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Items: 32


Prior infection with Type A Francisella tularensis antagonizes the pulmonary transcriptional response to an aerosolized Toll-like receptor 4 agonist.

Walters KA, Olsufka R, Kuestner RE, Wu X, Wang K, Skerrett SJ, Ozinsky A.

BMC Genomics. 2015 Oct 28;16:874. doi: 10.1186/s12864-015-2022-2.


Treatment with the reactive oxygen species scavenger EUK-207 reduces lung damage and increases survival during 1918 influenza virus infection in mice.

Kash JC, Xiao Y, Davis AS, Walters KA, Chertow DS, Easterbrook JD, Dunfee RL, Sandouk A, Jagger BW, Schwartzman LM, Kuestner RE, Wehr NB, Huffman K, Rosenthal RA, Ozinsky A, Levine RL, Doctrow SR, Taubenberger JK.

Free Radic Biol Med. 2014 Feb;67:235-47. doi: 10.1016/j.freeradbiomed.2013.10.014. Epub 2013 Oct 17.


Francisella tularensis subsp. tularensis induces a unique pulmonary inflammatory response: role of bacterial gene expression in temporal regulation of host defense responses.

Walters KA, Olsufka R, Kuestner RE, Cho JH, Li H, Zornetzer GA, Wang K, Skerrett SJ, Ozinsky A.

PLoS One. 2013 May 14;8(5):e62412. doi: 10.1371/journal.pone.0062412. Print 2013.


An overlapping protein-coding region in influenza A virus segment 3 modulates the host response.

Jagger BW, Wise HM, Kash JC, Walters KA, Wills NM, Xiao YL, Dunfee RL, Schwartzman LM, Ozinsky A, Bell GL, Dalton RM, Lo A, Efstathiou S, Atkins JF, Firth AE, Taubenberger JK, Digard P.

Science. 2012 Jul 13;337(6091):199-204. doi: 10.1126/science.1222213. Epub 2012 Jun 28.


Integrative analysis of N-linked human glycoproteomic data sets reveals PTPRF ectodomain as a novel plasma biomarker candidate for prostate cancer.

Whitmore TE, Peterson A, Holzman T, Eastham A, Amon L, McIntosh M, Ozinsky A, Nelson PS, Martin DB.

J Proteome Res. 2012 May 4;11(5):2653-65. doi: 10.1021/pr201200n. Epub 2012 Apr 19.


Lethal synergism of 2009 pandemic H1N1 influenza virus and Streptococcus pneumoniae coinfection is associated with loss of murine lung repair responses.

Kash JC, Walters KA, Davis AS, Sandouk A, Schwartzman LM, Jagger BW, Chertow DS, Li Q, Kuestner RE, Ozinsky A, Taubenberger JK.

mBio. 2011 Sep 20;2(5). pii: e00172-11. doi: 10.1128/mBio.00172-11. Print 2011.


Contributors to the emerging investigators issue.

Basu A, Cheung KC, Eddington DT, Günther A, Hansen C, Huang TJ, Juncker D, Kaji H, Khademhosseini A, Khan SA, Klapperich C, Love JC, Munson M, Murthy S, Ozcan A, Ozinsky A, Spotts JM, Squires T, Takeuchi S, Wang W, Williams J.

Lab Chip. 2010 Sep 21;10(18):2323-33. doi: 10.1039/c0lc90044c. Epub 2010 Aug 18. No abstract available.


Image-based feedback control for real-time sorting of microspheres in a microfluidic device.

Munson MS, Spotts JM, Niemistö A, Selinummi J, Kralj JG, Salit ML, Ozinsky A.

Lab Chip. 2010 Sep 21;10(18):2402-10. doi: 10.1039/c004708b. Epub 2010 Jun 30.


Bright field microscopy as an alternative to whole cell fluorescence in automated analysis of macrophage images.

Selinummi J, Ruusuvuori P, Podolsky I, Ozinsky A, Gold E, Yli-Harja O, Aderem A, Shmulevich I.

PLoS One. 2009 Oct 22;4(10):e7497. doi: 10.1371/journal.pone.0007497.


Resolving cell population heterogeneity: real-time PCR for simultaneous multiplexed gene detection in multiple single-cell samples.

Diercks A, Kostner H, Ozinsky A.

PLoS One. 2009 Jul 27;4(7):e6326. doi: 10.1371/journal.pone.0006326.


A microfluidic device for multiplexed protein detection in nano-liter volumes.

Diercks AH, Ozinsky A, Hansen CL, Spotts JM, Rodriguez DJ, Aderem A.

Anal Biochem. 2009 Mar 1;386(1):30-5. doi: 10.1016/j.ab.2008.12.012. Epub 2008 Dec 24.


Transcriptional noise and cellular heterogeneity in mammalian macrophages.

Ramsey S, Ozinsky A, Clark A, Smith KD, de Atauri P, Thorsson V, Orrell D, Bolouri H.

Philos Trans R Soc Lond B Biol Sci. 2006 Mar 29;361(1467):495-506. Review.


Binding specificity of Toll-like receptor cytoplasmic domains.

Brown V, Brown RA, Ozinsky A, Hesselberth JR, Fields S.

