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Items: 37

1.

WWOX somatic ablation in skeletal muscles alters glucose metabolism.

Abu-Remaileh M, Abu-Remaileh M, Akkawi R, Knani I, Udi S, Pacold ME, Tam J, Aqeilan RI.

Mol Metab. 2019 Apr;22:132-140. doi: 10.1016/j.molmet.2019.01.010. Epub 2019 Jan 31.

2.

SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism.

Kory N, Wyant GA, Prakash G, Uit de Bos J, Bottanelli F, Pacold ME, Chan SH, Lewis CA, Wang T, Keys HR, Guo YE, Sabatini DM.

Science. 2018 Nov 16;362(6416). pii: eaat9528. doi: 10.1126/science.aat9528.

3.

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.

Rohde JM, Brimacombe KR, Liu L, Pacold ME, Yasgar A, Cheff DM, Lee TD, Rai G, Baljinnyam B, Li Z, Simeonov A, Hall MD, Shen M, Sabatini DM, Boxer MB.

Bioorg Med Chem. 2018 May 1;26(8):1727-1739. doi: 10.1016/j.bmc.2018.02.016. Epub 2018 Feb 27.

4.

PIK3CA mutant tumors depend on oxoglutarate dehydrogenase.

Ilic N, Birsoy K, Aguirre AJ, Kory N, Pacold ME, Singh S, Moody SE, DeAngelo JD, Spardy NA, Freinkman E, Weir BA, Tsherniak A, Cowley GS, Root DE, Asara JM, Vazquez F, Widlund HR, Sabatini DM, Hahn WC.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):E3434-E3443. doi: 10.1073/pnas.1617922114. Epub 2017 Apr 10.

5.

Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.

Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu MR, Shaul YD, Liu CM, Zhou M, Koh MJ, Chung H, Davidson SM, Luengo A, Wang AQ, Xu X, Yasgar A, Liu L, Rai G, Westover KD, Heiden MG, Shen M, Gray NS, Boxer MB, Sabatini DM.

Nat Chem Biol. 2016 Jul 19;12(8):656. doi: 10.1038/nchembio0816-656. No abstract available.

PMID:
27434767
6.

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.

Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu-Remaileh M, Shaul YD, Liu CM, Zhou M, Koh MJ, Chung H, Davidson SM, Luengo A, Wang AQ, Xu X, Yasgar A, Liu L, Rai G, Westover KD, Vander Heiden MG, Shen M, Gray NS, Boxer MB, Sabatini DM.

Nat Chem Biol. 2016 Jun;12(6):452-8. doi: 10.1038/nchembio.2070. Epub 2016 Apr 25. Erratum in: Nat Chem Biol. 2016 Jul 19;12 (8):656.

7.

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway.

Saxton RA, Knockenhauer KE, Wolfson RL, Chantranupong L, Pacold ME, Wang T, Schwartz TU, Sabatini DM.

Science. 2016 Jan 1;351(6268):53-8. doi: 10.1126/science.aad2087. Epub 2015 Nov 19.

8.

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.

Kim D, Fiske BP, Birsoy K, Freinkman E, Kami K, Possemato RL, Chudnovsky Y, Pacold ME, Chen WW, Cantor JR, Shelton LM, Gui DY, Kwon M, Ramkissoon SH, Ligon KL, Kang SW, Snuderl M, Vander Heiden MG, Sabatini DM.

Nature. 2015 Apr 16;520(7547):363-7. doi: 10.1038/nature14363. Epub 2015 Apr 8.

9.

Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition.

Shaul YD, Freinkman E, Comb WC, Cantor JR, Tam WL, Thiru P, Kim D, Kanarek N, Pacold ME, Chen WW, Bierie B, Possemato R, Reinhardt F, Weinberg RA, Yaffe MB, Sabatini DM.

Cell. 2014 Aug 28;158(5):1094-1109. doi: 10.1016/j.cell.2014.07.032.

10.

Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites.

Schwartz S, Mumbach MR, Jovanovic M, Wang T, Maciag K, Bushkin GG, Mertins P, Ter-Ovanesyan D, Habib N, Cacchiarelli D, Sanjana NE, Freinkman E, Pacold ME, Satija R, Mikkelsen TS, Hacohen N, Zhang F, Carr SA, Lander ES, Regev A.

Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.

11.

Incidence and prevalence of intrasubtype HIV-1 dual infection in at-risk men in the United States.

Wagner GA, Pacold ME, Kosakovsky Pond SL, Caballero G, Chaillon A, Rudolph AE, Morris SR, Little SJ, Richman DD, Smith DM.

