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J Org Chem. 2003 Oct 3;68(20):7667-74.

Novel cytotoxic brominated diterpenes from the red alga Laurencia obtusa.

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Department of Pharmacy, Division of Pharmacognosy and Chemistry of Natural Products, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece.


Five new brominated diterpenes, along with two known, have been isolated from the organic extract of the red alga Laurencia obtusa, collected from the coastal rocks of Preveza in the Ionean Sea, Greece. The novel metabolites prevezols B-E possess two new carbon skeletons, to the best of our knowledge, unprecedented in the literature. The structures and the relative stereochemistry of the new natural products were established by means of spectral data analyses. The new metabolites were tested for their cytotoxic activity against five human cell lines. Two metabolites have exhibited significant cytotoxicity.

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