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Items: 19

1.

Allosteric Regulation of Phosphatidylinositol 4-Kinase III Beta by an Antipicornavirus Compound MDL-860.

Arita M, Dobrikov G, Pürstinger G, Galabov AS.

ACS Infect Dis. 2017 Aug 11;3(8):585-594. doi: 10.1021/acsinfecdis.7b00053. Epub 2017 Jun 28.

PMID:
28605587
2.

Anti-enteroviral triple combination of viral replication inhibitors: activity against coxsackievirus B1 neuroinfection in mice.

Stoyanova A, Nikolova I, Pürstinger G, Dobrikov G, Dimitrov V, Philipov S, Galabov AS.

Antivir Chem Chemother. 2015 Dec;24(5-6):136-147. doi: 10.1177/2040206616671571. Epub 2016 Nov 4.

3.

The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family.

van der Linden L, Vives-Adrián L, Selisko B, Ferrer-Orta C, Liu X, Lanke K, Ulferts R, De Palma AM, Tanchis F, Goris N, Lefebvre D, De Clercq K, Leyssen P, Lacroix C, Pürstinger G, Coutard B, Canard B, Boehr DD, Arnold JJ, Cameron CE, Verdaguer N, Neyts J, van Kuppeveld FJ.

PLoS Pathog. 2015 Mar 23;11(3):e1004733. doi: 10.1371/journal.ppat.1004733. eCollection 2015 Mar.

4.

Chemodiversity of cereulide, the emetic toxin of Bacillus cereus.

Marxen S, Stark TD, Frenzel E, Rütschle A, Lücking G, Pürstinger G, Pohl EE, Scherer S, Ehling-Schulz M, Hofmann T.

Anal Bioanal Chem. 2015 Mar;407(9):2439-53. doi: 10.1007/s00216-015-8511-y. Epub 2015 Feb 10.

PMID:
25665710
5.

H1PVAT is a novel and potent early-stage inhibitor of poliovirus replication that targets VP1.

Tijsma A, Thibaut HJ, Spieser SA, De Palma A, Koukni M, Rhoden E, Oberste S, Pürstinger G, Volny-Luraghi A, Martin J, Marchand A, Chaltin P, Neyts J, Leyssen P.

Antiviral Res. 2014 Oct;110:1-9. doi: 10.1016/j.antiviral.2014.07.003. Epub 2014 Jul 17.

PMID:
25043639
6.

Synthesis, cytotoxic, and antitumor activities of 2-pyridylhydrazones derived from 3-benzoylpyridazines.

Easmon J, Pürstinger G, Heinisch G, Fiebig HH, Roth T, Hofmann J.

Arch Pharm (Weinheim). 2014 Aug;347(8):599-608. doi: 10.1002/ardp.201400137. Epub 2014 Jun 11.

PMID:
24917378
7.

Substituted 2,6-bis(benzimidazol-2-yl)pyridines: a novel chemical class of pestivirus inhibitors that targets a hot spot for inhibition of pestivirus replication in the RNA-dependent RNA polymerase.

Musiu S, Pürstinger G, Stallinger S, Vrancken R, Haegeman A, Koenen F, Leyssen P, Froeyen M, Neyts J, Paeshuyse J.

Antiviral Res. 2014 Jun;106:71-9. doi: 10.1016/j.antiviral.2014.03.010. Epub 2014 Mar 27.

PMID:
24680957
8.

Toxicity of oxidized phospholipids in cultured macrophages.

Stemmer U, Dunai ZA, Koller D, Pürstinger G, Zenzmaier E, Deigner HP, Aflaki E, Kratky D, Hermetter A.

Lipids Health Dis. 2012 Sep 7;11:110. doi: 10.1186/1476-511X-11-110.

9.

Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication.

van der Schaar HM, van der Linden L, Lanke KH, Strating JR, Pürstinger G, de Vries E, de Haan CA, Neyts J, van Kuppeveld FJ.

Cell Res. 2012 Nov;22(11):1576-92. doi: 10.1038/cr.2012.129. Epub 2012 Sep 4.

10.

Mechanistic characterization of GS-9190 (Tegobuvir), a novel nonnucleoside inhibitor of hepatitis C virus NS5B polymerase.

