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Items: 39

1.

Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species.

Binderup T, Duivenvoorden R, Fay F, van Leent MMT, Malkus J, Baxter S, Ishino S, Zhao Y, Sanchez-Gaytan B, Teunissen AJP, Frederico YCA, Tang J, Carlucci G, Lyashchenko S, Calcagno C, Karakatsanis N, Soultanidis G, Senders ML, Robson PM, Mani V, Ramachandran S, Lobatto ME, Hutten BA, Granada JF, Reiner T, Swirski FK, Nahrendorf M, Kjaer A, Fisher EA, Fayad ZA, Pérez-Medina C, Mulder WJM.

Sci Transl Med. 2019 Aug 21;11(506). pii: eaaw7736. doi: 10.1126/scitranslmed.aaw7736.

PMID:
31434756
2.

A 89Zr-HDL PET tracer monitors response to a CSF1R inhibitor.

Mason C, Kossatz S, Carter L, Pirovano G, Brand C, Guru N, Pérez-Medina C, Lewis JS, Mulder W, Reiner T.

J Nucl Med. 2019 Aug 16. pii: jnumed.119.230466. doi: 10.2967/jnumed.119.230466. [Epub ahead of print]

PMID:
31420495
3.

Multimodal Positron Emission Tomography Imaging to Quantify Uptake of 89Zr-Labeled Liposomes in the Atherosclerotic Vessel Wall.

Lobatto ME, Binderup T, Robson PM, Giesen LFP, Calcagno C, Witjes J, Fay F, Baxter S, Wessel CH, Eldib M, Bini J, Carlin SD, Stroes ESG, Storm G, Kjaer A, Lewis JS, Reiner T, Fayad ZA, Mulder WJM, Pérez-Medina C.

Bioconjug Chem. 2019 Jun 7. doi: 10.1021/acs.bioconjchem.9b00256. [Epub ahead of print]

PMID:
31095372
4.

Author Correction: Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates.

Lameijer M, Binderup T, van Leent MMT, Senders ML, Fay F, Malkus J, Sanchez-Gaytan BL, Teunissen AJP, Karakatsanis N, Robson P, Zhou X, Ye Y, Wojtkiewicz G, Tang J, Seijkens TTP, Kroon J, Stroes ESG, Kjaer A, Ochando J, Reiner T, Pérez-Medina C, Calcagno C, Fisher EA, Zhang B, Temel RE, Swirski FK, Nahrendorf M, Fayad ZA, Lutgens E, Mulder WJM, Duivenvoorden R.

Nat Biomed Eng. 2018 Aug;2(8):623. doi: 10.1038/s41551-018-0281-3.

PMID:
31015637
5.

Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates.

Lameijer M, Binderup T, van Leent MMT, Senders ML, Fay F, Malkus J, Sanchez-Gaytan BL, Teunissen AJP, Karakatsanis N, Robson P, Zhou X, Ye Y, Wojtkiewicz G, Tang J, Seijkens TTP, Kroon J, Stroes ESG, Kjaer A, Ochando J, Reiner T, Pérez-Medina C, Calcagno C, Fisher EA, Zhang B, Temel RE, Swirski FK, Nahrendorf M, Fayad ZA, Lutgens E, Mulder WJM, Duivenvoorden R.

Nat Biomed Eng. 2018 May;2(5):279-292. doi: 10.1038/s41551-018-0221-2. Epub 2018 Apr 16. Erratum in: Nat Biomed Eng. 2018 Aug;2(8):623.

6.

Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance.

Braza MS, van Leent MMT, Lameijer M, Sanchez-Gaytan BL, Arts RJW, Pérez-Medina C, Conde P, Garcia MR, Gonzalez-Perez M, Brahmachary M, Fay F, Kluza E, Kossatz S, Dress RJ, Salem F, Rialdi A, Reiner T, Boros P, Strijkers GJ, Calcagno CC, Ginhoux F, Marazzi I, Lutgens E, Nicolaes GAF, Weber C, Swirski FK, Nahrendorf M, Fisher EA, Duivenvoorden R, Fayad ZA, Netea MG, Mulder WJM, Ochando J.

