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Items: 1 to 50 of 139

1.

Selective targeting of collagen IV in the cancer cell microenvironment reduces tumor burden.

Revert F, Revert-Ros F, Blasco R, Artigot A, López-Pascual E, Gozalbo-Rovira R, Ventura I, Gutiérrez-Carbonell E, Roda N, Ruíz-Sanchis D, Forteza J, Alcácer J, Pérez-Sastre A, Díaz A, Pérez-Payá E, Sanz-Cervera JF, Saus J.

Oncotarget. 2018 Jan 19;9(13):11020-11045. doi: 10.18632/oncotarget.24280. eCollection 2018 Feb 16.

2.

Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes.

Andreu-Fernández V, Sancho M, Genovés A, Lucendo E, Todt F, Lauterwasser J, Funk K, Jahreis G, Pérez-Payá E, Mingarro I, Edlich F, Orzáez M.

Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):310-315. doi: 10.1073/pnas.1612322114. Epub 2016 Dec 27. Erratum in: Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1574.

3.

Caspase 3 Targeted Cargo Delivery in Apoptotic Cells Using Capped Mesoporous Silica Nanoparticles.

de la Torre C, Mondragón L, Coll C, García-Fernández A, Sancenón F, Martínez-Máñez R, Amorós P, Pérez-Payá E, Orzáez M.

Chemistry. 2015 Oct 26;21(44):15506-10. doi: 10.1002/chem.201502413. Epub 2015 Sep 10.

PMID:
26493876
4.

Apaf1 inhibition promotes cell recovery from apoptosis.

Gortat A, Sancho M, Mondragón L, Messeguer À, Pérez-Payá E, Orzáez M.

Protein Cell. 2015 Nov;6(11):833-43. doi: 10.1007/s13238-015-0200-2. Epub 2015 Sep 11.

5.

Efficient Synthesis of Conformationally Restricted Apoptosis Inhibitors Bearing a Triazole Moiety.

Corredor M, Garrido M, Bujons J, Orzáez M, Pérez-Payá E, Alfonso I, Messeguer A.

Chemistry. 2015 Sep 28;21(40):14122-8. doi: 10.1002/chem.201502380. Epub 2015 Aug 13.

PMID:
26270744
6.

L-Aminoacid Oxidase from Bothrops leucurus Venom Induces Nephrotoxicity via Apoptosis and Necrosis.

Morais IC, Pereira GJ, Orzáez M, Jorge RJ, Bincoletto C, Toyama MH, Monteiro HS, Smaili SS, Pérez-Payá E, Martins AM.

PLoS One. 2015 Jul 20;10(7):e0132569. doi: 10.1371/journal.pone.0132569. eCollection 2015.

7.

Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity.

Orzáez M, Sancho M, Marchán S, Mondragón L, Montava R, Valero JG, Landeta O, Basañez G, Carbajo RJ, Pineda-Lucena A, Bujons J, Moure A, Messeguer A, Lagunas C, Herrero C, Pérez-Payá E.

PLoS One. 2014 Oct 20;9(10):e110979. doi: 10.1371/journal.pone.0110979. eCollection 2014.

8.

Cathepsin-B induced controlled release from peptide-capped mesoporous silica nanoparticles.

de la Torre C, Mondragón L, Coll C, Sancenón F, Marcos MD, Martínez-Máñez R, Amorós P, Pérez-Payá E, Orzáez M.

Chemistry. 2014 Nov 17;20(47):15309-14. doi: 10.1002/chem.201404382. Epub 2014 Oct 10.

PMID:
25303093
9.

Peptides derived from the transmembrane domain of Bcl-2 proteins as potential mitochondrial priming tools.

Andreu-Fernández V, Genoves A, Lee TH, Stellato M, Lucantoni F, Orzáez M, Mingarro I, Aguilar MI, Pérez-Payá E.

ACS Chem Biol. 2014 Aug 15;9(8):1799-811. doi: 10.1021/cb5002679. Epub 2014 Jun 17.

PMID:
24905660
10.

Enzyme-responsive intracellular-controlled release using silica mesoporous nanoparticles capped with ε-poly-L-lysine.

