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Items: 1 to 50 of 147

1.

Pathophysiology of the hepoxilins.

Pace-Asciak CR.

Biochim Biophys Acta. 2015 Apr;1851(4):383-96. doi: 10.1016/j.bbalip.2014.09.007. Epub 2014 Sep 19. Review.

PMID:
25240838
2.

Cyclooxygenase-2 inhibition partially protects against 60% O2 -mediated lung injury in neonatal rats.

Masood A, Yi M, Lau M, Belcastro R, Li J, Kantores C, Pace-Asciak CR, Jankov RP, Tanswell AK.

Pediatr Pulmonol. 2014 Oct;49(10):991-1002. doi: 10.1002/ppul.22921. Epub 2013 Nov 23.

PMID:
24273102
3.

Alterations in eicosanoid levels during U937 bcl-xL tumour growth suppression and recovery in NU/NU mice in vivo-Involvement of phospholipase A2.

Pace-Asciak CR, Li X, Reynaud D, Qiao N, Demin P, Abdelhaleem M.

Prostaglandins Other Lipid Mediat. 2013 Dec;107:43-7. doi: 10.1016/j.prostaglandins.2013.03.004. Epub 2013 Mar 30.

PMID:
23548786
4.

Hepoxilins in cancer and inflammation--use of hepoxilin antagonists.

Pace-Asciak CR.

Cancer Metastasis Rev. 2011 Dec;30(3-4):493-506. doi: 10.1007/s10555-011-9307-y. Review.

PMID:
22005952
5.

The hepoxilins and some analogues: a review of their biology.

Pace-Asciak CR.

Br J Pharmacol. 2009 Oct;158(4):972-81. doi: 10.1111/j.1476-5381.2009.00168.x. Epub 2009 Apr 30. Review.

6.

Hepoxilin analogs, PBT-3 and PBT-4, cause apoptosis of Gleevec-resistant K562 cells in vitro.

Qiao N, Reynaud D, Abdelhaleem M, Pace-Asciak CR.

In Vivo. 2007 Mar-Apr;21(2):267-71.

7.

Synthesis and pharmacological evaluation of novel nitrobenzenic thromboxane modulators as antiplatelet agents acting on both the alpha and beta isoforms of the human thromboxane receptor.

Hanson J, Reynaud D, Qiao N, Devel P, Moray AL, Renard JF, Kelley LP, Winum JY, Montero JL, Kinsella BT, Pirotte B, Pace-Asciak CR, Dogné JM.

J Med Chem. 2006 Jun 15;49(12):3701-9.

PMID:
16759113
8.

Hepoxilin analogs, potential new therapeutics in disease.

Pace-Asciak CR, Li X, Qiao N, Reynaud D, Demin P, Abdelhaleem M.

Curr Pharm Des. 2006;12(8):963-9.

PMID:
16533163
9.

From the design to the clinical application of thromboxane modulators.

Dogné JM, Hanson J, de Leval X, Pratico D, Pace-Asciak CR, Drion P, Pirotte B, Ruan KH.

Curr Pharm Des. 2006;12(8):903-23. Review.

PMID:
16533159
10.

PBT-3, a hepoxilin stable analog, causes long term inhibition of growth of K562 solid tumours in vivo.

Li X, Qiao N, Reynaud D, Abdelhaleem M, Pace-Asciak CR.

Biochem Biophys Res Commun. 2005 Dec 9;338(1):158-60. Epub 2005 Aug 10.

PMID:
16102726
11.
12.

The hepoxilin analog, PBT-3, inhibits growth of K-562 CML solid tumours in vivo in nude mice.

Li X, Qiao N, Reynaud D, Abdelhaleem M, Pace-Asciak CR.

In Vivo. 2005 Jan-Feb;19(1):185-9.

13.

The hepoxilin stable analogue, PBT-3, inhibits primary, platelet-related hemostasis in whole blood measured in vitro with the PFA-100.

Reynaud D, Clark D, Qiao N, Rand ML, Pace-Asciak CR.

Thromb Res. 2003;112(4):245-8. No abstract available.

