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[Effects of electronic cigarettes on health: a systematic review of the available evidence.]

Amato L, Cruciani F, Solimini R, Barca A, Pacifici R, Davoli M.

Recenti Prog Med. 2020 Jan;111(1):30-43. doi: 10.1701/3294.32651. Italian.


PTH induces bone loss via microbial-dependent expansion of intestinal TNF+ T cells and Th17 cells.

Yu M, Malik Tyagi A, Li JY, Adams J, Denning TL, Weitzmann MN, Jones RM, Pacifici R.

Nat Commun. 2020 Jan 24;11(1):468. doi: 10.1038/s41467-019-14148-4.


Microbiota dependent production of butyrate is required for the bone anabolic activity of PTH.

Li JY, Yu M, Pal S, Tyagi AM, Dar H, Adams J, Weitzmann MN, Jones RM, Pacifici R.

J Clin Invest. 2020 Jan 9. pii: 133473. doi: 10.1172/JCI133473. [Epub ahead of print]


Fast and sensitive UHPLC-MS/MS analysis of cannabinoids and their acid precursors in pharmaceutical preparations of medical cannabis and their metabolites in conventional and non-conventional biological matrices of treated individual.

Pichini S, Mannocchi G, Gottardi M, Pérez-Acevedo AP, Poyatos L, Papaseit E, Pérez-Mañá C, Farré M, Pacifici R, Busardò FP.

Talanta. 2020 Mar 1;209:120537. doi: 10.1016/j.talanta.2019.120537. Epub 2019 Nov 15.


Prevalence of tobacco smoking and electronic cigarette use among adolescents in Italy: Global Youth Tobacco Surveys (GYTS), 2010, 2014, 2018.

Gorini G, Gallus S, Carreras G, De Mei B, Masocco M, Faggiano F, Charrier L, Cavallo F, Spizzichino L, Galeone D, Minardi V, Lana S, Lachi A, Pacifici R; MADES Working Group.

Prev Med. 2020 Feb;131:105903. doi: 10.1016/j.ypmed.2019.105903. Epub 2019 Dec 5.


Pathways connecting socioeconomic variables, substance abuse and gambling behaviour: a cross-sectional study on a sample of Italian high-school students.

Buja A, Mortali C, Mastrobattista L, Minutillo A, Pichini S, Genetti B, Vian P, Andreotti A, Grotto G, Baldo V, Pacifici R.

BMJ Open. 2019 Nov 11;9(11):e031737. doi: 10.1136/bmjopen-2019-031737.


[Socioeconomic and regional inequalities in smoking cessation in Italy, 2014-2017].

Gorini G, Carreras G, Minardi V, Masocco M, Ferrante G, Coppo A, Gallus S, Faggiano F, Galeone D, Spizzichino L, Pacifici R; Gruppo di lavoro MADES, Vasselli S.

Epidemiol Prev. 2019 Jul-Aug;43(4):275-285. doi: 10.19191/EP19.4.P275.078. Italian.


Cannabinoids Identification in Lung Tissues of Young Cannabis Smokers Operated for Primary Spontaneous Pneumothorax and Correlation with Pathologic Findings.

Bisconti M, Marulli G, Pacifici R, Sollitto F, Nex G, Trabucco X, Ardò NP, Rotolo MC, De Iaco G, Panza T, Brascia D, Schiavone M, Signore F, Pistelli F, De Palma A.

Respiration. 2019;98(6):503-511. doi: 10.1159/000503456. Epub 2019 Oct 10.


New Psychoactive Substances: A Matter of Time.

Pantano F, Graziano S, Pacifici R, Busardò FP, Pichini S.

Curr Neuropharmacol. 2019;17(9):818-822. doi: 10.2174/1570159X1709190729101751.


Δ9-Tetrahydrocannabinol and Cannabidiol Time Courses in the Sera of "Light Cannabis" Smokers: Discriminating Light Cannabis Use from Illegal and Medical Cannabis Use.

Pichini S, Mannocchi G, Berretta P, Zaami S, Pirani F, Pacifici R, Busardò FP.

Ther Drug Monit. 2020 Feb;42(1):151-156. doi: 10.1097/FTD.0000000000000683.


The value of toxicological and forensic analyses in the global challenge to health risks caused by new psychoactive substances.

Zaami S, Busardò FP, Pichini S, Pacifici R, Marinelli E.

Eur Rev Med Pharmacol Sci. 2019 Jul;23(14):6008-6010. doi: 10.26355/eurrev_201907_18409. No abstract available.


The gut-bone axis: how bacterial metabolites bridge the distance.

Zaiss MM, Jones RM, Schett G, Pacifici R.

