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Items: 16

1.

Non-reducing trisaccharide fatty acid monoesters: novel detergents in membrane biochemistry.

Pérez-Victoria I, Pérez-Victoria FJ, Roldán-Vargas S, García-Hernández R, Carvalho L, Castanys S, Gamarro F, Morales JC, Pérez-Victoria JM.

Biochim Biophys Acta. 2011 Mar;1808(3):717-26. doi: 10.1016/j.bbamem.2010.11.031. Epub 2010 Dec 3.

2.

Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex.

Pérez-Victoria FJ, Schindler C, Magadán JG, Mardones GA, Delevoye C, Romao M, Raposo G, Bonifacino JS.

Mol Biol Cell. 2010 Oct 1;21(19):3386-95. doi: 10.1091/mbc.E10-05-0392. Epub 2010 Aug 4.

3.

Structural basis for the wobbler mouse neurodegenerative disorder caused by mutation in the Vps54 subunit of the GARP complex.

Pérez-Victoria FJ, Abascal-Palacios G, Tascón I, Kajava A, Magadán JG, Pioro EP, Bonifacino JS, Hierro A.

Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):12860-5. doi: 10.1073/pnas.1004756107. Epub 2010 Jul 6.

4.

Multilayered mechanism of CD4 downregulation by HIV-1 Vpu involving distinct ER retention and ERAD targeting steps.

Magadán JG, Pérez-Victoria FJ, Sougrat R, Ye Y, Strebel K, Bonifacino JS.

PLoS Pathog. 2010 Apr 29;6(4):e1000869. doi: 10.1371/journal.ppat.1000869.

5.

Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network.

Pérez-Victoria FJ, Bonifacino JS.

Mol Cell Biol. 2009 Oct;29(19):5251-63. doi: 10.1128/MCB.00495-09. Epub 2009 Jul 20.

6.

Low plasma membrane expression of the miltefosine transport complex renders Leishmania braziliensis refractory to the drug.

Sánchez-Cañete MP, Carvalho L, Pérez-Victoria FJ, Gamarro F, Castanys S.

Antimicrob Agents Chemother. 2009 Apr;53(4):1305-13. doi: 10.1128/AAC.01694-08. Epub 2009 Feb 2.

7.

Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes.

Pérez-Victoria FJ, Mardones GA, Bonifacino JS.

Mol Biol Cell. 2008 Jun;19(6):2350-62. doi: 10.1091/mbc.E07-11-1189. Epub 2008 Mar 26.

8.

Inactivation of the miltefosine transporter, LdMT, causes miltefosine resistance that is conferred to the amastigote stage of Leishmania donovani and persists in vivo.

Seifert K, Pérez-Victoria FJ, Stettler M, Sánchez-Cañete MP, Castanys S, Gamarro F, Croft SL.

Int J Antimicrob Agents. 2007 Sep;30(3):229-35. Epub 2007 Jul 12.

PMID:
17628445
9.

Combination of suboptimal doses of inhibitors targeting different domains of LtrMDR1 efficiently overcomes resistance of Leishmania spp. to Miltefosine by inhibiting drug efflux.

Pérez-Victoria JM, Cortés-Selva F, Parodi-Talice A, Bavchvarov BI, Pérez-Victoria FJ, Muñoz-Martínez F, Maitrejean M, Costi MP, Barron D, Di Pietro A, Castanys S, Gamarro F.

Antimicrob Agents Chemother. 2006 Sep;50(9):3102-10.

10.

Mechanisms of experimental resistance of Leishmania to miltefosine: Implications for clinical use.

Pérez-Victoria FJ, Sánchez-Cañete MP, Seifert K, Croft SL, Sundar S, Castanys S, Gamarro F.

Drug Resist Updat. 2006 Feb-Apr;9(1-2):26-39. Review.

PMID:
16814199
11.

Phospholipid translocation and miltefosine potency require both L. donovani miltefosine transporter and the new protein LdRos3 in Leishmania parasites.

Pérez-Victoria FJ, Sánchez-Cañete MP, Castanys S, Gamarro F.

J Biol Chem. 2006 Aug 18;281(33):23766-75. Epub 2006 Jun 19.

12.

Characterization of an ABCA-like transporter involved in vesicular trafficking in the protozoan parasite Trypanosoma cruzi.

Torres C, Pérez-Victoria FJ, Parodi-Talice A, Castanys S, Gamarro F.

Mol Microbiol. 2004 Nov;54(3):632-46.

13.

Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance.

Pérez-Victoria FJ, Gamarro F, Ouellette M, Castanys S.

J Biol Chem. 2003 Dec 12;278(50):49965-71. Epub 2003 Sep 27.

14.

Leishmania donovani resistance to miltefosine involves a defective inward translocation of the drug.

Pérez-Victoria FJ, Castanys S, Gamarro F.

Antimicrob Agents Chemother. 2003 Aug;47(8):2397-403.

15.

Alkyl-lysophospholipid resistance in multidrug-resistant Leishmania tropica and chemosensitization by a novel P-glycoprotein-like transporter modulator.

Pérez-Victoria JM, Pérez-Victoria FJ, Parodi-Talice A, Jiménez IA, Ravelo AG, Castanys S, Gamarro F.

Antimicrob Agents Chemother. 2001 Sep;45(9):2468-74.

16.

High-affinity binding of silybin derivatives to the nucleotide-binding domain of a Leishmania tropica P-glycoprotein-like transporter and chemosensitization of a multidrug-resistant parasite to daunomycin.

Pérez-Victoria JM, Pérez-Victoria FJ, Conseil G, Maitrejean M, Comte G, Barron D, Di Pietro A, Castanys S, Gamarro F.

Antimicrob Agents Chemother. 2001 Feb;45(2):439-46.

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