PMID:
14987919
14.

The hepoxilin analog PBT-3 induces apoptosis in BCR-ABL-positive K562 leukemia cells.

Qiao N, Lam J, Reynaud D, Abdelhaleem M, Pace-Asciak CR.

Anticancer Res. 2003 Sep-Oct;23(5A):3617-22.

PMID:
14666657
15.

The thromboxane receptor antagonist PBT-3, a hepoxilin stable analog, selectively antagonizes the TPalpha isoform in transfected COS-7 cells.

Qiao N, Reynaud D, Demin P, Halushka PV, Pace-Asciak CR.

J Pharmacol Exp Ther. 2003 Dec;307(3):1142-7. Epub 2003 Oct 14.

PMID:
14560042
16.

Hepoxilins and trioxilins in barnacles: an analysis of their potential roles in egg hatching and larval settlement.

Vogan CL, Maskrey BH, Taylor GW, Henry S, Pace-Asciak CR, Clare AS, Rowley AF.

J Exp Biol. 2003 Sep;206(Pt 18):3219-26.

17.

Effect of 8-isoprostaglandin F2alpha on the newborn rat pulmonary arterial muscle and endothelium.

Belik J, Jankov RP, Pan J, Yi M, Pace-Asciak CR, Tanswell AK.

J Appl Physiol (1985). 2003 Nov;95(5):1979-85. Epub 2003 Jul 11.

19.

A new family of thromboxane receptor antagonists with secondary thromboxane synthase inhibition.

Pace-Asciak CR, Reynaud D, Demin P, Aslam R, Sun A.

J Pharmacol Exp Ther. 2002 May;301(2):618-24.

PMID:
11961065
20.

Hepoxilin analogs inhibit bleomycin-induced pulmonary fibrosis in the mouse.

Jankov RP, Luo X, Demin P, Aslam R, Hannam V, Tanswell AK, Pace-Asciak CR.

J Pharmacol Exp Ther. 2002 May;301(2):435-40.

PMID:
11961041
21.

The hepoxilin analog PBT-3 inhibits heparin-activated platelet aggregation evoked by ADP.

Reynaud D, Hinek A, Pace-Asciak CR.

FEBS Lett. 2002 Mar 27;515(1-3):58-60.

22.

Novel platelet antiaggregating substances.

Reynaud D, Sun A, Demin P, Pace-Asciak CR.

Biochem Biophys Res Commun. 2001 Jun 15;284(3):580-2.

PMID:
11396939
23.

Hepoxilin A3 is metabolized into its omega-hydroxy metabolite by human neutrophils.

Pace-Asciak CR, Reynaud D, Rounova O, Demin P, Pivnitsky KK.

Adv Exp Med Biol. 1999;469:535-8. No abstract available.

PMID:
10667379
25.
26.

Hepoxilins raise circulating insulin levels in vivo.

Pace-Asciak CR, Demin PM, Estrada M, Liu G.

FEBS Lett. 1999 Nov 19;461(3):165-8.

27.
28.

Biochemical, hemodynamic, and vascular evidence concerning the free radical hypothesis of nitrate tolerance.

Milone SD, Pace-Asciak CR, Reynaud D, Azevedo ER, Newton GE, Parker JD.

J Cardiovasc Pharmacol. 1999 May;33(5):685-90.

PMID:
10226853
29.

Hepoxilin signaling in intact human neutrophils: biphasic elevation of intracellular calcium by unesterified hepoxilin A3.

Reynaud D, Demin PM, Sutherland M, Nigam S, Pace-Asciak CR.

FEBS Lett. 1999 Mar 12;446(2-3):236-8.

30.

The hepoxilins. A review.

Pace-Asciak CR, Reynaud D, Demin P, Nigam S.

Adv Exp Med Biol. 1999;447:123-32. Review.

PMID:
10086189
32.

Detection of 8-epi prostaglandin F2alpha in an extract of epidermal secretion of the catfish from the Arabian Gulf.

Al-Hassan JM, Ali M, Thomson M, Pace-Asciak CR.