J Clin Invest. 2019 Jul 15;129(8):3018-3028. doi: 10.1172/JCI128521. eCollection 2019 Jul 15. Review.


Sex enhancers: challenges, threats and the need for targeted measures.

Marinelli S, Berretta P, Pacifici R, Del Rio A.

Clin Ter. 2019 May-Jun;170(3):e181-e183. doi: 10.7417/CT.2019.2130. No abstract available.


Miniaturized analytical platform for cocaine detection in oral fluids by MicroNIR/Chemometrics.

Risoluti R, Pichini S, Pacifici R, Materazzi S.

Talanta. 2019 Sep 1;202:546-553. doi: 10.1016/j.talanta.2019.04.081. Epub 2019 May 8.


Editorial: The Challenge Posed by New Synthetic Opioids: Pharmacology and Toxicology.

Pichini S, Zaami S, Pacifici R, Tagliabracci A, Busardò FP.

Front Pharmacol. 2019 May 21;10:563. doi: 10.3389/fphar.2019.00563. eCollection 2019. No abstract available.


Cannabidiol Adverse Effects and Toxicity.

Huestis MA, Solimini R, Pichini S, Pacifici R, Carlier J, Busardò FP.

Curr Neuropharmacol. 2019;17(10):974-989. doi: 10.2174/1570159X17666190603171901.


Metabolic Pathways and Potencies of New Fentanyl Analogs.

Wilde M, Pichini S, Pacifici R, Tagliabracci A, Busardò FP, Auwärter V, Solimini R.

Front Pharmacol. 2019 Apr 5;10:238. doi: 10.3389/fphar.2019.00238. eCollection 2019. Review.


Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry Assay for Quantifying Fentanyl and 22 Analogs and Metabolites in Whole Blood, Urine, and Hair.

Busardò FP, Carlier J, Giorgetti R, Tagliabracci A, Pacifici R, Gottardi M, Pichini S.

Front Chem. 2019 Apr 2;7:184. doi: 10.3389/fchem.2019.00184. eCollection 2019.


THC and CBD concentrations in blood, oral fluid and urine following a single and repeated administration of "light cannabis".

Pacifici R, Pichini S, Pellegrini M, Rotolo MC, Giorgetti R, Tagliabracci A, Busardò FP, Huestis MA.

Clin Chem Lab Med. 2019 Apr 8. pii: /j/cclm.ahead-of-print/cclm-2019-0119/cclm-2019-0119.xml. doi: 10.1515/cclm-2019-0119. [Epub ahead of print]


Thrombolytic Therapy in Cocaine Users with Ischemic Stroke: A Review of Current Practice.

Siniscalchi A, De Sarro G, Pacifici R, Pisani E, Sanguigni S, Gallelli L.

Psychopharmacol Bull. 2019 Feb 15;49(1):70-79. Review.


Nails Analysis for Drugs Used in the Context of Chemsex: A Pilot Study.

Busardò FP, Gottardi M, Pacifici R, Varì MR, Tini A, Volpe AR, Giorgetti R, Pichini S.

J Anal Toxicol. 2019 Mar 11. pii: bkz009. doi: 10.1093/jat/bkz009. [Epub ahead of print]


Clarifying methodological issues in cannabinoids determination in bronchoalveolar lavages.

Rotolo MC, Pellegrini M, Martucci P, Giacobbe R, De Palma A, Pacifici R, Pichini S, Busardò FP, Bisconti M.

Clin Chem Lab Med. 2019 Mar 26;57(4):e43-e44. doi: 10.1515/cclm-2018-1374. No abstract available.


Electronic cigarettes in Italy: a tool for harm reduction or a gateway to smoking tobacco?

Liu X, Lugo A, Davoli E, Gorini G, Pacifici R, Fernández E, Gallus S.

Tob Control. 2019 Jan 18. pii: tobaccocontrol-2018-054726. doi: 10.1136/tobaccocontrol-2018-054726. [Epub ahead of print]


Stability of cannabinoids in cannabis FM1 flowering tops and oil preparation evaluated by ultra-high performance liquid chromatography tandem mass spectrometry.

Pacifici R, Marchei E, Salvatore F, Guandalini L, Busardò FP, Pichini S.

Clin Chem Lab Med. 2019 Jun 26;57(7):e165-e168. doi: 10.1515/cclm-2018-1145. No abstract available.


The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression.

Tyagi AM, Yu M, Darby TM, Vaccaro C, Li JY, Owens JA, Hsu E, Adams J, Weitzmann MN, Jones RM, Pacifici R.

Immunity. 2018 Dec 18;49(6):1116-1131.e7. doi: 10.1016/j.immuni.2018.10.013. Epub 2018 Nov 13.


