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Items: 1 to 50 of 336

1.

Alcohol inhibits T-cell glucose metabolism and hepatitis in ALDH2-deficient mice and humans: roles of acetaldehyde and glucocorticoids.

Gao Y, Zhou Z, Ren T, Kim SJ, He Y, Seo W, Guillot A, Ding Y, Wu R, Shao S, Wang X, Zhang H, Wang W, Feng D, Xu M, Han E, Zhong W, Zhou Z, Pacher P, Niu J, Gao B.

Gut. 2018 Aug 18. pii: gutjnl-2018-316221. doi: 10.1136/gutjnl-2018-316221. [Epub ahead of print]

2.

Age-dependent cardiovascular effects of sepsis in a murine model of cecal ligation and puncture: implications for the design of interventional studies.

Ungvari ZI, Yabluchanskiy A, Hasko G, Pacher P.

Am J Physiol Heart Circ Physiol. 2018 Aug 3. doi: 10.1152/ajpheart.00528.2018. [Epub ahead of print] No abstract available.

PMID:
30074837
3.

Quorum sensing in the immune system.

Antonioli L, Blandizzi C, Pacher P, Guilliams M, Haskó G.

Nat Rev Immunol. 2018 Sep;18(9):537-538. doi: 10.1038/s41577-018-0040-4. No abstract available.

PMID:
30006523
4.

Definition of hidden drug cardiotoxicity: paradigm change in cardiac safety testing and its clinical implications.

Ferdinandy P, Baczkó I, Bencsik P, Giricz Z, Görbe A, Pacher P, Varga ZV, Varró A, Schulz R.

Eur Heart J. 2018 Jul 2. doi: 10.1093/eurheartj/ehy365. [Epub ahead of print]

PMID:
29982507
5.

Macrophage P2X4 receptors augment bacterial killing and protect against sepsis.

Csóka B, Németh ZH, Szabó I, Davies DL, Varga ZV, Pálóczi J, Falzoni S, Di Virgilio F, Muramatsu R, Yamashita T, Pacher P, Haskó G.

JCI Insight. 2018 Jun 7;3(11). pii: 99431. doi: 10.1172/jci.insight.99431. [Epub ahead of print]

6.

Endothelial dysfunction and angiogenesis impairment in the ageing vasculature.

Ungvari Z, Tarantini S, Kiss T, Wren JD, Giles CB, Griffin CT, Murfee WL, Pacher P, Csiszar A.

Nat Rev Cardiol. 2018 Sep;15(9):555-565. doi: 10.1038/s41569-018-0030-z. Review.

PMID:
29795441
7.

Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1α Transactivation in Steatohepatitis.

Ouyang X, Han SN, Zhang JY, Dioletis E, Nemeth BT, Pacher P, Feng D, Bataller R, Cabezas J, Stärkel P, Caballeria J, LePine Pongratz R, Cai SY, Schnabl B, Hoque R, Chen Y, Yang WH, Garcia-Martinez I, Wang FS, Gao B, Torok NJ, Kibbey RG, Mehal WZ.

Cell Metab. 2018 May 1;27(5):1156. doi: 10.1016/j.cmet.2018.04.007. No abstract available.

PMID:
29719229
8.

Adenosine signaling and the immune system: When a lot could be too much.

Antonioli L, Fornai M, Blandizzi C, Pacher P, Haskó G.

Immunol Lett. 2018 Apr 24. pii: S0165-2478(18)30172-X. doi: 10.1016/j.imlet.2018.04.006. [Epub ahead of print] Review.

PMID:
29702147
9.

Disruption of Renal Arginine Metabolism Promotes Kidney Injury in Hepatorenal Syndrome in Mice.

Varga ZV, Erdelyi K, Paloczi J, Cinar R, Zsengeller ZK, Jourdan T, Matyas C, Nemeth BT, Guillot A, Xiang X, Mehal A, Haskó G, Stillman IE, Rosen S, Gao B, Kunos G, Pacher P.

Hepatology. 2018 Oct;68(4):1519-1533. doi: 10.1002/hep.29915.

PMID:
29631342
10.

Neutrophil-Hepatic Stellate Cell Interactions Promote Fibrosis in Experimental Steatohepatitis.

Zhou Z, Xu MJ, Cai Y, Wang W, Jiang JX, Varga ZV, Feng D, Pacher P, Kunos G, Torok NJ, Gao B.

Cell Mol Gastroenterol Hepatol. 2018 Jan 8;5(3):399-413. doi: 10.1016/j.jcmgh.2018.01.003. eCollection 2018 Mar.

