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STAT3 and STAT5 Targeting for Simultaneous Management of Melanoma and Autoimmune Diseases.

Logotheti S, Pützer BM.

Cancers (Basel). 2019 Sep 27;11(10). pii: E1448. doi: 10.3390/cancers11101448. Review.


Rewiring E2F1 with classical NHEJ via APLF suppression promotes bladder cancer invasiveness.

Richter C, Marquardt S, Li F, Spitschak A, Murr N, Edelhäuser BAH, Iliakis G, Pützer BM, Logotheti S.

J Exp Clin Cancer Res. 2019 Jul 8;38(1):292. doi: 10.1186/s13046-019-1286-9.


Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis.

von Knethen A, Schäfer A, Kuchler L, Knape T, Christen U, Hintermann E, Fißlthaler B, Schröder K, Brandes RP, Genz B, Abshagen K, Pützer BM, Sha LK, Weigert A, Syed SN, Schulz M, Shah AM, Ernst A, Putyrski M, Finkelmeier F, Pesic M, Greten F, Hogardt M, Kempf VAJ, Gunne S, Parnham MJ, Brüne B.

Theranostics. 2019 Mar 16;9(7):2003-2016. doi: 10.7150/thno.28057. eCollection 2019.


Drug Repositioning Inferred from E2F1-Coregulator Interactions Studies for the Prevention and Treatment of Metastatic Cancers.

Goody D, Gupta SK, Engelmann D, Spitschak A, Marquardt S, Mikkat S, Meier C, Hauser C, Gundlach JP, Egberts JH, Martin H, Schumacher T, Trauzold A, Wolkenhauer O, Logotheti S, Pützer BM.

Theranostics. 2019 Feb 20;9(5):1490-1509. doi: 10.7150/thno.29546. eCollection 2019.


p73-Governed miRNA Networks: Translating Bioinformatics Approaches to Therapeutic Solutions for Cancer Metastasis.

Logotheti S, Marquardt S, Pützer BM.

Methods Mol Biol. 2019;1912:33-52. doi: 10.1007/978-1-4939-8982-9_2. Review.


DNp73-induced degradation of tyrosinase links depigmentation with EMT-driven melanoma progression.

Fürst K, Steder M, Logotheti S, Angerilli A, Spitschak A, Marquardt S, Schumacher T, Engelmann D, Herchenröder O, Rupp RAW, Pützer BM.

Cancer Lett. 2019 Feb 1;442:299-309. doi: 10.1016/j.canlet.2018.11.009. Epub 2018 Nov 13.


Emerging functional markers for cancer stem cell-based therapies: Understanding signaling networks for targeting metastasis.

Marquardt S, Solanki M, Spitschak A, Vera J, Pützer BM.

Semin Cancer Biol. 2018 Dec;53:90-109. doi: 10.1016/j.semcancer.2018.06.006. Epub 2018 Jun 30. Review.


MiR-205-5p and miR-342-3p cooperate in the repression of the E2F1 transcription factor in the context of anticancer chemotherapy resistance.

Lai X, Gupta SK, Schmitz U, Marquardt S, Knoll S, Spitschak A, Wolkenhauer O, Pützer BM, Vera J.

Theranostics. 2018 Jan 1;8(4):1106-1120. doi: 10.7150/thno.19904. eCollection 2018.


A web platform for the network analysis of high-throughput data in melanoma and its use to investigate mechanisms of resistance to anti-PD1 immunotherapy.

Dreyer FS, Cantone M, Eberhardt M, Jaitly T, Walter L, Wittmann J, Gupta SK, Khan FM, Wolkenhauer O, Pützer BM, Jäck HM, Heinzerling L, Vera J.

Biochim Biophys Acta Mol Basis Dis. 2018 Jun;1864(6 Pt B):2315-2328. doi: 10.1016/j.bbadis.2018.01.020. Epub 2018 Feb 23.


Unraveling a tumor type-specific regulatory core underlying E2F1-mediated epithelial-mesenchymal transition to predict receptor protein signatures.

Khan FM, Marquardt S, Gupta SK, Knoll S, Schmitz U, Spitschak A, Engelmann D, Vera J, Wolkenhauer O, Pützer BM.

Nat Commun. 2017 Aug 4;8(1):198. doi: 10.1038/s41467-017-00268-2.


E2F1 Signalling is Predictive of Chemoresistance and Lymphogenic Metastasis in Penile Cancer: A Pilot Functional Study Reveals New Prognostic Biomarkers.

Fenner F, Goody D, Protzel C, Erbersdobler A, Richter C, Hartz JM, Naumann CM, Kalthoff H, Herchenröder O, Hakenberg OW, Pützer BM.

