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Items: 1 to 50 of 105

1.

Chlorogenic acid activates ERK1/2 and inhibits proliferation of osteosarcoma cells.

Sapio L, Salzillo A, Illiano M, Ragone A, Spina A, Chiosi E, Pacifico S, Catauro M, Naviglio S.

J Cell Physiol. 2019 Oct 10. doi: 10.1002/jcp.29269. [Epub ahead of print]

PMID:
31602671
2.

UHPLC-HR-MS/MS-Guided Recovery of Bioactive Flavonol Compounds from Greco di Tufo Vine Leaves.

Piccolella S, Crescente G, Volpe MG, Paolucci M, Pacifico S.

Molecules. 2019 Oct 8;24(19). pii: E3630. doi: 10.3390/molecules24193630.

3.

Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth.

Pacifico S, Santucci M, Luciani R, Saxena P, Linciano P, Ponterini G, Lauriola A, D'Arca D, Marverti G, Guerrini R, Costi MP.

Molecules. 2019 Sep 26;24(19). pii: E3493. doi: 10.3390/molecules24193493.

4.

Antiproliferative and antioxidant effect of polar hemp extracts (Cannabis sativa L., Fedora cv.) in human colorectal cell lines.

Moccia S, Siano F, Russo GL, Volpe MG, La Cara F, Pacifico S, Piccolella S, Picariello G.

Int J Food Sci Nutr. 2019 Sep 23:1-14. doi: 10.1080/09637486.2019.1666804. [Epub ahead of print]

PMID:
31544542
5.

Synthesis of folic acid functionalized gold nanoclusters for targeting folate receptor-positive cells.

Liu Z, Turyanska L, Zamberlan F, Pacifico S, Bradshaw TD, Moro F, Fay MW, Williams HEL, Thomas NR.

Nanotechnology. 2019 Sep 11;30(50):505102. doi: 10.1088/1361-6528/ab437c. [Epub ahead of print]

PMID:
31509807
6.

Tetrabranched Hetero-Conjugated Peptides as Bifunctional Agonists of the NOP and Mu Opioid Receptors.

Pacifico S, Albanese V, Illuminati D, Fantinati A, Marzola E, Ferrari F, Neto JA, Sturaro C, Ruzza C, Calò G, Preti D, Guerrini R.

Bioconjug Chem. 2019 Sep 18;30(9):2444-2451. doi: 10.1021/acs.bioconjchem.9b00519. Epub 2019 Sep 4.

PMID:
31461266
7.

Ageritin from poplar mushrooms: scale-up purification and cytotoxicity towards undifferentiated and differentiated SH-SY5Y cells.

Ragucci S, Pacifico S, Ruocco MR, Crescente G, Nasso R, Simonetti M, Masullo M, Piccolella S, Pedone PV, Landi N, Di Maro A.

Food Funct. 2019 Oct 16;10(10):6342-6350. doi: 10.1039/c9fo01483g.

PMID:
31441483
8.

Modulation of the NOP receptor signaling affects resilience to acute stress.

Holanda VAD, Pacifico S, Azevedo Neto J, Finetti L, Lobão-Soares B, Calo G, Gavioli EC, Ruzza C.

J Psychopharmacol. 2019 Jul 24:269881119864942. doi: 10.1177/0269881119864942. [Epub ahead of print]

PMID:
31337258
9.

Nutraceutical polyphenols: New analytical challenges and opportunities.

Piccolella S, Crescente G, Candela L, Pacifico S.

J Pharm Biomed Anal. 2019 Oct 25;175:112774. doi: 10.1016/j.jpba.2019.07.022. Epub 2019 Jul 15. Review.

PMID:
31336288
10.

A nutraceutical extract from Inula viscosa leaves: UHPLC-HR-MS/MS based polyphenol profile, and antioxidant and cytotoxic activities.

Brahmi-Chendouh N, Piccolella S, Crescente G, Pacifico F, Boulekbache L, Hamri-Zeghichi S, Akkal S, Madani K, Pacifico S.

J Food Drug Anal. 2019 Jul;27(3):692-702. doi: 10.1016/j.jfda.2018.11.006. Epub 2019 Jan 14.

11.

Synthesis and Biological Activity of Peptide α-Ketoamide Derivatives as Proteasome Inhibitors.

