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Items: 13


AhR Activation in Pharmaceutical Development: Applying Liver Gene Expression Biomarker Thresholds to Identify Doses Associated with Tumorigenic Risks in Rats.

Qin C, Aslamkhan AG, Pearson K, Tanis KQ, Podtelezhnikov A, Frank E, Pacchione S, Pippert T, Glaab WE, Sistare FD.

Toxicol Sci. 2019 May 25. pii: kfz125. doi: 10.1093/toxsci/kfz125. [Epub ahead of print]


Use of a Bile Salt Export Pump Knockdown Rat Susceptibility Model to Interrogate Mechanism of Drug-Induced Liver Toxicity.

Li Y, Evers R, Hafey MJ, Cheon K, Duong H, Lynch D, LaFranco-Scheuch L, Pacchione S, Tamburino AM, Tanis KQ, Geddes K, Holder D, Zhang NR, Kang W, Gonzalez RJ, Galijatovic-Idrizbegovic A, Pearson KM, Lebron JA, Glaab WE, Sistare FD.

Toxicol Sci. 2019 Jul 1;170(1):180-198. doi: 10.1093/toxsci/kfz079.


A multi-species assay for siRNA-mediated mRNA knockdown analysis without the need for RNA purification.

Wang Z, Pacchione SJ, Niu Z, Troilo PJ, Griffiths TG, Striano KL, Lebron JA, Wolf JJ.

J Pharmacol Toxicol Methods. 2011 Mar-Apr;63(2):174-9. doi: 10.1016/j.vascn.2010.09.006. Epub 2010 Sep 25.


Intracisternal A particle genes: Distribution in the mouse genome, active subtypes, and potential roles as species-specific mediators of susceptibility to cancer.

Qin C, Wang Z, Shang J, Bekkari K, Liu R, Pacchione S, McNulty KA, Ng A, Barnum JE, Storer RD.

Mol Carcinog. 2010 Jan;49(1):54-67. doi: 10.1002/mc.20576.


Femtosecond laser: a new intradermal DNA delivery method for efficient, long-term gene expression and genetic immunization.

Zeira E, Manevitch A, Manevitch Z, Kedar E, Gropp M, Daudi N, Barsuk R, Harati M, Yotvat H, Troilo PJ, Griffiths TG 2nd, Pacchione SJ, Roden DF, Niu Z, Nussbaum O, Zamir G, Papo O, Hemo I, Lewis A, Galun E.

FASEB J. 2007 Nov;21(13):3522-33. Epub 2007 Jun 15.


Tumorigenicity assessments of Per.C6 cells and of an Ad5-vectored HIV-1 vaccine produced on this continuous cell line.

Ledwith BJ, Lanning CL, Gumprecht LA, Anderson CA, Coleman JB, Gatto NT, Balasubramanian G, Farris GM, Kemp RK, Harper LB, Barnum AB, Pacchione SJ, Mauer KL, Troilo PF, Brown ER, Wolf JJ, Lebronl JA, Lewis JA, Nichols WW.

Dev Biol (Basel). 2006;123:251-63; discussion 265-6.


Adaptation of the WHO guideline for residual DNA in parenteral vaccines produced on continuous cell lines to a limit for oral vaccines.

Lebron JA, Troilol PJ, Pacchione S, Griffiths TG, Harper LB, Mixson LA, Jackson BE, Michna L, Barnum AB, Denisova L, Johnson CN, Maurer KL, Morgan-Hoffman S, Niu Z, Roden DF, Wang Z, Wolf JJ, Hamilton TR, Laux KM, Soper KA, Ledwith BJ.

Dev Biol (Basel). 2006;123:35-44; discussion 55-73.


Monoclonal antibodies reactive with the BAF155 (SMARCC1) and BAF170 (SMARCC2) components of human SWI/SNF-related complexes.

Wang X, Liao DW, Scoy MV, Pacchione S, Yaciuk P, Moran E.

Hybridoma (Larchmt). 2005 Feb;24(1):55-7.


Two related ARID family proteins are alternative subunits of human SWI/SNF complexes.

Wang X, Nagl NG, Wilsker D, Van Scoy M, Pacchione S, Yaciuk P, Dallas PB, Moran E.

Biochem J. 2004 Oct 15;383(Pt 2):319-25.


Detection of integration of plasmid DNA into host genomic DNA following intramuscular injection and electroporation.

Wang Z, Troilo PJ, Wang X, Griffiths TG, Pacchione SJ, Barnum AB, Harper LB, Pauley CJ, Niu Z, Denisova L, Follmer TT, Rizzuto G, Ciliberto G, Fattori E, Monica NL, Manam S, Ledwith BJ.

Gene Ther. 2004 Apr;11(8):711-21.


Plasmid DNA vaccines: tissue distribution and effects of DNA sequence, adjuvants and delivery method on integration into host DNA.

Manam S, Ledwith BJ, Barnum AB, Troilo PJ, Pauley CJ, Harper LB, Griffiths TG 2nd, Niu Z, Denisova L, Follmer TT, Pacchione SJ, Wang Z, Beare CM, Bagdon WJ, Nichols WW.

Intervirology. 2000;43(4-6):273-81.


The human SWI-SNF complex protein p270 is an ARID family member with non-sequence-specific DNA binding activity.

Dallas PB, Pacchione S, Wilsker D, Bowrin V, Kobayashi R, Moran E.

Mol Cell Biol. 2000 May;20(9):3137-46.


p300/CREB binding protein-related protein p270 is a component of mammalian SWI/SNF complexes.

Dallas PB, Cheney IW, Liao DW, Bowrin V, Byam W, Pacchione S, Kobayashi R, Yaciuk P, Moran E.

Mol Cell Biol. 1998 Jun;18(6):3596-603.

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