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Items: 1 to 50 of 434

1.

Epigenetic regulation of lipoprotein lipase gene via BRD4, which is potentially associated with adipocyte differentiation and insulin resistance.

Inoue T, Hariya N, Imamochi Y, Dey A, Ozato K, Goda T, Kubota T, Mochizuki K.

Eur J Pharmacol. 2019 Jun 21:172492. doi: 10.1016/j.ejphar.2019.172492. [Epub ahead of print]

PMID:
31233750
2.

IRF1 Maintains Optimal Constitutive Expression of Antiviral Genes and Regulates the Early Antiviral Response.

Panda D, Gjinaj E, Bachu M, Squire E, Novatt H, Ozato K, Rabin RL.

Front Immunol. 2019 May 15;10:1019. doi: 10.3389/fimmu.2019.01019. eCollection 2019.

3.

Macrophage centripetal migration drives spontaneous healing process after spinal cord injury.

Kobayakawa K, Ohkawa Y, Yoshizaki S, Tamaru T, Saito T, Kijima K, Yokota K, Hara M, Kubota K, Matsumoto Y, Harimaya K, Ozato K, Masuda T, Tsuda M, Tamura T, Inoue K, Edgerton VR, Iwamoto Y, Nakashima Y, Okada S.

Sci Adv. 2019 May 15;5(5):eaav5086. doi: 10.1126/sciadv.aav5086. eCollection 2019 May.

4.

BRD4 directs hematopoietic stem cell development and modulates macrophage inflammatory responses.

Dey A, Yang W, Gegonne A, Nishiyama A, Pan R, Yagi R, Grinberg A, Finkelman FD, Pfeifer K, Zhu J, Singer D, Zhu J, Ozato K.

EMBO J. 2019 Apr 1;38(7). pii: e100293. doi: 10.15252/embj.2018100293. Epub 2019 Mar 6.

5.

Inactivating Mutation in IRF8 Promotes Osteoclast Transcriptional Programs and Increases Susceptibility to Tooth Root Resorption.

Thumbigere-Math V, Foster BL, Bachu M, Yoshii H, Brooks SR, Coulter A, Chavez MB, Togi S, Neely AL, Deng Z, Mansky KC, Ozato K, Somerman MJ.

J Bone Miner Res. 2019 Mar 6. doi: 10.1002/jbmr.3690. [Epub ahead of print]

PMID:
30840779
6.

Epigenetic control of early dendritic cell lineage specification by the transcription factor IRF8 in mice.

Kurotaki D, Kawase W, Sasaki H, Nakabayashi J, Nishiyama A, Morse HC 3rd, Ozato K, Suzuki Y, Tamura T.

Blood. 2019 Apr 25;133(17):1803-1813. doi: 10.1182/blood-2018-06-857789. Epub 2019 Feb 22.

PMID:
30796024
7.

A versatile mouse model of epitope-tagged histone H3.3 to study epigenome dynamics.

Bachu M, Tamura T, Chen C, Narain A, Nehru V, Sarai N, Ghosh SB, Ghosh A, Kavarthapu R, Dufau ML, Ozato K.

J Biol Chem. 2019 Feb 8;294(6):1904-1914. doi: 10.1074/jbc.RA118.005550. Epub 2018 Dec 14.

PMID:
30552116
8.

An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion.

Klement JD, Paschall AV, Redd PS, Ibrahim ML, Lu C, Yang D, Celis E, Abrams SI, Ozato K, Liu K.

J Clin Invest. 2018 Dec 3;128(12):5549-5560. doi: 10.1172/JCI123360. Epub 2018 Nov 5.

9.

T follicular helper cells restricted by IRF8 contribute to T cell-mediated inflammation.

Zhang R, Qi CF, Hu Y, Shan Y, Hsieh YP, Xu F, Lu G, Dai J, Gupta M, Cui M, Peng L, Yang J, Xue Q, Chen-Liang R, Chen K, Zhang Y, Fung-Leung WP, Mora JR, Li L, Morse HC 3rd, Ozato K, Heeger PS, Xiong H.

J Autoimmun. 2019 Jan;96:113-122. doi: 10.1016/j.jaut.2018.09.001. Epub 2018 Sep 19.

PMID:
30241692
10.

Interferon stimulation creates chromatin marks and establishes transcriptional memory.