Immunity. 2018 Nov 20;49(5):819-828.e6. doi: 10.1016/j.immuni.2018.09.008. Epub 2018 Nov 6.

7.

Nanoemulsion-Based Delivery of Fluorescent PARP Inhibitors in Mouse Models of Small Cell Lung Cancer.

Gonzales J, Kossatz S, Roberts S, Pirovano G, Brand C, Pérez-Medina C, Donabedian P, de la Cruz MJ, Mulder WJM, Reiner T.

Bioconjug Chem. 2018 Nov 21;29(11):3776-3782. doi: 10.1021/acs.bioconjchem.8b00640. Epub 2018 Nov 7.

8.

Nanobody-Facilitated Multiparametric PET/MRI Phenotyping of Atherosclerosis.

Senders ML, Hernot S, Carlucci G, van de Voort JC, Fay F, Calcagno C, Tang J, Alaarg A, Zhao Y, Ishino S, Palmisano A, Boeykens G, Meerwaldt AE, Sanchez-Gaytan BL, Baxter S, Zendman L, Lobatto ME, Karakatsanis NA, Robson PM, Broisat A, Raes G, Lewis JS, Tsimikas S, Reiner T, Fayad ZA, Devoogdt N, Mulder WJM, Pérez-Medina C.

JACC Cardiovasc Imaging. 2019 Oct;12(10):2015-2026. doi: 10.1016/j.jcmg.2018.07.027. Epub 2018 Oct 17.

9.

Nanoimmunotherapy to treat ischaemic heart disease.

Duivenvoorden R, Senders ML, van Leent MMT, Pérez-Medina C, Nahrendorf M, Fayad ZA, Mulder WJM.

Nat Rev Cardiol. 2019 Jan;16(1):21-32. doi: 10.1038/s41569-018-0073-1. Review.

PMID:
30209355
10.

Investigating supramolecular systems using Förster resonance energy transfer.

Teunissen AJP, Pérez-Medina C, Meijerink A, Mulder WJM.

Chem Soc Rev. 2018 Sep 17;47(18):7027-7044. doi: 10.1039/c8cs00278a. Review.

11.

Sonophore-enhanced nanoemulsions for optoacoustic imaging of cancer.

Roberts S, Andreou C, Choi C, Donabedian P, Jayaraman M, Pratt EC, Tang J, Pérez-Medina C, Jason de la Cruz M, Mulder WJM, Grimm J, Kircher M, Reiner T.

Chem Sci. 2018 May 18;9(25):5646-5657. doi: 10.1039/c8sc01706a. eCollection 2018 Jul 7.

12.

Development and Multiparametric Evaluation of Experimental Atherosclerosis in Rabbits.

Senders ML, Lobatto ME, Soler R, Lairez O, Pérez-Medina C, Calcagno C, Fayad ZA, Mulder WJM, Fay F.

Methods Mol Biol. 2018;1816:385-400. doi: 10.1007/978-1-4939-8597-5_30.

PMID:
29987836
13.

Reversible Electroporation-Mediated Liposomal Doxorubicin Delivery to Tumors Can Be Monitored With 89Zr-Labeled Reporter Nanoparticles.

Srimathveeravalli G, Abdel-Atti D, Pérez-Medina C, Takaki H, Solomon SB, Mulder WJM, Reiner T.

Mol Imaging. 2018 Jan-Dec;17:1536012117749726. doi: 10.1177/1536012117749726.

14.

PET/MR Imaging of Malondialdehyde-Acetaldehyde Epitopes With a Human Antibody Detects Clinically Relevant Atherothrombosis.

Senders ML, Que X, Cho YS, Yeang C, Groenen H, Fay F, Calcagno C, Meerwaldt AE, Green S, Miu P, Lobatto ME, Reiner T, Fayad ZA, Witztum JL, Mulder WJM, Pérez-Medina C, Tsimikas S.

