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Items: 16


Non-reducing trisaccharide fatty acid monoesters: novel detergents in membrane biochemistry.

Pérez-Victoria I, Pérez-Victoria FJ, Roldán-Vargas S, García-Hernández R, Carvalho L, Castanys S, Gamarro F, Morales JC, Pérez-Victoria JM.

Biochim Biophys Acta. 2011 Mar;1808(3):717-26. doi: 10.1016/j.bbamem.2010.11.031. Epub 2010 Dec 3.


Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex.

Pérez-Victoria FJ, Schindler C, Magadán JG, Mardones GA, Delevoye C, Romao M, Raposo G, Bonifacino JS.

Mol Biol Cell. 2010 Oct 1;21(19):3386-95. doi: 10.1091/mbc.E10-05-0392. Epub 2010 Aug 4.


Structural basis for the wobbler mouse neurodegenerative disorder caused by mutation in the Vps54 subunit of the GARP complex.

Pérez-Victoria FJ, Abascal-Palacios G, Tascón I, Kajava A, Magadán JG, Pioro EP, Bonifacino JS, Hierro A.

Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):12860-5. doi: 10.1073/pnas.1004756107. Epub 2010 Jul 6.


Multilayered mechanism of CD4 downregulation by HIV-1 Vpu involving distinct ER retention and ERAD targeting steps.

Magadán JG, Pérez-Victoria FJ, Sougrat R, Ye Y, Strebel K, Bonifacino JS.

PLoS Pathog. 2010 Apr 29;6(4):e1000869. doi: 10.1371/journal.ppat.1000869.


Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network.

Pérez-Victoria FJ, Bonifacino JS.

Mol Cell Biol. 2009 Oct;29(19):5251-63. doi: 10.1128/MCB.00495-09. Epub 2009 Jul 20.


Low plasma membrane expression of the miltefosine transport complex renders Leishmania braziliensis refractory to the drug.

Sánchez-Cañete MP, Carvalho L, Pérez-Victoria FJ, Gamarro F, Castanys S.

Antimicrob Agents Chemother. 2009 Apr;53(4):1305-13. doi: 10.1128/AAC.01694-08. Epub 2009 Feb 2.


Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes.

Pérez-Victoria FJ, Mardones GA, Bonifacino JS.

Mol Biol Cell. 2008 Jun;19(6):2350-62. doi: 10.1091/mbc.E07-11-1189. Epub 2008 Mar 26.


Inactivation of the miltefosine transporter, LdMT, causes miltefosine resistance that is conferred to the amastigote stage of Leishmania donovani and persists in vivo.

Seifert K, Pérez-Victoria FJ, Stettler M, Sánchez-Cañete MP, Castanys S, Gamarro F, Croft SL.

Int J Antimicrob Agents. 2007 Sep;30(3):229-35. Epub 2007 Jul 12.


Combination of suboptimal doses of inhibitors targeting different domains of LtrMDR1 efficiently overcomes resistance of Leishmania spp. to Miltefosine by inhibiting drug efflux.

Pérez-Victoria JM, Cortés-Selva F, Parodi-Talice A, Bavchvarov BI, Pérez-Victoria FJ, Muñoz-Martínez F, Maitrejean M, Costi MP, Barron D, Di Pietro A, Castanys S, Gamarro F.

Antimicrob Agents Chemother. 2006 Sep;50(9):3102-10.


Mechanisms of experimental resistance of Leishmania to miltefosine: Implications for clinical use.

Pérez-Victoria FJ, Sánchez-Cañete MP, Seifert K, Croft SL, Sundar S, Castanys S, Gamarro F.

Drug Resist Updat. 2006 Feb-Apr;9(1-2):26-39. Review.


Phospholipid translocation and miltefosine potency require both L. donovani miltefosine transporter and the new protein LdRos3 in Leishmania parasites.

Pérez-Victoria FJ, Sánchez-Cañete MP, Castanys S, Gamarro F.

J Biol Chem. 2006 Aug 18;281(33):23766-75. Epub 2006 Jun 19.


Characterization of an ABCA-like transporter involved in vesicular trafficking in the protozoan parasite Trypanosoma cruzi.

Torres C, Pérez-Victoria FJ, Parodi-Talice A, Castanys S, Gamarro F.

Mol Microbiol. 2004 Nov;54(3):632-46.


Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance.

Pérez-Victoria FJ, Gamarro F, Ouellette M, Castanys S.

J Biol Chem. 2003 Dec 12;278(50):49965-71. Epub 2003 Sep 27.


Leishmania donovani resistance to miltefosine involves a defective inward translocation of the drug.

Pérez-Victoria FJ, Castanys S, Gamarro F.

Antimicrob Agents Chemother. 2003 Aug;47(8):2397-403.


Alkyl-lysophospholipid resistance in multidrug-resistant Leishmania tropica and chemosensitization by a novel P-glycoprotein-like transporter modulator.

Pérez-Victoria JM, Pérez-Victoria FJ, Parodi-Talice A, Jiménez IA, Ravelo AG, Castanys S, Gamarro F.

Antimicrob Agents Chemother. 2001 Sep;45(9):2468-74.


High-affinity binding of silybin derivatives to the nucleotide-binding domain of a Leishmania tropica P-glycoprotein-like transporter and chemosensitization of a multidrug-resistant parasite to daunomycin.

Pérez-Victoria JM, Pérez-Victoria FJ, Conseil G, Maitrejean M, Comte G, Barron D, Di Pietro A, Castanys S, Gamarro F.

Antimicrob Agents Chemother. 2001 Feb;45(2):439-46.

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