Eur Urol Focus. 2018 Jul;4(4):599-607. doi: 10.1016/j.euf.2017.02.009. Epub 2017 Mar 1.


Advances in cancer stem cell targeting: How to strike the evil at its root.

Pützer BM, Solanki M, Herchenröder O.

Adv Drug Deliv Rev. 2017 Oct 1;120:89-107. doi: 10.1016/j.addr.2017.07.013. Epub 2017 Jul 21. Review.


Non-canonical pathway induced by Wnt3a regulates β-catenin via Pyk2 in differentiating human neural progenitor cells.

Narendra Talabattula VA, Morgan P, Frech MJ, Uhrmacher AM, Herchenröder O, Pützer BM, Rolfs A, Luo J.

Biochem Biophys Res Commun. 2017 Sep 9;491(1):40-46. doi: 10.1016/j.bbrc.2017.07.030. Epub 2017 Jul 8.


MiR-182 promotes cancer invasion by linking RET oncogene activated NF-κB to loss of the HES1/Notch1 regulatory circuit.

Spitschak A, Meier C, Kowtharapu B, Engelmann D, Pützer BM.

Mol Cancer. 2017 Jan 26;16(1):24. doi: 10.1186/s12943-016-0563-x.


Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes In Vivo Attenuates Liver Fibrosis.

Song G, Pacher M, Balakrishnan A, Yuan Q, Tsay HC, Yang D, Reetz J, Brandes S, Dai Z, Pützer BM, Araúzo-Bravo MJ, Steinemann D, Luedde T, Schwabe RF, Manns MP, Schöler HR, Schambach A, Cantz T, Ott M, Sharma AD.

Cell Stem Cell. 2016 Jun 2;18(6):797-808. doi: 10.1016/j.stem.2016.01.010. Epub 2016 Feb 25.


Integrated Loss of miR-1/miR-101/miR-204 Discriminates Metastatic from Nonmetastatic Penile Carcinomas and Can Predict Patient Outcome.

Hartz JM, Engelmann D, Fürst K, Marquardt S, Spitschak A, Goody D, Protzel C, Hakenberg OW, Pützer BM.

J Urol. 2016 Aug;196(2):570-8. doi: 10.1016/j.juro.2016.01.115. Epub 2016 Feb 17.


Effect of 10 different polymorphisms on preoperative volumetric characteristics of glioblastoma multiforme.

Henker C, Kriesen T, Fürst K, Goody D, Glass Ä, Pützer BM, Piek J.

J Neurooncol. 2016 Feb;126(3):585-92. doi: 10.1007/s11060-015-2005-9. Epub 2015 Nov 25.


p73 and IGF1R Regulate Emergence of Aggressive Cancer Stem-like Features via miR-885-5p Control.

Meier C, Hardtstock P, Joost S, Alla V, Pützer BM.

Cancer Res. 2016 Jan 15;76(2):197-205. doi: 10.1158/0008-5472.CAN-15-1228. Epub 2015 Nov 10.


Epigenetic factor EPC1 is a master regulator of DNA damage response by interacting with E2F1 to silence death and activate metastasis-related gene signatures.

Wang Y, Alla V, Goody D, Gupta SK, Spitschak A, Wolkenhauer O, Pützer BM, Engelmann D.

Nucleic Acids Res. 2016 Jan 8;44(1):117-33. doi: 10.1093/nar/gkv885. Epub 2015 Sep 8.


Novel subventricular zone early progenitor cell-specific adenovirus for in vivo therapy of central nervous system disorders reinforces brain stem cell heterogeneity.

Reetz J, Hildebrandt S, Schmidt A, Meier C, Herchenröder O, Gläser A, Witt M, Pützer BM, Wree A.

Brain Struct Funct. 2016 May;221(4):2049-59. doi: 10.1007/s00429-015-1025-8. Epub 2015 Mar 12.


A balancing act: orchestrating amino-truncated and full-length p73 variants as decisive factors in cancer progression.

Engelmann D, Meier C, Alla V, Pützer BM.

Oncogene. 2015 Aug 13;34(33):4287-99. doi: 10.1038/onc.2014.365. Epub 2014 Nov 10. Review.


E2F1 induces miR-224/452 expression to drive EMT through TXNIP downregulation.

Knoll S, Fürst K, Kowtharapu B, Schmitz U, Marquardt S, Wolkenhauer O, Martin H, Pützer BM.

EMBO Rep. 2014 Dec;15(12):1315-29. doi: 10.15252/embr.201439392. Epub 2014 Oct 23.


Emerging from the shade of p53 mutants: N-terminally truncated variants of the p53 family in EMT signaling and cancer progression.

Engelmann D, Pützer BM.

Sci Signal. 2014 Sep 30;7(345):re9. doi: 10.1126/scisignal.2005699. Review.