J Am Coll Cardiol. 2018 Jan 23;71(3):321-335. doi: 10.1016/j.jacc.2017.11.036.

15.

High-Density Lipoprotein Nanobiologics for Precision Medicine.

Mulder WJM, van Leent MMT, Lameijer M, Fisher EA, Fayad ZA, Pérez-Medina C.

Acc Chem Res. 2018 Jan 16;51(1):127-137. doi: 10.1021/acs.accounts.7b00339. Epub 2017 Dec 27. Review.

PMID:
29281244
16.

Specific Binding of Liposomal Nanoparticles through Inverse Electron-Demand Diels-Alder Click Chemistry.

Brand C, Iacono P, Pérez-Medina C, Mulder WJM, Kircher MF, Reiner T.

ChemistryOpen. 2017 Aug 7;6(5):615-619. doi: 10.1002/open.201700105. eCollection 2017 Oct.

17.

Integrating nanomedicine and imaging.

Pérez-Medina C, Hak S, Reiner T, Fayad ZA, Nahrendorf M, Mulder WJM.

Philos Trans A Math Phys Eng Sci. 2017 Nov 28;375(2107). pii: 20170110. doi: 10.1098/rsta.2017.0110. Review.

18.

A systematic comparison of clinically viable nanomedicines targeting HMG-CoA reductase in inflammatory atherosclerosis.

Alaarg A, Senders ML, Varela-Moreira A, Pérez-Medina C, Zhao Y, Tang J, Fay F, Reiner T, Fayad ZA, Hennink WE, Metselaar JM, Mulder WJM, Storm G.

J Control Release. 2017 Sep 28;262:47-57. doi: 10.1016/j.jconrel.2017.07.013. Epub 2017 Jul 9.

19.

Applying nanomedicine in maladaptive inflammation and angiogenesis.

Alaarg A, Pérez-Medina C, Metselaar JM, Nahrendorf M, Fayad ZA, Storm G, Mulder WJM.

Adv Drug Deliv Rev. 2017 Sep 15;119:143-158. doi: 10.1016/j.addr.2017.05.009. Epub 2017 May 12. Review.

20.

Hyaluronan Nanoparticles Selectively Target Plaque-Associated Macrophages and Improve Plaque Stability in Atherosclerosis.

Beldman TJ, Senders ML, Alaarg A, Pérez-Medina C, Tang J, Zhao Y, Fay F, Deichmöller J, Born B, Desclos E, van der Wel NN, Hoebe RA, Kohen F, Kartvelishvily E, Neeman M, Reiner T, Calcagno C, Fayad ZA, de Winther MPJ, Lutgens E, Mulder WJM, Kluza E.

ACS Nano. 2017 Jun 27;11(6):5785-5799. doi: 10.1021/acsnano.7b01385. Epub 2017 May 15.

21.

Investigating the Cellular Specificity in Tumors of a Surface-Converting Nanoparticle by Multimodal Imaging.

Fay F, Hansen L, Hectors SJCG, Sanchez-Gaytan BL, Zhao Y, Tang J, Munitz J, Alaarg A, Braza MS, Gianella A, Aaronson SA, Reiner T, Kjems J, Langer R, Hoeben FJM, Janssen HM, Calcagno C, Strijkers GJ, Fayad ZA, Pérez-Medina C, Mulder WJM.

Bioconjug Chem. 2017 May 17;28(5):1413-1421. doi: 10.1021/acs.bioconjchem.7b00086. Epub 2017 May 5.

22.

A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines.

Tang J, Pérez-Medina C, Zhao Y, Sadique A, Mulder WJ, Reiner T.

J Vis Exp. 2017 Mar 4;(121). doi: 10.3791/55271.

23.

Real-Time Monitoring of Nanoparticle Formation by FRET Imaging.

Sanchez-Gaytan BL, Fay F, Hak S, Alaarg A, Fayad ZA, Pérez-Medina C, Mulder WJ, Zhao Y.