Pacifico S, Ferretti V, Albanese V, Fantinati A, Gallerani E, Nicoli F, Gavioli R, Zamberlan F, Preti D, Marastoni M.

ACS Med Chem Lett. 2019 Jun 6;10(7):1086-1092. doi: 10.1021/acsmedchemlett.9b00233. eCollection 2019 Jul 11.

PMID:
31312413
12.

Antagonistic Activity of Naphthoquinone-Based Hybrids toward Amyloids Associated with Alzheimer's Disease and Type-2 Diabetes.

Paul A, Viswanathan GK, Mahapatra S, Balboni G, Pacifico S, Gazit E, Segal D.

ACS Chem Neurosci. 2019 Aug 21;10(8):3510-3520. doi: 10.1021/acschemneuro.9b00123. Epub 2019 Jul 8.

PMID:
31282646
13.

Recovering Cucurbita pepo cv. 'Lungo Fiorentino' Wastes: UHPLC-HRMS/MS Metabolic Profile, the Basis for Establishing Their Nutra- and Cosmeceutical Valorisation.

Piccolella S, Bianco A, Crescente G, Santillo A, Chieffi Baccari G, Pacifico S.

Molecules. 2019 Apr 15;24(8). pii: E1479. doi: 10.3390/molecules24081479.

14.

Chlorogenic acid/PEG-based organic-inorganic hybrids: A versatile sol-gel synthesis route for new bioactive materials.

Catauro M, Barrino F, Poggetto GD, Pacifico F, Piccolella S, Pacifico S.

Mater Sci Eng C Mater Biol Appl. 2019 Jul;100:837-844. doi: 10.1016/j.msec.2019.03.035. Epub 2019 Mar 20.

PMID:
30948121
15.

Indole derivatives as multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity of indole hydrazones.

Demurtas M, Baldisserotto A, Lampronti I, Moi D, Balboni G, Pacifico S, Vertuani S, Manfredini S, Onnis V.

Bioorg Chem. 2019 Apr;85:568-576. doi: 10.1016/j.bioorg.2019.02.007. Epub 2019 Feb 10.

PMID:
30825715
16.

In vitro genotoxic effects of titanium dioxide nanoparticles (n-TiO2 ) in human sperm cells.

Santonastaso M, Mottola F, Colacurci N, Iovine C, Pacifico S, Cammarota M, Cesaroni F, Rocco L.

Mol Reprod Dev. 2019 Feb 25. doi: 10.1002/mrd.23134. [Epub ahead of print]

PMID:
30803093
17.

Chlorogenic Acid Entrapped in Hybrid Materials with High PEG Content: A Strategy to Obtain Antioxidant Functionalized Biomaterials?

Catauro M, Barrino F, Dal Poggetto G, Crescente G, Piccolella S, Pacifico S.

Materials (Basel). 2019 Jan 4;12(1). pii: E148. doi: 10.3390/ma12010148.

18.

Probing the Effect of Sildenafil on Progesterone and Testosterone Production by an Intracellular FRET/BRET Combined Approach.

Casarini L, Riccetti L, Limoncella S, Lazzaretti C, Barbagallo F, Pacifico S, Guerrini R, Tagliavini S, Trenti T, Simoni M, Sola M, Di Rocco G.

Biochemistry. 2019 Feb 12;58(6):799-808. doi: 10.1021/acs.biochem.8b01073. Epub 2018 Dec 21.

PMID:
30532959
19.

New insights into phenol and polyphenol composition of Stevia rebaudiana leaves.

Pacifico S, Piccolella S, Nocera P, Tranquillo E, Dal Poggetto F, Catauro M.

J Pharm Biomed Anal. 2019 Jan 30;163:45-57. doi: 10.1016/j.jpba.2018.09.046. Epub 2018 Sep 28.

PMID:
30286435
20.

pH-Promoted Release of a Novel Anti-Tumour Peptide by "Stealth" Liposomes: Effect of Nanocarriers on the Drug Activity in Cis-Platinum Resistant Cancer Cells.

Sacchetti F, Marverti G, D'Arca D, Severi L, Maretti E, Iannuccelli V, Pacifico S, Ponterini G, Costi MP, Leo E.

Pharm Res. 2018 Sep 12;35(11):206. doi: 10.1007/s11095-018-2489-z.

PMID:
30209680
21.