Prostaglandins Leukot Essent Fatty Acids. 1998 Nov;59(5):325-8.

PMID:
9888207
33.

Hepoxilin A3 is oxidized by human neutrophils into its omega-hydroxy metabolite by an activity independent of LTB4 omega-hydroxylase.

Reynaud D, Rounova O, Demin PM, Pivnitsky KK, Pace-Asciak CR.

Biochim Biophys Acta. 1997 Oct 18;1348(3):287-98.

PMID:
9366245
34.
35.

Hepoxilin-evoked intracellular reorganization of calcium in human neutrophils: a confocal microscopy study.

Mills L, Reynaud D, Pace-Asciak CR.

Exp Cell Res. 1997 Feb 1;230(2):337-41.

PMID:
9024792
36.

Hepoxilin A3 inhibits agonist-evoked rise in free intracellular calcium in human neutrophils.

Pace-Asciak CR, Reynaud D, Laneuville O, Grinstein S, Nigam S.

Adv Exp Med Biol. 1997;400A:375-80. No abstract available.

PMID:
9547579
37.

12-HETE and 12-HPETE potently stimulate intracellular release of calcium in intact human neutrophils.

Reynaud D, Pace-Asciak CR.

Prostaglandins Leukot Essent Fatty Acids. 1997 Jan;56(1):9-12.

PMID:
9044430
38.

Wine: does the colour count?

Goldberg DM, Garovic-Kocic V, Diamandis EP, Pace-Asciak CR.

Clin Chim Acta. 1996 Mar 15;246(1-2):183-93.

PMID:
8814966
39.

Wines and grape juices as modulators of platelet aggregation in healthy human subjects.

Pace-Asciak CR, Rounova O, Hahn SE, Diamandis EP, Goldberg DM.

Clin Chim Acta. 1996 Mar 15;246(1-2):163-82.

PMID:
8814965
40.

Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta.

Chen CK, Pace-Asciak CR.

Gen Pharmacol. 1996 Mar;27(2):363-6.

PMID:
8919657
41.

Hepoxilin A3-specific binding in human neutrophils.

Reynaud D, Demin P, Pace-Asciak CR.

Biochem J. 1996 Jan 15;313 ( Pt 2):537-41.

42.

Epimer-specific actions of hepoxilins A3 and B3 on PAF- and bradykinin-evoked vascular permeability in the rat skin in vivo.

Wang MM, Demin PM, Pace-Asciak CR.

Adv Exp Med Biol. 1996;416:239-41. No abstract available.

PMID:
9131155
43.

Chemical synthesis and actions of 11,12-thiirano-hepoxilin A3.

Demin PM, Reynaud D, Pace-Asciak CR.

J Lipid Mediat Cell Signal. 1996 Jan;13(1):63-72.

PMID:
8998598
44.

High-performance liquid chromatographic separation of fluorescent esters of hepoxilin enantiomers on a chiral stationary phase.

Demin P, Reynaud D, Pace-Asciak CR.

J Chromatogr B Biomed Appl. 1995 Oct 20;672(2):282-9.

PMID:
8581135
45.

Mechanistic aspects of hepoxilin biosynthesis.

Pace-Asciak CR, Reynaud D, Demin P.

J Lipid Mediat Cell Signal. 1995 Oct;12(2-3):307-11. Review. No abstract available.

PMID:
8777574
47.
48.

Hepoxilin binding in human neutrophils.

Reynaud D, Demin P, Pace-Asciak CR.

Biochem Biophys Res Commun. 1995 Feb 6;207(1):191-4.

PMID:
7857263
49.

Hepoxilins: a review on their enzymatic formation, metabolism and chemical synthesis.

Pace-Asciak CR, Reynaud D, Demin PM.

Lipids. 1995 Feb;30(2):107-14. Review.

PMID:
7769965
50.

Enzymatic formation of hepoxilin A3.

Reynaud D, Demin PM, Pace-Asciak CR.

Adv Prostaglandin Thromboxane Leukot Res. 1995;23:183-5. No abstract available.

PMID:
7732831

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