Angew Chem Int Ed Engl. 2017 Mar 6;56(11):2923-2926. doi: 10.1002/anie.201611288. Epub 2017 Jan 23.

24.

Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease.

Keliher EJ, Ye YX, Wojtkiewicz GR, Aguirre AD, Tricot B, Senders ML, Groenen H, Fay F, Perez-Medina C, Calcagno C, Carlucci G, Reiner T, Sun Y, Courties G, Iwamoto Y, Kim HY, Wang C, Chen JW, Swirski FK, Wey HY, Hooker J, Fayad ZA, Mulder WJ, Weissleder R, Nahrendorf M.

Nat Commun. 2017 Jan 16;8:14064. doi: 10.1038/ncomms14064.

25.

Near-Infrared Quantum Dot and 89Zr Dual-Labeled Nanoparticles for in Vivo Cerenkov Imaging.

Zhao Y, Shaffer TM, Das S, Pérez-Medina C, Mulder WJ, Grimm J.

Bioconjug Chem. 2017 Feb 15;28(2):600-608. doi: 10.1021/acs.bioconjchem.6b00687. Epub 2017 Jan 12.

26.

Imaging-guided revival of nanomedicine?

Senders ML, Fayad ZA, Reiner T, Mulder WJ, Pérez-Medina C.

Nanomedicine (Lond). 2017 Jan;12(2):89-90. Epub 2016 Nov 23. No abstract available.

27.

Immune cell screening of a nanoparticle library improves atherosclerosis therapy.

Tang J, Baxter S, Menon A, Alaarg A, Sanchez-Gaytan BL, Fay F, Zhao Y, Ouimet M, Braza MS, Longo VA, Abdel-Atti D, Duivenvoorden R, Calcagno C, Storm G, Tsimikas S, Moore KJ, Swirski FK, Nahrendorf M, Fisher EA, Pérez-Medina C, Fayad ZA, Reiner T, Mulder WJ.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):E6731-E6740. Epub 2016 Oct 17.

28.

Nanoreporter PET predicts the efficacy of anti-cancer nanotherapy.

Pérez-Medina C, Abdel-Atti D, Tang J, Zhao Y, Fayad ZA, Lewis JS, Mulder WJM, Reiner T.

Nat Commun. 2016 Jun 20;7:11838. doi: 10.1038/ncomms11838.

29.

In Vivo PET Imaging of HDL in Multiple Atherosclerosis Models.

Pérez-Medina C, Binderup T, Lobatto ME, Tang J, Calcagno C, Giesen L, Wessel CH, Witjes J, Ishino S, Baxter S, Zhao Y, Ramachandran S, Eldib M, Sánchez-Gaytán BL, Robson PM, Bini J, Granada JF, Fish KM, Stroes ES, Duivenvoorden R, Tsimikas S, Lewis JS, Reiner T, Fuster V, Kjær A, Fisher EA, Fayad ZA, Mulder WJ.

JACC Cardiovasc Imaging. 2016 Aug;9(8):950-61. doi: 10.1016/j.jcmg.2016.01.020. Epub 2016 May 25.

30.

Augmenting drug-carrier compatibility improves tumour nanotherapy efficacy.

Zhao Y, Fay F, Hak S, Manuel Perez-Aguilar J, Sanchez-Gaytan BL, Goode B, Duivenvoorden R, de Lange Davies C, Bjørkøy A, Weinstein H, Fayad ZA, Pérez-Medina C, Mulder WJ.

Nat Commun. 2016 Apr 13;7:11221. doi: 10.1038/ncomms11221.

31.

Imaging Macrophage and Hematopoietic Progenitor Proliferation in Atherosclerosis.

Ye YX, Calcagno C, Binderup T, Courties G, Keliher EJ, Wojtkiewicz GR, Iwamoto Y, Tang J, Pérez-Medina C, Mani V, Ishino S, Johnbeck CB, Knigge U, Fayad ZA, Libby P, Weissleder R, Tawakol A, Dubey S, Belanger AP, Di Carli MF, Swirski FK, Kjaer A, Mulder WJ, Nahrendorf M.