Kamada R, Yang W, Zhang Y, Patel MC, Yang Y, Ouda R, Dey A, Wakabayashi Y, Sakaguchi K, Fujita T, Tamura T, Zhu J, Ozato K.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9162-E9171. doi: 10.1073/pnas.1720930115. Epub 2018 Sep 10.

11.

Immature CD8 Single-Positive Thymocytes Are a Molecularly Distinct Subpopulation, Selectively Dependent on BRD4 for Their Differentiation.

Gegonne A, Chen QR, Dey A, Etzensperger R, Tai X, Singer A, Meerzaman D, Ozato K, Singer DS.

Cell Rep. 2018 Jul 3;24(1):117-129. doi: 10.1016/j.celrep.2018.06.007.

12.

Roles of Fc Domain and Exudation in L2 Antibody-Mediated Protection against Human Papillomavirus.

Wang JW, Wu WH, Huang TC, Wong M, Kwak K, Ozato K, Hung CF, Roden RBS.

J Virol. 2018 Jul 17;92(15). pii: e00572-18. doi: 10.1128/JVI.00572-18. Print 2018 Aug 1.

13.

SPT6 interacts with NSD2 and facilitates interferon-induced transcription.

Ouda R, Sarai N, Nehru V, Patel MC, Debrosse M, Bachu M, Chereji RV, Eriksson PR, Clark DJ, Ozato K.

FEBS Lett. 2018 May;592(10):1681-1692. doi: 10.1002/1873-3468.13069. Epub 2018 May 20.

14.

Microglia activation in Niemann-Pick disease, type C1 is amendable to therapeutic intervention.

Cougnoux A, Drummond RA, Collar AL, Iben JR, Salman A, Westgarth H, Wassif CA, Cawley NX, Farhat NY, Ozato K, Lionakis MS, Porter FD.

Hum Mol Genet. 2018 Jun 15;27(12):2076-2089. doi: 10.1093/hmg/ddy112.

15.

ZFR coordinates crosstalk between RNA decay and transcription in innate immunity.

Haque N, Ouda R, Chen C, Ozato K, Hogg JR.

Nat Commun. 2018 Mar 20;9(1):1145. doi: 10.1038/s41467-018-03326-5.

16.

Transcription Factor IRF8 Governs Enhancer Landscape Dynamics in Mononuclear Phagocyte Progenitors.

Kurotaki D, Nakabayashi J, Nishiyama A, Sasaki H, Kawase W, Kaneko N, Ochiai K, Igarashi K, Ozato K, Suzuki Y, Tamura T.

Cell Rep. 2018 Mar 6;22(10):2628-2641. doi: 10.1016/j.celrep.2018.02.048.

17.

Dysfunction of TRIM21 in interferon signature of systemic lupus erythematosus.

Kamiyama R, Yoshimi R, Takeno M, Iribe Y, Tsukahara T, Kishimoto D, Kunishita Y, Sugiyama Y, Tsuchida N, Nakano H, Minegishi K, Tamura M, Asami Y, Kirino Y, Ishigatsubo Y, Ozato K, Nakajima H.

Mod Rheumatol. 2018 Nov;28(6):993-1003. doi: 10.1080/14397595.2018.1436028. Epub 2018 Feb 23.

PMID:
29385873
18.

Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis.

Lee JE, Park YK, Park S, Jang Y, Waring N, Dey A, Ozato K, Lai B, Peng W, Ge K.

Nat Commun. 2017 Dec 20;8(1):2217. doi: 10.1038/s41467-017-02403-5.

19.

Chromatin remodeling: demethylating H3K4me3 of type I IFNs gene by Rbp2 through interacting with Piasy for transcriptional attenuation.

Yu X, Chen H, Zuo C, Jin X, Yin Y, Wang H, Jin M, Ozato K, Xu S.

FASEB J. 2018 Feb;32(2):552-567. doi: 10.1096/fj.201700088RR. Epub 2018 Jan 4.

20.

IRF-8 regulates expansion of myeloid-derived suppressor cells and Foxp3+ regulatory T cells and modulates Th2 immune responses to gastrointestinal nematode infection.

Valanparambil RM, Tam M, Gros PP, Auger JP, Segura M, Gros P, Jardim A, Geary TG, Ozato K, Stevenson MM.

PLoS Pathog. 2017 Oct 2;13(10):e1006647. doi: 10.1371/journal.ppat.1006647. eCollection 2017 Oct.