J Infect Dis. 2014 Apr 1;209(7):1032-8. doi: 10.1093/infdis/jit633. Epub 2013 Nov 22. Erratum in: J Infect Dis. 2014 Oct 1;210(7):1166.

12.

Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor.

Lim SM, Westover KD, Ficarro SB, Harrison RA, Choi HG, Pacold ME, Carrasco M, Hunter J, Kim ND, Xie T, Sim T, Jänne PA, Meyerson M, Marto JA, Engen JR, Gray NS.

Angew Chem Int Ed Engl. 2014 Jan 3;53(1):199-204. doi: 10.1002/anie.201307387. Epub 2013 Nov 20.

13.

Dynamics of viral evolution and neutralizing antibody response after HIV-1 superinfection.

Chaillon A, Wagner GA, Hepler NL, Little SJ, Kosakovsky Pond SL, Caballero G, Pacold ME, Phung P, Wrin T, Richman DD, Wertheim JO, Smith DM.

J Virol. 2013 Dec;87(23):12737-44. doi: 10.1128/JVI.02260-13. Epub 2013 Sep 18.

14.

mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin.

Kang SA, Pacold ME, Cervantes CL, Lim D, Lou HJ, Ottina K, Gray NS, Turk BE, Yaffe MB, Sabatini DM.

Science. 2013 Jul 26;341(6144):1236566. doi: 10.1126/science.1236566.

15.

HIV-1 clade B pol evolution following primary infection.

Hightower GK, May SJ, Pérez-Santiago J, Pacold ME, Wagner GA, Little SJ, Richman DD, Mehta SR, Smith DM, Pond SL.

PLoS One. 2013 Jun 28;8(6):e68188. doi: 10.1371/journal.pone.0068188. Print 2013.

16.

The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.

Floyd SR, Pacold ME, Huang Q, Clarke SM, Lam FC, Cannell IG, Bryson BD, Rameseder J, Lee MJ, Blake EJ, Fydrych A, Ho R, Greenberger BA, Chen GC, Maffa A, Del Rosario AM, Root DE, Carpenter AE, Hahn WC, Sabatini DM, Chen CC, White FM, Bradner JE, Yaffe MB.

Nature. 2013 Jun 13;498(7453):246-50. doi: 10.1038/nature12147. Epub 2013 Jun 2.

17.

Using ultradeep pyrosequencing to study HIV-1 coreceptor usage in primary and dual infection.

Wagner GA, Pacold ME, Vigil E, Caballero G, Morris SR, Kosakovsky Pond SL, Little SJ, Richman DD, Gianella S, Smith DM.

J Infect Dis. 2013 Jul 15;208(2):271-4. doi: 10.1093/infdis/jit168. Epub 2013 Apr 18.

18.

Revival of the abandoned therapeutic wortmannin by nanoparticle drug delivery.

Karve S, Werner ME, Sukumar R, Cummings ND, Copp JA, Wang EC, Li C, Sethi M, Chen RC, Pacold ME, Wang AZ.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):8230-5. doi: 10.1073/pnas.1120508109. Epub 2012 Apr 30.

19.

Clinical, virologic, and immunologic correlates of HIV-1 intraclade B dual infection among men who have sex with men.

Pacold ME, Pond SL, Wagner GA, Delport W, Bourque DL, Richman DD, Little SJ, Smith DM.

AIDS. 2012 Jan 14;26(2):157-65. doi: 10.1097/QAD.0b013e32834dcd26.

20.

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.

Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S, Woo HK, Jang HG, Jha AK, Chen WW, Barrett FG, Stransky N, Tsun ZY, Cowley GS, Barretina J, Kalaany NY, Hsu PP, Ottina K, Chan AM, Yuan B, Garraway LA, Root DE, Mino-Kenudson M, Brachtel EF, Driggers EM, Sabatini DM.

Nature. 2011 Aug 18;476(7360):346-50. doi: 10.1038/nature10350.

21.

Detection of minority resistance during early HIV-1 infection: natural variation and spurious detection rather than transmission and evolution of multiple viral variants.

Gianella S, Delport W, Pacold ME, Young JA, Choi JY, Little SJ, Richman DD, Kosakovsky Pond SL, Smith DM.

J Virol. 2011 Aug;85(16):8359-67. doi: 10.1128/JVI.02582-10. Epub 2011 Jun 1.

22.

Protease polymorphisms in HIV-1 subtype CRF01_AE represent selection by antiretroviral therapy and host immune pressure.