Eradication of metastatic melanoma through cooperative expression of RNA-based HDAC1 inhibitor and p73 by oncolytic adenovirus.

Schipper H, Alla V, Meier C, Nettelbeck DM, Herchenröder O, Pützer BM.

Oncotarget. 2014 Aug 15;5(15):5893-907.


Association of RHAMM with E2F1 promotes tumour cell extravasation by transcriptional up-regulation of fibronectin.

Meier C, Spitschak A, Abshagen K, Gupta S, Mor JM, Wolkenhauer O, Haier J, Vollmar B, Alla V, Pützer BM.

J Pathol. 2014 Nov;234(3):351-64. doi: 10.1002/path.4400. Epub 2014 Aug 28.


Adenoviral overexpression of Lhx2 attenuates cell viability but does not preserve the stem cell like phenotype of hepatic stellate cells.

Genz B, Thomas M, Pützer BM, Siatkowski M, Fuellen G, Vollmar B, Abshagen K.

Exp Cell Res. 2014 Nov 1;328(2):429-43. doi: 10.1016/j.yexcr.2014.06.019. Epub 2014 Jul 1.


Peptide-based technologies to alter adenoviral vector tropism: ways and means for systemic treatment of cancer.

Reetz J, Herchenröder O, Pützer BM.

Viruses. 2014 Apr 2;6(4):1540-63. doi: 10.3390/v6041540. Review.


DNp73: oncotarget in invasion and metastasis.

Pützer BM.

Oncotarget. 2014 Jan 15;5(1):3-4. No abstract available.


DNp73 exerts function in metastasis initiation by disconnecting the inhibitory role of EPLIN on IGF1R-AKT/STAT3 signaling.

Steder M, Alla V, Meier C, Spitschak A, Pahnke J, Fürst K, Kowtharapu BS, Engelmann D, Petigk J, Egberts F, Schäd-Trcka SG, Gross G, Nettelbeck DM, Niemetz A, Pützer BM.

Cancer Cell. 2013 Oct 14;24(4):512-27. doi: 10.1016/j.ccr.2013.08.023.


E2F1 promotes angiogenesis through the VEGF-C/VEGFR-3 axis in a feedback loop for cooperative induction of PDGF-B.

Engelmann D, Mayoli-Nüssle D, Mayrhofer C, Fürst K, Alla V, Stoll A, Spitschak A, Abshagen K, Vollmar B, Ran S, Pützer BM.

J Mol Cell Biol. 2013 Dec;5(6):391-403. doi: 10.1093/jmcb/mjt035. Epub 2013 Sep 6.


Chikungunya virus capsid protein contains nuclear import and export signals.

Thomas S, Rai J, John L, Schaefer S, Pützer BM, Herchenröder O.

Virol J. 2013 Aug 28;10:269. doi: 10.1186/1743-422X-10-269.


Development of Adenoviral Delivery Systems to Target Hepatic Stellate Cells In Vivo.

Reetz J, Genz B, Meier C, Kowtharapu BS, Timm F, Vollmar B, Herchenröder O, Abshagen K, Pützer BM.

PLoS One. 2013 Jun 18;8(6):e67091. doi: 10.1371/journal.pone.0067091. Print 2013. Erratum in: PLoS One. 2013;8(7). doi:10.1371/annotation/981389e9-e5a1-4be6-bf55-841a7102a623.


Hybrid modeling of the crosstalk between signaling and transcriptional networks using ordinary differential equations and multi-valued logic.

Khan FM, Schmitz U, Nikolov S, Engelmann D, Pützer BM, Wolkenhauer O, Vera J.

Biochim Biophys Acta. 2014 Jan;1844(1 Pt B):289-98. doi: 10.1016/j.bbapap.2013.05.007. Epub 2013 May 18.


Kinetic modeling-based detection of genetic signatures that provide chemoresistance via the E2F1-p73/DNp73-miR-205 network.

Vera J, Schmitz U, Lai X, Engelmann D, Khan FM, Wolkenhauer O, Pützer BM.

Cancer Res. 2013 Jun 15;73(12):3511-24. doi: 10.1158/0008-5472.CAN-12-4095. Epub 2013 Feb 27.


The E2F1-miRNA cancer progression network.

Knoll S, Emmrich S, Pützer BM.

Adv Exp Med Biol. 2013;774:135-47. doi: 10.1007/978-94-007-5590-1_8. Review.


E2F1 apoptosis counterattacked: evil strikes back.

Pützer BM, Engelmann D.

Trends Mol Med. 2013 Feb;19(2):89-98. doi: 10.1016/j.molmed.2012.10.009. Epub 2012 Dec 5. Review.


E2F1 confers anticancer drug resistance by targeting ABC transporter family members and Bcl-2 via the p73/DNp73-miR-205 circuitry.

