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Targeted therapies for ROS1-rearranged non-small cell lung cancer.

Patil T, Simons E, Mushtaq R, Pacheco JM, Doebele RC, Bowles DW.

Drugs Today (Barc). 2019 Oct;55(10):641-652. doi: 10.1358/dot.2019.55.10.3030646.


Reward and punishment in climate change dilemmas.

Góis AR, Santos FP, Pacheco JM, Santos FC.

Sci Rep. 2019 Nov 7;9(1):16193. doi: 10.1038/s41598-019-52524-8.


Extended follow-up on KEYNOTE-024 suggests significant survival benefit for pembrolizumab in patients with PD-L1 ≥50%, but unanswered questions remain.

Pacheco JM, Gao D, Camidge DR.

Ann Transl Med. 2019 Jul;7(Suppl 3):S127. doi: 10.21037/atm.2019.05.72. No abstract available.


Temozolomide plus PARP Inhibition in Small-Cell Lung Cancer: Could Patient-Derived Xenografts Accelerate Discovery of Biomarker Candidates?

Pacheco JM, Byers LA.

Cancer Discov. 2019 Oct;9(10):1340-1342. doi: 10.1158/2159-8290.CD-19-0850.


Duration of protection and humoral immunity induced by an adenovirus-vectored subunit vaccine for foot-and-mouth disease (FMD) in Holstein steers.

Sitt T, Kenney M, Barrera J, Pandya M, Eckstrom K, Warner M, Pacheco JM, LaRocco M, Palarea-Albaladejo J, Brake D, Rieder E, Arzt J, Barlow JW, Golde WT.

Vaccine. 2019 Sep 30;37(42):6221-6231. doi: 10.1016/j.vaccine.2019.08.017. Epub 2019 Sep 5.


A Changing of the Guard: Immune Checkpoint Inhibitors With and Without Chemotherapy as First Line Treatment for Metastatic Non-small Cell Lung Cancer.

Pacheco JM, Camidge DR, Doebele RC, Schenk E.

Front Oncol. 2019 Mar 29;9:195. doi: 10.3389/fonc.2019.00195. eCollection 2019. Review.


Searching for a chemoimmunotherapy signal in patients with non-small-cell lung cancer and EGFR mutations.

Pacheco JM, Camidge DR.

Lancet Respir Med. 2019 May;7(5):366-367. doi: 10.1016/S2213-2600(19)30112-2. Epub 2019 Mar 25. No abstract available.


Is long-term survival possible for patients with stage IV ALK+ non-small cell lung cancer?

Pacheco JM, Camidge DR.

Expert Rev Respir Med. 2019 May;13(5):399-401. doi: 10.1080/17476348.2019.1596028. Epub 2019 Mar 20. No abstract available.


Correction for Gladue et al., "Foot-and-Mouth Disease Virus Modulates Cellular Vimentin for Virus Survival".

Gladue DP, O'Donnell V, Baker-Branstetter R, Holinka LG, Pacheco JM, Fernández Sainz I, Lu Z, Ambroggio X, Rodriguez L, Borca MV.

J Virol. 2019 Jan 4;93(2). pii: e01799-18. doi: 10.1128/JVI.01799-18. Print 2019 Jan 15. No abstract available.


Natural History and Factors Associated with Overall Survival in Stage IV ALK-Rearranged Non-Small Cell Lung Cancer.

Pacheco JM, Gao D, Smith D, Purcell T, Hancock M, Bunn P, Robin T, Liu A, Karam S, Gaspar L, Kavanagh B, Rusthoven C, Aisner D, Doebele R, Camidge DR.

J Thorac Oncol. 2019 Apr;14(4):691-700. doi: 10.1016/j.jtho.2018.12.014. Epub 2018 Dec 30.


Miliary Metastases in Non-Small-Cell Lung Cancer.

Patil T, Pacheco JM.

N Engl J Med. 2018 Nov 15;379(20):1945. doi: 10.1056/NEJMicm1803514. No abstract available.


Antibody drug conjugates in thoracic malignancies.

Pacheco JM, Camidge DR.

Lung Cancer. 2018 Oct;124:260-269. doi: 10.1016/j.lungcan.2018.07.001. Epub 2018 Jul 19. Review.


Direct and transdentinal biostimulatory effects of grape seed extract rich in proanthocyanidin on pulp cells.

Dos Santos AF, Pacheco JM, Silva PAO, Bedran-Russo AK, Rezende TMB, Pereira PNR, Ribeiro APD.