IL-17 Receptor Signaling in Osteoblasts/Osteocytes Mediates PTH-Induced Bone Loss and Enhances Osteocytic RANKL Production.

Li JY, Yu M, Tyagi AM, Vaccaro C, Hsu E, Adams J, Bellido T, Weitzmann MN, Pacifici R.

J Bone Miner Res. 2019 Feb;34(2):349-360. doi: 10.1002/jbmr.3600. Epub 2018 Nov 6.


Proceedings of the 2018 Santa Fe Bone Symposium: Advances in the Management of Osteoporosis.

Lewiecki EM, Bilezikian JP, Giangregorio L, Greenspan SL, Khosla S, Kostenuik P, Krohn K, McClung MR, Miller PD, Pacifici R.

J Clin Densitom. 2019 Jan - Mar;22(1):1-19. doi: 10.1016/j.jocd.2018.09.010. Epub 2018 Sep 22. Review.


Determination of cannabinoids in oral fluid and urine of "light cannabis" consumers: a pilot study.

Pacifici R, Pichini S, Pellegrini M, Tittarelli R, Pantano F, Mannocchi G, Rotolo MC, Busardò FP.

Clin Chem Lab Med. 2018 Dec 19;57(2):238-243. doi: 10.1515/cclm-2018-0566.


Cannabinoids determination in bronchoalveolar lavages of cannabis smokers with lung disease.

Rotolo MC, Pellegrini M, Martucci P, Giacobbe R, De Palma A, Pacifici R, Pichini S, Busardò FP, Bisconti M.

Clin Chem Lab Med. 2019 Mar 26;57(4):498-503. doi: 10.1515/cclm-2018-0426.


A long way to go: 20-year trends from multiple surveillance systems show a still huge use of tobacco in minors in Italy.

Gorini G, Gallus S, Carreras G, Cortini B, Vannacci V, Charrier L, Cavallo F, Molinaro S, Galeone D, Spizzichino L, De Mei B, Pacifici R, Faggiano F; MADES Working Group.

Eur J Public Health. 2019 Feb 1;29(1):164-169. doi: 10.1093/eurpub/cky132.


Pharmacotoxicology of Non-fentanyl Derived New Synthetic Opioids.

Solimini R, Pichini S, Pacifici R, Busardò FP, Giorgetti R.

Front Pharmacol. 2018 Jun 20;9:654. doi: 10.3389/fphar.2018.00654. eCollection 2018.


Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery.

Coussens NP, Sittampalam GS, Guha R, Brimacombe K, Grossman A, Chung TDY, Weidner JR, Riss T, Trask OJ, Auld D, Dahlin JL, Devanaryan V, Foley TL, McGee J, Kahl SD, Kales SC, Arkin M, Baell J, Bejcek B, Gal-Edd N, Glicksman M, Haas JV, Iversen PW, Hoeppner M, Lathrop S, Sayers E, Liu H, Trawick B, McVey J, Lemmon VP, Li Z, McManus O, Minor L, Napper A, Wildey MJ, Pacifici R, Chin WW, Xia M, Xu X, Lal-Nag M, Hall MD, Michael S, Inglese J, Simeonov A, Austin CP.

Clin Transl Sci. 2018 Sep;11(5):461-470. doi: 10.1111/cts.12570. Epub 2018 Jul 24. Review.


Global Prevalence of Fetal Alcohol Spectrum Disorder in Italy.

Pichini S, Pacifici R, Busardò FP.

JAMA Pediatr. 2018 May 1;172(5):497-498. doi: 10.1001/jamapediatrics.2018.0044. No abstract available.


The challenge of clinical application of FM2 cannabis oil produced in Italy for the treatment of neuropathic pain.

Pichini S, Pacifici R, Busardò FP, Tagliabracci A, Giorgetti R.

Eur Rev Med Pharmacol Sci. 2018 Feb;22(4):863-865. doi: 10.26355/eurrev_201802_14363. No abstract available.


CTLA-4Ig (abatacept) balances bone anabolic effects of T cells and Wnt-10b with antianabolic effects of osteoblastic sclerostin.

Roser-Page S, Vikulina T, Weiss D, Habib MM, Beck GR Jr, Pacifici R, Lane TF, Weitzmann MN.

Ann N Y Acad Sci. 2018 Mar;1415(1):21-33. doi: 10.1111/nyas.13643. Epub 2018 Mar 3.


Heat-not-burn tobacco products: concerns from the Italian experience.

Liu X, Lugo A, Spizzichino L, Tabuchi T, Pacifici R, Gallus S.

Tob Control. 2019 Jan;28(1):113-114. doi: 10.1136/tobaccocontrol-2017-054054. Epub 2018 Jan 26. No abstract available.