Mondragón L, Mas N, Ferragud V, de la Torre C, Agostini A, Martínez-Máñez R, Sancenón F, Amorós P, Pérez-Payá E, Orzáez M.

Chemistry. 2014 Apr 25;20(18):5271-81. doi: 10.1002/chem.201400148. Epub 2014 Apr 2.

PMID:
24700694
11.

Role of CDK5/cyclin complexes in ischemia-induced death and survival of renal tubular cells.

Guevara T, Sancho M, Pérez-Payá E, Orzáez M.

Cell Cycle. 2014;13(10):1617-26. doi: 10.4161/cc.28628. Epub 2014 Mar 25.

12.

Temperature-controlled release by changes in the secondary structure of peptides anchored onto mesoporous silica supports.

de la Torre C, Agostini A, Mondragón L, Orzáez M, Sancenón F, Martínez-Máñez R, Marcos MD, Amorós P, Pérez-Payá E.

Chem Commun (Camb). 2014 Mar 25;50(24):3184-6. doi: 10.1039/c3cc49421g. Epub 2014 Feb 12.

PMID:
24519805
13.

Altered mitochondria morphology and cell metabolism in Apaf1-deficient cells.

Sancho M, Gortat A, Herrera AE, Andreu-Fernández V, Ferraro E, Cecconi F, Orzáez M, Pérez-Payá E.

PLoS One. 2014 Jan 9;9(1):e84666. doi: 10.1371/journal.pone.0084666. eCollection 2014.

14.

Inactivation of Apaf1 reduces the formation of mutant huntingtin-dependent aggregates and cell death.

Sancho M, Herrera AE, Orzáez M, Pérez-Payá E.

Neuroscience. 2014 Mar 14;262:83-91. doi: 10.1016/j.neuroscience.2013.12.062. Epub 2014 Jan 8.

PMID:
24412373
15.

Selective, highly sensitive, and rapid detection of genomic DNA by using gated materials: Mycoplasma detection.

Climent E, Mondragón L, Martínez-Máñez R, Sancenón F, Marcos MD, Murguía JR, Amorós P, Rurack K, Pérez-Payá E.

Angew Chem Int Ed Engl. 2013 Aug 19;52(34):8938-42. doi: 10.1002/anie.201302954. Epub 2013 Jul 10. No abstract available.

PMID:
23843346
16.

Optimizing the control of apoptosis by amide/triazole isosteric substitution in a constrained peptoid.

Corredor M, Bujons J, Orzáez M, Sancho M, Pérez-Payá E, Alfonso I, Messeguer A.

Eur J Med Chem. 2013 May;63:892-6. doi: 10.1016/j.ejmech.2013.03.004. Epub 2013 Mar 14.

17.

BH3-mimetics- and cisplatin-induced cell death proceeds through different pathways depending on the availability of death-related cellular components.

Andreu-Fernández V, Genovés A, Messeguer A, Orzáez M, Sancho M, Pérez-Payá E.

PLoS One. 2013;8(2):e56881. doi: 10.1371/journal.pone.0056881. Epub 2013 Feb 21.

18.

Enzyme-responsive silica mesoporous supports capped with azopyridinium salts for controlled delivery applications.

Mas N, Agostini A, Mondragón L, Bernardos A, Sancenón F, Marcos MD, Martínez-Máñez R, Costero AM, Gil S, Merino-Sanjuán M, Amorós P, Orzáez M, Pérez-Payá E.

Chemistry. 2013 Jan 21;19(4):1346-56. doi: 10.1002/chem.201202740. Epub 2012 Dec 7.

PMID:
23225567
19.

Intrinsic caspase-8 activation mediates sensitization of erlotinib-resistant tumor cells to erlotinib/cell-cycle inhibitors combination treatment.

Orzáez M, Guevara T, Sancho M, Pérez-Payá E.

Cell Death Dis. 2012 Oct 25;3:e415. doi: 10.1038/cddis.2012.155.

20.

Amidase-responsive controlled release of antitumoral drug into intracellular media using gluconamide-capped mesoporous silica nanoparticles.

Candel I, Aznar E, Mondragón L, de la Torre C, Martínez-Máñez R, Sancenón F, Marcos MD, Amorós P, Guillem C, Pérez-Payá E, Costero A, Gil S, Parra M.

