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Items: 37


Discovery of niclosamide and its O-alkylamino-tethered derivatives as potent antibacterial agents against carbapenemase-producing and/or colistin resistant Enterobacteriaceae isolates.

Xu J, Pachón-Ibáñez ME, Cebrero-Cangueiro T, Chen H, Sánchez-Céspedes J, Zhou J.

Bioorg Med Chem Lett. 2019 Jun 1;29(11):1399-1402. doi: 10.1016/j.bmcl.2019.03.032. Epub 2019 Mar 23.


In vitro Activity of Pentamidine Alone and in Combination With Aminoglycosides, Tigecycline, Rifampicin, and Doripenem Against Clinical Strains of Carbapenemase-Producing and/or Colistin-Resistant Enterobacteriaceae.

Cebrero-Cangueiro T, Álvarez-Marín R, Labrador-Herrera G, Smani Y, Cordero-Matía E, Pachón J, Pachón-Ibáñez ME.

Front Cell Infect Microbiol. 2018 Oct 18;8:363. doi: 10.3389/fcimb.2018.00363. eCollection 2018.


Synergistic Activity of Niclosamide in Combination With Colistin Against Colistin-Susceptible and Colistin-Resistant Acinetobacter baumannii and Klebsiella pneumoniae.

Ayerbe-Algaba R, Gil-Marqués ML, Jiménez-Mejías ME, Sánchez-Encinales V, Parra-Millán R, Pachón-Ibáñez ME, Pachón J, Smani Y.

Front Cell Infect Microbiol. 2018 Oct 3;8:348. doi: 10.3389/fcimb.2018.00348. eCollection 2018.


Synergistic activity of an OmpA inhibitor and colistin against colistin-resistant Acinetobacter baumannii: mechanistic analysis and in vivo efficacy.

Parra-Millán R, Vila-Farrés X, Ayerbe-Algaba R, Varese M, Sánchez-Encinales V, Bayó N, Pachón-Ibáñez ME, Teixidó M, Vila J, Pachón J, Giralt E, Smani Y.

J Antimicrob Chemother. 2018 Dec 1;73(12):3405-3412. doi: 10.1093/jac/dky343.


Effect of Hypoxia on the Pathogenesis of Acinetobacter baumannii and Pseudomonas aeruginosa In Vitro and in Murine Experimental Models of Infection.

Gil-Marqués ML, Pachón-Ibáñez ME, Pachón J, Smani Y.

Infect Immun. 2018 Sep 21;86(10). pii: e00543-18. doi: 10.1128/IAI.00543-18. Print 2018 Oct.


Efficacy of Colistin and Its Combination With Rifampin in Vitro and in Experimental Models of Infection Caused by Carbapenemase-Producing Clinical Isolates of Klebsiella pneumoniae.

Pachón-Ibáñez ME, Labrador-Herrera G, Cebrero-Cangueiro T, Díaz C, Smani Y, Del Palacio JP, Rodríguez-Baño J, Pascual A, Pachón J, Conejo MC.

Front Microbiol. 2018 May 15;9:912. doi: 10.3389/fmicb.2018.00912. eCollection 2018.


Intracellular Trafficking and Persistence of Acinetobacter baumannii Requires Transcription Factor EB.

Parra-Millán R, Guerrero-Gómez D, Ayerbe-Algaba R, Pachón-Ibáñez ME, Miranda-Vizuete A, Pachón J, Smani Y.

mSphere. 2018 Mar 28;3(2). pii: e00106-18. doi: 10.1128/mSphere.00106-18. eCollection 2018 Mar-Apr.


Combating virulence of Gram-negative bacilli by OmpA inhibition.

Vila-Farrés X, Parra-Millán R, Sánchez-Encinales V, Varese M, Ayerbe-Algaba R, Bayó N, Guardiola S, Pachón-Ibáñez ME, Kotev M, García J, Teixidó M, Vila J, Pachón J, Giralt E, Smani Y.

Sci Rep. 2017 Oct 31;7(1):14683. doi: 10.1038/s41598-017-14972-y.


Perspectives for clinical use of engineered human host defense antimicrobial peptides.

Pachón-Ibáñez ME, Smani Y, Pachón J, Sánchez-Céspedes J.

