.007. Epub 2013 Dec 19. Review.

13.

Differential effects of mutations on the transport properties of the Na+/H+ antiporter NhaA from Escherichia coli.

Mager T, Braner M, Kubsch B, Hatahet L, Alkoby D, Rimon A, Padan E, Fendler K.

J Biol Chem. 2013 Aug 23;288(34):24666-75. doi: 10.1074/jbc.M113.484071. Epub 2013 Jul 8.

14.

The unwound portion dividing helix IV of NhaA undergoes a conformational change at physiological pH and lines the cation passage.

Rimon A, Kozachkov-Magrisso L, Padan E.

Biochemistry. 2012 Nov 27;51(47):9560-9. doi: 10.1021/bi301030x. Epub 2012 Nov 13.

PMID:
23131124
15.

Revealing the ligand binding site of NhaA Na+/H+ antiporter and its pH dependence.

Maes M, Rimon A, Kozachkov-Magrisso L, Friedler A, Padan E.

J Biol Chem. 2012 Nov 2;287(45):38150-7. doi: 10.1074/jbc.M112.391128. Epub 2012 Aug 22.

16.

Conformational changes in NhaA Na+/H+ antiporter.

Kozachkov L, Padan E.

Mol Membr Biol. 2013 Feb;30(1):90-100. doi: 10.3109/09687688.2012.693209. Epub 2012 Jun 14.

PMID:
22694117
17.

A model-structure of a periplasm-facing state of the NhaA antiporter suggests the molecular underpinnings of pH-induced conformational changes.

Schushan M, Rimon A, Haliloglu T, Forrest LR, Padan E, Ben-Tal N.

J Biol Chem. 2012 May 25;287(22):18249-61. doi: 10.1074/jbc.M111.336446. Epub 2012 Mar 19.

18.

Regulation of NhaA by protons.

Padan E.

Compr Physiol. 2011 Oct;1(4):1711-9. doi: 10.1002/cphy.c100078. Review.

PMID:
23733686
19.

Helix VIII of NhaA Na(+)/H(+) antiporter participates in the periplasmic cation passage and pH regulation of the antiporter.

Diab M, Rimon A, Tzubery T, Padan E.

J Mol Biol. 2011 Oct 28;413(3):604-14. doi: 10.1016/j.jmb.2011.08.046. Epub 2011 Sep 3.

PMID:
21907722
20.

Site-directed tryptophan fluorescence reveals two essential conformational changes in the Na+/H+ antiporter NhaA.

Kozachkov L, Padan E.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15769-74. doi: 10.1073/pnas.1109256108. Epub 2011 Aug 23.

21.

Two conflicting NHE1 model structures: compatibility with experimental data and implications for the transport mechanism.

Schushan M, Landau M, Padan E, Ben-Tal N.

J Biol Chem. 2011 May 27;286(21):le9; author reply Ie10. doi: 10.1074/jbc.L110.159202. No abstract available.

22.

Transport mechanism and pH regulation of the Na+/H+ antiporter NhaA from Escherichia coli: an electrophysiological study.

Mager T, Rimon A, Padan E, Fendler K.

J Biol Chem. 2011 Jul 1;286(26):23570-81. doi: 10.1074/jbc.M111.230235. Epub 2011 May 12.

23.

Molecular aspects of bacterial pH sensing and homeostasis.

Krulwich TA, Sachs G, Padan E.

Nat Rev Microbiol. 2011 May;9(5):330-43. doi: 10.1038/nrmicro2549. Epub 2011 Apr 5. Review.

24.

Model-guided mutagenesis drives functional studies of human NHA2, implicated in hypertension.

Schushan M, Xiang M, Bogomiakov P, Padan E, Rao R, Ben-Tal N.

J Mol Biol. 2010 Mar 12;396(5):1181-96. doi: 10.1016/j.jmb.2009.12.055. Epub 2010 Jan 4.

25.

Transmembrane segment II of NhaA Na+/H+ antiporter lines the cation passage, and Asp65 is critical for pH activation of the antiporter.

Herz K, Rimon A, Olkhova E, Kozachkov L, Padan E.

J Biol Chem. 2010 Jan 15;285(3):2211-20. doi: 10.1074/jbc.M109.047134. Epub 2009 Nov 18.

26.

NhaA crystal structure: functional-structural insights.

Padan E, Kozachkov L, Herz K, Rimon A.

J Exp Biol. 2009 Jun;212(Pt 11):1593-603. doi: 10.1242/jeb.026708. Review.

28.