Circ Res. 2015 Oct 23;117(10):835-45. doi: 10.1161/CIRCRESAHA.115.307024. Epub 2015 Sep 22.

32.

Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation.

Tang J, Lobatto ME, Hassing L, van der Staay S, van Rijs SM, Calcagno C, Braza MS, Baxter S, Fay F, Sanchez-Gaytan BL, Duivenvoorden R, Sager H, Astudillo YM, Leong W, Ramachandran S, Storm G, Pérez-Medina C, Reiner T, Cormode DP, Strijkers GJ, Stroes ES, Swirski FK, Nahrendorf M, Fisher EA, Fayad ZA, Mulder WJ.

Sci Adv. 2015 Apr;1(3). pii: e1400223.

33.

Labeling galectin-3 for the assessment of myocardial infarction in rats.

Arias T, Petrov A, Chen J, de Haas H, Pérez-Medina C, Strijkers GJ, Hajjar RJ, Fayad ZA, Fuster V, Narula J.

EJNMMI Res. 2014 Dec;4(1):75. doi: 10.1186/s13550-014-0075-x. Epub 2014 Dec 14.

34.

PET Imaging of Tumor-Associated Macrophages with 89Zr-Labeled High-Density Lipoprotein Nanoparticles.

Pérez-Medina C, Tang J, Abdel-Atti D, Hogstad B, Merad M, Fisher EA, Fayad ZA, Lewis JS, Mulder WJ, Reiner T.

J Nucl Med. 2015 Aug;56(8):1272-7. doi: 10.2967/jnumed.115.158956. Epub 2015 Jun 25.

35.

A modular labeling strategy for in vivo PET and near-infrared fluorescence imaging of nanoparticle tumor targeting.

Pérez-Medina C, Abdel-Atti D, Zhang Y, Longo VA, Irwin CP, Binderup T, Ruiz-Cabello J, Fayad ZA, Lewis JS, Mulder WJ, Reiner T.

J Nucl Med. 2014 Oct;55(10):1706-11. doi: 10.2967/jnumed.114.141861. Epub 2014 Jul 24.

36.

Synthesis and evaluation of a 125I-labeled iminodihydroquinoline-derived tracer for imaging of voltage-gated sodium channels.

Pérez-Medina C, Patel N, Robson M, Lythgoe MF, Arstad E.

Bioorg Med Chem Lett. 2013 Sep 15;23(18):5170-3. doi: 10.1016/j.bmcl.2013.07.014. Epub 2013 Jul 18.

37.

Evaluation of a 125I-labelled benzazepinone derived voltage-gated sodium channel blocker for imaging with SPECT.

Pérez-Medina C, Patel N, Robson M, Badar A, Lythgoe MF, Årstad E.

Org Biomol Chem. 2012 Dec 21;10(47):9474-80. doi: 10.1039/c2ob26695d. Epub 2012 Nov 2.

PMID:
23117159
38.

Synthesis and biological evaluation of indazole derivatives.

Claramunt RM, López C, López A, Pérez-Medina C, Pérez-Torralba M, Alkorta I, Elguero J, Escames G, Acuña-Castroviejo D.

Eur J Med Chem. 2011 Apr;46(4):1439-47. doi: 10.1016/j.ejmech.2011.01.027. Epub 2011 Jan 28.

PMID:
21334118
39.

Fluorinated indazoles as novel selective inhibitors of nitric oxide synthase (NOS): synthesis and biological evaluation.

Claramunt RM, López C, Pérez-Medina C, Pérez-Torralba M, Elguero J, Escames G, Acuña-Castroviejo D.

Bioorg Med Chem. 2009 Sep 1;17(17):6180-7. doi: 10.1016/j.bmc.2009.07.067. Epub 2009 Aug 6.

PMID:
19679481

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