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Items: 13


Biochemical, crystallographic, and mutagenic characterization of hint, the AMP-lysine hydrolase, with novel substrates and inhibitors.

Krakowiak A, Pace HC, Blackburn GM, Adams M, Mekhalfia A, Kaczmarek R, Baraniak J, Stec WJ, Brenner C.

J Biol Chem. 2004 Apr 30;279(18):18711-6. Epub 2004 Feb 24.


Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding.

Trapasso F, Krakowiak A, Cesari R, Arkles J, Yendamuri S, Ishii H, Vecchione A, Kuroki T, Bieganowski P, Pace HC, Huebner K, Croce CM, Brenner C.

Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1592-7. Epub 2003 Feb 6.


Scaffolding functions of arrestin-2 revealed by crystal structure and mutagenesis.

Milano SK, Pace HC, Kim YM, Brenner C, Benovic JL.

Biochemistry. 2002 Mar 12;41(10):3321-8.


The nitrilase superfamily: classification, structure and function.

Pace HC, Brenner C.

Genome Biol. 2001;2(1):REVIEWS0001. Epub 2001 Jan 15. Review.


Crystal structure of the worm NitFhit Rosetta Stone protein reveals a Nit tetramer binding two Fhit dimers.

Pace HC, Hodawadekar SC, Draganescu A, Huang J, Bieganowski P, Pekarsky Y, Croce CM, Brenner C.

Curr Biol. 2000 Jul 27-Aug 10;10(15):907-17.


The histidine triad superfamily of nucleotide-binding proteins.

Brenner C, Bieganowski P, Pace HC, Huebner K.

J Cell Physiol. 1999 Nov;181(2):179-87. Review.


Purification and crystallization of complexes modeling the active state of the fragile histidine triad protein.

Brenner C, Pace HC, Garrison PN, Robinson AK, Rosler A, Liu XH, Blackburn GM, Croce CM, Huebner K, Barnes LD.

Protein Eng. 1997 Dec;10(12):1461-3.


Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit.

Pace HC, Garrison PN, Robinson AK, Barnes LD, Draganescu A, Rösler A, Blackburn GM, Siprashvili Z, Croce CM, Huebner K, Brenner C.

Proc Natl Acad Sci U S A. 1998 May 12;95(10):5484-9.


Lac repressor genetic map in real space.

Pace HC, Kercher MA, Lu P, Markiewicz P, Miller JH, Chang G, Lewis M.

Trends Biochem Sci. 1997 Sep;22(9):334-9. Review.


Crystal structure of the lactose operon repressor and its complexes with DNA and inducer.

Lewis M, Chang G, Horton NC, Kercher MA, Pace HC, Schumacher MA, Brennan RG, Lu P.

Science. 1996 Mar 1;271(5253):1247-54.


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