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Items: 32

1.

A functional genetic screen defines the AKT-induced senescence signaling network.

Chan KT, Blake S, Zhu H, Kang J, Trigos AS, Madhamshettiwar PB, Diesch J, Paavolainen L, Horvath P, Hannan RD, George AJ, Sanij E, Hannan KM, Simpson KJ, Pearson RB.

Cell Death Differ. 2019 Jul 8. doi: 10.1038/s41418-019-0384-8. [Epub ahead of print]

PMID:
31285545
2.

Association of tamoxifen resistance and lipid reprogramming in breast cancer.

Hultsch S, Kankainen M, Paavolainen L, Kovanen RM, Ikonen E, Kangaspeska S, Pietiäinen V, Kallioniemi O.

BMC Cancer. 2018 Aug 24;18(1):850. doi: 10.1186/s12885-018-4757-z.

3.

Intelligent image-based in situ single-cell isolation.

Brasko C, Smith K, Molnar C, Farago N, Hegedus L, Balind A, Balassa T, Szkalisity A, Sukosd F, Kocsis K, Balint B, Paavolainen L, Enyedi MZ, Nagy I, Puskas LG, Haracska L, Tamas G, Horvath P.

Nat Commun. 2018 Jan 15;9(1):226. doi: 10.1038/s41467-017-02628-4.

4.

Systems pathology by multiplexed immunohistochemistry and whole-slide digital image analysis.

Blom S, Paavolainen L, Bychkov D, Turkki R, Mäki-Teeri P, Hemmes A, Välimäki K, Lundin J, Kallioniemi O, Pellinen T.

Sci Rep. 2017 Nov 14;7(1):15580. doi: 10.1038/s41598-017-15798-4.

5.

UNC-45a promotes myosin folding and stress fiber assembly.

Lehtimäki JI, Fenix AM, Kotila TM, Balistreri G, Paavolainen L, Varjosalo M, Burnette DT, Lappalainen P.

J Cell Biol. 2017 Dec 4;216(12):4053-4072. doi: 10.1083/jcb.201703107. Epub 2017 Oct 20.

6.

Data-analysis strategies for image-based cell profiling.

Caicedo JC, Cooper S, Heigwer F, Warchal S, Qiu P, Molnar C, Vasilevich AS, Barry JD, Bansal HS, Kraus O, Wawer M, Paavolainen L, Herrmann MD, Rohban M, Hung J, Hennig H, Concannon J, Smith I, Clemons PA, Singh S, Rees P, Horvath P, Linington RG, Carpenter AE.

Nat Methods. 2017 Aug 31;14(9):849-863. doi: 10.1038/nmeth.4397.

PMID:
28858338
7.

Advanced Cell Classifier: User-Friendly Machine-Learning-Based Software for Discovering Phenotypes in High-Content Imaging Data.

Piccinini F, Balassa T, Szkalisity A, Molnar C, Paavolainen L, Kujala K, Buzas K, Sarazova M, Pietiainen V, Kutay U, Smith K, Horvath P.

Cell Syst. 2017 Jun 28;4(6):651-655.e5. doi: 10.1016/j.cels.2017.05.012. Epub 2017 Jun 21.

8.

Echovirus 1 internalization negatively regulates epidermal growth factor receptor downregulation.

Huttunen M, Turkki P, Mäki A, Paavolainen L, Ruusuvuori P, Marjomäki V.

Cell Microbiol. 2017 Mar;19(3). doi: 10.1111/cmi.12671. Epub 2016 Oct 20.

PMID:
27665309
9.

Combining High-Content Imaging and Phenotypic Classification Analysis of Senescence-Associated Beta-Galactosidase Staining to Identify Regulators of Oncogene-Induced Senescence.

Chan KT, Paavolainen L, Hannan KM, George AJ, Hannan RD, Simpson KJ, Horvath P, Pearson RB.

Assay Drug Dev Technol. 2016 Sep;14(7):416-28. doi: 10.1089/adt.2016.739.

PMID:
27552145
10.

Ellagitannin-rich cloudberry inhibits hepatocyte growth factor induced cell migration and phosphatidylinositol 3-kinase/AKT activation in colon carcinoma cells and tumors in Min mice.