11.

DEP domain-containing mTOR-interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease.

Chen H, Shen F, Sherban A, Nocon A, Li Y, Wang H, Xu MJ, Rui X, Han J, Jiang B, Lee D, Li N, Keyhani-Nejad F, Fan JG, Liu F, Kamat A, Musi N, Guarente L, Pacher P, Gao B, Zang M.

Hepatology. 2018 Aug;68(2):496-514. doi: 10.1002/hep.29849. Epub 2018 May 21.

PMID:
29457836
12.

Selective Photoaffinity Probe That Enables Assessment of Cannabinoid CB2 Receptor Expression and Ligand Engagement in Human Cells.

Soethoudt M, Stolze SC, Westphal MV, van Stralen L, Martella A, van Rooden EJ, Guba W, Varga ZV, Deng H, van Kasteren SI, Grether U, IJzerman AP, Pacher P, Carreira EM, Overkleeft HS, Ioan-Facsinay A, Heitman LH, van der Stelt M.

J Am Chem Soc. 2018 May 16;140(19):6067-6075. doi: 10.1021/jacs.7b11281. Epub 2018 Feb 16.

13.

Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1α Transactivation in Steatohepatitis.

Ouyang X, Han SN, Zhang JY, Dioletis E, Nemeth BT, Pacher P, Feng D, Bataller R, Cabezas J, Stärkel P, Caballeria J, Pongratz RL, Cai SY, Schnabl B, Hoque R, Chen Y, Yang WH, Garcia-Martinez I, Wang FS, Gao B, Torok NJ, Kibbey RG, Mehal WZ.

Cell Metab. 2018 Feb 6;27(2):339-350.e3. doi: 10.1016/j.cmet.2018.01.007. Erratum in: Cell Metab. 2018 May 1;27(5):1156.

PMID:
29414684
14.

Feasibility Evaluation of Myocardial Cannabinoid Type 1 Receptor Imaging in Obesity: A Translational Approach.

Valenta I, Varga ZV, Valentine H, Cinar R, Horti A, Mathews WB, Dannals RF, Steele K, Kunos G, Wahl RL, Pomper MG, Wong DF, Pacher P, Schindler TH.

JACC Cardiovasc Imaging. 2018 Feb;11(2 Pt 2):320-332. doi: 10.1016/j.jcmg.2017.11.019.

PMID:
29413441
15.

Alternative Splicing of NOX4 in the Failing Human Heart.

Varga ZV, Pipicz M, Baán JA, Baranyai T, Koncsos G, Leszek P, Kuśmierczyk M, Sánchez-Cabo F, García-Pavía P, Brenner GJ, Giricz Z, Csont T, Mendler L, Lara-Pezzi E, Pacher P, Ferdinandy P.

Front Physiol. 2017 Nov 22;8:935. doi: 10.3389/fphys.2017.00935. eCollection 2017.

16.

Cannabinoid-1 receptor deletion in podocytes mitigates both glomerular and tubular dysfunction in a mouse model of diabetic nephropathy.

Jourdan T, Park JK, Varga ZV, Pálóczi J, Coffey NJ, Rosenberg AZ, Godlewski G, Cinar R, Mackie K, Pacher P, Kunos G.

Diabetes Obes Metab. 2018 Mar;20(3):698-708. doi: 10.1111/dom.13150. Epub 2017 Dec 3.

PMID:
29106063
17.

Psoriasis-Related Visceral Adiposity and Arterial Inflammation: A New Adiposity Disease Entity?

Schindler TH, Pacher P.

JACC Cardiovasc Imaging. 2018 Feb;11(2 Pt 2):358-360. doi: 10.1016/j.jcmg.2017.09.004. Epub 2017 Oct 18. No abstract available.

PMID:
29055627
18.

Alcohol Misuse and Kidney Injury: Epidemiological Evidence and Potential Mechanisms.

Varga ZV, Matyas C, Paloczi J, Pacher P.

Alcohol Res. 2017;38(2):283-288. Review.

19.

Adenosine receptors differentially regulate type 2 cytokine production by IL-33-activated bone marrow cells, ILC2s, and macrophages.

Csóka B, Németh ZH, Duerr CU, Fritz JH, Pacher P, Haskó G.

FASEB J. 2018 Feb;32(2):829-837. doi: 10.1096/fj.201700770R. Epub 2018 Jan 4.

PMID:
28982732
20.

Cannabidiol attenuates alcohol-induced liver steatosis, metabolic dysregulation, inflammation and neutrophil-mediated injury.

