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Items: 48


A case of added value of 123I-mIBG SPECT/CT imaging in the diagnosis of a pheochromocytoma extending into the left adrenal vein.

Paques F, Hamoir E, Lovinfosse P, Hustinx R, Withofs N.

Acta Chir Belg. 2017 Jun;117(3):192-195. doi: 10.1080/00015458.2016.1240917. Epub 2016 Oct 13.


Lentiviral protein delivery of meganucleases in human cells mediates gene targeting and alleviates toxicity.

He C, Gouble A, Bourdel A, Manchev V, Poirot L, Paques F, Duchateau P, Edelman A, Danos O.

Gene Ther. 2014 Aug;21(8):759-66. doi: 10.1038/gt.2014.51. Epub 2014 Jun 12.


Variable correction of Artemis deficiency by I-Sce1-meganuclease-assisted homologous recombination in murine hematopoietic stem cells.

Rivière J, Hauer J, Poirot L, Brochet J, Souque P, Mollier K, Gouble A, Charneau P, Fischer A, Pâques F, de Villartay JP, Cavazzana M.

Gene Ther. 2014 May;21(5):529-32. doi: 10.1038/gt.2014.20. Epub 2014 Mar 13.


Targeted gene therapy of xeroderma pigmentosum cells using meganuclease and TALEN™.

Dupuy A, Valton J, Leduc S, Armier J, Galetto R, Gouble A, Lebuhotel C, Stary A, Pâques F, Duchateau P, Sarasin A, Daboussi F.

PLoS One. 2013 Nov 13;8(11):e78678. doi: 10.1371/journal.pone.0078678. eCollection 2013.


Gene correction of a duchenne muscular dystrophy mutation by meganuclease-enhanced exon knock-in.

Popplewell L, Koo T, Leclerc X, Duclert A, Mamchaoui K, Gouble A, Mouly V, Voit T, Pâques F, Cédrone F, Isman O, Yáñez-Muñoz RJ, Dickson G.

Hum Gene Ther. 2013 Jul;24(7):692-701. doi: 10.1089/hum.2013.081.


High frequency targeted mutagenesis using engineered endonucleases and DNA-end processing enzymes.

Delacôte F, Perez C, Guyot V, Duhamel M, Rochon C, Ollivier N, Macmaster R, Silva GH, Pâques F, Daboussi F, Duchateau P.

PLoS One. 2013;8(1):e53217. doi: 10.1371/journal.pone.0053217. Epub 2013 Jan 24.


Coupling endonucleases with DNA end-processing enzymes to drive gene disruption.

Certo MT, Gwiazda KS, Kuhar R, Sather B, Curinga G, Mandt T, Brault M, Lambert AR, Baxter SK, Jacoby K, Ryu BY, Kiem HP, Gouble A, Paques F, Rawlings DJ, Scharenberg AM.

Nat Methods. 2012 Oct;9(10):973-5. doi: 10.1038/nmeth.2177. Epub 2012 Sep 2.


Chromosomal context and epigenetic mechanisms control the efficacy of genome editing by rare-cutting designer endonucleases.

Daboussi F, Zaslavskiy M, Poirot L, Loperfido M, Gouble A, Guyot V, Leduc S, Galetto R, Grizot S, Oficjalska D, Perez C, Delacôte F, Dupuy A, Chion-Sotinel I, Le Clerre D, Lebuhotel C, Danos O, Lemaire F, Oussedik K, Cédrone F, Epinat JC, Smith J, Yáñez-Muñoz RJ, Dickson G, Popplewell L, Koo T, VandenDriessche T, Chuah MK, Duclert A, Duchateau P, Pâques F.

Nucleic Acids Res. 2012 Jul;40(13):6367-79. Epub 2012 Mar 29.


Identification of genes regulating gene targeting by a high-throughput screening approach.

Delacôte F, Perez C, Guyot V, Mikonio C, Potrel P, Cabaniols JP, Delenda C, Pâques F, Duchateau P.

J Nucleic Acids. 2011;2011:947212. doi: 10.4061/2011/947212. Epub 2011 Feb 13.


Efficient gene targeting mediated by a lentiviral vector-associated meganuclease.

Izmiryan A, Basmaciogullari S, Henry A, Paques F, Danos O.

Nucleic Acids Res. 2011 Sep 1;39(17):7610-9. doi: 10.1093/nar/gkr524. Epub 2011 Jun 28.


Context dependence between subdomains in the DNA binding interface of the I-CreI homing endonuclease.

Grizot S, Duclert A, Thomas S, Duchateau P, Pâques F.

Nucleic Acids Res. 2011 Aug;39(14):6124-36. doi: 10.1093/nar/gkr186. Epub 2011 Apr 10.


Meganuclease-mediated Inhibition of HSV1 Infection in Cultured Cells.

Grosse S, Huot N, Mahiet C, Arnould S, Barradeau S, Clerre DL, Chion-Sotinel I, Jacqmarcq C, Chapellier B, Ergani A, Desseaux C, Cédrone F, Conseiller E, Pâques F, Labetoulle M, Smith J.