Alla V, Kowtharapu BS, Engelmann D, Emmrich S, Schmitz U, Steder M, Pützer BM.

Cell Cycle. 2012 Aug 15;11(16):3067-78. doi: 10.4161/cc.21476. Epub 2012 Aug 8.


Immune responses to RHAMM in patients with acute myeloid leukemia after chemotherapy and allogeneic stem cell transplantation.

Casalegno-Garduño R, Meier C, Schmitt A, Spitschak A, Hilgendorf I, Rohde S, Hirt C, Freund M, Pützer BM, Schmitt M.

Clin Dev Immunol. 2012;2012:146463. doi: 10.1155/2012/146463. Epub 2012 Jun 6.


Senescence determines the fate of activated rat pancreatic stellate cells.

Fitzner B, Müller S, Walther M, Fischer M, Engelmann R, Müller-Hilke B, Pützer BM, Kreutzer M, Nizze H, Jaster R.

J Cell Mol Med. 2012 Nov;16(11):2620-30. doi: 10.1111/j.1582-4934.2012.01573.x.


Adenoviral transduction supports matrix expression of alginate cultured articular chondrocytes.

Pohle D, Kasch R, Herlyn P, Bader R, Mittlmeier T, Pützer BM, Müller-Hilke B.

Biotechnol Bioeng. 2012 Sep;109(9):2402-8. doi: 10.1002/bit.24505. Epub 2012 Apr 17.


The dark side of E2F1: in transit beyond apoptosis.

Engelmann D, Pützer BM.

Cancer Res. 2012 Feb 1;72(3):571-5. doi: 10.1158/0008-5472.CAN-11-2575. Review.


Dissection of cell context-dependent interactions between HBx and p53 family members in regulation of apoptosis: a role for HBV-induced HCC.

Knoll S, Fürst K, Thomas S, Villanueva Baselga S, Stoll A, Schaefer S, Pützer BM.

Cell Cycle. 2011 Oct 15;10(20):3554-65. doi: 10.4161/cc.10.20.17856. Epub 2011 Oct 15.


Hepatitis E virus ORF2 protein activates the pro-apoptotic gene CHOP and anti-apoptotic heat shock proteins.

John L, Thomas S, Herchenröder O, Pützer BM, Schaefer S.

PLoS One. 2011;6(9):e25378. doi: 10.1371/journal.pone.0025378. Epub 2011 Sep 23.


Germline RET sequence variation I852M and occult medullary thyroid cancer: harmless polymorphism or causative mutation?

Machens A, Spitschak A, Lorenz K, Pützer BM, Dralle H.

Clin Endocrinol (Oxf). 2011 Dec;75(6):801-5. doi: 10.1111/j.1365-2265.2011.04158.x.


Evaluation of systemic targeting of RET oncogene-based MTC with tumor-selective peptide-tagged Ad vectors in clinical mouse models.

Schmidt A, Eipel C, Fürst K, Sommer N, Pahnke J, Pützer BM.

Gene Ther. 2011 Apr;18(4):418-23. doi: 10.1038/gt.2010.165. Epub 2011 Jan 13.


GRAMD4 mimics p53 and mediates the apoptotic function of p73 at mitochondria.

John K, Alla V, Meier C, Pützer BM.

Cell Death Differ. 2011 May;18(5):874-86. doi: 10.1038/cdd.2010.153. Epub 2010 Dec 3. Erratum in: Cell Death Differ. 2012 Mar;19(3):552.


Functional dissection of the alphavirus capsid protease: sequence requirements for activity.

Thomas S, Rai J, John L, Günther S, Drosten C, Pützer BM, Schaefer S.

Virol J. 2010 Nov 18;7:327. doi: 10.1186/1743-422X-7-327.


Predicting and preventing melanoma invasiveness: advances in clarifying E2F1 function.

Pützer BM, Steder M, Alla V.

Expert Rev Anticancer Ther. 2010 Nov;10(11):1707-20. doi: 10.1586/era.10.153. Review.


Translating DNA damage into cancer cell death-A roadmap for E2F1 apoptotic signalling and opportunities for new drug combinations to overcome chemoresistance.

Engelmann D, Pützer BM.

Drug Resist Updat. 2010 Aug-Oct;13(4-5):119-31. doi: 10.1016/j.drup.2010.06.001. Epub 2010 Aug 1. Review.


Targeting of neural stem cells in the hippocampus of adult rats by custom-made Ad vectors.

Hildebrandt S, Schmidt A, Stoll A, Schmitt O, Köhling R, Wree A, Haas SJ, Pützer BM.

Brain Struct Funct. 2010 Aug;215(2):105-13. doi: 10.1007/s00429-010-0275-8. Epub 2010 Jul 22.


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