FEMS Microbiol Rev. 2017 May 1;41(3):323-342. doi: 10.1093/femsre/fux012. Review.


Overproduction of Outer Membrane Protein A by Acinetobacter baumannii as a Risk Factor for Nosocomial Pneumonia, Bacteremia, and Mortality Rate Increase.

Sánchez-Encinales V, Álvarez-Marín R, Pachón-Ibáñez ME, Fernández-Cuenca F, Pascual A, Garnacho-Montero J, Martínez-Martínez L, Vila J, Tomás MM, Cisneros JM, Bou G, Rodríguez-Baño J, Pachón J, Smani Y.

J Infect Dis. 2017 Mar 15;215(6):966-974. doi: 10.1093/infdis/jix010.


Efficacy of Lysophosphatidylcholine in Combination with Antimicrobial Agents against Acinetobacter baumannii in Experimental Murine Peritoneal Sepsis and Pneumonia Models.

Parra Millán R, Jiménez Mejías ME, Sánchez Encinales V, Ayerbe Algaba R, Gutiérrez Valencia A, Pachón Ibáñez ME, Díaz C, Pérez Del Palacio J, López Cortés LF, Pachón J, Smani Y.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4464-70. doi: 10.1128/AAC.02708-15. Print 2016 Aug.


New molecules and adjuvants in the treatment of infections by Acinetobacter baumannii.

Smani Y, Pachón-Ibáñez ME, Pachón J.

Expert Opin Pharmacother. 2016 Jun;17(9):1207-14. doi: 10.1080/14656566.2016.1176144. Epub 2016 Apr 28. Review.


Draft Genome Sequences of Seven Multidrug-Resistant Acinetobacter baumannii Strains, Isolated from Respiratory Samples in Spain.

Labrador-Herrera G, Álvarez R, López-Rojas R, Smani Y, Cebrero-Cangueiro T, Rueda A, Pérez Florido J, Pachón J, Pachón-Ibáñez ME.

Genome Announc. 2016 Mar 31;4(2). pii: e00083-16. doi: 10.1128/genomeA.00083-16.


Use of adjuvants in the treatment of Acinetobacter baumannii.

Pachón-Ibáñez ME, Smani Y, Pachón J.

Expert Rev Anti Infect Ther. 2016;14(2):153-5. doi: 10.1586/14787210.2016.1126508. Epub 2015 Dec 19.


Sequence-activity relationship, and mechanism of action of mastoparan analogues against extended-drug resistant Acinetobacter baumannii.

Vila-Farrés X, López-Rojas R, Pachón-Ibáñez ME, Teixidó M, Pachón J, Vila J, Giralt E.

Eur J Med Chem. 2015 Aug 28;101:34-40. doi: 10.1016/j.ejmech.2015.06.016. Epub 2015 Jun 9.


Experimental study of the efficacy of linezolid alone and in combinations against experimental meningitis due to Staphylococcus aureus strains with decreased susceptibility to beta-lactams and glycopeptides.

Cabellos C, Garrigós C, Taberner F, Force E, Pachón-Ibañez ME.

J Infect Chemother. 2014 Sep;20(9):563-8. doi: 10.1016/j.jiac.2014.05.008. Epub 2014 Jun 25.


Efficacy of cecropin A-melittin peptides on a sepsis model of infection by pan-resistant Acinetobacter baumannii.

López-Rojas R, Docobo-Pérez F, Pachón-Ibáñez ME, de la Torre BG, Fernández-Reyes M, March C, Bengoechea JA, Andreu D, Rivas L, Pachón J.

Eur J Clin Microbiol Infect Dis. 2011 Nov;30(11):1391-8. doi: 10.1007/s10096-011-1233-y. Epub 2011 Apr 12.


Efficacy of rifampin, in monotherapy and in combinations, in an experimental murine pneumonia model caused by panresistant Acinetobacter baumannii strains.

Pachón-Ibáñez ME, Docobo-Pérez F, Jiménez-Mejias ME, Ibáñez-Martínez J, García-Curiel A, Pichardo C, Pachón J.