Int Endod J. 2019 Apr;52(4):424-438. doi: 10.1111/iej.13019. Epub 2018 Oct 23.


Structural and temporal patterns of the first global trading market.

Ribeiro AS, Pinheiro FL, Santos FC, Polónia A, Pacheco JM.

R Soc Open Sci. 2018 Aug 22;5(8):180577. doi: 10.1098/rsos.180577. eCollection 2018 Aug.


Increased Virulence of an Epidemic Strain of Vesicular Stomatitis Virus Is Associated With Interference of the Innate Response in Pigs.

Velazquez-Salinas L, Pauszek SJ, Stenfeldt C, O'Hearn ES, Pacheco JM, Borca MV, Verdugo-Rodriguez A, Arzt J, Rodriguez LL.

Front Microbiol. 2018 Aug 15;9:1891. doi: 10.3389/fmicb.2018.01891. eCollection 2018.


Evolutionary dynamics of paroxysmal nocturnal hemoglobinuria.

Mon Père N, Lenaerts T, Pacheco JM, Dingli D.

PLoS Comput Biol. 2018 Jun 18;14(6):e1006133. doi: 10.1371/journal.pcbi.1006133. eCollection 2018 Jun.


Social norm complexity and past reputations in the evolution of cooperation.

Santos FP, Santos FC, Pacheco JM.

Nature. 2018 Mar 7;555(7695):242-245. doi: 10.1038/nature25763.


A partial deletion within foot-and-mouth disease virus non-structural protein 3A causes clinical attenuation in cattle but does not prevent subclinical infection.

Stenfeldt C, Arzt J, Pacheco JM, Gladue DP, Smoliga GR, Silva EB, Rodriguez LL, Borca MV.

Virology. 2018 Mar;516:115-126. doi: 10.1016/j.virol.2018.01.008. Epub 2018 Jan 12.


KEYNOTE-028: how do we use immunotherapy in small cell lung cancer?

Pacheco JM, Camidge DR.

Transl Lung Cancer Res. 2017 Dec;6(Suppl 1):S84-S87. doi: 10.21037/tlcr.2017.10.02. No abstract available.


Excellent Outcomes with Radiosurgery for Multiple Brain Metastases in ALK and EGFR Driven Non-Small Cell Lung Cancer.

Robin TP, Camidge DR, Stuhr K, Nath SK, Breeze RE, Pacheco JM, Liu AK, Gaspar LE, Purcell WT, Doebele RC, Kavanagh BD, Rusthoven CG.

J Thorac Oncol. 2018 May;13(5):715-720. doi: 10.1016/j.jtho.2017.12.006. Epub 2017 Dec 19.


Advances in lung cancer.

Pacheco JM, Dimou A, Bunn PA.

Oncotarget. 2017 Sep 13;8(45):78247-78248. doi: 10.18632/oncotarget.20854. eCollection 2017 Oct 3. No abstract available.


Foot-and-Mouth Disease (FMD) Virus 3C Protease Mutant L127P: Implications for FMD Vaccine Development.

Puckette M, Clark BA, Smith JD, Turecek T, Martel E, Gabbert L, Pisano M, Hurtle W, Pacheco JM, Barrera J, Neilan JG, Rasmussen M.

J Virol. 2017 Oct 27;91(22). pii: e00924-17. doi: 10.1128/JVI.00924-17. Print 2017 Nov 15.


Efficacy of a high potency O1 Manisa monovalent vaccine against heterologous challenge with foot-and-mouth disease virus of O/SEA/Mya-98 lineage in sheep.

Singanallur NB, Pacheco JM, Arzt J, Stenfeldt C, Fosgate GT, Rodriguez L, Vosloo W.

Antiviral Res. 2017 Sep;145:114-122. doi: 10.1016/j.antiviral.2017.07.020. Epub 2017 Aug 3.


Pathogenesis of virulent and attenuated foot-and-mouth disease virus in cattle.

Arzt J, Pacheco JM, Stenfeldt C, Rodriguez LL.

Virol J. 2017 May 2;14(1):89. doi: 10.1186/s12985-017-0758-9.


Structural power and the evolution of collective fairness in social networks.

Santos FP, Pacheco JM, Paiva A, Santos FC.

PLoS One. 2017 Apr 14;12(4):e0175687. doi: 10.1371/journal.pone.0175687. eCollection 2017.


Stochastic Dynamics through Hierarchically Embedded Markov Chains.

Vasconcelos VV, Santos FP, Santos FC, Pacheco JM.

Phys Rev Lett. 2017 Feb 3;118(5):058301. doi: 10.1103/PhysRevLett.118.058301. Epub 2017 Feb 1.


