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J Bacteriol. 2005 Feb;187(4):1515-8.

SOS-independent induction of dinB transcription by beta-lactam-mediated inhibition of cell wall synthesis in Escherichia coli.

Author information

1
Departamento de Biotecnología Microbiana, Centro Nacional de Biotechnología, Universidad Autónoma de Madrid, Spain.

Abstract

Transcription of the dinB gene, encoding DNA polymerase IV, is induced by the inhibition of cell wall synthesis at different levels. Using the beta-lactam antibiotic ceftazidime, a PBP3 inhibitor, as a model, we have shown that this induction is independent of the LexA/RecA regulatory system. Induction of dinB transcription mediated by ceftazidime produces an increase in the reversion of a +1 Lac frameshift mutation.

PMID:
15687217
PMCID:
PMC545630
DOI:
10.1128/JB.187.4.1515-1518.2005
[Indexed for MEDLINE]
Free PMC Article

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