Eur J Clin Microbiol Infect Dis. 2011 Jul;30(7):895-901. doi: 10.1007/s10096-011-1173-6. Epub 2011 Feb 19.


Local imipenem activity against Pseudomonas aeruginosa decreases in vivo in the presence of siliconized latex.

Pichardo C, Conejo MC, Docobo-Pérez F, Velasco C, López-Rojas R, García I, Pachón-Ibáñez ME, Rodríguez JM, Pachón J, Pascual A.

Eur J Clin Microbiol Infect Dis. 2011 Feb;30(2):289-91. doi: 10.1007/s10096-010-1084-y. Epub 2010 Oct 10.


Efficacy of fosfomycin and its combination with linezolid, vancomycin and imipenem in an experimental peritonitis model caused by a Staphylococcus aureus strain with reduced susceptibility to vancomycin.

Pachón-Ibáñez ME, Ribes S, Domínguez MA, Fernández R, Tubau F, Ariza J, Gudiol F, Cabellos C.

Eur J Clin Microbiol Infect Dis. 2011 Jan;30(1):89-95. doi: 10.1007/s10096-010-1058-0. Epub 2010 Sep 16.


In vitro and in vivo activities of linezolid alone and combined with vancomycin and imipenem against Staphylococcus aureus with reduced susceptibility to glycopeptides.

Ribes S, Pachón-Ibáñez ME, Domínguez MA, Fernández R, Tubau F, Ariza J, Gudiol F, Cabellos C.

Eur J Clin Microbiol Infect Dis. 2010 Nov;29(11):1361-7. doi: 10.1007/s10096-010-1007-y. Epub 2010 Aug 1.


Efficacy of tigecycline vs. imipenem in the treatment of experimental Acinetobacter baumannii murine pneumonia.

Pichardo C, Pachón-Ibañez ME, Docobo-Perez F, López-Rojas R, Jiménez-Mejías ME, Garcia-Curiel A, Pachon J.

Eur J Clin Microbiol Infect Dis. 2010 May;29(5):527-31. doi: 10.1007/s10096-010-0890-6. Epub 2010 Feb 25.


Efficacy of rifampin and its combinations with imipenem, sulbactam, and colistin in experimental models of infection caused by imipenem-resistant Acinetobacter baumannii.

Pachón-Ibáñez ME, Docobo-Pérez F, López-Rojas R, Domínguez-Herrera J, Jiménez-Mejias ME, García-Curiel A, Pichardo C, Jiménez L, Pachón J.

Antimicrob Agents Chemother. 2010 Mar;54(3):1165-72. doi: 10.1128/AAC.00367-09. Epub 2010 Jan 4.


Molecular screening of Bartonella species in rodents from south western Spain.

Márquez FJ, Rodríguez-Liébana JJ, Pachón-Ibáñez ME, Docobo-Pérez F, Hidalgo-Fontiveros A, Bernabeu-Wittel M, Muniain MA, Pachón J.

Vector Borne Zoonotic Dis. 2008 Oct;8(5):695-700. doi: 10.1089/vbz.2007.0257.


Activity of ciprofloxacin and levofloxacin in experimental pneumonia caused by Klebsiella pneumoniae deficient in porins, expressing active efflux and producing QnrA1.

Rodríguez-Martínez JM, Pichardo C, García I, Pachón-Ibañez ME, Docobo-Pérez F, Pascual A, Pachón J, Martínez-Martínez L.

Clin Microbiol Infect. 2008 Jul;14(7):691-7. doi: 10.1111/j.1469-0691.2008.02020.x.


Efficacy of amoxycillin-clavulanate in an experimental model of murine pneumonia caused by AmpC-non-hyperproducing clinical isolates of Escherichia coli resistant to cefoxitin.

Docobo-Pérez F, Fernández-Cuenca F, Pachón-Ibáñez ME, Pascual A, Pichardo C, Martínez-Martínez L, Pachón J.

Clin Microbiol Infect. 2008 Jun;14(6):582-7. doi: 10.1111/j.1469-0691.2008.01948.x. Epub 2008 Feb 22.


Prevention of rifampicin resistance in Acinetobacter baumannii in an experimental pneumonia murine model, using rifampicin associated with imipenem or sulbactam.

