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Resolution of Cellular Heterogeneity in Human Prostate Cancers: Implications for Diagnosis and Treatment.

Maitland NJ, Frame FM, Rane JK, Erb HH, Packer JR, Archer LK, Pellacani D.

Adv Exp Med Biol. 2019;1164:207-224. doi: 10.1007/978-3-030-22254-3_16. Review.


A lineage-resolved molecular atlas of C. elegans embryogenesis at single-cell resolution.

Packer JS, Zhu Q, Huynh C, Sivaramakrishnan P, Preston E, Dueck H, Stefanik D, Tan K, Trapnell C, Kim J, Waterston RH, Murray JI.

Science. 2019 Sep 20;365(6459). pii: eaax1971. doi: 10.1126/science.aax1971. Epub 2019 Sep 5.


Notch signalling is a potential resistance mechanism of progenitor cells within patient-derived prostate cultures following ROS-inducing treatments.

Packer JR, Hirst AM, Droop AP, Adamson R, Simms MS, Mann VM, Frame FM, O'Connell D, Maitland NJ.

FEBS Lett. 2019 Aug 30. doi: 10.1002/1873-3468.13589. [Epub ahead of print]


Outcomes of Anterior Cruciate Ligament Reconstruction in Obese and Overweight Patients: A Systematic Review.

DiSilvestro KJ, Jauregui JJ, Glazier E, Cherkalin D, Bennett CH, Packer JD, Henn RF 3rd.

Clin J Sport Med. 2019 Jul;29(4):257-261. doi: 10.1097/JSM.0000000000000521.


Thyroid hormone regulates distinct paths to maturation in pigment cell lineages.

Saunders LM, Mishra AK, Aman AJ, Lewis VM, Toomey MB, Packer JS, Qiu X, McFaline-Figueroa JL, Corbo JC, Trapnell C, Parichy DM.

Elife. 2019 May 29;8. pii: e45181. doi: 10.7554/eLife.45181.


Evaluation of Preoperative Pain Using PROMIS Pain Interference in Knee Surgery Patients.

Nadarajah V, Glazier E, Miller K, Jauregui JJ, Smuda MP, Bennett CH, Packer JD, Henn RF 3rd.

J Knee Surg. 2019 May 16. doi: 10.1055/s-0039-1688769. [Epub ahead of print]


Evaluation of the PROMIS Physical Function Computer Adaptive Test in Patients Undergoing Knee Surgery.

Miles M, Nadarajah V, Jauregui JJ, Dubina AG, Smuda MP, Bennett CH, Packer JD, Henn RF 3rd.

J Knee Surg. 2019 May 8. doi: 10.1055/s-0039-1688691. [Epub ahead of print]


The Cliff Sign: A New Radiographic Sign of Hip Instability.

Packer JD, Cowan JB, Rebolledo BJ, Shibata KR, Riley GM, Finlay AK, Safran MR.

Orthop J Sports Med. 2018 Nov 12;6(11):2325967118807176. doi: 10.1177/2325967118807176. eCollection 2018 Nov.


Patients' Use and Perception of Internet-Based Orthopaedic Sports Medicine Resources.

Koenig S, Nadarajah V, Smuda MP, Meredith S, Packer JD, Henn RF 3rd.

Orthop J Sports Med. 2018 Sep 20;6(9):2325967118796469. doi: 10.1177/2325967118796469. eCollection 2018 Sep.


Whole-body net protein balance plateaus in response to increasing protein intakes during post-exercise recovery in adults and adolescents.

Mazzulla M, Volterman KA, Packer JE, Wooding DJ, Brooks JC, Kato H, Moore DR.

Nutr Metab (Lond). 2018 Sep 24;15:62. doi: 10.1186/s12986-018-0301-z. eCollection 2018.


3D printed biofunctionalized scaffolds for microfracture repair of cartilage defects.

Guo T, Noshin M, Baker HB, Taskoy E, Meredith SJ, Tang Q, Ringel JP, Lerman MJ, Chen Y, Packer JD, Fisher JP.

Biomaterials. 2018 Dec;185:219-231. doi: 10.1016/j.biomaterials.2018.09.022. Epub 2018 Sep 14.


Joint profiling of chromatin accessibility and gene expression in thousands of single cells.

Cao J, Cusanovich DA, Ramani V, Aghamirzaie D, Pliner HA, Hill AJ, Daza RM, McFaline-Figueroa JL, Packer JS, Christiansen L, Steemers FJ, Adey AC, Trapnell C, Shendure J.

Science. 2018 Sep 28;361(6409):1380-1385. doi: 10.1126/science.aau0730. Epub 2018 Aug 30.


Orthopaedic surgery patients who use recreational marijuana have less pre-operative pain.

Medina SH, Nadarajah V, Jauregui JJ, Smuda MP, Foster M, Meredith SJ, Packer JD, Henn RF 3rd.

