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Items: 31

1.

Using Target Engagement Biomarkers to Predict Clinical Efficacy of MetAP2 Inhibitors.

Farrell PJ, Zopf CJ, Huang HJ, Balakrishna D, Holub C, Bilakovics J, Fanjul A, Matuszkiewicz J, Plonowski A, Rolzin P, Banerjee U, Ermolieff J, Cheruvallath ZS, McBride C, Bartkowski D, Mazur C, Pachori A, Larson CJ.

J Pharmacol Exp Ther. 2019 Nov;371(2):299-308. doi: 10.1124/jpet.119.259028. Epub 2019 Sep 19.

PMID:
31537613
2.

Evaluation of Changes in Salivary pH after Intake of Different Eatables and Beverages in Children at Different Time Intervals.

Pachori A, Kambalimath H, Maran S, Niranjan B, Bhambhani G, Malhotra G.

Int J Clin Pediatr Dent. 2018 May-Jun;11(3):177-182. doi: 10.5005/jp-journals-10005-1507. Epub 2018 Jun 1.

3.

Basal insulin peglispro increases lipid oxidation, metabolic flexibility, thermogenesis and ketone bodies compared to insulin glargine in subjects with type 1 diabetes mellitus.

Porksen NK, Linnebjerg H, Lam ECQ, Garhyan P, Pachori A, Pratley RE, Smith SR.

Diabetes Obes Metab. 2018 May;20(5):1193-1201. doi: 10.1111/dom.13215. Epub 2018 Feb 4.

PMID:
29316143
4.

Reduced skeletal muscle secreted frizzled-related protein 3 is associated with inflammation and insulin resistance.

Pachori AS, Madan M, Nunez Lopez YO, Yi F, Meyer C, Seyhan AA.

Obesity (Silver Spring). 2017 Apr;25(4):697-703. doi: 10.1002/oby.21787. Epub 2017 Feb 27.

5.

Inhibition of JNK mitochondrial localization and signaling is protective against ischemia/reperfusion injury in rats.

Chambers JW, Pachori A, Howard S, Iqbal S, LoGrasso PV.

J Biol Chem. 2013 Feb 8;288(6):4000-11. doi: 10.1074/jbc.M112.406777. Epub 2012 Dec 20.

6.

Small Molecule c-jun-N-terminal Kinase (JNK) Inhibitors Protect Dopaminergic Neurons in a Model of Parkinson's Disease.

Chambers JW, Pachori A, Howard S, Ganno M, Hansen D Jr, Kamenecka T, Song X, Duckett D, Chen W, Ling YY, Cherry L, Cameron MD, Lin L, Ruiz CH, Lograsso P.

ACS Chem Neurosci. 2011 Apr 20;2(4):198-206.

7.

Tetrahydroisoquinoline derivatives as highly selective and potent Rho kinase inhibitors.

Fang X, Yin Y, Chen YT, Yao L, Wang B, Cameron MD, Lin L, Khan S, Ruiz C, Schröter T, Grant W, Weiser A, Pocas J, Pachori A, Schürer S, Lograsso P, Feng Y.

J Med Chem. 2010 Aug 12;53(15):5727-37. doi: 10.1021/jm100579r.

PMID:
20684608
8.

Discovery of Potent and Selective Urea-Based ROCK Inhibitors and Their Effects on Intraocular Pressure in Rats.

Yin Y, Cameron MD, Lin L, Khan S, Schröter T, Grant W, Pocas J, Chen YT, Schürer S, Pachori A, LoGrasso P, Feng Y.

ACS Med Chem Lett. 2010 Apr 5;1(4):175-9. doi: 10.1021/ml1000382. eCollection 2010 Jul 8.

9.

Bone morphogenetic protein 4 mediates myocardial ischemic injury through JNK-dependent signaling pathway.

Pachori AS, Custer L, Hansen D, Clapp S, Kemppa E, Klingensmith J.

J Mol Cell Cardiol. 2010 Jun;48(6):1255-65. doi: 10.1016/j.yjmcc.2010.01.010. Epub 2010 Jan 20.

PMID:
20096288
10.

Nasal vaccination with troponin reduces troponin specific T-cell responses and improves heart function in myocardial ischemia-reperfusion injury.

Frenkel D, Pachori AS, Zhang L, Dembinsky-Vaknin A, Farfara D, Petrovic-Stojkovic S, Dzau VJ, Weiner HL.

Int Immunol. 2009 Jul;21(7):817-29. doi: 10.1093/intimm/dxp051. Epub 2009 Jun 10.

11.

Secreted frizzled related protein 2 protects cells from apoptosis by blocking the effect of canonical Wnt3a.

Zhang Z, Deb A, Zhang Z, Pachori A, He W, Guo J, Pratt R, Dzau VJ.

J Mol Cell Cardiol. 2009 Mar;46(3):370-7. doi: 10.1016/j.yjmcc.2008.11.016. Epub 2008 Dec 9.

12.

Heme-oxygenase-1-induced protection against hypoxia/reoxygenation is dependent on biliverdin reductase and its interaction with PI3K/Akt pathway.

Pachori AS, Smith A, McDonald P, Zhang L, Dzau VJ, Melo LG.

J Mol Cell Cardiol. 2007 Nov;43(5):580-92. Epub 2007 Aug 17.

13.

Preemptive heme oxygenase-1 gene delivery reveals reduced mortality and preservation of left ventricular function 1 yr after acute myocardial infarction.