Nanoscale. 2012 Nov 21;4(22):7237-45. doi: 10.1039/c2nr32062b.

PMID:
23072883
21.

Azobenzene polyesters used as gate-like scaffolds in nanoscopic hybrid systems.

Bernardos A, Mondragón L, Javakhishvili I, Mas N, de la Torre C, Martínez-Máñez R, Sancenón F, Barat JM, Hvilsted S, Orzaez M, Pérez-Payá E, Amorós P.

Chemistry. 2012 Oct 8;18(41):13068-78. doi: 10.1002/chem.201200787. Epub 2012 Aug 24.

PMID:
22927363
22.

Identification of new snake venom metalloproteinase inhibitors using compound screening and rational Peptide design.

Villalta-Romero F, Gortat A, Herrera AE, Arguedas R, Quesada J, de Melo RL, Calvete JJ, Montero M, Murillo R, Rucavado A, Gutiérrez JM, Pérez-Payá E.

ACS Med Chem Lett. 2012 Jun 14;3(7):540-3. doi: 10.1021/ml300068r. eCollection 2012 Jul 12.

23.

Dual enzyme-triggered controlled release on capped nanometric silica mesoporous supports.

Agostini A, Mondragón L, Coll C, Aznar E, Marcos MD, Martínez-Máñez R, Sancenón F, Soto J, Pérez-Payá E, Amorós P.

ChemistryOpen. 2012 Feb;1(1):17-20. doi: 10.1002/open.201200003. Epub 2012 Feb 17. No abstract available.

24.

Polypeptide modulators of caspase recruitment domain (CARD)-CARD-mediated protein-protein interactions.

Palacios-Rodríguez Y, García-Laínez G, Sancho M, Gortat A, Orzáez M, Pérez-Payá E.

J Biol Chem. 2011 Dec 30;286(52):44457-66. doi: 10.1074/jbc.M111.255364. Epub 2011 Nov 7.

25.

Membrane-transferring regions of gp41 as targets for HIV-1 fusion inhibition and viral neutralization.

Huarte N, Lorizate M, Pérez-Payá E, Nieva JL.

Curr Top Med Chem. 2011 Dec;11(24):2985-96. Review.

26.

Apaf1 plays a pro-survival role by regulating centrosome morphology and function.

Ferraro E, Pesaresi MG, De Zio D, Cencioni MT, Gortat A, Cozzolino M, Berghella L, Salvatore AM, Oettinghaus B, Scorrano L, Pérez-Payà E, Cecconi F.

J Cell Sci. 2011 Oct 15;124(Pt 20):3450-63. doi: 10.1242/jcs.086298. Epub 2011 Oct 7.

27.

Finely tuned temperature-controlled cargo release using paraffin-capped mesoporous silica nanoparticles.

Aznar E, Mondragón L, Ros-Lis JV, Sancenón F, Marcos MD, Martínez-Máñez R, Soto J, Pérez-Payá E, Amorós P.

Angew Chem Int Ed Engl. 2011 Nov 18;50(47):11172-5. doi: 10.1002/anie.201102756. Epub 2011 Sep 27. No abstract available.

PMID:
21953879
28.

Trivalent PEGylated platform for the conjugation of bioactive compounds.

Torres A, Mas-Moruno C, Pérez-Payá E, Albericio F, Royo M.

Bioconjug Chem. 2011 Oct 19;22(10):2172-8. doi: 10.1021/bc100393g. Epub 2011 Sep 7.

PMID:
21863883
29.

In vivo discovery of a peptide that prevents CUG-RNA hairpin formation and reverses RNA toxicity in myotonic dystrophy models.

García-López A, Llamusí B, Orzáez M, Pérez-Payá E, Artero RD.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11866-71. doi: 10.1073/pnas.1018213108. Epub 2011 Jul 5.

30.

Tyrosine phosphorylation turns alkaline transition into a biologically relevant process and makes human cytochrome c behave as an anti-apoptotic switch.

García-Heredia JM, Díaz-Quintana A, Salzano M, Orzáez M, Pérez-Payá E, Teixeira M, De la Rosa MA, Díaz-Moreno I.