Mol Ther. 2011 Apr;19(4):694-702. doi: 10.1038/mt.2010.302. Epub 2011 Jan 11.


Meganucleases and other tools for targeted genome engineering: perspectives and challenges for gene therapy.

Silva G, Poirot L, Galetto R, Smith J, Montoya G, Duchateau P, Pâques F.

Curr Gene Ther. 2011 Feb;11(1):11-27. Review.


The I-CreI meganuclease and its engineered derivatives: applications from cell modification to gene therapy.

Arnould S, Delenda C, Grizot S, Desseaux C, Pâques F, Silva GH, Smith J.

Protein Eng Des Sel. 2011 Jan;24(1-2):27-31. doi: 10.1093/protein/gzq083. Epub 2010 Nov 3. Review.


Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus.

Muñoz IG, Prieto J, Subramanian S, Coloma J, Redondo P, Villate M, Merino N, Marenchino M, D'Abramo M, Gervasio FL, Grizot S, Daboussi F, Smith J, Chion-Sotinel I, Pâques F, Duchateau P, Alibés A, Stricher F, Serrano L, Blanco FJ, Montoya G.

Nucleic Acids Res. 2011 Jan;39(2):729-43. doi: 10.1093/nar/gkq801. Epub 2010 Sep 16.


Meganuclease-driven targeted integration in CHO-K1 cells for the fast generation of HTS-compatible cell-based assays.

Cabaniols JP, Ouvry C, Lamamy V, Fery I, Craplet ML, Moulharat N, Guenin SP, Bedut S, Nosjean O, Ferry G, Devavry S, Jacqmarcq C, Lebuhotel C, Mathis L, Delenda C, Boutin JA, Duchâteau P, Cogé F, Pâques F.

J Biomol Screen. 2010 Sep;15(8):956-67. doi: 10.1177/1087057110375115. Epub 2010 Jul 12.


Meganucleases can restore the reading frame of a mutated dystrophin.

Chapdelaine P, Pichavant C, Rousseau J, Pâques F, Tremblay JP.

Gene Ther. 2010 Jul;17(7):846-58. doi: 10.1038/gt.2010.26. Epub 2010 Apr 15.


Generation of redesigned homing endonucleases comprising DNA-binding domains derived from two different scaffolds.

Grizot S, Epinat JC, Thomas S, Duclert A, Rolland S, Pâques F, Duchateau P.

Nucleic Acids Res. 2010 Apr;38(6):2006-18. doi: 10.1093/nar/gkp1171. Epub 2009 Dec 21.


Reduced immunoglobulin class switch recombination in the absence of Artemis.

Rivera-Munoz P, Soulas-Sprauel P, Le Guyader G, Abramowski V, Bruneau S, Fischer A, Pâques F, de Villartay JP.

Blood. 2009 Oct 22;114(17):3601-9. doi: 10.1182/blood-2008-11-188383. Epub 2009 Aug 19.


Targeted approaches for gene therapy and the emergence of engineered meganucleases.

Galetto R, Duchateau P, Pâques F.

Expert Opin Biol Ther. 2009 Oct;9(10):1289-303. doi: 10.1517/14712590903213669. Review.


Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease.

Grizot S, Smith J, Daboussi F, Prieto J, Redondo P, Merino N, Villate M, Thomas S, Lemaire L, Montoya G, Blanco FJ, Pâques F, Duchateau P.

Nucleic Acids Res. 2009 Sep;37(16):5405-19. doi: 10.1093/nar/gkp548. Epub 2009 Jul 7.


Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases.

Redondo P, Prieto J, Muñoz IG, Alibés A, Stricher F, Serrano L, Cabaniols JP, Daboussi F, Arnould S, Perez C, Duchateau P, Pâques F, Blanco FJ, Montoya G.

Nature. 2008 Nov 6;456(7218):107-11. doi: 10.1038/nature07343.


Crystal structure of I-DmoI in complex with its target DNA provides new insights into meganuclease engineering.

Marcaida MJ, Prieto J, Redondo P, Nadra AD, Alibés A, Serrano L, Grizot S, Duchateau P, Pâques F, Blanco FJ, Montoya G.

Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):16888-93. doi: 10.1073/pnas.0804795105. Epub 2008 Oct 30.


Stable and functional lymphoid reconstitution in artemis-deficient mice following lentiviral artemis gene transfer into hematopoietic stem cells.

Benjelloun F, Garrigue A, Demerens-de Chappedelaine C, Soulas-Sprauel P, Malassis-Séris M, Stockholm D, Hauer J, Blondeau J, Rivière J, Lim A, Le Lorc'h M, Romana S, Brousse N, Pâques F, Galy A, Charneau P, Fischer A, de Villartay JP, Cavazzana-Calvo M.

Mol Ther. 2008 Aug;16(8):1490-9. doi: 10.1038/mt.2008.118. Epub 2008 Jun 17.


Robust cell line development using meganucleases.

Cabaniols JP, Pâques F.