Wang Y, Mukhopadhyay P, Cao Z, Wang H, Feng D, Haskó G, Mechoulam R, Gao B, Pacher P.

Sci Rep. 2017 Sep 21;7(1):12064. doi: 10.1038/s41598-017-10924-8.

21.

Cardiovascular effects of marijuana and synthetic cannabinoids: the good, the bad, and the ugly.

Pacher P, Steffens S, Haskó G, Schindler TH, Kunos G.

Nat Rev Cardiol. 2018 Mar;15(3):151-166. doi: 10.1038/nrcardio.2017.130. Epub 2017 Sep 14. Review.

PMID:
28905873
22.

Pepcan-12 (RVD-hemopressin) is a CB2 receptor positive allosteric modulator constitutively secreted by adrenals and in liver upon tissue damage.

Petrucci V, Chicca A, Glasmacher S, Paloczi J, Cao Z, Pacher P, Gertsch J.

Sci Rep. 2017 Aug 25;7(1):9560. doi: 10.1038/s41598-017-09808-8.

23.

A2A adenosine receptors control pancreatic dysfunction in high-fat-diet-induced obesity.

Csóka B, Törő G, Vindeirinho J, Varga ZV, Koscsó B, Németh ZH, Kókai E, Antonioli L, Suleiman M, Marchetti P, Cseri K, Deák Á, Virág L, Pacher P, Bai P, Haskó G.

FASEB J. 2017 Nov;31(11):4985-4997. doi: 10.1096/fj.201700398R. Epub 2017 Aug 1.

24.

Neuroprotection in Oxidative Stress-Related Neurodegenerative Diseases: Role of Endocannabinoid System Modulation.

Paloczi J, Varga ZV, Hasko G, Pacher P.

Antioxid Redox Signal. 2018 Jul 1;29(1):75-108. doi: 10.1089/ars.2017.7144. Epub 2017 Jul 18.

PMID:
28497982
25.

Glycogen phosphorylase inhibition improves beta cell function.

Nagy L, Márton J, Vida A, Kis G, Bokor É, Kun S, Gönczi M, Docsa T, Tóth A, Antal M, Gergely P, Csóka B, Pacher P, Somsák L, Bai P.

Br J Pharmacol. 2018 Jan;175(2):301-319. doi: 10.1111/bph.13819. Epub 2017 Jun 18.

PMID:
28409826
26.

Inflammation is independent of steatosis in a murine model of steatohepatitis.

Wang W, Xu MJ, Cai Y, Zhou Z, Cao H, Mukhopadhyay P, Pacher P, Zheng S, Gonzalez FJ, Gao B.

Hepatology. 2017 Jul;66(1):108-123. doi: 10.1002/hep.29129. Epub 2017 May 18.

27.

Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases.

Berger NA, Besson VC, Boulares AH, Bürkle A, Chiarugi A, Clark RS, Curtin NJ, Cuzzocrea S, Dawson TM, Dawson VL, Haskó G, Liaudet L, Moroni F, Pacher P, Radermacher P, Salzman AL, Snyder SH, Soriano FG, Strosznajder RP, Sümegi B, Swanson RA, Szabo C.

Br J Pharmacol. 2018 Jan;175(2):192-222. doi: 10.1111/bph.13748. Epub 2017 Mar 26. Review.

PMID:
28213892
28.

β-Caryophyllene protects against alcoholic steatohepatitis by attenuating inflammation and metabolic dysregulation in mice.

Varga ZV, Matyas C, Erdelyi K, Cinar R, Nieri D, Chicca A, Nemeth BT, Paloczi J, Lajtos T, Corey L, Hasko G, Gao B, Kunos G, Gertsch J, Pacher P.

Br J Pharmacol. 2018 Jan;175(2):320-334. doi: 10.1111/bph.13722. Epub 2017 Feb 22.

29.

Design, Synthesis, and Biological Evaluation of Novel, Non-Brain-Penetrant, Hybrid Cannabinoid CB1R Inverse Agonist/Inducible Nitric Oxide Synthase (iNOS) Inhibitors for the Treatment of Liver Fibrosis.

Iyer MR, Cinar R, Katz A, Gao M, Erdelyi K, Jourdan T, Coffey NJ, Pacher P, Kunos G.

J Med Chem. 2017 Feb 9;60(3):1126-1141. doi: 10.1021/acs.jmedchem.6b01504. Epub 2017 Jan 27.

PMID:
28085283
30.

Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity.