Pachón-Ibáñez ME, Fernández-Cuenca F, Docobo-Pérez F, Pachón J, Pascual A.

J Antimicrob Chemother. 2006 Sep;58(3):689-92. Epub 2006 Jul 26.


[Nosocomial pneumonia due to Acinetobacter baumannii].

Cisneros-Herreros JM, Garnacho-Montero J, Pachón-Ibáñez ME.

Enferm Infecc Microbiol Clin. 2005 Dec;23 Suppl 3:46-51. Review. Spanish.


Studies on the antimicrobial activity of cecropin A-melittin hybrid peptides in colistin-resistant clinical isolates of Acinetobacter baumannii.

Rodríguez-Hernández MJ, Saugar J, Docobo-Pérez F, de la Torre BG, Pachón-Ibáñez ME, García-Curiel A, Fernández-Cuenca F, Andreu D, Rivas L, Pachón J.

J Antimicrob Chemother. 2006 Jul;58(1):95-100. Epub 2006 Apr 24.


Activity of cecropin A-melittin hybrid peptides against colistin-resistant clinical strains of Acinetobacter baumannii: molecular basis for the differential mechanisms of action.

Saugar JM, Rodríguez-Hernández MJ, de la Torre BG, Pachón-Ibañez ME, Fernández-Reyes M, Andreu D, Pachón J, Rivas L.

Antimicrob Agents Chemother. 2006 Apr;50(4):1251-6.


Efficacy of beta-lactams against experimental pneumococcal endocarditis caused by strains with different susceptibilities to penicillin.

Pichardo C, Docobo-Pérez F, Pachón-Ibáñez ME, Jiménez-Mejías ME, García-Curiel A, Caballero-Granado FJ, Moreno-Maqueda I, Pachón J.

J Antimicrob Chemother. 2005 Oct;56(4):732-7. Epub 2005 Sep 8.


Efficacy of cefepime and imipenem in experimental murine pneumonia caused by porin-deficient Klebsiella pneumoniae producing CMY-2 beta-Lactamase.

Pichardo C, Rodríguez-Martínez JM, Pachón-Ibañez ME, Conejo C, Ibáñez-Martínez J, Martínez-Martínez L, Pachón J, Pascual A.

Antimicrob Agents Chemother. 2005 Aug;49(8):3311-6.


Pharmacokinetic/pharmacodynamic assessment of the in-vivo efficacy of imipenem alone or in combination with amikacin for the treatment of experimental multiresistant Acinetobacter baumannii pneumonia.

Bernabeu-Wittel M, Pichardo C, García-Curiel A, Pachón-Ibáñez ME, Ibáñez-Martínez J, Jiménez-Mejías ME, Pachón J.

Clin Microbiol Infect. 2005 Apr;11(4):319-25.


Reliability of the E-test method for detection of colistin resistance in clinical isolates of Acinetobacter baumannii.

Arroyo LA, García-Curiel A, Pachón-Ibañez ME, Llanos AC, Ruiz M, Pachón J, Aznar J.

J Clin Microbiol. 2005 Feb;43(2):903-5.


Activity of cefepime and carbapenems in experimental pneumonia caused by porin-deficient Klebsiella pneumoniae producing FOX-5 beta-lactamase.

Pichardo C, del Carmen Conejo M, Bernabéu-Wittel M, Pascual A, Jiménez-Mejías ME, de Cueto M, Pachón-Ibáñez ME, García I, Pachón J, Martínez-Martínez L.

Clin Microbiol Infect. 2005 Jan;11(1):31-8.


Activity of tigecycline (GAR-936) against Acinetobacter baumannii strains, including those resistant to imipenem.

Pachón-Ibáñez ME, Jiménez-Mejías ME, Pichardo C, Llanos AC, Pachón J.

Antimicrob Agents Chemother. 2004 Nov;48(11):4479-81.


Morphological changes induced by imipenem and meropenem at sub-inhibitory concentrations in Acinetobacter baumannii.

Bernabeu-Wittel M, García-Curiel A, Pichardo C, Pachón-Ibáñez ME, Jiménez-Mejías ME, Pachón J.

Clin Microbiol Infect. 2004 Oct;10(10):931-4.

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