Methods Mol Biol. 2008;435:31-45. doi: 10.1007/978-1-59745-232-8_3.


Computer design of obligate heterodimer meganucleases allows efficient cutting of custom DNA sequences.

Fajardo-Sanchez E, Stricher F, Pâques F, Isalan M, Serrano L.

Nucleic Acids Res. 2008 Apr;36(7):2163-73. doi: 10.1093/nar/gkn059. Epub 2008 Feb 14.


Generation and analysis of mesophilic variants of the thermostable archaeal I-DmoI homing endonuclease.

Prieto J, Epinat JC, Redondo P, Ramos E, Padró D, Cédrone F, Montoya G, Pâques F, Blanco FJ.

J Biol Chem. 2008 Feb 15;283(7):4364-74. Epub 2007 Nov 12.


Engineered I-CreI derivatives cleaving sequences from the human XPC gene can induce highly efficient gene correction in mammalian cells.

Arnould S, Perez C, Cabaniols JP, Smith J, Gouble A, Grizot S, Epinat JC, Duclert A, Duchateau P, Pâques F.

J Mol Biol. 2007 Aug 3;371(1):49-65. Epub 2007 May 10.


The C-terminal loop of the homing endonuclease I-CreI is essential for site recognition, DNA binding and cleavage.

Prieto J, Redondo P, Padró D, Arnould S, Epinat JC, Pâques F, Blanco FJ, Montoya G.

Nucleic Acids Res. 2007;35(10):3262-71. Epub 2007 Apr 22.


Meganucleases and DNA double-strand break-induced recombination: perspectives for gene therapy.

Pâques F, Duchateau P.

Curr Gene Ther. 2007 Feb;7(1):49-66. Review.


A combinatorial approach to create artificial homing endonucleases cleaving chosen sequences.

Smith J, Grizot S, Arnould S, Duclert A, Epinat JC, Chames P, Prieto J, Redondo P, Blanco FJ, Bravo J, Montoya G, Pâques F, Duchateau P.

Nucleic Acids Res. 2006;34(22):e149. Epub 2006 Nov 27.


Efficient in toto targeted recombination in mouse liver by meganuclease-induced double-strand break.

Gouble A, Smith J, Bruneau S, Perez C, Guyot V, Cabaniols JP, Leduc S, Fiette L, Avé P, Micheau B, Duchateau P, Pâques F.

J Gene Med. 2006 May;8(5):616-22.


Engineering of large numbers of highly specific homing endonucleases that induce recombination on novel DNA targets.

Arnould S, Chames P, Perez C, Lacroix E, Duclert A, Epinat JC, Stricher F, Petit AS, Patin A, Guillier S, Rolland S, Prieto J, Blanco FJ, Bravo J, Montoya G, Serrano L, Duchateau P, Pâques F.

J Mol Biol. 2006 Jan 20;355(3):443-58. Epub 2005 Nov 15.


In vivo selection of engineered homing endonucleases using double-strand break induced homologous recombination.

Chames P, Epinat JC, Guillier S, Patin A, Lacroix E, Pâques F.

Nucleic Acids Res. 2005 Nov 23;33(20):e178.


Factors affecting double-strand break-induced homologous recombination in mammalian cells.

Perez C, Guyot V, Cabaniols JP, Gouble A, Micheaux B, Smith J, Leduc S, Pâques F, Duchateau P.

Biotechniques. 2005 Jul;39(1):109-15.


A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells.

Epinat JC, Arnould S, Chames P, Rochaix P, Desfontaines D, Puzin C, Patin A, Zanghellini A, Pâques F, Lacroix E.

Nucleic Acids Res. 2003 Jun 1;31(11):2952-62.


Expansions and contractions in 36-bp minisatellites by gene conversion in yeast.

Pâques F, Richard GF, Haber JE.

Genetics. 2001 May;158(1):155-66.


Mini- and microsatellite expansions: the recombination connection.

Richard GF, Pâques F.

EMBO Rep. 2000 Aug;1(2):122-6. Review.


Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae.

Pâques F, Haber JE.

Microbiol Mol Biol Rev. 1999 Jun;63(2):349-404. Review.


Expansions and contractions in a tandem repeat induced by double-strand break repair.

Pâques F, Leung WY, Haber JE.

Mol Cell Biol. 1998 Apr;18(4):2045-54.


Role of Saccharomyces cerevisiae Msh2 and Msh3 repair proteins in double-strand break-induced recombination.

Sugawara N, Pâques F, Colaiácovo M, Haber JE.

Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9214-9.


Structural evolution of the Drosophila 5S ribosomal genes.

Päques F, Samson ML, Jordan P, Wegnez M.

J Mol Evol. 1995 Nov;41(5):615-21.


Genetic analysis of the folded structure of yeast mitochondrial cytochrome b by selection of intragenic second-site revertants.

di Rago JP, Hermann-Le Denmat S, Pâques F, Risler FP, Netter P, Slonimski PP.

J Mol Biol. 1995 May 12;248(4):804-11.


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