Soethoudt M, Grether U, Fingerle J, Grim TW, Fezza F, de Petrocellis L, Ullmer C, Rothenhäusler B, Perret C, van Gils N, Finlay D, MacDonald C, Chicca A, Gens MD, Stuart J, de Vries H, Mastrangelo N, Xia L, Alachouzos G, Baggelaar MP, Martella A, Mock ED, Deng H, Heitman LH, Connor M, Di Marzo V, Gertsch J, Lichtman AH, Maccarrone M, Pacher P, Glass M, van der Stelt M.

Nat Commun. 2017 Jan 3;8:13958. doi: 10.1038/ncomms13958.

31.

PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis.

Mukhopadhyay P, Horváth B, Rajesh M, Varga ZV, Gariani K, Ryu D, Cao Z, Holovac E, Park O, Zhou Z, Xu MJ, Wang W, Godlewski G, Paloczi J, Nemeth BT, Persidsky Y, Liaudet L, Haskó G, Bai P, Boulares AH, Auwerx J, Gao B, Pacher P.

J Hepatol. 2017 Mar;66(3):589-600. doi: 10.1016/j.jhep.2016.10.023. Epub 2016 Oct 29.

PMID:
27984176
32.

Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression.

Ramirez T, Li YM, Yin S, Xu MJ, Feng D, Zhou Z, Zang M, Mukhopadhyay P, Varga ZV, Pacher P, Gao B, Wang H.

J Hepatol. 2017 Mar;66(3):601-609. doi: 10.1016/j.jhep.2016.11.004. Epub 2016 Nov 18.

33.

Trastuzumab cardiotoxicity: from clinical trials to experimental studies.

Nemeth BT, Varga ZV, Wu WJ, Pacher P.

Br J Pharmacol. 2017 Nov;174(21):3727-3748. doi: 10.1111/bph.13643. Epub 2016 Nov 25. Review.

34.

PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier.

Rom S, Zuluaga-Ramirez V, Reichenbach NL, Dykstra H, Gajghate S, Pacher P, Persidsky Y.

J Neuroinflammation. 2016 Sep 27;13(1):254.

35.

Hybrid inhibitor of peripheral cannabinoid-1 receptors and inducible nitric oxide synthase mitigates liver fibrosis.

Cinar R, Iyer MR, Liu Z, Cao Z, Jourdan T, Erdelyi K, Godlewski G, Szanda G, Liu J, Park JK, Mukhopadhyay B, Rosenberg AZ, Liow JS, Lorenz RG, Pacher P, Innis RB, Kunos G.

JCI Insight. 2016 Jul 21;1(11). pii: e87336.

36.

Diastolic dysfunction in prediabetic male rats: Role of mitochondrial oxidative stress.

Koncsos G, Varga ZV, Baranyai T, Boengler K, Rohrbach S, Li L, Schlüter KD, Schreckenberg R, Radovits T, Oláh A, Mátyás C, Lux Á, Al-Khrasani M, Komlódi T, Bukosza N, Máthé D, Deres L, Barteková M, Rajtík T, Adameová A, Szigeti K, Hamar P, Helyes Z, Tretter L, Pacher P, Merkely B, Giricz Z, Schulz R, Ferdinandy P.

Am J Physiol Heart Circ Physiol. 2016 Oct 1;311(4):H927-H943. doi: 10.1152/ajpheart.00049.2016. Epub 2016 Aug 12.

37.

A Mechanistic Review of Cell Death in Alcohol-Induced Liver Injury.

Wang S, Pacher P, De Lisle RC, Huang H, Ding WX.

Alcohol Clin Exp Res. 2016 Jun;40(6):1215-23. doi: 10.1111/acer.13078. Epub 2016 Apr 30. Review.

38.

Chronic plus binge ethanol feeding induces myocardial oxidative stress, mitochondrial and cardiovascular dysfunction, and steatosis.

Matyas C, Varga ZV, Mukhopadhyay P, Paloczi J, Lajtos T, Erdelyi K, Nemeth BT, Nan M, Hasko G, Gao B, Pacher P.

Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1658-70. doi: 10.1152/ajpheart.00214.2016. Epub 2016 Apr 22.

39.

Anti-CD73 in cancer immunotherapy: awakening new opportunities.

Antonioli L, Yegutkin GG, Pacher P, Blandizzi C, Haskó G.

Trends Cancer. 2016 Feb 1;2(2):95-109.

40.

Endocannabinoids in cerebrovascular regulation.

Benyó Z, Ruisanchez É, Leszl-Ishiguro M, Sándor P, Pacher P.