Structural Characterization of the Lactobacillus Plantarum FlmC Protein Involved in Biofilm Formation.

D'Abrosca G, Paladino A, Cuoco E, Marasco R, Pacifico S, Piccolella S, Vastano V, Sacco M, Isernia C, Muscariello L, Malgieri G.

Molecules. 2018 Sep 4;23(9). pii: E2252. doi: 10.3390/molecules23092252.

22.

Discovery of Novel 1,3,8-Triazaspiro[4.5]decane Derivatives That Target the c Subunit of F1/FO-Adenosine Triphosphate (ATP) Synthase for the Treatment of Reperfusion Damage in Myocardial Infarction.

Morciano G, Preti D, Pedriali G, Aquila G, Missiroli S, Fantinati A, Caroccia N, Pacifico S, Bonora M, Talarico A, Morganti C, Rizzo P, Ferrari R, Wieckowski MR, Campo G, Giorgi C, Trapella C, Pinton P.

J Med Chem. 2018 Aug 23;61(16):7131-7143. doi: 10.1021/acs.jmedchem.8b00278. Epub 2018 Aug 9.

PMID:
30060655
23.

Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth.

Saxena P, Severi L, Santucci M, Taddia L, Ferrari S, Luciani R, Marverti G, Marraccini C, Tondi D, Mor M, Scalvini L, Vitiello S, Losi L, Fonda S, Pacifico S, Guerrini R, D'Arca D, Ponterini G, Costi MP.

J Med Chem. 2018 Aug 23;61(16):7374-7380. doi: 10.1021/acs.jmedchem.7b01699. Epub 2018 Aug 13.

PMID:
30035541
24.

Ultrasound-assisted aqueous extraction, LC-MS/MS analysis and radiomodulating capability of autochthonous Italian sweet cherry fruits.

Piccolella S, Crescente G, Nocera P, Pacifico F, Manti L, Pacifico S.

Food Funct. 2018 Mar 1;9(3):1840-1849. doi: 10.1039/c7fo01977g. Epub 2018 Mar 8.

PMID:
29517778
25.

Ferucarbotran-loaded red blood cells as long circulating MRI contrast agents: first in vivo results in mice.

Antonelli A, Pacifico S, Sfara C, Tamma M, Magnani M.

Nanomedicine (Lond). 2018 Apr 1;13(7):675-687. doi: 10.2217/nnm-2017-0339. Epub 2018 Feb 28.

PMID:
29488423
26.

Study of SH-SY5Y Cancer Cell Response to Treatment with Polyphenol Extracts Using FT-IR Spectroscopy.

Ricciardi V, Portaccio M, Piccolella S, Manti L, Pacifico S, Lepore M.

Biosensors (Basel). 2017 Nov 30;7(4). pii: E57. doi: 10.3390/bios7040057.

27.

Fluorometric detection of protein-ligand engagement: The case of phosphodiesterase5.

Di Rocco G, Martinelli I, Pacifico S, Guerrini R, Cichero E, Fossa P, Franchini S, Cardarelli S, Giorgi M, Sola M, Ponterini G.

J Pharm Biomed Anal. 2018 Feb 5;149:335-342. doi: 10.1016/j.jpba.2017.11.014. Epub 2017 Nov 11.

PMID:
29132113
28.

Peptide welding technology - A simple strategy for generating innovative ligands for G protein coupled receptors.

Calo' G, Rizzi A, Ruzza C, Ferrari F, Pacifico S, Gavioli EC, Salvadori S, Guerrini R.

Peptides. 2018 Jan;99:195-204. doi: 10.1016/j.peptides.2017.10.004. Epub 2017 Oct 13. Review.

PMID:
29031796
29.

Synthesis of Bioactive Chlorogenic Acid-Silica Hybrid Materials via the Sol-Gel Route and Evaluation of Their Biocompatibility.

Catauro M, Pacifico S.

Materials (Basel). 2017 Jul 21;10(7). pii: E840. doi: 10.3390/ma10070840.

30.

Activation of nociceptin/orphanin FQ receptors inhibits contextual fear memory reconsolidation.

Rekik K, Faria Da Silva R, Colom M, Pacifico S, Zaveri NT, Calo' G, Rampon C, Frances B, Mouledous L.

Neuropharmacology. 2017 Oct;125:39-49. doi: 10.1016/j.neuropharm.2017.07.006. Epub 2017 Jul 10.