Beta-sheet-dependent dimerization is essential for the stability of NhaA Na+/H+ antiporter.

Herz K, Rimon A, Jeschke G, Padan E.

J Biol Chem. 2009 Mar 6;284(10):6337-47. doi: 10.1074/jbc.M807720200. Epub 2009 Jan 7.

29.

The enlightening encounter between structure and function in the NhaA Na+-H+ antiporter.

Padan E.

Trends Biochem Sci. 2008 Sep;33(9):435-43. doi: 10.1016/j.tibs.2008.06.007. Epub 2008 Aug 15. Review.

PMID:
18707888
30.

Epitope mapping of conformational monoclonal antibodies specific to NhaA Na+/H+ antiporter: structural and functional implications.

Rimon A, Hunte C, Michel H, Padan E.

J Mol Biol. 2008 Jun 6;379(3):471-81. doi: 10.1016/j.jmb.2008.03.067. Epub 2008 Apr 4.

PMID:
18452948
31.
32.

Model structure of the Na+/H+ exchanger 1 (NHE1): functional and clinical implications.

Landau M, Herz K, Padan E, Ben-Tal N.

J Biol Chem. 2007 Dec 28;282(52):37854-63. Epub 2007 Nov 2.

33.

High-resolution structure of a Na+/H+ antiporter dimer obtained by pulsed electron paramagnetic resonance distance measurements.

Hilger D, Polyhach Y, Padan E, Jung H, Jeschke G.

Biophys J. 2007 Nov 15;93(10):3675-83. Epub 2007 Aug 17.

35.

The influence of protonation states on the dynamics of the NhaA antiporter from Escherichia coli.

Olkhova E, Padan E, Michel H.

Biophys J. 2007 Jun 1;92(11):3784-91. Epub 2007 Mar 9.

36.
37.

Crucial steps in the structure determination of the Na+/H+ antiporter NhaA in its native conformation.

Screpanti E, Padan E, Rimon A, Michel H, Hunte C.

J Mol Biol. 2006 Sep 15;362(2):192-202. Epub 2006 Jul 15.

PMID:
16919297
38.

Multiconformation continuum electrostatics analysis of the NhaA Na+/H+ antiporter of Escherichia coli with functional implications.

Olkhova E, Hunte C, Screpanti E, Padan E, Michel H.

Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2629-34. Epub 2006 Feb 13.

39.

Alkaline pH homeostasis in bacteria: new insights.

Padan E, Bibi E, Ito M, Krulwich TA.

Biochim Biophys Acta. 2005 Nov 30;1717(2):67-88. Epub 2005 Sep 26. Review.

40.

Kinetics of charge translocation in the passive downhill uptake mode of the Na+/H+ antiporter NhaA of Escherichia coli.

Zuber D, Krause R, Venturi M, Padan E, Bamberg E, Fendler K.

Biochim Biophys Acta. 2005 Sep 30;1709(3):240-50.

41.

Structure of a Na+/H+ antiporter and insights into mechanism of action and regulation by pH.

Hunte C, Screpanti E, Venturi M, Rimon A, Padan E, Michel H.

Nature. 2005 Jun 30;435(7046):1197-202.

PMID:
15988517
42.

Do physiological roles foster persistence of drug/multidrug-efflux transporters? A case study.

Krulwich TA, Lewinson O, Padan E, Bibi E.

Nat Rev Microbiol. 2005 Jul;3(7):566-72. Review.

PMID:
15953929
43.

Assessing oligomerization of membrane proteins by four-pulse DEER: pH-dependent dimerization of NhaA Na+/H+ antiporter of E. coli.

Hilger D, Jung H, Padan E, Wegener C, Vogel KP, Steinhoff HJ, Jeschke G.

Biophys J. 2005 Aug;89(2):1328-38. Epub 2005 May 13.

44.

2-Aminoperimidine, a specific inhibitor of bacterial NhaA Na(+)/H(+) antiporters.

Dibrov P, Rimon A, Dzioba J, Winogrodzki A, Shalitin Y, Padan E.

FEBS Lett. 2005 Jan 17;579(2):373-8.

45.

Alkalitolerance: a biological function for a multidrug transporter in pH homeostasis.

Lewinson O, Padan E, Bibi E.

Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14073-8. Epub 2004 Sep 15.

46.

NhaA of Escherichia coli, as a model of a pH-regulated Na+/H+antiporter.

Padan E, Tzubery T, Herz K, Kozachkov L, Rimon A, Galili L.

Biochim Biophys Acta. 2004 Jul 23;1658(1-2):2-13. Review.

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