Shih IH, Vliegen I, Peng B, Yang H, Hebner C, Paeshuyse J, Pürstinger G, Fenaux M, Tian Y, Mabery E, Qi X, Bahador G, Paulson M, Lehman LS, Bondy S, Tse W, Reiser H, Lee WA, Schmitz U, Neyts J, Zhong W.

Antimicrob Agents Chemother. 2011 Sep;55(9):4196-203. doi: 10.1128/AAC.00307-11. Epub 2011 Jul 11.

11.

Substituted imidazopyridines as potent inhibitors of HCV replication.

Vliegen I, Paeshuyse J, De Burghgraeve T, Lehman LS, Paulson M, Shih IH, Mabery E, Boddeker N, De Clercq E, Reiser H, Oare D, Lee WA, Zhong W, Bondy S, Pürstinger G, Neyts J.

J Hepatol. 2009 May;50(5):999-1009. doi: 10.1016/j.jhep.2008.12.028. Epub 2009 Feb 26.

PMID:
19303654
12.

Synthesis and anti-CVB 3 evaluation of substituted 5-nitro-2-phenoxybenzonitriles.

Pürstinger G, De Palma AM, Zimmerhofer G, Huber S, Ladurner S, Neyts J.

Bioorg Med Chem Lett. 2008 Sep 15;18(18):5123-5. doi: 10.1016/j.bmcl.2008.07.099. Epub 2008 Jul 30.

PMID:
18710805
13.

Potential use of antiviral agents in polio eradication.

De Palma AM, Pürstinger G, Wimmer E, Patick AK, Andries K, Rombaut B, De Clercq E, Neyts J.

Emerg Infect Dis. 2008 Apr;14(4):545-51. doi: 10.3201/eid1404.070439.

14.

The thiazolobenzimidazole TBZE-029 inhibits enterovirus replication by targeting a short region immediately downstream from motif C in the nonstructural protein 2C.

De Palma AM, Heggermont W, Lanke K, Coutard B, Bergmann M, Monforte AM, Canard B, De Clercq E, Chimirri A, Pürstinger G, Rohayem J, van Kuppeveld F, Neyts J.

J Virol. 2008 May;82(10):4720-30. doi: 10.1128/JVI.01338-07. Epub 2008 Mar 12.

15.

Anti-enterovirus activity and structure-activity relationship of a series of 2,6-dihalophenyl-substituted 1H,3H-thiazolo[3,4-a]benzimidazoles.

De Palma AM, Heggermont W, Leyssen P, Pürstinger G, Wimmer E, De Clercq E, Rao A, Monforte AM, Chimirri A, Neyts J.

Biochem Biophys Res Commun. 2007 Feb 16;353(3):628-32. Epub 2006 Dec 19.

PMID:
17194441
16.

Synthesis, structure-activity relationships, and antitumor studies of 2-benzoxazolyl hydrazones derived from alpha-(N)-acyl heteroaromatics.

Easmon J, Pürstinger G, Thies KS, Heinisch G, Hofmann J.

J Med Chem. 2006 Oct 19;49(21):6343-50.

PMID:
17034140
17.

Synthesis, cytotoxicity, and antitumor activity of copper(II) and iron(II) complexes of (4)N-azabicyclo[3.2.2]nonane thiosemicarbazones derived from acyl diazines.

Easmon J, Pürstinger G, Heinisch G, Roth T, Fiebig HH, Holzer W, Jäger W, Jenny M, Hofmann J.

J Med Chem. 2001 Jun 21;44(13):2164-71.

PMID:
11405653
18.

Investigations on the mechanism of action of the novel antitumor agents 2-benzothiazolyl, 2-benzoxazolyl, and 2-benzimidazolyl hydrazones derived from 2-acetylpyridine.

Hall IH, Peaty NJ, Henry JR, Easmon J, Heinisch G, Pürstinger G.

Arch Pharm (Weinheim). 1999 Apr;332(4):115-23.

PMID:
10327884
19.

Azinyl and diazinyl hydrazones derived from aryl N-heteroaryl ketones: synthesis and antiproliferative activity.

Easmon J, Heinisch G, Pürstinger G, Langer T, Osterreicher JK, Grunicke HH, Hofmann J.

J Med Chem. 1997 Dec 19;40(26):4420-5.

PMID:
9435912

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