Eur J Immunol. 2006 Mar;36(3):742-53.


Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses.

Yang K, Puel A, Zhang S, Eidenschenk C, Ku CL, Casrouge A, Picard C, von Bernuth H, Senechal B, Plancoulaine S, Al-Hajjar S, Al-Ghonaium A, Maródi L, Davidson D, Speert D, Roifman C, Garty BZ, Ozinsky A, Barrat FJ, Coffman RL, Miller RL, Li X, Lebon P, Rodriguez-Gallego C, Chapel H, Geissmann F, Jouanguy E, Casanova JL.

Immunity. 2005 Nov;23(5):465-78.


Hyper-IgE syndrome is not associated with defects in several candidate toll-like receptor pathway genes.

Hawn TR, Ozinsky A, Williams LM, Rodrigues S, Clark A, Pham U, Hill HR, Ochs H, Aderem A, Liles WC.

Hum Immunol. 2005 Jul;66(7):842-7.


A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease.

Hawn TR, Verbon A, Lettinga KD, Zhao LP, Li SS, Laws RJ, Skerrett SJ, Beutler B, Schroeder L, Nachman A, Ozinsky A, Smith KD, Aderem A.

J Exp Med. 2003 Nov 17;198(10):1563-72.


Involvement of the AP-1 adaptor complex in early steps of phagocytosis and macropinocytosis.

Lefkir Y, Malbouyres M, Gotthardt D, Ozinsky A, Cornillon S, Bruckert F, Aderem AA, Soldati T, Cosson P, Letourneur F.

Mol Biol Cell. 2004 Feb;15(2):861-9. Epub 2003 Nov 14.


Differential role of MyD88 in macrophage-mediated responses to opportunistic fungal pathogens.

Marr KA, Balajee SA, Hawn TR, Ozinsky A, Pham U, Akira S, Aderem A, Liles WC.

Infect Immun. 2003 Sep;71(9):5280-6.


Pyogenic bacterial infections in humans with IRAK-4 deficiency.

Picard C, Puel A, Bonnet M, Ku CL, Bustamante J, Yang K, Soudais C, Dupuis S, Feinberg J, Fieschi C, Elbim C, Hitchcock R, Lammas D, Davies G, Al-Ghonaium A, Al-Rayes H, Al-Jumaah S, Al-Hajjar S, Al-Mohsen IZ, Frayha HH, Rucker R, Hawn TR, Aderem A, Tufenkeji H, Haraguchi S, Day NK, Good RA, Gougerot-Pocidalo MA, Ozinsky A, Casanova JL.

Science. 2003 Mar 28;299(5615):2076-9. Epub 2003 Mar 13.


Toll-like receptor-5 and the innate immune response to bacterial flagellin.

Smith KD, Ozinsky A.

Curr Top Microbiol Immunol. 2002;270:93-108. Review.


Leishmania major activates IL-1 alpha expression in macrophages through a MyD88-dependent pathway.

Hawn TR, Ozinsky A, Underhill DM, Buckner FS, Akira S, Aderem A.

Microbes Infect. 2002 Jul;4(8):763-71.


Phagocytosis of microbes: complexity in action.

Underhill DM, Ozinsky A.

Annu Rev Immunol. 2002;20:825-52. Epub 2001 Dec 7. Review.


Toll-like receptors: key mediators of microbe detection.

Underhill DM, Ozinsky A.

Curr Opin Immunol. 2002 Feb;14(1):103-10. Review.


Co-operative induction of pro-inflammatory signaling by Toll-like receptors.

Ozinsky A, Smith KD, Hume D, Underhill DM.

J Endotoxin Res. 2000;6(5):393-6.


The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5.

Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, Eng JK, Akira S, Underhill DM, Aderem A.

Nature. 2001 Apr 26;410(6832):1099-103.


Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism.

Werts C, Tapping RI, Mathison JC, Chuang TH, Kravchenko V, Saint Girons I, Haake DA, Godowski PJ, Hayashi F, Ozinsky A, Underhill DM, Kirschning CJ, Wagner H, Aderem A, Tobias PS, Ulevitch RJ.

Nat Immunol. 2001 Apr;2(4):346-52.


Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin.

Hajjar AM, O'Mahony DS, Ozinsky A, Underhill DM, Aderem A, Klebanoff SJ, Wilson CB.

J Immunol. 2001 Jan 1;166(1):15-9.


The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors.

Ozinsky A, Underhill DM, Fontenot JD, Hajjar AM, Smith KD, Wilson CB, Schroeder L, Aderem A.

Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13766-71.


Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages.

Underhill DM, Ozinsky A, Smith KD, Aderem A.

Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14459-63.


Isolation and characterization of monoclonal antibodies directed against novel components of macrophage phagosomes.

Morrissette NS, Gold ES, Guo J, Hamerman JA, Ozinsky A, Bedian V, Aderem AA.

J Cell Sci. 1999 Dec;112 ( Pt 24):4705-13.


The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens.

Underhill DM, Ozinsky A, Hajjar AM, Stevens A, Wilson CB, Bassetti M, Aderem A.

Nature. 1999 Oct 21;401(6755):811-5.


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