PMID:
28705439
31.

A diastereoselective synthesis of Cebranopadol, a novel analgesic showing NOP/mu mixed agonism.

Fantinati A, Bianco S, Guerrini R, Salvadori S, Pacifico S, Cerlesi MC, Calo G, Trapella C.

Sci Rep. 2017 May 25;7(1):2416. doi: 10.1038/s41598-017-02502-9.

32.

Urotensin-II peptidomimetic incorporating a non-reducible 1,5-triazole disulfide bond reveals a pseudo-irreversible covalent binding mechanism to the urotensin G-protein coupled receptor.

Pacifico S, Kerckhoffs A, Fallow AJ, Foreman RE, Guerrini R, McDonald J, Lambert DG, Jamieson AG.

Org Biomol Chem. 2017 May 31;15(21):4704-4710. doi: 10.1039/c7ob00959c.

PMID:
28524918
33.

Pioppino mushroom in southern Italy: an undervalued source of nutrients and bioactive compounds.

Landi N, Pacifico S, Ragucci S, Di Giuseppe AM, Iannuzzi F, Zarrelli A, Piccolella S, Di Maro A.

J Sci Food Agric. 2017 Dec;97(15):5388-5397. doi: 10.1002/jsfa.8428. Epub 2017 Jun 13.

PMID:
28503801
34.

Structure- and conformation-activity studies of nociceptin/orphanin FQ receptor dimeric ligands.

Pacifico S, Carotenuto A, Brancaccio D, Novellino E, Marzola E, Ferrari F, Cerlesi MC, Trapella C, Preti D, Salvadori S, Calò G, Guerrini R.

Sci Rep. 2017 Apr 6;7:45817. doi: 10.1038/srep45817.

35.

Purification, characterization and cytotoxicity assessment of Ageritin: The first ribotoxin from the basidiomycete mushroom Agrocybe aegerita.

Landi N, Pacifico S, Ragucci S, Iglesias R, Piccolella S, Amici A, Di Giuseppe AMA, Di Maro A.

Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt A):1113-1121. doi: 10.1016/j.bbagen.2017.02.023. Epub 2017 Feb 20.

PMID:
28232091
36.

Conveying a newly designed hydrophilic anti-human thymidylate synthase peptide to cisplatin resistant cancer cells: are pH-sensitive liposomes more effective than conventional ones?

Sacchetti F, D'Arca D, Genovese F, Pacifico S, Maretti E, Hanuskova M, Iannuccelli V, Costi MP, Leo E.

Drug Dev Ind Pharm. 2017 Mar;43(3):465-473. doi: 10.1080/03639045.2016.1262870. Epub 2016 Dec 26.

PMID:
27885848
37.

Neuropeptide S receptor ligands: a patent review (2005-2016).

Ruzza C, Calò G, Di Maro S, Pacifico S, Trapella C, Salvadori S, Preti D, Guerrini R.

Expert Opin Ther Pat. 2017 Mar;27(3):347-362. doi: 10.1080/13543776.2017.1254195. Epub 2016 Nov 9. Review.

PMID:
27788040
38.

Durum wheat seedling responses to simultaneous high light and salinity involve a fine reconfiguration of amino acids and carbohydrate metabolism.

Woodrow P, Ciarmiello LF, Annunziata MG, Pacifico S, Iannuzzi F, Mirto A, D'Amelia L, Dell'Aversana E, Piccolella S, Fuggi A, Carillo P.

Physiol Plant. 2017 Mar;159(3):290-312. doi: 10.1111/ppl.12513. Epub 2016 Oct 19.

PMID:
27653956
39.

Entrapping quercetin in silica/polyethylene glycol hybrid materials: Chemical characterization and biocompatibility.

Catauro M, Bollino F, Nocera P, Piccolella S, Pacifico S.

Mater Sci Eng C Mater Biol Appl. 2016 Nov 1;68:205-212. doi: 10.1016/j.msec.2016.05.082. Epub 2016 May 19.

PMID:
27524014
40.

An apolar Pistacia lentiscus L. leaf extract: GC-MS metabolic profiling and evaluation of cytotoxicity and apoptosis inducing effects on SH-SY5Y and SK-N-BE(2)C cell lines.

Piccolella S, Nocera P, Carillo P, Woodrow P, Greco V, Manti L, Fiorentino A, Pacifico S.