Int Orthop. 2019 Feb;43(2):283-292. doi: 10.1007/s00264-018-4101-x. Epub 2018 Aug 22.


End-of-life Decision-making for People in a Minimally Conscious State: A Review of the Application of the Mental Capacity Act 2005.

Curtice M, Two J, Packer J.

Indian J Palliat Care. 2018 Jul-Sep;24(3):334-344. doi: 10.4103/IJPC.IJPC_215_17.


Cicero Predicts cis-Regulatory DNA Interactions from Single-Cell Chromatin Accessibility Data.

Pliner HA, Packer JS, McFaline-Figueroa JL, Cusanovich DA, Daza RM, Aghamirzaie D, Srivatsan S, Qiu X, Jackson D, Minkina A, Adey AC, Steemers FJ, Shendure J, Trapnell C.

Mol Cell. 2018 Sep 6;71(5):858-871.e8. doi: 10.1016/j.molcel.2018.06.044. Epub 2018 Aug 2.


Single-Cell Multi-omics: An Engine for New Quantitative Models of Gene Regulation.

Packer J, Trapnell C.

Trends Genet. 2018 Sep;34(9):653-665. doi: 10.1016/j.tig.2018.06.001. Epub 2018 Jul 11. Review.


Preoperative Opioid Use in Knee Surgery Patients.

Meredith SJ, Nadarajah V, Jauregui JJ, Smuda MP, Medina SH, Bennett CH, Packer JD, Henn RF 3rd.

J Knee Surg. 2019 Jul;32(7):630-636. doi: 10.1055/s-0038-1666868. Epub 2018 Jul 10.


A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease.

Abul-Husn NS, Cheng X, Li AH, Xin Y, Schurmann C, Stevis P, Liu Y, Kozlitina J, Stender S, Wood GC, Stepanchick AN, Still MD, McCarthy S, O'Dushlaine C, Packer JS, Balasubramanian S, Gosalia N, Esopi D, Kim SY, Mukherjee S, Lopez AE, Fuller ED, Penn J, Chu X, Luo JZ, Mirshahi UL, Carey DJ, Still CD, Feldman MD, Small A, Damrauer SM, Rader DJ, Zambrowicz B, Olson W, Murphy AJ, Borecki IB, Shuldiner AR, Reid JG, Overton JD, Yancopoulos GD, Hobbs HH, Cohen JC, Gottesman O, Teslovich TM, Baras A, Mirshahi T, Gromada J, Dewey FE.

N Engl J Med. 2018 Mar 22;378(12):1096-1106. doi: 10.1056/NEJMoa1712191.


The Use of Vibrational Energy to Isolate Adipose-Derived Stem Cells.

Packer JD, Chang WT, Dragoo JL.

Plast Reconstr Surg Glob Open. 2018 Jan 11;6(1):e1620. doi: 10.1097/GOX.0000000000001620. eCollection 2018 Jan.


On the design of CRISPR-based single-cell molecular screens.

Hill AJ, McFaline-Figueroa JL, Starita LM, Gasperini MJ, Matreyek KA, Packer J, Jackson D, Shendure J, Trapnell C.

Nat Methods. 2018 Apr;15(4):271-274. doi: 10.1038/nmeth.4604. Epub 2018 Feb 19.


Applying Attention Restoration Theory to Understand and Address Clergy's Need to Restore Cognitive Capacity.

Gill C, Packer J, Ballantyne R.

J Relig Health. 2018 Oct;57(5):1779-1792. doi: 10.1007/s10943-018-0571-9.


Variable-Intensity Simulated Team-Sport Exercise Increases Daily Protein Requirements in Active Males.

Packer JE, Wooding DJ, Kato H, Courtney-Martin G, Pencharz PB, Moore DR.

Front Nutr. 2017 Dec 21;4:64. doi: 10.3389/fnut.2017.00064. eCollection 2017.


Ibuprofen impairs capsulolabral healing in a rat model of anterior glenohumeral instability.

Packer JD, Varthi AG, Zhu DS, Javier FG, Young JD, Garver JV, Henry H, Tommasini SM, Blaine TA.

J Shoulder Elbow Surg. 2018 Feb;27(2):315-324. doi: 10.1016/j.jse.2017.09.027. Epub 2017 Nov 29.


Outcomes of Anterior Cruciate Ligament Reconstruction in Obese and Overweight Patients: A Systematic Review.

DiSilvestro KJ, Jauregui JJ, Glazier E, Cherkalin D, Bennett CH, Packer JD, Henn RF 3rd.

Clin J Sport Med. 2017 Nov 20. doi: 10.1097/JSM.0000000000000521. [Epub ahead of print]


Comprehensive single-cell transcriptional profiling of a multicellular organism.