J Biol Inorg Chem. 2011 Dec;16(8):1155-68. doi: 10.1007/s00775-011-0804-9. Epub 2011 Jun 25.

PMID:
21706253
31.

Minocycline inhibits cell death and decreases mutant Huntingtin aggregation by targeting Apaf-1.

Sancho M, Herrera AE, Gortat A, Carbajo RJ, Pineda-Lucena A, Orzáez M, Pérez-Payá E.

Hum Mol Genet. 2011 Sep 15;20(18):3545-53. doi: 10.1093/hmg/ddr271. Epub 2011 Jun 9.

PMID:
21659333
32.

Chemical modulation of peptoids: synthesis and conformational studies on partially constrained derivatives.

Moure A, Sanclimens G, Bujons J, Masip I, Alvarez-Larena A, Pérez-Payá E, Alfonso I, Messeguer A.

Chemistry. 2011 Jul 4;17(28):7927-39. doi: 10.1002/chem.201100216. Epub 2011 May 24.

PMID:
21611988
33.

Enzyme-mediated controlled release systems by anchoring peptide sequences on mesoporous silica supports.

Coll C, Mondragón L, Martínez-Máñez R, Sancenón F, Marcos MD, Soto J, Amorós P, Pérez-Payá E.

Angew Chem Int Ed Engl. 2011 Feb 25;50(9):2138-40. doi: 10.1002/anie.201004133. Epub 2011 Feb 1. No abstract available.

PMID:
21344569
34.

Characterization of dequalinium as a XIAP antagonist that targets the BIR2 domain.

Orzáez M, Gortat A, Sancho M, Carbajo RJ, Pineda-Lucena A, Palacios-Rodríguez Y, Pérez-Payá E.

Apoptosis. 2011 May;16(5):460-7. doi: 10.1007/s10495-011-0582-4.

35.

Enzyme-responsive intracellular controlled release using nanometric silica mesoporous supports capped with "saccharides".

Bernardos A, Mondragon L, Aznar E, Marcos MD, Martinez-Mañez R, Sancenon F, Soto J, Barat JM, Perez-Paya E, Guillem C, Amoros P.

ACS Nano. 2010 Nov 23;4(11):6353-68. doi: 10.1021/nn101499d. Epub 2010 Oct 19.

PMID:
20958020
36.

Nitration of tyrosine 74 prevents human cytochrome c to play a key role in apoptosis signaling by blocking caspase-9 activation.

García-Heredia JM, Díaz-Moreno I, Nieto PM, Orzáez M, Kocanis S, Teixeira M, Pérez-Payá E, Díaz-Quintana A, De la Rosa MA.

Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):981-93. doi: 10.1016/j.bbabio.2010.03.009. Epub 2010 Mar 20.

37.

Molecules that modulate Apaf-1 activity.

Pérez-Payá E, Orzáez M, Mondragón L, Wolan D, Wells JA, Messeguer A, Vicent MJ.

Med Res Rev. 2011 Jul;31(4):649-75. doi: 10.1002/med.20198. Epub 2010 Jan 22. Review.

PMID:
20099266
38.

A fluorescent polarization-based assay for the identification of disruptors of the RCAN1-calcineurin A protein complex.

Carme Mulero M, Orzáez M, Messeguer J, Messeguer A, Pérez-Payá E, Pérez-Riba M.

Anal Biochem. 2010 Mar 1;398(1):99-103. doi: 10.1016/j.ab.2009.10.045. Epub 2009 Nov 3.

39.

Nanoconjugates as intracorporeal neutralizers of bacterial endotoxins.

Vicent MJ, Cascales L, Carbajo RJ, Cortés N, Messeguer A, Pérez Payá E.

J Control Release. 2010 Mar 3;142(2):277-85. doi: 10.1016/j.jconrel.2009.10.026. Epub 2009 Oct 30.

PMID:
19883706
40.

Membrane promotes tBID interaction with BCL(XL).

García-Sáez AJ, Ries J, Orzáez M, Pérez-Payà E, Schwille P.

