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Items: 1 to 50 of 87

1.

An improved zinc-finger nuclease architecture for highly specific genome editing.

Miller JC, Holmes MC, Wang J, Guschin DY, Lee YL, Rupniewski I, Beausejour CM, Waite AJ, Wang NS, Kim KA, Gregory PD, Pabo CO, Rebar EJ.

Nat Biotechnol. 2007 Jul;25(7):778-85. Epub 2007 Jul 1.

PMID:
17603475
2.

Specificity by design.

Pabo CO.

Nat Biotechnol. 2006 Aug;24(8):954-5. No abstract available.

PMID:
16900141
3.

Allosteric inhibition of zinc-finger binding in the major groove of DNA by minor-groove binding ligands.

Nguyen-Hackley DH, Ramm E, Taylor CM, Joung JK, Dervan PB, Pabo CO.

Biochemistry. 2004 Apr 6;43(13):3880-90.

PMID:
15049695
4.

Cell lines for drug discovery: elevating target-protein levels using engineered transcription factors.

Liu PQ, Morton MF, Reik A, de la Rosa R, Mendel MC, Li XY, Case CC, Pabo CO, Moreno V, Kempf A, Pyati J, Shankley NP.

J Biomol Screen. 2004 Feb;9(1):44-51.

PMID:
15006148
5.

Repression of vascular endothelial growth factor A in glioblastoma cells using engineered zinc finger transcription factors.

Snowden AW, Zhang L, Urnov F, Dent C, Jouvenot Y, Zhong X, Rebar EJ, Jamieson AC, Zhang HS, Tan S, Case CC, Pabo CO, Wolffe AP, Gregory PD.

Cancer Res. 2003 Dec 15;63(24):8968-76.

6.

Structure of a designed dimeric zinc finger protein bound to DNA.

Wolfe SA, Grant RA, Pabo CO.

Biochemistry. 2003 Nov 25;42(46):13401-9.

PMID:
14621985
7.

Engineered zinc finger proteins for controlling stem cell fate.

Bartsevich VV, Miller JC, Case CC, Pabo CO.

Stem Cells. 2003;21(6):632-7.

8.

Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection.

Hurt JA, Thibodeau SA, Hirsh AS, Pabo CO, Joung JK.

Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12271-6. Epub 2003 Oct 3.

9.

Zinc-finger protein-targeted gene regulation: genomewide single-gene specificity.

Tan S, Guschin D, Davalos A, Lee YL, Snowden AW, Jouvenot Y, Zhang HS, Howes K, McNamara AR, Lai A, Ullman C, Reynolds L, Moore M, Isalan M, Berg LP, Campos B, Qi H, Spratt SK, Case CC, Pabo CO, Campisi J, Gregory PD.

Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):11997-2002. Epub 2003 Sep 26.

10.
11.

Drug discovery with engineered zinc-finger proteins.

Jamieson AC, Miller JC, Pabo CO.

Nat Rev Drug Discov. 2003 May;2(5):361-8. Review.

PMID:
12750739
12.

Gene-specific targeting of H3K9 methylation is sufficient for initiating repression in vivo.

Snowden AW, Gregory PD, Case CC, Pabo CO.

Curr Biol. 2002 Dec 23;12(24):2159-66.

13.
14.

Beyond the "recognition code": structures of two Cys2His2 zinc finger/TATA box complexes.

Wolfe SA, Grant RA, Elrod-Erickson M, Pabo CO.

Structure. 2001 Aug;9(8):717-23.

15.
16.

Design and selection of novel Cys2His2 zinc finger proteins.

Pabo CO, Peisach E, Grant RA.

Annu Rev Biochem. 2001;70:313-40. Review.

PMID:
11395410
17.
18.

DNA recognition by Cys2His2 zinc finger proteins.

Wolfe SA, Nekludova L, Pabo CO.

Annu Rev Biophys Biomol Struct. 2000;29:183-212. Review.