Manosuthi W, Butler DM, Pérez-Santiago J, Poon AF, Pillai SK, Mehta SR, Pacold ME, Richman DD, Pond SK, Smith DM.

AIDS. 2010 Jan 28;24(3):411-6. doi: 10.1097/QAD.0b013e3283350eef.

23.

The efficiency of single genome amplification and sequencing is improved by quantitation and use of a bioinformatics tool.

Butler DM, Pacold ME, Jordan PS, Richman DD, Smith DM.

J Virol Methods. 2009 Dec;162(1-2):280-3. doi: 10.1016/j.jviromet.2009.08.002. Epub 2009 Aug 19.

24.

A public health model for the molecular surveillance of HIV transmission in San Diego, California.

Smith DM, May SJ, Tweeten S, Drumright L, Pacold ME, Kosakovsky Pond SL, Pesano RL, Lie YS, Richman DD, Frost SD, Woelk CH, Little SJ.

AIDS. 2009 Jan 14;23(2):225-32. doi: 10.1097/QAD.0b013e32831d2a81.

25.

Slow self-activation enhances the potency of viridin prodrugs.

Blois J, Yuan H, Smith A, Pacold ME, Weissleder R, Cantley LC, Josephson L.

J Med Chem. 2008 Aug 14;51(15):4699-707. doi: 10.1021/jm800374f. Epub 2008 Jul 17.

26.

Herpes simplex virus type 2 acquisition during recent HIV infection does not influence plasma HIV levels.

Cachay ER, Frost SD, Poon AF, Looney D, Rostami SM, Pacold ME, Richman DD, Little SJ, Smith DM.

J Acquir Immune Defic Syndr. 2008 Apr 15;47(5):592-6. doi: 10.1097/QAI.0b013e318163bd87.

27.

Sodium channel auxiliary subunits.

Tseng TT, McMahon AM, Johnson VT, Mangubat EZ, Zahm RJ, Pacold ME, Jakobsson E.

J Mol Microbiol Biotechnol. 2007;12(3-4):249-62. Review.

PMID:
17587873
28.

Calcium channel auxiliary subunits.

Tseng TT, McMahon AM, Zahm RJ, Pacold ME, Jakobsson E.

J Mol Microbiol Biotechnol. 2006;11(6):326-44. Review.

PMID:
17114897
29.

Using a small molecule inhibitor of peptide: N-glycanase to probe its role in glycoprotein turnover.

Misaghi S, Pacold ME, Blom D, Ploegh HL, Korbel GA.

Chem Biol. 2004 Dec;11(12):1677-87.

30.

The role of phosphoinositides and phosphorylation in regulation of NADPH oxidase.

Perisic O, Wilson MI, Karathanassis D, Bravo J, Pacold ME, Ellson CD, Hawkins PT, Stephens L, Williams RL.

Adv Enzyme Regul. 2004;44:279-98. Review. No abstract available.

PMID:
15581496
31.

Yeast N-glycanase distinguishes between native and non-native glycoproteins.

Hirsch C, Misaghi S, Blom D, Pacold ME, Ploegh HL.

EMBO Rep. 2004 Feb;5(2):201-6. Epub 2004 Jan 9.

32.

Identification of domain required for catalytic activity of auxilin in supporting clathrin uncoating by Hsc70.

Ma Y, Greener T, Pacold ME, Kaushal S, Greene LE, Eisenberg E.

J Biol Chem. 2002 Dec 20;277(51):49267-74. Epub 2002 Oct 10.

33.

The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate.

Bravo J, Karathanassis D, Pacold CM, Pacold ME, Ellson CD, Anderson KE, Butler PJ, Lavenir I, Perisic O, Hawkins PT, Stephens L, Williams RL.

Mol Cell. 2001 Oct;8(4):829-39.

34.

Brakes and gas pedals. Meeting: Spetses 2000, molecular mechanisms of development and disease.

Clapier CR, de Boer J, Pacold ME, Tamme R, van Dinten LC.

EMBO Rep. 2001 Jul;2(7):563-7. No abstract available.

35.

Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma.

Pacold ME, Suire S, Perisic O, Lara-Gonzalez S, Davis CT, Walker EH, Hawkins PT, Stephens L, Eccleston JF, Williams RL.

Cell. 2000 Dec 8;103(6):931-43.

36.

Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine.

Walker EH, Pacold ME, Perisic O, Stephens L, Hawkins PT, Wymann MP, Williams RL.

Mol Cell. 2000 Oct;6(4):909-19.

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