21.

BRD4 regulates adiponectin gene induction by recruiting the P-TEFb complex to the transcribed region of the gene.

Sakurai N, Inamochi Y, Inoue T, Hariya N, Kawamura M, Yamada M, Dey A, Nishiyama A, Kubota T, Ozato K, Goda T, Mochizuki K.

Sci Rep. 2017 Sep 20;7(1):11962. doi: 10.1038/s41598-017-12342-2.

22.

On the role of H3.3 in retroviral silencing.

Wolf G, Rebollo R, Karimi MM, Ewing AD, Kamada R, Wu W, Wu B, Bachu M, Ozato K, Faulkner GJ, Mager DL, Lorincz MC, Macfarlan TS.

Nature. 2017 Aug 2;548(7665):E1-E3. doi: 10.1038/nature23277. No abstract available.

23.

Erratum: BRD4 is a histone acetyltransferase that evicts nucleosomes from chromatin.

Devaiah BN, Case-Borden C, Gegonne A, Hsu CH, Chen Q, Meerzaman D, Dey A, Ozato K, Singer DS.

Nat Struct Mol Biol. 2017 Feb 6;24(2):194. doi: 10.1038/nsmb0217-194c. No abstract available.

PMID:
28169998
24.

Biallelic mutations in IRF8 impair human NK cell maturation and function.

Mace EM, Bigley V, Gunesch JT, Chinn IK, Angelo LS, Care MA, Maisuria S, Keller MD, Togi S, Watkin LB, LaRosa DF, Jhangiani SN, Muzny DM, Stray-Pedersen A, Coban Akdemir Z, Smith JB, Hernández-Sanabria M, Le DT, Hogg GD, Cao TN, Freud AG, Szymanski EP, Savic S, Collin M, Cant AJ, Gibbs RA, Holland SM, Caligiuri MA, Ozato K, Paust S, Doody GM, Lupski JR, Orange JS.

J Clin Invest. 2017 Jan 3;127(1):306-320. doi: 10.1172/JCI86276. Epub 2016 Nov 28.

25.

Smad4 is required to inhibit osteoclastogenesis and maintain bone mass.

Morita M, Yoshida S, Iwasaki R, Yasui T, Sato Y, Kobayashi T, Watanabe R, Oike T, Miyamoto K, Takami M, Ozato K, Deng CX, Aburatani H, Tanaka S, Yoshimura A, Toyama Y, Matsumoto M, Nakamura M, Kawana H, Nakagawa T, Miyamoto T.

Sci Rep. 2016 Oct 12;6:35221. doi: 10.1038/srep35221.

26.

Essential Requirement for IFN Regulatory Factor 7 in Autoantibody Production but Not Development of Nephritis in Murine Lupus.

Miyagawa F, Tagaya Y, Ozato K, Asada H.

J Immunol. 2016 Sep 15;197(6):2167-76. doi: 10.4049/jimmunol.1502445. Epub 2016 Aug 15.

27.

Chromatin Landscape of the IRF Genes and Role of the Epigenetic Reader BRD4.

Bachu M, Dey A, Ozato K.

J Interferon Cytokine Res. 2016 Jul;36(7):470-5. doi: 10.1089/jir.2015.0179. Review.

28.

Introduction to a Special Issue on IFN Regulatory Factors in Innate Immune Responses.

Ozato K.

J Interferon Cytokine Res. 2016 Jul;36(7):413. doi: 10.1089/jir.2016.29002.koz. No abstract available.

29.

Mysm1 is required for interferon regulatory factor expression in maintaining HSC quiescence and thymocyte development.

Huang XF, Nandakumar V, Tumurkhuu G, Wang T, Jiang X, Hong B, Jones L, Won H, Yoshii H, Ozato K, Masumi A, Chen SY.

Cell Death Dis. 2016 Jun 9;7(6):e2260. doi: 10.1038/cddis.2016.162.

30.

Transcription elongation factor Brd4-P-TEFb accelerates intestinal differentiation-associated SLC2A5 gene expression.

Inamochi Y, Dey A, Nishiyama A, Kubota T, Ozato K, Goda T, Mochizuki K.

Biochem Biophys Rep. 2016 Jun 1;7:150-156. doi: 10.1016/j.bbrep.2016.05.016. eCollection 2016 Sep.