Nat Struct Mol Biol. 2009 Nov;16(11):1178-85. doi: 10.1038/nsmb.1671. Epub 2009 Oct 11.

PMID:
19820711
41.

A nanoconjugate Apaf-1 inhibitor protects mesothelial cells from cytokine-induced injury.

Santamaría B, Benito-Martin A, Ucero AC, Aroeira LS, Reyero A, Vicent MJ, Orzáez M, Celdrán A, Esteban J, Selgas R, Ruíz-Ortega M, Cabrera ML, Egido J, Pérez-Payá E, Ortiz A.

PLoS One. 2009 Aug 13;4(8):e6634. doi: 10.1371/journal.pone.0006634.

42.

Design and facile solid-phase synthesis of peptide-based LPS-inhibitors containing PEG-like functionalities.

Mas-Moruno C, Cascales L, Mora P, Cruz LJ, Pérez-Payá E, Albericio F.

Biopolymers. 2009;92(6):508-17. doi: 10.1002/bip.21285.

PMID:
19637366
43.

Deciphering the antitumoral activity of quinacrine: Binding to and inhibition of Bcl-xL.

Orzáez M, Mondragón L, García-Jareño A, Mosulén S, Pineda-Lucena A, Pérez-Payá E.

Bioorg Med Chem Lett. 2009 Mar 15;19(6):1592-5. doi: 10.1016/j.bmcl.2009.02.020. Epub 2009 Feb 8.

PMID:
19237284
44.

Inhibiting the calcineurin-NFAT (nuclear factor of activated T cells) signaling pathway with a regulator of calcineurin-derived peptide without affecting general calcineurin phosphatase activity.

Mulero MC, Aubareda A, Orzáez M, Messeguer J, Serrano-Candelas E, Martínez-Hoyer S, Messeguer A, Pérez-Payá E, Pérez-Riba M.

J Biol Chem. 2009 Apr 3;284(14):9394-401. doi: 10.1074/jbc.M805889200. Epub 2009 Feb 3.

45.

A chemical inhibitor of Apaf-1 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint.

Mondragón L, Galluzzi L, Mouhamad S, Orzáez M, Vicencio JM, Vitale I, Moure A, Messeguer A, Perez-Paya E, Kroemer G.

Apoptosis. 2009 Feb;14(2):182-90. doi: 10.1007/s10495-008-0310-x.

PMID:
19152031
46.

ATP-noncompetitive inhibitors of CDK-cyclin complexes.

Orzáez M, Gortat A, Mondragón L, Bachs O, Pérez-Payá E.

ChemMedChem. 2009 Jan;4(1):19-24. doi: 10.1002/cmdc.200800185. Review.

PMID:
19039815
47.

Peptides and peptide mimics as modulators of apoptotic pathways.

Orzáez M, Gortat A, Mondragón L, Pérez-Payá E.

ChemMedChem. 2009 Feb;4(2):146-60. doi: 10.1002/cmdc.200800246. Review.

PMID:
19021159
48.

Tiratricol neutralizes bacterial endotoxins and reduces lipopolysaccharide-induced TNF-alpha production in the cell.

Cascales L, Mas-Moruno C, Tamborero S, Aceña JL, Sanz-Cervera JF, Fustero S, Cruz LJ, Mora P, Albericio F, Pérez-Payá E.

Chem Biol Drug Des. 2008 Oct;72(4):320-8. doi: 10.1111/j.1747-0285.2008.00703.x.

PMID:
18844678
49.

Nanostructure formation enhances the activity of LPS-neutralizing peptides.

Mas-Moruno C, Cascales L, Cruz LJ, Mora P, Pérez-Payá E, Albericio F.

ChemMedChem. 2008 Nov;3(11):1748-55. doi: 10.1002/cmdc.200800209.

PMID:
18833552
50.

A synthetic hexapeptide (Argireline) with antiwrinkle activity.

Blanes-Mira C, Clemente J, Jodas G, Gil A, Fernández-Ballester G, Ponsati B, Gutierrez L, Pérez-Payá E, Ferrer-Montiel A.

Int J Cosmet Sci. 2002 Oct;24(5):303-10. doi: 10.1046/j.1467-2494.2002.00153.x.

PMID:
18498523

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