Pajari AM, Päivärinta E, Paavolainen L, Vaara E, Koivumäki T, Garg R, Heiman-Lindh A, Mutanen M, Marjomäki V, Ridley AJ.

Oncotarget. 2016 Jul 12;7(28):43907-43923. doi: 10.18632/oncotarget.9724.

11.

Comprehensive Drug Testing of Patient-derived Conditionally Reprogrammed Cells from Castration-resistant Prostate Cancer.

Saeed K, Rahkama V, Eldfors S, Bychkov D, Mpindi JP, Yadav B, Paavolainen L, Aittokallio T, Heckman C, Wennerberg K, Peehl DM, Horvath P, Mirtti T, Rannikko A, Kallioniemi O, Östling P, Af Hällström TM.

Eur Urol. 2017 Mar;71(3):319-327. doi: 10.1016/j.eururo.2016.04.019. Epub 2016 May 6.

12.

Trimeric HIV Env provides epitope occlusion mediated by hypervariable loops.

Moscoso CG, Xing L, Hui J, Hu J, Kalkhoran MB, Yenigun OM, Sun Y, Paavolainen L, Martin L, Vahlne A, Zambonelli C, Barnett SW, Srivastava IK, Cheng RH.

Sci Rep. 2014 Nov 14;4:7025. doi: 10.1038/srep07025.

13.

Permeability changes of integrin-containing multivesicular structures triggered by picornavirus entry.

Soonsawad P, Paavolainen L, Upla P, Weerachatyanukul W, Rintanen N, Espinoza J, McNerney G, Marjomäki V, Cheng RH.

PLoS One. 2014 Oct 9;9(10):e108948. doi: 10.1371/journal.pone.0108948. eCollection 2014.

14.

Compensation of missing wedge effects with sequential statistical reconstruction in electron tomography.

Paavolainen L, Acar E, Tuna U, Peltonen S, Moriya T, Soonsawad P, Marjomäki V, Cheng RH, Ruotsalainen U.

PLoS One. 2014 Oct 3;9(10):e108978. doi: 10.1371/journal.pone.0108978. eCollection 2014.

15.

Quantitative analysis of dynamic association in live biological fluorescent samples.

Ruusuvuori P, Paavolainen L, Rutanen K, Mäki A, Huttunen H, Marjomäki V.

PLoS One. 2014 Apr 11;9(4):e94245. doi: 10.1371/journal.pone.0094245. eCollection 2014.

16.

Automatic detection and analysis of cell motility in phase-contrast time-lapse images using a combination of maximally stable extremal regions and Kalman filter approaches.

Kaakinen M, Huttunen S, Paavolainen L, Marjomäki V, Heikkilä J, Eklund L.

J Microsc. 2014 Jan;253(1):65-78. doi: 10.1111/jmi.12098. Epub 2013 Nov 26.

17.

ADC measurements in diffuse large B-cell lymphoma and follicular lymphoma: a DWI and cellularity study.

Wu X, Pertovaara H, Dastidar P, Vornanen M, Paavolainen L, Marjomäki V, Järvenpää R, Eskola H, Kellokumpu-Lehtinen PL.

Eur J Radiol. 2013 Apr;82(4):e158-64. doi: 10.1016/j.ejrad.2012.11.021. Epub 2012 Dec 17.

PMID:
23254159
18.

BioImageXD: an open, general-purpose and high-throughput image-processing platform.

Kankaanpää P, Paavolainen L, Tiitta S, Karjalainen M, Päivärinne J, Nieminen J, Marjomäki V, Heino J, White DJ.

Nat Methods. 2012 Jun 28;9(7):683-9. doi: 10.1038/nmeth.2047.

PMID:
22743773
19.

Calpains promote α2β1 integrin turnover in nonrecycling integrin pathway.

Rintanen N, Karjalainen M, Alanko J, Paavolainen L, Mäki A, Nissinen L, Lehkonen M, Kallio K, Cheng RH, Upla P, Ivaska J, Marjomäki V.

Mol Biol Cell. 2012 Feb;23(3):448-63. doi: 10.1091/mbc.E11-06-0548. Epub 2011 Dec 7.