Am J Physiol Heart Circ Physiol. 2016 Apr 1;310(7):H785-801. doi: 10.1152/ajpheart.00571.2015. Epub 2016 Jan 29. Review.

41.

Cannabidiol Limits T Cell-Mediated Chronic Autoimmune Myocarditis: Implications to Autoimmune Disorders and Organ Transplantation.

Lee WS, Erdelyi K, Matyas C, Mukhopadhyay P, Varga ZV, Liaudet L, Haskú G, Čiháková D, Mechoulam R, Pacher P.

Mol Med. 2016 Sep;22:136-146. doi: 10.2119/molmed.2016.00007. Epub 2016 Jan 8.

42.

Ado-Trastuzumab Emtansine Targets Hepatocytes Via Human Epidermal Growth Factor Receptor 2 to Induce Hepatotoxicity.

Yan H, Endo Y, Shen Y, Rotstein D, Dokmanovic M, Mohan N, Mukhopadhyay P, Gao B, Pacher P, Wu WJ.

Mol Cancer Ther. 2016 Mar;15(3):480-90. doi: 10.1158/1535-7163.MCT-15-0580. Epub 2015 Dec 28.

43.

Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue.

Godlewski G, Jourdan T, Szanda G, Tam J, Cinar R, Harvey-White J, Liu J, Mukhopadhyay B, Pacher P, Ming Mo F, Osei-Hyiaman D, Kunos G.

Sci Rep. 2015 Oct 12;5:14953. doi: 10.1038/srep14953.

44.

Protection from Radiation-Induced Pulmonary Fibrosis by Peripheral Targeting of Cannabinoid Receptor-1.

Bronova I, Smith B, Aydogan B, Weichselbaum RR, Vemuri K, Erdelyi K, Makriyannis A, Pacher P, Berdyshev EV.

Am J Respir Cell Mol Biol. 2015 Oct;53(4):555-62. doi: 10.1165/rcmb.2014-0331OC.

45.

The novel, orally available and peripherally restricted selective cannabinoid CB2 receptor agonist LEI-101 prevents cisplatin-induced nephrotoxicity.

Mukhopadhyay P, Baggelaar M, Erdelyi K, Cao Z, Cinar R, Fezza F, Ignatowska-Janlowska B, Wilkerson J, van Gils N, Hansen T, Ruben M, Soethoudt M, Heitman L, Kunos G, Maccarrone M, Lichtman A, Pacher P, Van der Stelt M.

Br J Pharmacol. 2016 Feb;173(3):446-58. doi: 10.1111/bph.13338. Epub 2016 Jan 15.

46.

Drug-induced mitochondrial dysfunction and cardiotoxicity.

Varga ZV, Ferdinandy P, Liaudet L, Pacher P.

Am J Physiol Heart Circ Physiol. 2015 Nov;309(9):H1453-67. doi: 10.1152/ajpheart.00554.2015. Epub 2015 Sep 18. Review.

47.

New Piece in the Jigsaw Puzzle: Adipose Tissue-Derived Stem Cells From Obese Subjects Drive Th17 Polarization.

Csóka B, Pacher P, Bai P, Haskó G.

Diabetes. 2015 Jul;64(7):2341-3. doi: 10.2337/db15-0437. No abstract available.

48.

Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans.

Xu MJ, Cai Y, Wang H, Altamirano J, Chang B, Bertola A, Odena G, Lu J, Tanaka N, Matsusue K, Matsubara T, Mukhopadhyay P, Kimura S, Pacher P, Gonzalez FJ, Bataller R, Gao B.

Gastroenterology. 2015 Oct;149(4):1030-41.e6. doi: 10.1053/j.gastro.2015.06.009. Epub 2015 Jun 20.

49.

Oxidative/Nitrative Stress and Inflammation Drive Progression of Doxorubicin-Induced Renal Fibrosis in Rats as Revealed by Comparing a Normal and a Fibrosis-Resistant Rat Strain.

Szalay CI, Erdélyi K, Kökény G, Lajtár E, Godó M, Révész C, Kaucsár T, Kiss N, Sárközy M, Csont T, Krenács T, Szénási G, Pacher P, Hamar P.

PLoS One. 2015 Jun 18;10(6):e0127090. doi: 10.1371/journal.pone.0127090. eCollection 2015.

50.

Role of the endocannabinoid system in diabetes and diabetic complications.

Gruden G, Barutta F, Kunos G, Pacher P.

Br J Pharmacol. 2016 Apr;173(7):1116-27. doi: 10.1111/bph.13226. Epub 2015 Aug 20. Review.

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