31.

BRD4 is a histone acetyltransferase that evicts nucleosomes from chromatin.

Devaiah BN, Case-Borden C, Gegonne A, Hsu CH, Chen Q, Meerzaman D, Dey A, Ozato K, Singer DS.

Nat Struct Mol Biol. 2016 Jun;23(6):540-8. doi: 10.1038/nsmb.3228. Epub 2016 May 9. Erratum in: Nat Struct Mol Biol. 2017 Feb 6;24(2):194.

32.

Interferon Regulatory Factor 8 (IRF8) Impairs Induction of Interferon Induced with Tetratricopeptide Repeat Motif (IFIT) Gene Family Members.

White CL, Kessler PM, Dickerman BK, Ozato K, Sen GC.

J Biol Chem. 2016 Jun 24;291(26):13535-45. doi: 10.1074/jbc.M115.705467. Epub 2016 May 2.

33.

TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis.

Pan JA, Sun Y, Jiang YP, Bott AJ, Jaber N, Dou Z, Yang B, Chen JS, Catanzaro JM, Du C, Ding WX, Diaz-Meco MT, Moscat J, Ozato K, Lin RZ, Zong WX.

Mol Cell. 2016 Apr 7;62(1):149-51. doi: 10.1016/j.molcel.2016.03.015. No abstract available.

34.

TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis.

Pan JA, Sun Y, Jiang YP, Bott AJ, Jaber N, Dou Z, Yang B, Chen JS, Catanzaro JM, Du C, Ding WX, Diaz-Meco MT, Moscat J, Ozato K, Lin RZ, Zong WX.

Mol Cell. 2016 Mar 3;61(5):720-733. doi: 10.1016/j.molcel.2016.02.007. Erratum in: Mol Cell. 2016 Apr 7;62(1):149-51.

35.

Tripartite Motif (TRIM) 12c, a Mouse Homolog of TRIM5, Is a Ubiquitin Ligase That Stimulates Type I IFN and NF-κB Pathways along with TNFR-Associated Factor 6.

Chang TH, Yoshimi R, Ozato K.

J Immunol. 2015 Dec 1;195(11):5367-79. doi: 10.4049/jimmunol.1402064. Epub 2015 Oct 26.

36.

Mechanisms of immunity in post-exposure vaccination against Ebola virus infection.

Bradfute SB, Anthony SM, Stuthman KS, Ayithan N, Tailor P, Shaia CI, Bray M, Ozato K, Bavari S.

PLoS One. 2015 Mar 18;10(3):e0118434. doi: 10.1371/journal.pone.0118434. eCollection 2015.

37.

IRF8 directs stress-induced autophagy in macrophages and promotes clearance of Listeria monocytogenes.

Gupta M, Shin DM, Ramakrishna L, Goussetis DJ, Platanias LC, Xiong H, Morse HC 3rd, Ozato K.

Nat Commun. 2015 Mar 16;6:6379. doi: 10.1038/ncomms7379.

38.

Virus-like particles activate type I interferon pathways to facilitate post-exposure protection against Ebola virus infection.

Ayithan N, Bradfute SB, Anthony SM, Stuthman KS, Bavari S, Bray M, Ozato K.

PLoS One. 2015 Feb 26;10(2):e0118345. doi: 10.1371/journal.pone.0118345. eCollection 2015.

39.

IFN regulatory factor 8 represses GM-CSF expression in T cells to affect myeloid cell lineage differentiation.

Paschall AV, Zhang R, Qi CF, Bardhan K, Peng L, Lu G, Yang J, Merad M, McGaha T, Zhou G, Mellor A, Abrams SI, Morse HC 3rd, Ozato K, Xiong H, Liu K.

J Immunol. 2015 Mar 1;194(5):2369-79. doi: 10.4049/jimmunol.1402412. Epub 2015 Feb 2.

40.

A dual cis-regulatory code links IRF8 to constitutive and inducible gene expression in macrophages.

Mancino A, Termanini A, Barozzi I, Ghisletti S, Ostuni R, Prosperini E, Ozato K, Natoli G.

Genes Dev. 2015 Feb 15;29(4):394-408. doi: 10.1101/gad.257592.114. Epub 2015 Jan 30.

41.

Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells.