Evaluation of long-term stability of cannabinoids in standardized preparations of cannabis flowering tops and cannabis oil by ultra-high-performance liquid chromatography tandem mass spectrometry.

Pacifici R, Marchei E, Salvatore F, Guandalini L, Busardò FP, Pichini S.

Clin Chem Lab Med. 2018 Mar 28;56(4):94-96. doi: 10.1515/cclm-2017-0758. No abstract available.


Analytical Strategies to Disclose Repeated Consumption of New Psychoactive Substances by Hair Analysis.

Rotolo MC, Klein J, Pacifici R, Busardo FP, Pichini S, Marchei E.

Curr Pharm Biotechnol. 2017;18(10):834-839. doi: 10.2174/1389201018666171122114526.


European Drug Users at Risk from Illicit Fentanyls Mix.

Pichini S, Pacifici R, Marinelli E, Busardò FP.

Front Pharmacol. 2017 Oct 31;8:785. doi: 10.3389/fphar.2017.00785. eCollection 2017. No abstract available.


Regulatory T cells are expanded by Teriparatide treatment in humans and mediate intermittent PTH-induced bone anabolism in mice.

Yu M, D'Amelio P, Tyagi AM, Vaccaro C, Li JY, Hsu E, Buondonno I, Sassi F, Adams J, Weitzmann MN, DiPaolo R, Pacifici R.

EMBO Rep. 2018 Jan;19(1):156-171. doi: 10.15252/embr.201744421. Epub 2017 Nov 20.


Acute Intoxications and Fatalities From Illicit Fentanyl and Analogues: An Update.

Pichini S, Solimini R, Berretta P, Pacifici R, Busardò FP.

Ther Drug Monit. 2018 Feb;40(1):38-51. doi: 10.1097/FTD.0000000000000465. Review.


From Osteoimmunology to Osteomicrobiology: How the Microbiota and the Immune System Regulate Bone.

Hsu E, Pacifici R.

Calcif Tissue Int. 2018 May;102(5):512-521. doi: 10.1007/s00223-017-0321-0. Epub 2017 Oct 10. Review.


Trends in lung cancer and smoking behavior in Italy: an alarm bell for women.

Trama A, Boffi R, Contiero P, Buzzoni C, Pacifici R, Mangone L; AIRTUM Working Group.

Tumori. 2017 Nov 23;103(6):543-550. doi: 10.5301/tj.5000684. Epub 2017 Sep 21.


Bone Remodeling and the Microbiome.

Pacifici R.

Cold Spring Harb Perspect Med. 2018 Apr 2;8(4). pii: a031203. doi: 10.1101/cshperspect.a031203. Review.


Nuclear factor (erythroid-derived 2)-like 2 (NRF2) drug discovery: Biochemical toolbox to develop NRF2 activators by reversible binding of Kelch-like ECH-associated protein 1 (KEAP1).

Bresciani A, Missineo A, Gallo M, Cerretani M, Fezzardi P, Tomei L, Cicero DO, Altamura S, Santoprete A, Ingenito R, Bianchi E, Pacifici R, Dominguez C, Munoz-Sanjuan I, Harper S, Toledo-Sherman L, Park LC.

Arch Biochem Biophys. 2017 Oct 1;631:31-41. doi: 10.1016/ Epub 2017 Aug 8. Review.


Hair testing of GHB: an everlasting issue in forensic toxicology.

Busardò FP, Pichini S, Zaami S, Pacifici R, Kintz P.

Clin Chem Lab Med. 2018 Jan 26;56(2):198-208. doi: 10.1515/cclm-2017-0397. Review.


Adulteration Practices of Psychoactive Illicit Drugs: An Updated Review.

Solimini R, Rotolo MC, Pellegrini M, Minutillo A, Pacifici R, Busardò FP, Zaami S.

Curr Pharm Biotechnol. 2017;18(7):524-530. doi: 10.2174/1389201018666170710184531. Review.


Nails in Forensic Toxicology: An Update.

Solimini R, Minutillo A, Kyriakou C, Pichini S, Pacifici R, Busardo FP.

Curr Pharm Des. 2017;23(36):5468-5479. doi: 10.2174/1381612823666170704123126. Review.


Mass spectrometry vs. immunoassay in clinical and forensic toxicology: qui modus in rebus est?

Busardò FP, Pacifici R, Pichini S.

Clin Chem Lab Med. 2017 Aug 28;55(10):e236-e237. doi: 10.1515/cclm-2017-0418. No abstract available.


The microbiome: current and future view of an ancient paradigm.

Neish AS, Pacifici R, Mulle JG, Kraft CS, Stephens DS.

Future Microbiol. 2017 Aug;12:831-834. doi: 10.2217/fmb-2017-0083. Epub 2017 Jun 29. No abstract available.

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