Format

Send to

Choose Destination
Nat Commun. 2017 Jun 23;8:15674. doi: 10.1038/ncomms15674.

Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus.

Author information

1
Unit of Comparative Medicine, Caribbean Primate Research Center, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico 00952, USA.
2
Department of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico 00936, USA.
3
Department of Microbiology and Immunology, University of North Carolina-Chapel Hill, North Carolina 27599, USA.
4
Texas Biomedical Research Institute, San Antonio, Texas 78227, USA.
5
Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri 63104, USA.
6
Department of Internal Medicine, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico 00936, USA.

Abstract

Zika virus (ZIKV) is a re-emerging virus that has recently spread into dengue virus (DENV) endemic regions and cross-reactive antibodies (Abs) could potentially affect ZIKV pathogenesis. Using DENV-immune serum, it has been shown in vitro that antibody-dependent enhancement (ADE) of ZIKV infection can occur. Here we study the effects of pre-existing DENV immunity on ZIKV infection in vivo. We infect two cohorts of rhesus macaques with ZIKV; one cohort has been exposed to DENV 2.8 years earlier and a second control cohort is naïve to flaviviral infection. Our results, while confirming ADE in vitro, suggest that pre-existing DENV immunity does not result in more severe ZIKV disease. Rather our results show a reduction in the number of days of ZIKV viremia compared to naïve macaques and that the previous exposure to DENV may result in modulation of the immune response without resulting in enhancement of ZIKV pathogenesis.

PMID:
28643775
PMCID:
PMC5490051
DOI:
10.1038/ncomms15674
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center