20.

N- and O-methylation of sphingomyelin markedly affects its membrane properties and interactions with cholesterol.

Björkbom A, Róg T, Kankaanpää P, Lindroos D, Kaszuba K, Kurita M, Yamaguchi S, Yamamoto T, Jaikishan S, Paavolainen L, Päivärinne J, Nyholm TK, Katsumura S, Vattulainen I, Slotte JP.

Biochim Biophys Acta. 2011 Apr;1808(4):1179-86. doi: 10.1016/j.bbamem.2011.01.009. Epub 2011 Jan 22.

21.

Fatigue during a 5-km running time trial.

Nummela AT, Heath KA, Paavolainen LM, Lambert MI, St Clair Gibson A, Rusko HK, Noakes TD.

Int J Sports Med. 2008 Sep;29(9):738-45. doi: 10.1055/s-2007-989404. Epub 2008 Jan 22.

PMID:
18213535
22.

Concurrent endurance and explosive type strength training increases activation and fast force production of leg extensor muscles in endurance athletes.

Mikkola JS, Rusko HK, Nummela AT, Paavolainen LM, Häkkinen K.

J Strength Cond Res. 2007 May;21(2):613-20.

PMID:
17530970
23.

Neuromuscular factors determining 5 km running performance and running economy in well-trained athletes.

Nummela AT, Paavolainen LM, Sharwood KA, Lambert MI, Noakes TD, Rusko HK.

Eur J Appl Physiol. 2006 May;97(1):1-8. Epub 2006 Feb 3.

PMID:
16456672
24.

Neuromuscular adaptations during concurrent strength and endurance training versus strength training.

Häkkinen K, Alen M, Kraemer WJ, Gorostiaga E, Izquierdo M, Rusko H, Mikkola J, Häkkinen A, Valkeinen H, Kaarakainen E, Romu S, Erola V, Ahtiainen J, Paavolainen L.

Eur J Appl Physiol. 2003 Mar;89(1):42-52. Epub 2002 Dec 14.

PMID:
12627304
25.

Heart rate during aerobics classes in women with different previous experience of aerobics.

Laukkanen RM, Kalaja MK, Kalaja SP, Holmala EB, Paavolainen LM, Tummavuori M, Virtanen P, Rusko HK.

Eur J Appl Physiol. 2001 Jan-Feb;84(1-2):64-8.

PMID:
11394255
26.

Muscle power factors and VO2max as determinants of horizontal and uphill running performance.

Paavolainen L, Nummela A, Rusko H.

Scand J Med Sci Sports. 2000 Oct;10(5):286-91.

PMID:
11001396
27.

Neuromuscular characteristics and fatigue during 10 km running.

Paavolainen L, Nummela A, Rusko H, Häkkinen K.

Int J Sports Med. 1999 Nov;20(8):516-21.

PMID:
10606214
28.

Explosive-strength training improves 5-km running time by improving running economy and muscle power.

Paavolainen L, Häkkinen K, Hämäläinen I, Nummela A, Rusko H.

J Appl Physiol (1985). 1999 May;86(5):1527-33.

29.

Neuromuscular characteristics and muscle power as determinants of 5-km running performance.

Paavolainen LM, Nummela AT, Rusko HK.

Med Sci Sports Exerc. 1999 Jan;31(1):124-30.

PMID:
9927020
30.

Comparison of two maximal anaerobic cycling tests.

Tossavainen M, Nummela A, Paavolainen L, Mero A, Rusko H.

Int J Sports Med. 1996 Jul;17 Suppl 2:S120-4.

PMID:
8844276
31.

Neuromuscular characteristics and fatigue in endurance and sprint athletes during a new anaerobic power test.

Paavolainen L, Häkkinen K, Nummela A, Rusko H.

Eur J Appl Physiol Occup Physiol. 1994;69(2):119-26.

PMID:
7805665
32.

Effects of explosive type strength training on physical performance characteristics in cross-country skiers.

Paavolainen L, Häkkinen K, Rusko H.

Eur J Appl Physiol Occup Physiol. 1991;62(4):251-5.

PMID:
2044534

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