Role of central opioid on the antinociceptive effect of sulfated polysaccharide from the red seaweed Solieria filiformis in induced temporomandibular joint pain.

Araújo IW, Chaves HV, Pachêco JM, Val DR, Vieira LV, Santos R, Freitas RS, Rivanor RL, Monteiro VS, Clemente-Napimoga JT, Bezerra MM, Benevides NM.

Int Immunopharmacol. 2017 Mar;44:160-167. doi: 10.1016/j.intimp.2017.01.005. Epub 2017 Jan 17.


Paradigm shifts and the interplay between state, business and civil sectors.

Encarnação S, Santos FP, Santos FC, Blass V, Pacheco JM, Portugali J.

R Soc Open Sci. 2016 Dec 21;3(12):160753. doi: 10.1098/rsos.160753. eCollection 2016 Dec.


Transmission of Foot-and-Mouth Disease Virus during the Incubation Period in Pigs.

Stenfeldt C, Pacheco JM, Brito BP, Moreno-Torres KI, Branan MA, Delgado AH, Rodriguez LL, Arzt J.

Front Vet Sci. 2016 Nov 21;3:105. eCollection 2016.


Evolution of cooperation under indirect reciprocity and arbitrary exploration rates.

Santos FP, Pacheco JM, Santos FC.

Sci Rep. 2016 Nov 28;6:37517. doi: 10.1038/srep37517.


About the discrete-continuous nature of a hematopoiesis model for Chronic Myeloid Leukemia.

Gaudiano ME, Lenaerts T, Pacheco JM.

Math Biosci. 2016 Dec;282:174-180. doi: 10.1016/j.mbs.2016.11.001. Epub 2016 Nov 2. Erratum in: Math Biosci. 2017 Jun;288:166.


Infection Dynamics of Foot-and-Mouth Disease Virus in Cattle Following Intranasopharyngeal Inoculation or Contact Exposure.

Pacheco JM, Stenfeldt C, Rodriguez LL, Arzt J.

J Comp Pathol. 2016 Nov;155(4):314-325. doi: 10.1016/j.jcpa.2016.08.005. Epub 2016 Sep 30.


Transcriptomic Analysis of Persistent Infection with Foot-and-Mouth Disease Virus in Cattle Suggests Impairment of Apoptosis and Cell-Mediated Immunity in the Nasopharynx.

Eschbaumer M, Stenfeldt C, Smoliga GR, Pacheco JM, Rodriguez LL, Li RW, Zhu J, Arzt J.

PLoS One. 2016 Sep 19;11(9):e0162750. doi: 10.1371/journal.pone.0162750. eCollection 2016.


Systemic immune response and virus persistence after foot-and-mouth disease virus infection of naïve cattle and cattle vaccinated with a homologous adenovirus-vectored vaccine.

Eschbaumer M, Stenfeldt C, Rekant SI, Pacheco JM, Hartwig EJ, Smoliga GR, Kenney MA, Golde WT, Rodriguez LL, Arzt J.

BMC Vet Res. 2016 Sep 15;12:205. doi: 10.1186/s12917-016-0838-x.


African swine fever virus Georgia isolate harboring deletions of 9GL and MGF360/505 genes is highly attenuated in swine but does not confer protection against parental virus challenge.

O'Donnell V, Holinka LG, Sanford B, Krug PW, Carlson J, Pacheco JM, Reese B, Risatti GR, Gladue DP, Borca MV.

Virus Res. 2016 Aug 2;221:8-14. doi: 10.1016/j.virusres.2016.05.014. Epub 2016 May 12.


The Foot-and-Mouth Disease Carrier State Divergence in Cattle.

Stenfeldt C, Eschbaumer M, Rekant SI, Pacheco JM, Smoliga GR, Hartwig EJ, Rodriguez LL, Arzt J.

J Virol. 2016 Jun 24;90(14):6344-64. doi: 10.1128/JVI.00388-16. Print 2016 Jul 15.


Linking Individual and Collective Behavior in Adaptive Social Networks.

Pinheiro FL, Santos FC, Pacheco JM.

Phys Rev Lett. 2016 Mar 25;116(12):128702. doi: 10.1103/PhysRevLett.116.128702. Epub 2016 Mar 24.


Social Norms of Cooperation in Small-Scale Societies.

Santos FP, Santos FC, Pacheco JM.

PLoS Comput Biol. 2016 Jan 25;12(1):e1004709. doi: 10.1371/journal.pcbi.1004709. eCollection 2016 Jan.