PMID:
10940247
19.
20.
21.

A bacterial two-hybrid selection system for studying protein-DNA and protein-protein interactions.

Joung JK, Ramm EI, Pabo CO.

Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7382-7.

22.
23.

Dimerization of zinc fingers mediated by peptides evolved in vitro from random sequences.

Wang BS, Pabo CO.

Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9568-73.

24.

Basis for recognition of cisplatin-modified DNA by high-mobility-group proteins.

Ohndorf UM, Rould MA, He Q, Pabo CO, Lippard SJ.

Nature. 1999 Jun 17;399(6737):708-12.

PMID:
10385126
26.
27.

Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP.

Zheng N, Fraenkel E, Pabo CO, Pavletich NP.

Genes Dev. 1999 Mar 15;13(6):666-74.

28.

Analysis of zinc fingers optimized via phage display: evaluating the utility of a recognition code.

Wolfe SA, Greisman HA, Ramm EI, Pabo CO.

J Mol Biol. 1999 Feb 5;285(5):1917-34.

PMID:
9925775
29.
30.

Comparison of X-ray and NMR structures for the Antennapedia homeodomain-DNA complex.

Fraenkel E, Pabo CO.

Nat Struct Biol. 1998 Aug;5(8):692-7.

PMID:
9699632
31.
32.
33.

Structure-based design of a dimeric zinc finger protein.

Pomerantz JL, Wolfe SA, Pabo CO.

Biochemistry. 1998 Jan 27;37(4):965-70.

PMID:
9467467
34.
35.

Engrailed (Gln50-->Lys) homeodomain-DNA complex at 1.9 A resolution: structural basis for enhanced affinity and altered specificity.

Tucker-Kellogg L, Rould MA, Chambers KA, Ades SE, Sauer RT, Pabo CO.

Structure. 1997 Aug 15;5(8):1047-54.

36.

Design of TATA box-binding protein/zinc finger fusions for targeted regulation of gene expression.

Kim JS, Kim J, Cepek KL, Sharp PA, Pabo CO.

Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3616-20.

37.
38.

Zif268 protein-DNA complex refined at 1.6 A: a model system for understanding zinc finger-DNA interactions.

Elrod-Erickson M, Rould MA, Nekludova L, Pabo CO.

Structure. 1996 Oct 15;4(10):1171-80.

39.

Phage display methods for selecting zinc finger proteins with novel DNA-binding specificities.

Rebar EJ, Greisman HA, Pabo CO.

Methods Enzymol. 1996;267:129-49. No abstract available.

PMID:
8743314
41.

Analysis of homeodomain function by structure-based design of a transcription factor.

Pomerantz JL, Pabo CO, Sharp PA.

Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9752-6.

42.
43.

Structure-based design of transcription factors.

Pomerantz JL, Sharp PA, Pabo CO.

Science. 1995 Jan 6;267(5194):93-6.

PMID:
7809612
44.

Structural studies of the engrailed homeodomain.

Clarke ND, Kissinger CR, Desjarlais J, Gilliland GL, Pabo CO.

Protein Sci. 1994 Oct;3(10):1779-87.

45.
46.
47.

Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules.

Klemm JD, Rould MA, Aurora R, Herr W, Pabo CO.

Cell. 1994 Apr 8;77(1):21-32.

PMID:
8156594
48.

DNA recognition by beta-sheets in the Arc repressor-operator crystal structure.

Raumann BE, Rould MA, Pabo CO, Sauer RT.

Nature. 1994 Feb 24;367(6465):754-7.

PMID:
8107872
49.

Zinc finger phage: affinity selection of fingers with new DNA-binding specificities.

Rebar EJ, Pabo CO.

Science. 1994 Feb 4;263(5147):671-3.

PMID:
8303274
50.

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots.

Pavletich NP, Chambers KA, Pabo CO.

Genes Dev. 1993 Dec;7(12B):2556-64.

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