Cao J, Packer JS, Ramani V, Cusanovich DA, Huynh C, Daza R, Qiu X, Lee C, Furlan SN, Steemers FJ, Adey A, Waterston RH, Trapnell C, Shendure J.

Science. 2017 Aug 18;357(6352):661-667. doi: 10.1126/science.aam8940.


How Should We Secure Our Transplanted Meniscus? A Meta-analysis.

Jauregui JJ, Wu ZD, Meredith S, Griffith C, Packer JD, Henn RF 3rd.

Am J Sports Med. 2018 Jul;46(9):2285-2290. doi: 10.1177/0363546517720183. Epub 2017 Aug 17.


Increased Protein Requirements in Female Athletes after Variable-Intensity Exercise.

Wooding DJ, Packer JE, Kato H, West DWD, Courtney-Martin G, Pencharz PB, Moore DR.

Med Sci Sports Exerc. 2017 Nov;49(11):2297-2304. doi: 10.1249/MSS.0000000000001366.


Single-cell mRNA quantification and differential analysis with Census.

Qiu X, Hill A, Packer J, Lin D, Ma YA, Trapnell C.

Nat Methods. 2017 Mar;14(3):309-315. doi: 10.1038/nmeth.4150. Epub 2017 Jan 23.


Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study.

Dewey FE, Murray MF, Overton JD, Habegger L, Leader JB, Fetterolf SN, O'Dushlaine C, Van Hout CV, Staples J, Gonzaga-Jauregui C, Metpally R, Pendergrass SA, Giovanni MA, Kirchner HL, Balasubramanian S, Abul-Husn NS, Hartzel DN, Lavage DR, Kost KA, Packer JS, Lopez AE, Penn J, Mukherjee S, Gosalia N, Kanagaraj M, Li AH, Mitnaul LJ, Adams LJ, Person TN, Praveen K, Marcketta A, Lebo MS, Austin-Tse CA, Mason-Suares HM, Bruse S, Mellis S, Phillips R, Stahl N, Murphy A, Economides A, Skelding KA, Still CD, Elmore JR, Borecki IB, Yancopoulos GD, Davis FD, Faucett WA, Gottesman O, Ritchie MD, Shuldiner AR, Reid JG, Ledbetter DH, Baras A, Carey DJ.

Science. 2016 Dec 23;354(6319). pii: aaf6814. doi: 10.1126/science.aaf6814.


Impact of Isometric Contraction of Anterior Cervical Muscles on Cervical Lordosis.

Fedorchuk CA, McCoy M, Lightstone DF, Bak DA, Moser J, Kubricht B, Packer J, Walton D, Binongo J.

J Radiol Case Rep. 2016 Sep 30;10(9):13-25. eCollection 2016 Sep.


Intersystem Implications of the Developmental Origins of Health and Disease: Advancing Health Promotion in the 21st Century.

Barnes MD, Heaton TL, Goates MC, Packer JM.

Healthcare (Basel). 2016 Jul 15;4(3). pii: E45. doi: 10.3390/healthcare4030045.


Comparative Population Genetic Structure of the Endangered Southern Brown Bandicoot, Isoodon obesulus, in Fragmented Landscapes of Southern Australia.

Li Y, Cooper SJ, Lancaster ML, Packer JG, Carthew SM.

PLoS One. 2016 Apr 20;11(4):e0152850. doi: 10.1371/journal.pone.0152850. eCollection 2016.


The etiology of primary femoroacetabular impingement: genetics or acquired deformity?

Packer JD, Safran MR.

J Hip Preserv Surg. 2015 Jun 18;2(3):249-57. doi: 10.1093/jhps/hnv046. eCollection 2015 Oct. Review.


The molecular and cellular origin of human prostate cancer.

Packer JR, Maitland NJ.

Biochim Biophys Acta. 2016 Jun;1863(6 Pt A):1238-60. doi: 10.1016/j.bbamcr.2016.02.016. Epub 2016 Feb 26. Review.


CLAMMS: a scalable algorithm for calling common and rare copy number variants from exome sequencing data.

Packer JS, Maxwell EK, O'Dushlaine C, Lopez AE, Dewey FE, Chernomorsky R, Baras A, Overton JD, Habegger L, Reid JG.

Bioinformatics. 2016 Jan 1;32(1):133-5. doi: 10.1093/bioinformatics/btv547. Epub 2015 Sep 17.


Antimicrobial activity of customary medicinal plants of the Yaegl Aboriginal community of northern New South Wales, Australia: a preliminary study.

Packer J, Naz T; Yaegl Community Elders, Harrington D, Jamie JF, Vemulpad SR.

BMC Res Notes. 2015 Jun 30;8:276. doi: 10.1186/s13104-015-1258-x.


A Case-matched Comparative Study of Laparoscopic Versus Open Distal Pancreatectomy.