Food Chem Toxicol. 2016 Sep;95:64-74. doi: 10.1016/j.fct.2016.06.028. Epub 2016 Jun 29.

PMID:
27375189
41.

Intracellular quantitative detection of human thymidylate synthase engagement with an unconventional inhibitor using tetracysteine-diarsenical-probe technology.

Ponterini G, Martello A, Pavesi G, Lauriola A, Luciani R, Santucci M, Pelà M, Gozzi G, Pacifico S, Guerrini R, Marverti G, Costi MP, D'Arca D.

Sci Rep. 2016 Jun 2;6:27198. doi: 10.1038/srep27198.

42.

Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones.

Onnis V, Demurtas M, Deplano A, Balboni G, Baldisserotto A, Manfredini S, Pacifico S, Liekens S, Balzarini J.

Molecules. 2016 Apr 30;21(5). pii: E579. doi: 10.3390/molecules21050579.

43.

Influence of harvest season on chemical composition and bioactivity of wild rue plant hydroalcoholic extracts.

Pacifico S, Piccolella S, Galasso S, Fiorentino A, Kretschmer N, Pan SP, Bauer R, Monaco P.

Food Chem Toxicol. 2016 Apr;90:102-11. doi: 10.1016/j.fct.2016.02.009. Epub 2016 Feb 13.

PMID:
26879584
44.

Sol-gel synthesis and characterization of SiO2/PCL hybrid materials containing quercetin as new materials for antioxidant implants.

Catauro M, Bollino F, Papale F, Piccolella S, Pacifico S.

Mater Sci Eng C Mater Biol Appl. 2016 Jan 1;58:945-52. doi: 10.1016/j.msec.2015.09.054. Epub 2015 Sep 16.

PMID:
26478390
45.

1H NMR based metabolic profiling of eleven Algerian aromatic plants and evaluation of their antioxidant and cytotoxic properties.

Brahmi N, Scognamiglio M, Pacifico S, Mekhoukhe A, Madani K, Fiorentino A, Monaco P.

Food Res Int. 2015 Oct;76(Pt 3):334-341. doi: 10.1016/j.foodres.2015.07.005. Epub 2015 Jul 8.

PMID:
28455012
46.

Anti-genotoxic ability of α-tocopherol and Anthocyanin to counteract fish DNA damage induced by musk xylene.

Rocco L, Mottola F, Santonastaso M, Saputo V, Cusano E, Costagliola D, Suero T, Pacifico S, Stingo V.

Ecotoxicology. 2015 Nov;24(9):2026-35. doi: 10.1007/s10646-015-1538-1. Epub 2015 Sep 25.

PMID:
26407710
47.

Valle Agricola lentil, an unknown lentil (Lens culinaris Medik.) seed from Southern Italy as a novel antioxidant and prebiotic source.

Landi N, Pacifico S, Piccolella S, Di Giuseppe AM, Mezzacapo MC, Ragucci S, Iannuzzi F, Zarrelli A, Di Maro A.

Food Funct. 2015 Sep;6(9):3155-64. doi: 10.1039/c5fo00604j.

PMID:
26222801
48.

Red-fleshed Apples: Old Autochthonous Fruits as a Novel Source of Anthocyanin Antioxidants.

Faramarzi S, Pacifico S, Yadollahi A, Lettieri A, Nocera P, Piccolella S.

Plant Foods Hum Nutr. 2015 Sep;70(3):324-30. doi: 10.1007/s11130-015-0497-2.

PMID:
26134879
49.

Silica/quercetin sol-gel hybrids as antioxidant dental implant materials.

Catauro M, Papale F, Bollino F, Piccolella S, Marciano S, Nocera P, Pacifico S.

Sci Technol Adv Mater. 2015 May 5;16(3):035001. eCollection 2015 Jun.

50.

Structure activity studies of nociceptin/orphanin FQ(1-13)-NH2 derivatives modified in position 5.

Guerrini R, Marzola E, Trapella C, Pacifico S, Cerlesi MC, Malfacini D, Ferrari F, Bird MF, Lambert DG, Salvadori S, Calo G.

Bioorg Med Chem. 2015 Apr 1;23(7):1515-20. doi: 10.1016/j.bmc.2015.02.008. Epub 2015 Feb 12.

PMID:
25716007

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