Effect of storage conditions on subpopulations of peripheral blood T lymphocytes isolated from naïve cattle and cattle infected with foot-and-mouth disease virus.

Eschbaumer M, Stenfeldt C, Pacheco JM, Rekant SI, Arzt J.

Vet Clin Pathol. 2016 Mar;45(1):110-5. doi: 10.1111/vcp.12327. Epub 2016 Jan 23.


Evaluation of Infectivity, Virulence and Transmission of FDMV Field Strains of Serotypes O and A Isolated In 2010 from Outbreaks in the Republic of Korea.

Pacheco JM, Lee KN, Eschbaumer M, Bishop EA, Hartwig EJ, Pauszek SJ, Smoliga GR, Kim SM, Park JH, Ko YJ, Lee HS, Tark D, Cho IS, Kim B, Rodriguez LL, Arzt J.

PLoS One. 2016 Jan 6;11(1):e0146445. doi: 10.1371/journal.pone.0146445. eCollection 2016.


Veterinary applications of infrared thermography.

Rekant SI, Lyons MA, Pacheco JM, Arzt J, Rodriguez LL.

Am J Vet Res. 2016 Jan;77(1):98-107. doi: 10.2460/ajvr.77.1.98. Review.


Pathogenesis of Primary Foot-and-Mouth Disease Virus Infection in the Nasopharynx of Vaccinated and Non-Vaccinated Cattle.

Stenfeldt C, Eschbaumer M, Pacheco JM, Rekant SI, Rodriguez LL, Arzt J.

PLoS One. 2015 Nov 23;10(11):e0143666. doi: 10.1371/journal.pone.0143666. eCollection 2015.


Evolutionary dynamics of collective index insurance.

Pacheco JM, Santos FC, Levin SA.

J Math Biol. 2016 Mar;72(4):997-1010. doi: 10.1007/s00285-015-0939-3. Epub 2015 Oct 20.


Intracranial epithelioid hemangioendothelioma causing subacute loss of vision.

Pacheco JM, Goodman JC, Mandel J.

Neurology. 2015 Aug 25;85(8):735-6. doi: 10.1212/WNL.0000000000001873. No abstract available.


Early Detection of Foot-And-Mouth Disease Virus from Infected Cattle Using A Dry Filter Air Sampling System.

Pacheco JM, Brito B, Hartwig E, Smoliga GR, Perez A, Arzt J, Rodriguez LL.

Transbound Emerg Dis. 2017 Apr;64(2):564-573. doi: 10.1111/tbed.12404. Epub 2015 Aug 25.


An Integrative Analysis of Foot-and-Mouth Disease Virus Carriers in Vietnam Achieved Through Targeted Surveillance and Molecular Epidemiology.

de Carvalho Ferreira HC, Pauszek SJ, Ludi A, Huston CL, Pacheco JM, Le VT, Nguyen PT, Bui HH, Nguyen TD, Nguyen T, Nguyen TT, Ngo LT, Do DH, Rodriguez L, Arzt J.

Transbound Emerg Dis. 2017 Apr;64(2):547-563. doi: 10.1111/tbed.12403. Epub 2015 Aug 24.


How low is too low: Statin induced hemolysis.

Pacheco JM, Yilmaz M, Rice L.

Am J Hematol. 2016 Feb;91(2):267. doi: 10.1002/ajh.24105. Epub 2015 Oct 16. No abstract available.


Persistent Foot-and-Mouth Disease Virus Infection in the Nasopharynx of Cattle; Tissue-Specific Distribution and Local Cytokine Expression.

Pacheco JM, Smoliga GR, O'Donnell V, Brito BP, Stenfeldt C, Rodriguez LL, Arzt J.

PLoS One. 2015 May 21;10(5):e0125698. doi: 10.1371/journal.pone.0125698. eCollection 2015.


Clinical and virological dynamics of a serotype O 2010 South East Asia lineage foot-and-mouth disease virus in sheep using natural and simulated natural inoculation and exposure systems.

Stenfeldt C, Pacheco JM, Singanallur NB, Ferreira HC, Vosloo W, Rodriguez LL, Arzt J.

Vet Microbiol. 2015 Jul 9;178(1-2):50-60. doi: 10.1016/j.vetmic.2015.04.004. Epub 2015 Apr 15.


Evolutionary dynamics of group fairness.

Santos FP, Santos FC, Paiva A, Pacheco JM.

J Theor Biol. 2015 Aug 7;378:96-102. doi: 10.1016/j.jtbi.2015.04.025. Epub 2015 Apr 30.


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