Khaled YS, Malde DJ, Packer J, De Liguori Carino N, Deshpande R, O'Reilly DA, Sherlock DJ, Ammori BJ.

Surg Laparosc Endosc Percutan Tech. 2015 Aug;25(4):363-7. doi: 10.1097/SLE.0000000000000179.


Bioactivity and chemical characterisation of Lophostemon suaveolens--an endemic Australian Aboriginal traditional medicinal plant.

Naz T, Packer J, Yin P, Brophy JJ, Wohlmuth H, Renshaw DE, Smith J, Elders YC, Vemulpad SR, Jamie JF.

Nat Prod Res. 2016;30(6):693-6. doi: 10.1080/14786419.2015.1038260. Epub 2015 May 5.


An online spatial database of Australian Indigenous Biocultural Knowledge for contemporary natural and cultural resource management.

Pert PL, Ens EJ, Locke J, Clarke PA, Packer JM, Turpin G.

Sci Total Environ. 2015 Nov 15;534:110-21. doi: 10.1016/j.scitotenv.2015.01.073. Epub 2015 Feb 11.


Laparoscopic versus open cystgastrostomy for pancreatic pseudocysts: a case-matched comparative study.

Khaled YS, Malde DJ, Packer J, Fox T, Laftsidis P, Ajala-Agbo T, De Liguori Carino N, Deshpande R, O'Reilly DA, Sherlock DJ, Ammori BJ.

J Hepatobiliary Pancreat Sci. 2014 Nov;21(11):818-23. doi: 10.1002/jhbp.138. Epub 2014 Jul 31.


Effect of immediate and delayed high-strain loading on tendon-to-bone healing after anterior cruciate ligament reconstruction.

Packer JD, Bedi A, Fox AJ, Gasinu S, Imhauser CW, Stasiak M, Deng XH, Rodeo SA.

J Bone Joint Surg Am. 2014 May 7;96(9):770-7. doi: 10.2106/JBJS.L.01354.


Recovery coaching in an acute older people rehabiliation ward.

Kibble S, Gray D, Prat-Sala M, Ross K, Johnson K, Packer J, Shire E, Cross R, Harden B.

BMJ Qual Improv Rep. 2014 Oct 16;3(1). pii: u205646.w2316. doi: 10.1136/bmjquality.u205646.w2316. eCollection 2014.


The effect of sonophoresis on topical anesthesia: a pilot project.

Packer JL, Krall B, Makki A, Torabinejad M.

Anesth Prog. 2013 Summer;60(2):37-41. doi: 10.2344/0003-3006-60.2.37.


Shoulder and elbow arthroplasty in younger patients.

Packer JD, Blaine TA.

Phys Sportsmed. 2013 Feb;41(1):40-8. doi: 10.3810/psm.2013.02.1998. Review.


Functional outcomes and patient satisfaction after fasciotomy for chronic exertional compartment syndrome.

Packer JD, Day MS, Nguyen JT, Hobart SJ, Hannafin JA, Metzl JD.

Am J Sports Med. 2013 Feb;41(2):430-6. doi: 10.1177/0363546512471330.


Early LQT2 nonsense mutation generates N-terminally truncated hERG channels with altered gating properties by the reinitiation of translation.

Stump MR, Gong Q, Packer JD, Zhou Z.

J Mol Cell Cardiol. 2012 Nov;53(5):725-33. doi: 10.1016/j.yjmcc.2012.08.021. Epub 2012 Sep 3.


Deliberate self-harm and the elderly: a volatile combination-an overview from the plastic surgery perspective.

Packer J, Hussain MA, Shah SH, Srinivasan JR.

Plast Surg Int. 2012;2012:740378. doi: 10.1155/2012/740378. Epub 2012 Jun 19.


Specific non-peroxide antibacterial effect of manuka honey on the Staphylococcus aureus proteome.

Packer JM, Irish J, Herbert BR, Hill C, Padula M, Blair SE, Carter DA, Harry EJ.

Int J Antimicrob Agents. 2012 Jul;40(1):43-50. doi: 10.1016/j.ijantimicag.2012.03.012. Epub 2012 May 11.


Dilator-assisted banding for managing complications associated with excessive hemodialysis access flow.

Wang S, Almehmi A, Packer J.

Semin Dial. 2013 Jan-Feb;26(1):100-5. doi: 10.1111/j.1525-139X.2012.01082.x. Epub 2012 Apr 30.


An ethnobotanical study of medicinal plants used by the Yaegl Aboriginal community in northern New South Wales, Australia.

Packer J, Brouwer N, Harrington D, Gaikwad J, Heron R, Yaegl Community Elders, Ranganathan S, Vemulpad S, Jamie J.

J Ethnopharmacol. 2012 Jan 6;139(1):244-55. doi: 10.1016/j.jep.2011.11.008. Epub 2011 Nov 11.


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