Liu X, Simpson JA, Brunt KR, Ward CA, Hall SR, Kinobe RT, Barrette V, Tse MY, Pang SC, Pachori AS, Dzau VJ, Ogunyankin KO, Melo LG.

Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H48-59. Epub 2007 Feb 23.

14.

Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair.

Mirotsou M, Zhang Z, Deb A, Zhang L, Gnecchi M, Noiseux N, Mu H, Pachori A, Dzau V.

Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1643-8. Epub 2007 Jan 24.

15.

Gene therapy: role in myocardial protection.

Pachori AS, Melo LG, Dzau VJ.

Handb Exp Pharmacol. 2006;(176 Pt 2):335-50. Review.

PMID:
16999232
16.

Chronic recurrent myocardial ischemic injury is significantly attenuated by pre-emptive adeno-associated virus heme oxygenase-1 gene delivery.

Pachori AS, Melo LG, Zhang L, Solomon SD, Dzau VJ.

J Am Coll Cardiol. 2006 Feb 7;47(3):635-43. Epub 2006 Jan 18.

17.

Heme oxygenase-1 (HO-1) inhibits postmyocardial infarct remodeling and restores ventricular function.

Liu X, Pachori AS, Ward CA, Davis JP, Gnecchi M, Kong D, Zhang L, Murduck J, Yet SF, Perrella MA, Pratt RE, Dzau VJ, Melo LG.

FASEB J. 2006 Feb;20(2):207-16.

PMID:
16449792
18.

Enhancing stem cell therapy through genetic modification.

Dzau VJ, Gnecchi M, Pachori AS.

J Am Coll Cardiol. 2005 Oct 4;46(7):1351-3. No abstract available.

19.

Therapeutic potential of endothelial progenitor cells in cardiovascular diseases.

Dzau VJ, Gnecchi M, Pachori AS, Morello F, Melo LG.

Hypertension. 2005 Jul;46(1):7-18. Epub 2005 Jun 13. Review.

PMID:
15956118
20.

Genetic therapies for cardiovascular diseases.

Melo LG, Pachori AS, Gnecchi M, Dzau VJ.

Trends Mol Med. 2005 May;11(5):240-50. Review.

PMID:
15882612
21.

Endothelium-targeted gene and cell-based therapies for cardiovascular disease.

Melo LG, Gnecchi M, Pachori AS, Kong D, Wang K, Liu X, Pratt RE, Dzau VJ.

Arterioscler Thromb Vasc Biol. 2004 Oct;24(10):1761-74. Epub 2004 Aug 12. Review.

PMID:
15308553
22.

Hypoxia-regulated therapeutic gene as a preemptive treatment strategy against ischemia/reperfusion tissue injury.

Pachori AS, Melo LG, Hart ML, Noiseux N, Zhang L, Morello F, Solomon SD, Stahl GL, Pratt RE, Dzau VJ.

Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12282-7. Epub 2004 Aug 9.

23.

Molecular and cell-based therapies for protection, rescue, and repair of ischemic myocardium: reasons for cautious optimism.

Melo LG, Pachori AS, Kong D, Gnecchi M, Wang K, Pratt RE, Dzau VJ.

Circulation. 2004 May 25;109(20):2386-93. Review. No abstract available.

PMID:
15159329
24.

Gene and cell-based therapies for heart disease.

Melo LG, Pachori AS, Kong D, Gnecchi M, Wang K, Pratt RE, Dzau VJ.

FASEB J. 2004 Apr;18(6):648-63. Review.

PMID:
15054087
25.

Potential for germ line transmission after intramyocardial gene delivery by adeno-associated virus.

Pachori AS, Melo LG, Zhang L, Loda M, Pratt RE, Dzau VJ.

Biochem Biophys Res Commun. 2004 Jan 16;313(3):528-33.

PMID:
14697221
26.

Blood pressure-independent attenuation of cardiac hypertrophy by AT(1)R-AS gene therapy.

Pachori AS, Numan MT, Ferrario CM, Diz DM, Raizada MK, Katovich MJ.

Hypertension. 2002 May;39(5):969-75.

PMID:
12019278
27.

Gene therapy attenuates the elevated blood pressure and glucose intolerance in an insulin-resistant model of hypertension.

Katovich MJ, Reaves PY, Francis SC, Pachori AS, Wang HW, Raizada MK.

J Hypertens. 2001 Sep;19(9):1553-8.

PMID:
11564974
28.

The future of hypertension therapy: sense, antisense, or nonsense?

Pachori AS, Huentelman MJ, Francis SC, Gelband CH, Katovich MJ, Raizada MK.

Hypertension. 2001 Feb;37(2 Pt 2):357-64. Review.

PMID:
11230300
29.

Effects of inhibition of the renin-angiotensin system on the cardiovascular actions of insulin.

Katovich MJ, Pachori A.

Diabetes Obes Metab. 2000 Jan;2(1):3-14. Review. No abstract available.

PMID:
11220351
30.

Inability to induce hypertension in normotensive rat expressing AT(1) receptor antisense.

Pachori AS, Wang H, Gelband CH, Ferrario CM, Katovich MJ, Raizada MK.

Circ Res. 2000 Jun 9;86(11):1167-72.

PMID:
10850969
31.

Primary intertrochanteric osteotomy in fracture of the neck of femur.

Srivastava KP, Vyas ON, Pruthi KK, Chandra H, Pachori AK.

J Indian Med Assoc. 1978 Dec 16;71(12):307-10. No abstract available.

PMID:
755082

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