Sasaki H, Kurotaki D, Osato N, Sato H, Sasaki I, Koizumi S, Wang H, Kaneda C, Nishiyama A, Kaisho T, Aburatani H, Morse HC 3rd, Ozato K, Tamura T.

Blood. 2015 Jan 8;125(2):358-69. doi: 10.1182/blood-2014-02-557983. Epub 2014 Nov 14.

42.

BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones.

Kanno T, Kanno Y, LeRoy G, Campos E, Sun HW, Brooks SR, Vahedi G, Heightman TD, Garcia BA, Reinberg D, Siebenlist U, O'Shea JJ, Ozato K.

Nat Struct Mol Biol. 2014 Dec;21(12):1047-57. doi: 10.1038/nsmb.2912. Epub 2014 Nov 10.

43.

IRF8 inhibits C/EBPα activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils.

Kurotaki D, Yamamoto M, Nishiyama A, Uno K, Ban T, Ichino M, Sasaki H, Matsunaga S, Yoshinari M, Ryo A, Nakazawa M, Ozato K, Tamura T.

Nat Commun. 2014 Sep 19;5:4978. doi: 10.1038/ncomms5978.

PMID:
25236377
44.

A reporter mouse reveals lineage-specific and heterogeneous expression of IRF8 during lymphoid and myeloid cell differentiation.

Wang H, Yan M, Sun J, Jain S, Yoshimi R, Abolfath SM, Ozato K, Coleman WG Jr, Ng AP, Metcalf D, DiRago L, Nutt SL, Morse HC 3rd.

J Immunol. 2014 Aug 15;193(4):1766-77. doi: 10.4049/jimmunol.1301939. Epub 2014 Jul 14. Erratum in: J Immunol. 2014 Nov 1;193(9):4749.

45.

The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation.

Yoshida Y, Yoshimi R, Yoshii H, Kim D, Dey A, Xiong H, Munasinghe J, Yazawa I, O'Donovan MJ, Maximova OA, Sharma S, Zhu J, Wang H, Morse HC 3rd, Ozato K.

Immunity. 2014 Feb 20;40(2):187-98. doi: 10.1016/j.immuni.2013.11.022. Epub 2014 Jan 30.

46.

BRD4 short isoform interacts with RRP1B, SIPA1 and components of the LINC complex at the inner face of the nuclear membrane.

Alsarraj J, Faraji F, Geiger TR, Mattaini KR, Williams M, Wu J, Ha NH, Merlino T, Walker RC, Bosley AD, Xiao Z, Andresson T, Esposito D, Smithers N, Lugo D, Prinjha R, Day A, Crawford NP, Ozato K, Gardner K, Hunter KW.

PLoS One. 2013 Nov 19;8(11):e80746. doi: 10.1371/journal.pone.0080746. eCollection 2013.

47.

Batf3 and Id2 have a synergistic effect on Irf8-directed classical CD8α+ dendritic cell development.

Jaiswal H, Kaushik M, Sougrat R, Gupta M, Dey A, Verma R, Ozato K, Tailor P.

J Immunol. 2013 Dec 15;191(12):5993-6001. doi: 10.4049/jimmunol.1203541. Epub 2013 Nov 13.

48.

Ebola virus-like particles stimulate type I interferons and proinflammatory cytokine expression through the toll-like receptor and interferon signaling pathways.

Ayithan N, Bradfute SB, Anthony SM, Stuthman KS, Dye JM, Bavari S, Bray M, Ozato K.

J Interferon Cytokine Res. 2014 Feb;34(2):79-89. doi: 10.1089/jir.2013.0035. Epub 2013 Oct 8.

49.

Cooperation of TLR12 and TLR11 in the IRF8-dependent IL-12 response to Toxoplasma gondii profilin.

Raetz M, Kibardin A, Sturge CR, Pifer R, Li H, Burstein E, Ozato K, Larin S, Yarovinsky F.

J Immunol. 2013 Nov 1;191(9):4818-27. doi: 10.4049/jimmunol.1301301. Epub 2013 Sep 27.

50.

WHSC1 links transcription elongation to HIRA-mediated histone H3.3 deposition.

Sarai N, Nimura K, Tamura T, Kanno T, Patel MC, Heightman TD, Ura K, Ozato K.

EMBO J. 2013 Aug 28;32(17):2392-406. doi: 10.1038/emboj.2013.176. Epub 2013 Aug 6.

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